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| 1 | Role of Epstein-Barr Virus Encoded Latent Membrane Protein 1 in the Carcinogenesis of Nasopharyngeal Carcinoma显示文摘Epstein-Barr virus (EBV)-encoded latent membrane protein 1 (LMP1) has been known to have oncogenic properties during latent infection in nasopharyngeal carcinoma (NPC). Our studies focused on the role of LMP1 in NPC, and showed that LMP1 triggers the NF-κB, AP-1 and STAT signaling pathways. Strikingly, LMP1 was found to mediate the formation of a new heterodimer between c-Jun and JunB. Also, we have identified JAK/STAT and PI-PLC-PKC activation triggered by LMP1 through upregulating the expression of JAK3 and enhancing the phosphorylation of STAT. The constitutive activation of these signaling cascades explains LMP1’s ability to induce such a diverse array of morphological and phenotypic effects in cells and provides insight into how LMP1 may induce cell transformation, in which multihit targeted genes in the downstream play an essential role. All signaling cascades triggered by LMP1 ultimately lead to the disruption of the cell cycle: the acceleration of G1/S phase and the arrest of G2/M phase. We also found that LMP1 induced the expression of hTERT and promoted cell immortalization. Importantly, by intervening physical intracellular signal transduction pathways and disturbing the progression of the cell cycle, LMP1, an important oncoprotein encoded by EBV, is thought to be a key modulator in the pathogenesis of NPC. Interfering LMP1 signaling could be a promising strategy to target the malignant phenotype of NPC. | Hui Zheng Lili Li Duosha Hu Xiyun Deng Ya Cao | 2007 | Cellular & Molecular Immunology2007，4，3： | 34 |
| 2 | Factor Analysis on the Factors that Influencing Rural Environmental Pollution in the Hilly Area of Sichuan Province,China显示文摘By using factor analysis method and establishing analysis indicator system from four aspects including crop production,poultry farming,rural life and township enterprises,the difference,features,and types of factors influencing the rural environmental pollution in the hilly area in Sichuan Province,China.Results prove that the major factor influencing rural environmental pollution in the study area is livestock and poultry breeding,flowed by crop planting,rural life,and township enterprises.Hence future pollution prevention and control should set about from livestock and poultry breeding.Meanwhile,attention should be paid to the prevention and control of rural environmental pollution caused by rural life and township enterprise production. | LING Jing1,2,DENG Liang-ji1,2 1.School of Resource and Environment,Sichuan Agricultural University,Ya’an 625014,China 2.Key Laboratory of Land Information in Sichuan Province,Ya’an 625014,China | 2011 | Asian Agricultural Research2011，3，2： | 13 |
| 3 | MicroTom Metabolic Network: Rewiring Tomato Metabolic Regulatory Network throughout the Growth Cycle显示文摘Tomato(Solanum lycopersicum)is a major horticultural crop worldwide and has emerged as a preeminent model for metabolic research.Although many research efforts have focused on the analysis of metabolite differences between varieties and species,the dynamics of metabolic changes during the tomato growth cycle and the regulatory networks that underlie these changes are poorly understood.In this study,we integrated high-resolution spatio-temporal metabolome and transcriptome data to systematically explore the metabolic landscape across 20 major tomato tissues and growth stages.In the resulting MicroTom Metabolic Network,the 540 detected metabolites and their co-expressed genes could be divided into 10 distinct clusters based on their biological functions.Using this dataset,we constructed a global map of the major metabolic changes that occur throughout the tomato growth cycle and dissected the underlying regulatory network.In addition to verifying previously