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| 1 | Management of gastroesophageal reflux disease: Patient and physician communication challenges and shared decision making显示文摘Gastroesophageal reflux disease(GERD) is a common upper esophageal condition and typical symptoms can include heartburn and sensation of regurgitation while atypical symptoms include chronic cough, asthma, hoarseness, dyspepsia and nausea. Typically, diag-nosis is presumptive given the presence of typical and atypical symptoms and is an indication for empiric therapy. Treatment management can include lifestyle modifications and/or medication therapy with proton pump inhibitor(PPI) class being the preferred and most effective. Complete symptom resolution is not always achieved and long-term PPI therapy can put patients at risk for serious side effects and needless expense. The brain-gut connection and hypervigilance plays an important role in symptom resolution and treatment success, especially in the case of non-PPI responders. Hypervigilance is a combination of increased esophageal sensory sensitivity in combination with exaggerated threat perception surrounding esophageal symptoms. Hypervigilance requires a different approach to GERD managements, where continued PPI therapy and surgery are usually not recommended. Rather, helping physicians and patients understand the brain-gut connection can guide and improve care.Education and reassurance should be the main pillars or treatment. However, it is important not to suggest the symptoms are due to anxiety alone, this often leads to patient dissatisfaction. Patient dissatisfaction with treatment reveals the need for a more patient-centered approach to GERD management and better communication between patients and providers. Shared decision making(SDM) with the incorporation of patient-reported outcomes(PRO) promotes patient adherence and satisfaction. SDM is a joint discussion between clinician and patient in which a mutually shared solution is explored for GERD symptoms. For SDM to work the physician needs to capture patients' perceptions which may not be obtained in the standard interview. This can be done through the use of PROs which promote a dialogue with patients about their symptoms and treatment priorities in the context of the SDM patient encounter. SDM could potentially help in the management of patient expectations for GERD treatment, ultimately positively impacting their health-related quality of life. | Scott Klenzak Igor Danelisen Grace D Brannan Melissa A Holland Miranda AL van Tilburg | 2018 | World Journal of Clinical Cases2018，6，15： | 10 |
| 2 | Myenteric neurons and intestinal mucosa of diabetic rats after ascorbic acid supplementation显示文摘AIM: To investigate the effect of ascorbic acid (AA) dietary supplementation on myenteric neurons and epithelial cell proliferation of the jejunum of adult rats with chronic diabetes mellitus. METHODS: Thirty rats at 90 d of age were divided into three groups: Non-diabetic, diabetic and diabetic treated with AA (DA) (1 g/L). After 120 d of treatment with AA the animals were killed. The myenteric neurons were stained for myosin-V and analyzed quantitatively in an area of 11.2 mm2/animal. We further measured the cellular area of 500 neurons per group. We also determined the metaphasic index (MI) of the jejunum mucosa layer of about 2500 cells in the intestinal crypts, as well as the dimensions of 30 villi and 30 crypts/animal. The data area was analyzed using the Olympus BX40 microscope. RESULTS: There was an increase of 14% in the neuronal density (792.6 ± 46.52 vs 680.6 ± 30.27) and 4.4% in the cellular area (303.4 ± 5.19 vs 291.1 ± 6.0) respectively of the diabetic group treated with AA when compared to control diabetic animals. There were no signifi cant differences in MI parameters, villi height or crypt depths among the groups.CONCLUSION: Supplementation with AA in the diabetic animal promoted moderate neuroprotection. There was no observation of alteration of the cellular proliferation of the jejunum mucosa layer of rats with chronic diabetes mellitus with or without supplementation with AA. | Priscila de Freitas Maria Raquel Maral Natali Renata Virginia Fernandes Pereira Marcilio Hubner Miranda Neto Jacqueline Nelisis Zanoni | 2008 | World Journal of Gastroenterology2008，14，42： | 3 |
