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| 1 | Biomechanics of the anterior cruciate ligament:Physiology,rupture and reconstruction techniques显示文摘The influences and mechanisms of the physiology,rupture and reconstruction of the anterior cruciate ligament(ACL)on kinematics and clinical outcomes have been investigated in many biomechanical and clinical studies over the last several decades.The knee is a complex joint with shifting contact points,pressures and axes that are affected when a ligament is injured.The ACL,as one of the intra-articular ligaments,has a strong influence on the resulting kinematics.Often,other meniscal or ligamentous injuries accompany ACL ruptures and further deteriorate the resulting kinematics and clinical outcomes.Knowing the surgical options,anatomic relations and current evidence to restore ACL function and considering the influence of concomitant injuries on resulting kinematics to restore full function can together help to achieve an optimal outcome. | Christoph Domnick Michael J Raschke Mirco Herbort | 2016 | World Journal of Orthopedics2016，7，2： | 9 |
| 2 | A totally mini-invasive approach for colorectal laparoscopic surgery显示文摘AIM:To study the short-term outcome of patients treated with laparoscopic right colectomy and how intracorporeal anastomosis has improved the outcome.METHODS:We retrospectively examined all patients affected by colorectal cancer who underwent a laparoscopic right colectomy between January 2006 and December 2010 in our department.Our evaluation criteria were:diagnosis of colorectal carcinoma at presurgical biopsy,elective surgery,and the same surgeon.We excluded:emergency surgery,conversions from laparotomic colectomy,and other surgeons.The endpoints we examined were:surgical time,number of lymph nodes removed,length of stay(removal of nasogastric tube,bowel movements,gas evacuation,solid and liquid feeding,hospitalization),and major complications.Seventy-two patients were divided into two groups:intracorporeal anastomosis(39 patients)and extracorporeal anastomosis(33 patients).RESULTS:Significant differences were observed between intracorporeal vs extracorporeal anastomosis,respectively,for surgical times(186.8 min vs 184.1 min,P < 0.001),time to resumption of gas evacuation(3 d vs 3.5 d,P < 0.001),days until resumption of bowel movements(3.8 d vs 4.9 d,P < 0.001),days until resumption of liquid diet(3.5 d vs 4.5 d,P < 0.001),days until resuming a solid diet(4.6 d vs 5.7 d,P < 0.001),and total hospitalization duration(7.4 d vs 8.5 d,P < 0.001).In the intracorporeal group,on average,19 positive lymph nodes were removed;in the extracorporeal group,on average,14 were removed P < 0.001).Thus,intracorporeal anastomosis for right laparoscopic colectomy improved patient outcome by providing faster recovery of nutrition,faster recovery of intestinal function,and shorter hospitalization than extracorporeal anastomosis.CONCLUSION:Short-term outcomes favor intracorporeal anastomosis,confirming that a less traumatic surgical approach improves patient outcome. | Gabriele Anania Mirco Santini Lucia Scagliarini Alice Marzetti Laura Vedana Serafino Marino Claudio Gregorio Giuseppe Resta Giorgio Cavallesco | 2012 | World Journal of Gastroenterology2012，18，29： | 8 |
| 3 | Coagulopathy and transfusion therapy in pediatric livertransplantation显示文摘Bleeding and coagulopathy are critical issues complicating pediatric liver transplantation and contributing to morbidity and mortality in the cirrhotic child. The complexity of coagulopathy in the pediatric patient is illustrated by the interaction between three basic models. The first model, 'developmental hemostasis', demonstrates how a different balance between pro- and anticoagulation factors leads to a normal hemostatic capacity in the pediatric patient at various ages. The second, the 'cell based model of coagulation', takes into account the interaction between plasma proteins and cells. In the last, the concept of 'rebalanced coagulation' highlights how the reduction of both pro- and anticoagulation factors leads to a normal, although unstable, coagulation profile. This new concept has led to the development of novel techniques used to analyze the coagulation capacity of whole blood for all patients. For example, viscoelastic methodologies are increasingly used on adult patients to test hemostatic capacity and to guide transfusion protocols. However, results are often confounding or have limited impact on morbidity and mortality. Moreover, data from pediatric patients remain inadequate. In addition, several interventions have been proposed to limit blood loss during transplantation, including the use of antifibrinolytic drugs and surgical techniques, such as the piggyback and lowering the central venous pressure during the hepatic dissection phase. The rationale for the use of these interventions is quite solid and has led to their incorporation into clinical practice; yet few of them have been rigorously tested in adults, let alone in children. Finally, the postoperative period in pediatric cohorts of patients has been characterized by an enhanced risk of hepatic vessel thrombosis. Thrombosis in fact remains the primary cause of early graft failure and re-transplantation within the first 30 d following surgery, and it occurs despite prolongation of standard coagulation assays. Data, however, are currently lacking regarding the use of anti-aggregation/anticoagulation therapies and how to best monitor for thrombosis in the early postoperative period in pediatric patients. Therefore, further studies are necessary to elucidate the interaction between the development of the coagulation system and cirrhosis in children. Moreover, strategies to optimize blood transfusion and anticoagulation must be tested specifically in pediatric patients. In conclusion, data from the adult world can be translated with difficulty into the pediatric field as indication for transplantation, baseline pathologies and levels of pro- and anticoagulation factors are not comparable between the two populations. | Mirco Nacoti Davide Corbella Francesco Fazzi Francesca Rapido Ezio Bonanomi | 2016 | World Journal of Gastroenterology2016，22，6： | 5 |