well-established regulatory networks for important metabolites,we identified novel transcription factors that regulate the biosynthesis of important secondary metabolites such as steroidal glycoalkaloids and flavonoids.Our findings provide insights into spatiotemporal changes in tomato metabolism and generate a valuable resource for the study of metabolic regulatory processes in model plants. | Yan Li Yang Chen Lu Zhou Shengjie You Heng Deng Ya Chen Saleh Alseekh Yong Yuan Rao Fu Zixin Zhang Dan Su Alisdair R.Fernie Mondher Bouzayen Tao Ma Mingchun Liu Yang Zhang | 2020 | Molecular Plant2020，13，8： | 10 |
| 4 | BRAF^(V600E) vs. TIRADS in predicting papillary thyroid cancers in Bethesda system Ⅰ, Ⅲ, and Ⅴ nodules显示文摘Objective: Bethesda System for Reporting Thyroid Cytopathology(BSRTC) categories Ⅰ, Ⅲ, and Ⅴaccount for a significant proportion of fine needle aspiration cytology(FNAC) diagnoses. This study aimed to compare the diagnostic efficacy of BRAF^(V600E) mutation and the Thyroid Imaging Reporting and Data System(TIRADS) classification in differentiating papillary thyroid cancers(PTCs) from benign lesions among BSRTC I, III, and V nodules.Methods: A total of 472 patients with 479 nodules were enrolled in this prospective study. Ultrasound, BRAF^(V600E) mutation testing, and FNAC were performed in each nodule, followed by surgery or regular ultrasound examination.Results: In the BSRTC I category, BRAF^(V600E) showed similar sensitivity, higher specificity, and lower accuracy when compared with TIRADS. In the BSRTC III/V category, the sensitivity, specificity, and accuracy of BRAF^(V600E) were similar to those of TIRADS. In comparison to BRAF^(V600E) alone, the combination of the two methods significantly improved sensitivity(BSRTC Ⅰ:93.6% vs. 67.7%, P < 0.01; BSRTC Ⅲ: 93.8% vs. 75.0%, P < 0.01; BSRTC V: 96.0% vs. 85.3%, P < 0.001). When compared with TIRADS alone, the combination improved sensitivity in BSRTC Ⅰ nodules(93.6% vs. 74.2%, P < 0.05), increased sensitivity and decreased accuracy in BSRTC III nodules(93.8% vs. 75.0%, P < 0.01, 91.0% vs. 93.6%, P < 0.01), and improved both sensitivity and accuracy in BSRTC V nodules(96.0% vs. 82.0%, P < 0.001; 94.2% vs. 81.3%, P < 0.001).Conclusions: BRAF^(V600E) exhibited higher specificity and lower accuracy compared with TIRADS in BSRTC Ⅰ nodules, while the two methods showed similar diagnostic value in BSRTC Ⅲ/Ⅴ nodules. The combination of the two methods distinctly improved sensitivity in the diagnosis of PTCs in BSRTC Ⅰ, Ⅲ, and Ⅴ nodules. | Ya Wu Ting Xu Xingyue Cao Xin Zhao Hongyan Deng Jianxiang Wang Xiao Li Qing Yao Xinhua Ye Meiping Shen Xiaohong Wu | 2019 | Cancer Biology & Medicine2019，16，1： | 9 |
| 5 | The Lyman-alpha Solar Telescope(LST) for the ASO-S mission——Ⅱ. design of LST显示文摘As one of the three payloads for the Advanced Space-based Solar Observatory(ASO-S)mission,the Lyman-alpha(Lyα)Solar Telescope(LST)is composed of three instruments:a Solar Corona Imager(SCI),a LyαSolar Disk Imager(SDI)and a full-disk White-light Solar Telescope(WST).When working in-orbit,LST will simultaneously perform high-resolution imaging observations of all regions from the solar disk to the inner corona up to 2.5 R⊙(R⊙stands for the mean solar radius)with a spatial resolution of 4.8′′and 1.2′′for coronal and disk observations,respectively,and a temporal resolution of 30–120 s and 1–120 s for coronal and disk observations,respectively.The maximum exposure time can be up to20 s due to precise pointing and image stabilization function.Among the three telescopes of LST,SCI is a dual-waveband coronagraph simultaneously and independently observing the inner corona in the HI Lyα(121.6±10 nm)line and white light(WL)(700±40 nm)wavebands by using a narrowband Lyαbeam splitter and has a field of view(FOV)from 1.1 to 2.5 R⊙.The stray-light suppression level can attain<10^-6 B⊙(B⊙is the mean brightness of the solar disk)at 