| 3 | Psychosocial mechanisms for the transmission of somatic symptoms from parents to children显示文摘AIM: To examine familial aggregation of irritable bowel syndrome(IBS) via parental reinforcement/modeling of symptoms, coping, psychological distress, and exposure to stress.METHODS:Mothers of children between the ages of8 and 15 years with and without IBS were identified through the Group Health Cooperative of Puget Sound.Mothers completed questionnaires,including the Child Behavior Checklist(child psychological distress),the Family Inventory of Life Events(family exposure to stress),SCL-90R(mother psychological distress),and the Pain Response Inventory(beliefs about pain).Children were interviewed separately from their parents and completed the Pain Beliefs Questionnaire(beliefs about pain),Pain Response Inventory(coping)and Child Symptom Checklist[gastrointestinal(GI)symptoms].In addition,health care utilization data was obtained from the automated database of Group Health Cooperative.Mothers with IBS(n=207)and their 296 children were compared to 240 control mothers and their 335 children,while controlling for age and education.RESULTS:Hypothesis 1:reinforcement of expression of GI problems is only related to GI symptoms,but not others(cold symptoms)in children.There was no significant correlation between parental reinforcement of symptoms and child expression of GI or other symptoms.Hypothesis 2:modeling of GI symptomsis related to GI but not non-GI symptom reporting in children.Children of parents with IBS reported more non-GI(8.97 vs 6.70,P<0.01)as well as more GI(3.24 vs 2.27,P<0.01)symptoms.Total health care visits made by the mother correlated with visits made by the child(rho=0.35,P<0.001 for cases,rho=0.26,P<0.001 for controls).Hypothesis 3:children learn to share the methods of coping with illness that their mothers exhibit.Methods used by children to cope with stomachaches differed from methods used by their mothers.Only 2/16 scales showed weak but significant correlations(stoicism rho=0.13,P<0.05;acceptance rho=0.13,P<0.05).Hypothesis 4:mothers and children share psychological traits such as anxiety,depression,and somatization.Child psychological distress correlated with mother’s psychological distress(rho=0.41,P<0.001 for cases,rho=0.38,P<0.001 for controls).Hypothesis 5:stress that affects the whole family might explain the similarities between mothers and their children.Family exposure to stress was not a significant predictor of children’s symptom reports.Hypothesis 6:the intergenerational transmission of GI illness behavior may be due to multiple mechanisms.Regression analysis identified multiple independent predictors of the child’s GI complaints,which were similar to the predictors of the child’s non-GI symptoms(mother’s IBS status,child psychological symptoms,child catastrophizing,and child age).CONCLUSION:Multiple factors influence the reporting of children’s gastrointestinal and non-gastrointestinal symptoms.The clustering of illness within families is best understood using a model that incorporates all these factors. | Miranda AL van Tilburg Rona L Levy Lynn S Walker Michael Von Korff Lauren D Feld Michelle Garner Andrew D Feld William E Whitehead | 2015 | World Journal of Gastroenterology2015，21，18： | 2 |
| 4 | Chronological age when health care transition skills are mastered in adolescents/young adults with inflammatory bowel disease显示文摘AIM To describe the longitudinal course of acquisition of healthcare transition skills among adolescents and young adults with inflammatory bowel diseases.METHODS We recruited adolescents and young adults(AYA) with inflammatory bowel diseases(IBD), from the pediatric IBD clinic at the University of North Carolina. Participants completed the TRx ANSITION Scale? at least once during the study period(2006-2015). We used the electronic medical record to extract participants' clinical and demographic data. We used ordinary least square regressions with robust standard error clustered at patient level to explore the variations in the levels and growths of healthcare transition