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| 1 | 人脑前扣带回皮质喙部在^11C—PIB PET诊断阿尔茨海默病型痴呆中的价值显示文摘目的研究人脑前扣带回皮质喙部(rACC)与[N-甲基-^11C]2-[4′-(甲氨基)苯基]-6-羟基苯并噻唑(^11C—PIB)的黏附能力(BP)对阿尔茨海默病型痴呆(DAT)的诊断价值。方法受试对象为美国华盛顿大学医学院通过广告方式招募,按临床痴呆评定量表(CDR)评定的健康受试者(CDR=0)和痴呆患者(CDR〉0),分别为129名和40例(其中有rACC PIB BP数据的健康受试者和DAT患者分别为120名和34例。所有169例受试者均有其他被研究脑局部的PIB BP数据)。脑MRI用于脑局部精确定位。^11C—PIB经肘静脉注射后行PET脑显像。用软件融合MRI和PET图像。用Logan分析软件计算BP。和其他脑局部比较,分析rACC部位PIB BP特点。采用SPSS11.5软件对数据进行线性相关分析、t检验或方差分析。结果有rACC PIB BP数据的健康受试者(CDR=0)和痴呆患者(CDR〉0)分别为120例和34例,而所有169例受试者均有其他脑部位的PIB BP数据。rACC PIB BP和CDR呈直线相关(BP为0.2865±0.442,CDR为0.143±0.290,r=0.545,P〈0.01)。CDR=0.5和1的2组人群中rACC PIB BP值差异无统计学意义(0.6719±0.1545和0.8933±0.0880,t=-1.245,P〉0.05),但CDR=0和〉0的2组人群中差异有统计学意义(0.1589±0.0219和0.7370±0.1125,t=-7.998,P〈0.01)。rACC PIB BP的阈值为0.4592,用该阈值诊断DAT的灵敏度为67.65%(23/34),特异性为88.33%(106/120)。DAT患者和健康人群之间BP有交叉在已被研究的脑局部中,DAT患者楔前回、rACC和额前回各自的PIB BP均值及这3个脑局部各自在DAT患者组和HC组间的PIB BP均值之差都高居前3位。结论rACC PIB BP有鉴别诊断DAT的价值,rACC、楔前回、额前回均是用PIB BP诊断DAT的较敏感脑部区域。 | 余大富 Mark A. Mintun | 2009 | 中华核医学杂志2009，29，4： | 2 |
| 2 | Brain work and brain imaging显示文摘 | Raichle ME Mintun MA | 2006 | Annu Rev Neurosci2006，29，： | 1 |
| 3 | Assessing tumor hypoxia in cervical cancer by positron emission tomography with 60Cu-ATSM:relationship to therapeutic response-a preliminary report显示文摘 | Dehdashti F Grigsby P W Mintun MA | 2003 | Int J Radiat Oncol Biol Phys2003，55，5： | 1 |
| 4 | PET brain mapping study of auditory verbal supraspan memory versus visual fixation in schizophrenia 显示文摘 | Ganguli K Carter C Mintun M | 1997 | Biol Psychiatry1997，41，1： | 1 |
| 5 | In vivo assessment of tumor hypoxia in lung cancer with 60Cu-ATSM显示文摘 | Dehdashti F Mintun MA Lewis JS | 2003 | Eur J Nucl Med Mol Imaging2003，30，6： | 1 |
| 6 | Interference and facilitation effects during selective attention,an H215 O PET study of Stroop task performance显示文摘 | Carter CS Mintun M Cohen JD | 1995 | NeuroImage1995，2，4： | 1 |
| 7 | Amyloid deposition, hypometabolism, and longitudinal cognitive decline 显示文摘 | Landau SM Mintun MA Joshi AD | 2012 | Ann Neurol2012，72，4： | 1 |
| 8 | Enhanced detection of focal brain responses using intersubject averaging and change-distribution analysis of subtracted PET images显示文摘 | Fox PT Mintun MA Reiman EM | 1988 | Journal of Cerebral Blood Flow and Metabolism1988，8，5： | 1 |
| 9 | Breast cancer:PET imaging of estrogen receptors显示文摘 | Mintun MA Welch MJ Siegel BA Mathias | 1988 | Radiology1988，169，： | 1 |
| 10 | In vivo assessment of tumor hypoxia in lung cancer with ^60Cu-ATSM 显示文摘 | Dehdashti F Mintun MA Lewis JS | 2003 | Eur J Nucl Med Mol Imaging2003，30，： | 1 |
| 11 | PIB in a nondemented population: Potential antecedent marker of Al?zheimer disease 显示文摘 | Mintun MA Larossa GN Sheline YIM | 2006 | Neurology2006，67，： | 1 |
| 12 | The hippoeampus and depression显示文摘 | Sheline YI Mittler BL Mintun MA | 2002 | Eur Psytchiatry2002，17，3： | 1 |
| 13 | Positron emission tomography in limited-stage small-cell lung cancer:a prospective study显示文摘 | Bradley JD Dehdashti F Mintun MA | 2004 | Chin Ocol2004，22，16： | 1 |
| 14 | Assessing tumor hypoxia in cervical cancer by positron emission tomography with ^60Cu-ATSM: relationship to therapeutic response a preliminary report显示文摘 | Dehdashti F Grigsby PW Mintun MA | 2003 | Int J Radiat Oncol Biol Phys2003，55，： | 1 |
| 15 | The hippocampus and depression显示文摘 | Sheline Y Mittler B Mintun M | 2002 | European Psychiatry2002，17，3： | 1 |
| 16 | PIB in a nondemented population: potential antecedent marker of Alzheimer disease 显示文摘 | Mintun MA Larossa GN Sheline YI | 2006 | Neurology2006，67，3： | 1 |
| 17 | Depres- sion duration but not age predicts hippocampal volume loss in medically healthy women with recurrent depression 显示文摘 | SHELINE Y I SANGHAVI M MINTUN M A at al | 1999 | J Neurosci1999，19，： | 1 |
| 18 | Depression du- ation but not age predicts hippocampal volume loss in medicallyhealthy women with recurrent major depression显示文摘 | Shelin YI Sanghavi M Mintun MA | 1999 | J Neuros- ci1999，19，12： | 1 |
| 19 | Comparing positron emission tomography imaging and cerebrospinal fluid measurements of β‐amyloid显示文摘 | Susan M. Landau Ming Lu Abhinay D. Joshi Michael Pontecorvo Mark A. Mintun John Q. Trojanowski Leslie M. Shaw William J. Jagust | 2013 | Ann Neurol2013，，： | 1 |
| 20 | Positron emission tomography in limited-stage small-cell lung cancer:a prospective study显示文摘 | Bradley JD Dehdashti F Mintun MA | 2004 | J Clin Oncol2004，22，16： | 1 |
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