1.1 R⊙and≤5×10^-8 B⊙at 2.5 R⊙.SDI and WST are solar disk imagers working in the Lyαline and 360.0 nm wavebands,respectively,which adopt an off-axis two-mirror reflective structure with an FOV up to 1.2 R⊙,covering the inner coronal edge area and relating to coronal imaging.We present the up-to-date design for the LST payload. | Bo Chen Hui Li Ke-Fei Song Quan-Feng Guo Pei-Jie Zhang Ling-Ping He Shuang Dai Xiao-Dong Wang Hai-Feng Wang Chun-Long Liu Hong-Ji Zhang Guang Zhang Yunqi Wang Shi-Jie Liu Hong-Xin Zhang Lei Liu Shi-Lei Mao Yang Liu Jia-Hao Peng Peng Wang Liang Sun Yang Liu Zhen-Wei Han Yan-Long Wang Kun Wu Guang-Xing Ding Peng Zhou Xin Zheng Ming-Yi Xia Qing-Wen Wu Jin-Jiang Xie Ya Chen Shu-Mei Song Hong Wang Bo Zhu Chang-Bo Chu Wen-Gang Yang Li Feng Yu Huang Wei-Qun Gan Ying Li Jing-Wei Li Lei Lu Jian-Chao Xue Bei-Li Ying Ming-Zhe Sun Cheng Zhu Wei-Min Bao Lei Deng Zeng-Shan Yin | 2019 | Research in Astronomy and Astrophysics2019，19，11： | 6 |
| 6 | The Quantitative Analysis of Land Use Structure Characteristics of County in Mountainous Areas in Sichuan Province of China——A Case Study of Rong County显示文摘Based on the data concerning detailed survey on land in the year 2009 and land change in the year 2010 in Rong County,a mountainous region of Sichuan Province,by using quantitative geographical model,we conduct quantitative analysis of the status quo of land use in Rong County in terms of land use diversification,land use centralization,land use combination type,land use geographic significance and comprehensive use degree of land use.The results show some characteristics as follows.Firstly,land use in study area displays prominent characteristic of diversification;there is a high degree of completeness land use type;there is a great similarity among towns.Secondly,there is limited combination number of land use type;mostly the combination number of the towns is 2-3;the holistic function of regional land is fragile;the proportion of farmland areas is big,reaching 40.09%;the land use type of 21 towns is farmland.Thirdly,the towns with prominent characteristic of diversification of land use in Rong County,have low degree of centralization of land use and relatively big combination number of land use type,and vice versa.Fourthly,the type and quantity of agricultural land resources with geographical significance are relatively complete with nothing missing;it abounds in untapped land,but the overall index values of land use are all smaller than 300,with low overall use degree of land. | ZHOU Wei1,2,WANG Chen1,2,SONG Xing1,2,DENG Liang-ji1,2 1.College of Resource and Environment,Sichuan Agricultural University,Ya’an 625014,China 2.Key Laboratory of Land Information in Sichuan Province,Ya’an 625014,China | 2011 | Asian Agricultural Research2011，3，5： | 6 |
| 7 | Cells in G_2/M phase increased in human nasopharyngeal carcinoma cell line by EBV-LMP1 through activation of NF-кB and AP-1显示文摘Although previous studies showed that the principal oncoprotein encoded by Epstein-Barr virus, latent membrane protein 1 (LMP1), could induce the nasopharyngeal carcinoma cells in G2/M phase increased, littleis known about the target molecules and mechanisms. The present study demonstrated that LMP1 couldinduce the accumulation of p53 protein and upregulate its transactivity in a dose dependent manner, whichresulted in the decrease of the kinase activity of cdc2/cyclin B complex and inducing arrest at G2/M phasethrough the activation of NF-kB and AP-1 signaling pathways, and the effect of NF-kB was more obviousthan that of AP-1. This study provided some significant evidence for further elucidating the molecular mechanisms that LMP1 had effects on the surveillance mechanism of cell cycle and promoting the survivalof transformed cells and tumorigenesis. | LIN DENG,JING YANG,XIAO RONG ZHAO,XI YUN DENG,LIANG ZENG,HUAN HUA GU,MIN TANG,YA CAOCancer Research Institute,Xiangya School of Medicine,Central South University,Xiangya Road 88,Chang-sha,Hunan 410078,China | 2003 | Cell Research2003，13，3： | 5 |