readiness.RESULTS Our sample(n = 144) ranged in age from 14-22 years. Age was significantly and positively associated with both the level and growth of TRx ANSITION Scale? scores(P < 0.01). Many healthcare transition(HCT) skills were acquired between ages 12 and 14 years, but others were not mastered until after age 18, including self-management skills.CONCLUSION This is one of the first studies to describe the longitudinal course of HCT skill acquisition among AYA with IBD, providing benchmarks for evaluating transition interventions. | Natalie Stollon Yi Zhong Maria Ferris Suneet Bhansali Brian Pitts Eniko Rak Maureen Kelly Sandra Kim Miranda AL van Tilburg | 2017 | World Journal of Gastroenterology2017，23，18： | 2 |
| 5 | Psoriasis, lymphoma and etanercept : is there a correlation 显示文摘 | Miranda LQ Bressan AL Rehfeldt FV | 2012 | An Bras Dermatol2012，87，1： | 1 |
| 6 | Endoplasmic reticu- lum dysfunction in neurological disease 显示文摘 | Roussel BD Kruppa A J Miranda E ct al | 2013 | Lancet Neurol2013，12，1： | 1 |
| 7 | Epidemiology study of Pseudomonas aeruginosa in critical patients and reservoirs显示文摘 | Corona Nakamura AL Miranda Novales MG leanos Miranda B | 2001 | Archives Medical Res2001，32，3： | 1 |
| 8 | 03:K6 serotype ofVibrio parahaemolyticus identical to the global pandemicclone associated with diarrhea in Peru显示文摘 | Gil Al Miranda H Lanata CF | 2007 | InternationalJournal of Infectious Diseases2007，11，4： | 1 |
| 9 | Apparent phosphorusavailability in food for the Nile tilapia (Oreochromis niloticus) 显示文摘 | Miranda E C de Pezzato A C Pezzato L al | 2000 | Acta Scien-tiarum2000，22，66： | 1 |
| 10 | The use of 2%chlorhexidine gel and toothbrushing for oral hygiene of patients re- ceiving mechanical ventilation: effects on ventilator-associated pneumonia显示文摘 | Meinberg MC Cheade MD Miranda AL | 2012 | Rev Bras Ter Intensiva2012，24，4： | 1 |
| 11 | The use of2%chlorhexidine gel and toothbrushing for oral hygiene of patients receiving mechanical ventilation:effects on ventilator-associated pneumonia显示文摘 | Meinberg MC Cheade Mde F Miranda AL | 2012 | Rev Bras Ter Intensiva2012，24，4： | 1 |
| 12 | Anti-in-flammatory and analgesic activities of the latex containing triterpenes from Himatanthus sucuuba显示文摘 | DE MIRANDA AL SILVA JR REZENDE CM | 2000 | Planta Med2000，66，3： | 1 |
| 13 | Circulating Glial-derived neurotrophic factor is reduced in late-life depression显示文摘 | Diniz BS Teixeira AL Miranda AS | 2012 | J Psychiatr Res2012，46，1： | 1 |
| 14 | The use of2%chlorhexidine gel and toothbrushing for oral hygiene of patients receiving mechanical ventilation:effects on ventilator-associated pneumonia显示文摘 | Meinberg MC Cheade Mde F Miranda AL | 2012 | Rev Bras Ter Intensiva2012，24，4： | 1 |
| 15 | Chronic subdural Jlmatomain lhe elderly :not a benign disease 显示文摘 | Miranda LB Braxlon E Hobbs J el al | 2011 | J Neurosurg2011，114，1： | 1 |
| 16 | Sintering and Robocasting of β- Tricalcium Phosphate Scaffolds lot Orthopaedic Applications 显示文摘 | Miranda P Saiz E Grye K el al | 2006 | Acta Materialia2006，2，4： | 1 |
| 17 | Correlations of mutations in katG, oxyR-ahpC and inhA genes and in vitro suseeptibility in Mycobacterium tuberculosis clinical strains segregated by spoligotype families from tuberculosis prevalent countries in South America显示文摘 | Dalla Costa ER Ribeiro MO Silva MS Arnold LS Rostirolla DC Cafrune PI Espinoza RC Palaci M Telles MA Ritaeeo V Suffys PN Lopes ML Campelo CL Miranda SS Kremer K da Silva PE Fonseea Lde S Ho JL Kritski AL Rossetti ML | 2009 | BMC Microbiol2009，9，： | 1 |
| 18 | Immunophannacological properties of flavonoids 显示文摘 | Ielpo M T L Basile A Miranda R et al | 2000 | Fitoterapia2000，71，11： | 1 |
| 19 | Identificationand in vitro biological activities of hop proanthocyanidins :Inhibition of nNOS activity and scavenging of reactive nitrogenspecies显示文摘 | Stevens JF Miranda CL Wolthers KR ei al | 2002 | Journal of Agricultural and Food Chemistry2002，50，： | 1 |
| 20 | Successful management of recurrent coccygeal hernia with the de- epithelialised rectus abdominis musculocutaneous flap 显示文摘 | Miranda EP Anderson AL Dosanjh AS | 2009 | J Plast Reconstr Aesthet Surg2009，62，1： | 1 |
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