| 8 | Comparisons of nozzle orifice processing methods using synchrotron X-ray micro-tomography显示文摘Based on the high flux synchrotron X-ray of the Shanghai Synchrotron Radiation Facility (SSRF), high precision 3D digital models of diesel nozzle tips have been established by X-ray micro-tomography technology, which reveal the internal surfaces and structures of orifices. To analyze the machining precision and characteristics of orifice processing methods, an ap- proach is presented based on the parameters of the internal structures of nozzle orifices, including the nozzle diameter, the orifice inner surface waviness, the eccentricity distance and the angle between orifices. Using this approach, two kinds of nozzle orifice processing methods, computerized numerical control drilling and electric discharge machining, have been studied and compared. The results show that this approach enables a simple, direct, and comprehensive contrastive analysis of nozzle orifice processing methods. When processing a single orifice, the electric discharge machining method has obvious advantages. However, when there are multiple orifices, the error levels of the two methods are similar in relation to the symmetry of distribution of the orifices. | Zhi-jun WU Zhi-long LI Wei-di HUANG Hui-feng GONG Ya GAO Jun DENG Zong-jie HU | 2012 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2012，13，3： | 4 |
| 9 | The microarray analysis for gene expression in haploids and diploids derived from twin-seedling rice显示文摘In this study, microarray technique was employed to analyze the gene expression at the RNA level between haploids and corresponding diploids derived from a rice twin-seedling line SARII-628. Differ- ent degrees of expression variations were observed in the plant after haploidization. The main results are as follows: (1) after haploidization, the ratio of the sensitive loci was 2.47% of the total loci designed on chip. Those loci were randomly distributed on the 12 pairs of rice chromosomes and the activated loci were more than the silenced ones. (2) Gene clusters on chromosome were observed for 33 se- quences. (3) GoPipe function classification for 575 sensitive loci revealed an involvement in the bio- logical process, cell component and molecular function. (4) RT-PCR generally validated the result from microarray with a coincidence rate of 83.78%. And for the randomly-selected activated or silenced loci in chip analysis, the coincidence rate was up to 91.86%. | ZHANG HongYu1,3, PENG Hai2*, LI PingChuan1, DENG QiMing1, XU PeiZhou1, LI Yun4, WANG XuDong1 & WU XianJun1,3 1 Rice Research Institute of Sichuan Agricultural University, Chengdu 611130, China 2 Laboratory of Germplasm and Genetics, College of Life Science, Jianghan University, Wuhan 430056, China 3 Key Laboratory of Southwest Crop Genetic Resources and Improvement, Ministry of Education, Sichuan Agricultural University, Ya′an 620514, China 4 Crop Research Institute of Agricultural and Forestal Science Academy of Chengdu, Chengdu 611130, China | 2008 | Science China(Life Sciences)2008，51，6： | 4 |
| 10 | Nanoprobes for super-resolution fluorescence imaging at the nanoscale显示文摘Compared with other imaging techniques,fluorescence microscopy has become an essential tool to study cell biology due to its high compatibility with living cells.Owing to the resolution limit set by the diffraction of light,fluorescence microscopy could not resolve the nanostructures in the range of<200 nm.Recently,many techniques have been emerged to overcome the diffraction barrier,providing nanometer spatial resolution.In the course of development,the progress in fluorescent probes has helped to promote the development of the high-resolution fluorescence nanoscopy.Here,we describe the contributions of the fluorescent probes to far-field super resolution imaging,focusing on concepts of the existing super-resolution nanoscopy based on the photophysics of fluorescent nanoprobes,like photoswitching,bleaching and blinking.Fluorescent probe technology is crucial in the design and implementation of super-resolution imaging methods. | HOU ShangGuo LIANG Le DENG SuHui CHEN JianFang HUANG Qing CHENG Ya FAN ChunHai | 2014 | Science China Chemistry2014，57，1： | 4 |
| 11 | Evodiamine activates cellular apoptosis through suppressing PI3K/AKT and activating MAPK in glioma显示文摘OBJECTIVE Glioblastoma multiforme(GBM) is the most malignant primary tumor of the central nervous system and is associated with a very poor prognosis.No further improvements in outcomes have been reported since radiotherapy-temozolomide therapy was introduced.Therefore,de.veloping new agents to treat GBM is important.This study aimed to evaluate the anti-tumor effect of evodiamine(Evo) on GBM cells,and to determine the underlying mechanisms involved.METHODS U251,LN229,HEB and PC12 cells were treated with various concentrations of evodiamine for 24 and48 hours,cell viability was measured by MTT assay.The U251 and LN229 cells were treated with evo.diamine(0-10 μmol·L^(-1)) for 24 h,and then stained with Hoechst 33258.An Annexin V-FITC Apoptosis Detection Kit was used to detect apoptosis in the cells.Reactive oxygen species(ROS) production was detected using dichlorofluorescein diacetate(DCFH-DA) staining.The changes in mitochondrial mem.brane potential(MMP) were assessed by JC-1 after cells were treated with evodiamine.The expres.sion levels of p-PI3K,PI3K,p-Akt,Akt,Bax,Bcl-2,p-p38,p38,p-JNK,JNK,p-ERK,ERK,Cytochrome c,Caspase-3,cleaved Caspase-3,PRAP,and cleaved PARP were measured by Western blot analy.ses.RESULTS According to MTT assay results,Evo significantly inhibited the cell proliferation in a time-and dose-dependent manner.Fluorescence microscopy and flow cytometry analyses revealed that Evo induced cell apoptosis in a concentration-dependent manner.Moreover,Evo induced reactive oxygen species(ROS) production and mitochondrial membrane potential(MMP) disruption.Finally,Evo induced apoptosis in cancer cells by suppressing PI3K/AKT signaling and inducing MAPK phos.phorylation(p38 and JNK,but not ERK) to regulate apoptotic proteins(Bax,Bcl-2,Cytochrome c,Cas.pase-3,and PARP).CONCLUSION In summary,Evo inhibits cell proliferation by inducing cellular apoptosis via suppressing PI3K/AKT and activating MAPK in GBM;these results indicate that Evo may be regarded as a new approach for GBM treatment. | Feng ZHI Rong WANG Dan-hi DENG Nai-yuan SHAO Yuan XU Lian XUE Ya PENG Ya-tian LIU | 2018 | 中国药理学与毒理学杂志2018，32，4： | 4 |
| 12 | Electro-optic tuning of a single-frequencyultranarrow linewidth microdisk laser显示文摘Single-frequency ultranarrow linewidth on-chip microlasers with a fast wavelength tunability play a game-changing role in a broad spectrum of applications ranging from coherent communication,light detection and ranging,to metrology and sensing.Design and fabrication of such light sources remain a challenge due to the difficulties in making a laser cavity that has an ultrahigh optical quality(Q)factor and supports only a single lasing frequency simultaneously.Here,we demonstrate a unique single-frequency ultranarrow linewidth lasing mechanism on an erbium ion-doped lithium niobate(LN)microdisk through simultaneous excitation of high-Q polygon modes at both pump and laser wavelengths.As the polygon modes are sparse within the optical gain bandwidth compared with the whispering gallery mode counterpart,while their Q factors(above 10 million)are even higher due to the significantly reduced scattering on their propagation paths,single-frequency lasing with a linewidth as narrow as 322 Hz is observed.The measured linewidth is three orders of magnitude narrower than the previous record in on-chip LN microlasers.Finally,enabled by the strong linear electro-optic effect of LN,real-time electro-optical tuning of the microlaser with a high tuning efficiency of∼50 pm∕100 V is demonstrated. | Jintian Lin Saeed Farajollahi Zhiwei Fang Ni Yao Renhong Gao Jianglin Guan Li Deng Tao Lu Min Wang Haisu Zhang Wei Fang Lingling Qiao Ya Cheng | 2022 | Advanced Photonics2022，4，3： | 4 |
| 13 | Preparation and performance of lipophilic α-zirconium phosphate with high thermal stability and its application in thermal-plastic polymers显示文摘To prepare lipophilic α-zirconium phosphate with high grafting ratio and thermal stability(OZrP-HT) and explore its potential application in thermal-plastic polymers,a novel method was developed by surface lipophilicity enhancement strategy.The commercial a-zirconium phosphate(a-ZrP) was pre-intercalated by n-propylamine(PA) and grafted by silane coupling agents.Then the pre-intercalated PA was removed by heattreatment,and the obtained OZrP-HT was utilized to fabricate the phosphorous-containing polyester(P-co-PET)/OZrP-HT nanocomposites by melt-blending method.The prepared OZrP-HT and P-co-PET/OZrP-HT nanocomposites were characterized by Wide Angle X-ray Diffraction(WAXD),Fourier Transform Infrared Spectroscopy(FTIR),Thermogravimetric Analysis(TGA),Transmission Electron Microscope(TEM),etc.The results show that OZrP-HT with high grafting ratio(13.78 wt%) and thermal stability(T_(onset)= 368℃) was successfully prepared via this novel method and was uniformly intercalated by P-co-PET molecular chains.OZrP-HT had no significant effect on the fiber processability of P-co-PET polymer,and flame retardant properties of(P-co-PET)/OZrP-HT nanocomposites were improved.This method may be suitable for organic modification of general inorganic layered compounds and could extend the potential applications in thermo-plastic polymers. | Ya Du Feng Deng Xiaoze Jiang Huquan Ji Dan Yu Wei Wang Bin Sun Meifang Zhu | 2015 | Progress in Natural Science:Materials International2015，25，5： | 3 |
| 14 | The effect of polymerization conditions on crystalline of polybutene-1 catalyzed by metallocene catalyst显示文摘Polybutene-1 was synthesized stereoselectively with the precursorη5-(pentamethyl-cyclopentadienyl) tribenzyloxide titanium (Cp*Ti(OBz)3) and methylaluminoxane (MAO). The effects of polymerization conditions, trimethyl alumina (TMA) content in MAO and temperature on the crystalline and molecular weight of the products, and catalytic activity were investigated. The structural properties of the polybutene-1 were characterized with 13C NMR and WAXD. | Qi Gu Huang Ya Ping Sheng Kun Xue Deng Li Fu Ma Yi Xian Wu Wan Tai Yang | 2007 | Chinese Chemical Letters2007，18，2： | 3 |
| 15 | Single nucleotide polymorphisms in chicken lmbr1 gene were associated with chicken growth and carcass traits显示文摘Lmbr1 is the key candidate gene controlling vertebrate limb development, but its effects on animal growth and carcass traits have never been reported. In this experiment, lmbr1 was taken as the candi-date gene affecting chicken growth and carcass traits. T/C and G/A mutations located in exon 16 and one A/C mutation located in intron 5 of chicken lmbr1 were detected from Silky, White Plymouth Rock broilers and their F2 crossing chickens by PCR-SSCP and sequencing methods. The analysis of vari-ance (ANOVA) results suggests that T/C polymorphism of exon 16 had significant association with eviscerated yield rate (EYR), gizzard rate (GR), shank and claw rate (SCR) and shank girth (SG); A/C polymorphism of intron 5 was significantly associated with SCR, liver rate and head-neck weight (HNW), while both sites had no significant association with other growth and carcass traits. These results demonstrate that lmbr1 gene could be a genetic locus or linked to a major gene significantly affecting these growth and carcass traits in chicken. | HUANG YanQun1,2,3, DU XiaoHui2, DENG XueMei4, QIU XiangPin2, WANG ChunKao4, CHEN Wen3, LI Ning1 & WU ChangXin4 1 State Key Laboratory for Agrobiotechnology, China Agricultural University, Beijing 100094, China 2 College of Animal Science, Sichuan Agricultural University, Ya’an 625014, China 3 College of Animal Husbandry and Veterinary, Henan Agricultural University, Zhengzhou 450002, China 4 College of Animal Science and Technology, China Agricultural University, Beijing 100094, China | 2007 | Science China(Life Sciences)2007，50，1： | 3 |
| 16 | Diagnostic value of fecal occult blood testing for screening colorectal cancer显示文摘DiagnosticvalueoffecaloccultbloodtestingforscreeningcolorectalcancerCHENKun1,JIAODengAo1,ZHENGShu2,ZHOULun2,YUHai2,YUANYaC... | CHEN Kun 1, JIAO Deng Ao 1, ZHENG Shu 2, ZHOU Lun 2, YU Hai 2, YUAN Ya Chang 3, YAO Kai Yan 3, MA Xing Yuan 3 and ZHANG Yang 1 | 1997 | World Journal of Gastroenterology1997，3，3： | 3 |
| 17 | Synthesis of biodegradable waterborne phosphatidylcholine polyurethanes for soft tissue engineering applications显示文摘To further improve the biocompatibility of polyurethanes,a new lysine 2-(2-aminoethoxy)ethanol phosphatidylcholine(LAPC)is synthesized to use as chain extender for preparing a series of phosphatidylcholine polyurethanes(PCPUs).Poly(e-caprolactone)(PCL)and poly(ethylene glycol)(PEG)are used as soft segments,and L-lysine ethyl ester diisocyanate(LDI),LAPC and L-lysine are used as hard segments.The obtained PCPUs exhibit appropriate mechanical properties with break elongation of 1000–1700%,tensile strength of 7–22 MPa,and relatively high elastic modulus of 11–18 MPa,which could admirably satisfy the requirement for soft tissue engineering scaffolds.The phosphatidylcholine structures can increase the hydrophilicity of PCPU surfaces,which effectively reduce protein adsorption and platelet adhesion while promoting the cell proliferation.In addition,the LAPC chain extender,PCPU films and ultimate degradation products of PCPUs are proved to be nontoxic in cytotoxicity test.More interestingly,the cytokine release test of macrophages manifests that both LAPC and PCPU degradation products could effectively improve the proliferation of macrophages and induce them into a wound-healing phenotype.Thus,the obtained PCPUs have greatly potential applications of soft tissue engineering scaffolds for tissue repair and wound healing. | Hongye Hao Ya Deng Yingke Wu Siyuan Liu Weiwei Lin Jiehua Li Feng Luo | 2017 | Regenerative Biomaterials2017，4，2： | 3 |
| 18 | State-chain sequential feedback reinforcement learning for path planning of autonomous mobile robots显示文摘This paper deals with a new approach based on Q-learning for solving the problem of mobile robot path planning in complex unknown static environments.As a computational approach to learning through interaction with the environment,reinforcement learning algorithms have been widely used for intelligent robot control,especially in the field of autonomous mobile robots.However,the learning process is slow and cumbersome.For practical applications,rapid rates of convergence are required.Aiming at the problem of slow convergence and long learning time for Q-learning based mobile robot path planning,a state-chain sequential feedback Q-learning algorithm is proposed for quickly searching for the optimal path of mobile robots in complex unknown static environments.The state chain is built during the searching process.After one action is chosen and the reward is received,the Q-values of the state-action pairs on the previously built state chain are sequentially updated with one-step Q-learning.With the increasing number of Q-values updated after one action,the number of actual steps for convergence decreases and thus,the learning time decreases,where a step is a state transition.Extensive simulations validate the efficiency of the newly proposed approach for mobile robot path planning in complex environments.The results show that the new approach has a high convergence speed and that the robot can find the collision-free optimal path in complex unknown static environments with much shorter time,compared with the one-step Q-learning algorithm and the Q(λ)-learning algorithm. | Xin MA Ya XU Guo-qiang SUN Li-xia DENG Yi-bin LI | 2013 | Journal of Zhejiang University-Science C(Computers and Electronics)2013，14，3： | 3 |
| 19 | The MING proposal at SHINE:megahertz cavity enhanced X‑ray generation显示文摘The cavity-based X-ray free-electron laser(XFEL)has promise in producing fully coherent pulses with a bandwidth of a few meV and very stable intensity,whereas the currently existing self-amplified spontaneous emission(SASE)XFEL is capable of generating ultra-short pulses with chaotic spectra.In general,a cavity-based XFEL can provide a spectral brightness three orders of magnitude higher than that of the SASE mode,thereby opening a new door for cutting-edge scientific research.With the development of superconducting MHz repetition-rate XFEL facilities such as FLASH,European-XFEL,LCLS-II,and SHINE,practical cavity-based XFEL operations are becoming increasingly achievable.In this study,megahertz cavity enhanced X-ray generation(MING)is proposed based on China’s first hard XFEL facility-SHINE,which we refer to as MING@SHINE. | Nan‑Shun Huang Zi‑Peng Liu Bang‑Jie Deng Zi‑Han Zhu Shao‑Hua Li Tao Liu Zheng Qi Jia‑Wei Yan Wei Zhang Sheng‑Wang Xiang Yang‑Yang Lei Ya Zhu Yong‑Zhou He Qi‑Bing Yuan Fei Gao Rong‑Bing Deng Sen Sun Zhi‑Di Lei Zhi‑Qiang Jiang Meng‑Qi Duan Yuan Zhuan Xue‑Fang Huang Peng‑Cheng Dong Zhong‑Liang Li Shang‑Yu Si Lian Xue Si Chen Yong‑Fang Liu Ya‑Jun Tong Hai‑Xiao Deng Zhen‑Tang Zhao | 2023 | Nuclear Science and Techniques2023，34，1： | 2 |
| 20 | Inverted U-Shaped Associations between Glycemic Indices and Serum Uric Acid Levels in the General Chinese Population:Findings from the China Cardiometabolic Disease and Cancer Cohort(4C)Study显示文摘Objective The relationship between serum uric acid(SUA)levels and glycemic indices,including plasma glucose(FPG),2-hour postload glucose(2 h-PG),and glycated hemoglobin(HbA1 c),remains inconclusive.We aimed to explore the associations between glycemic indices and SUA levels in the general Chinese population.Methods The current study was a cross-sectional analysis using the first follow-up survey data from The China Cardiometabolic Disease and Cancer Cohort Study.A total of 105,922 community-dwelling adults aged≥40 years underwent the oral glucose tolerance test and uric acid assessment.The nonlinear relationships between glycemic indices and SUA levels were explored using generalized additive models.Results A total of 30,941 men and 62,361 women were eligible for the current analysis.Generalized additive models verified the inverted U-shaped association between glycemic indices and SUA levels,but with different inflection points in men and women.The thresholds for FPG,2 h-PG,and HbA1 c for men and women were 6.5/8.0 mmol/L,11.0/14.0 mmol/L,and 6.1/6.5,respectively(SUA levels increased with increasing glycemic indices before the inflection points and then eventually decreased with further increases in the glycemic indices).Conclusion An inverted U-shaped association was observed between major glycemic indices and uric acid levels in both sexes,while the inflection points were reached earlier in men than in women. | ZHU Yuan Yue ZHENG Rui Zhi WANG Gui Xia CHEN Li SHI Li Xin SU Qing XU Min XU Yu CHEN Yu Hong YU Xue Feng YAN Li WANG Tian Ge ZHAO Zhi Yun QIN Gui Jun WAN Qin CHEN Gang GAO Zheng Nan SHEN Fei Xia LUO Zuo Jie QIN Ying Fen HUO Ya Nan LI Qiang YE Zhen ZHANG Yin Fei LIU Chao WANG You Min WU Sheng Li YANG Tao DENG Hua Cong ZHAO Jia Jun CHEN Lu Lu MU Yi Ming TANG Xu Lei HU Ru Ying WANG Wei Qing NING Guang LI Mian LU Jie Li BI Yu Fang | 2021 | Biomedical and Environmental Sciences2021，34，1： | 2 |
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