| 4 | Micro‐RNA profiling reveals a role for miR‐29 in human and murine liver fibrosis显示文摘 | Christoph Roderburg Gerd‐Willem Urban Kira Bettermann Mihael Vucur Henning Zimmermann Sabine Schmidt J?rn Janssen Christiane Koppe Percy Knolle Mirco Castoldi Frank Tacke Christian Trautwein Tom Luedde | 2011 | Hepatology2011，，1： | 3 |
| 5 | Thrombosis prophylaxis in pediatric liver transplantation: A systematic review显示文摘AIM To review current literature of thrombosis prophylaxis in pediatric liver transplantation(PLT) as thrombosis remains a critical complication.METHODS Studies were identified by electronic search of MEDLINE, EMBASE and Cochrane Library(CENTRAL) databases until March 2018. The search was supplemented by manually reviewing the references of included studies and the references of the main published systematic reviews on thrombosis and PLT. We excluded from this review case report, small case series, commentaries, conference abstracts, papers which describing less than 10 pediatric liver transplants/year and articles published before 1990. Two reviewers performed study selection independently, with disagreements solved through discussion and by the opinion of a third reviewer when necessary.RESULTS Nine retrospective studies were included in this review. The overall quality of studies was poor. A pooled analysis of results from studies was not possible due to the retrospective design and heterogeneity of included studies. We found an incidence of portal vein thrombosis(PVT) ranging from 2% to 10% in pediatric living donorliver transplantation(LDLT) and from 4% to 33% in pediatric deceased donor liver transplantation(DDLT). Hepatic artery thrombosis(HAT) was observed mostly in mixed LDLT and DDLT pediatric population with an incidence ranging from 0% to 29%. In most of the studies Doppler ultrasonography was used as a first line diagnostic screening for thrombosis. Four different surgical techniques for portal vein anastomosis were reported with similar efficacy in terms of PVT reduction. Reduced size liver transplant was associated with a low risk of both PVT(incidence 4%) and HAT(incidence 0%, P < 0.05). Similarly, aortic arterial anastomosis without graft interposition and microsurgical hepatic arterial reconstruction were associated with a significant reduced HAT incidence(6% and 0%, respectively). According to our inclusion and exclusion criteria, we did not find eligible studies that evaluated pharmacological prevention of thrombosis. CONCLUSION Poor quality retrospective studies show the use of tailored surgical strategies might be useful to reduce HAT and PVT after PLT; prospective studies are urgently needed. | Mirco Nacoti Giulia Maria Ruggeri Giovanna Colombo Ezio Bonanomi Federico Lussana | 2018 | World Journal of Hepatology2018，10，10： | 3 |
| 6 | Spatial variability and optimal sampling strategy of soil respiration显示文摘 | Mirco Rodeghiero Alessandro Cescatti | 2007 | Forest Ecology and Management2007，，1： | 2 |
| 7 | Acute hepatitis B caused by a vaccine-escape HBV strain in vaccinated subject: Sequence analysis and therapeutic strategy显示文摘 | Monica Luongo Rosina Critelli Antonella Grottola Stefano Gitto Veronica Bernabucci Mirco Bevini Chiara Vecchi Giuliano Montagnani Erica Villa | 2014 | Journal of Clinical Virology2014，，： | 2 |
| 8 | 5-fluorouracil pharmacogenomics: still rocking after all these years?显示文摘 | Mario Scartozzi Elena Maccaroni Riccardo Giampieri Mirco Pistelli Alessandro Bittoni Michela Del Prete Rossana Berardi Stefano Cascinu | 2011 | Pharmacogenomics2011，，2： | 1 |
| 9 | A Framework for Multi-re- gion Delay Tolerant Networking显示文摘 | Mirco Musolesi Cecilia Mascolo | | ACM0，，： | 1 |
| 10 | Time-focused clustering of trajectories of moving objects显示文摘 | Mirco Nanni Dino Pedreschi | 2006 | Journal of Intelligent Information Systems2006，，： | 1 |
| 11 | Optical digital signal processing in a single SOA without assist probe ligbt显示文摘 | Claudio Porzi Mirco Seaffardi Luca Poti Antonella Bogoni | 2010 | Journal of Selected Topics in Quantum Electronics2010，16，5： | 1 |
| 12 | Monitoring paddy rice crops through remote sensing: productivity estimation by light use efficiency model显示文摘 | Mirco B Emanuela M Chiara G | 2004 | Remote Sensing for Agriculture Ecosystems and Hydrology VI Proceedings of SPIE2004，5568，： | 1 |
| 13 | Defective DNA mismatch repair determines a characteristic transcriptional profile in proximal colon cancers 显示文摘 | Massimiliano di Pietro Jacob Sabates Bellver Mirco Menigatti | 2005 | Gastroenterology2005，129，3： | 1 |
| 14 | Preinvasive colorectal lesion transcriptomes correlate with endoscopic morphology (polypoid vs. nonpolypoid)显示文摘 | Elisa Cattaneo Endre Laczko Federico Buffoli Fausto Zorzi Maria Antonia Bianco Mirco Menigatti Zdena Bartosova Ritva Haider Birgit Helmchen Jacob Sabates‐Bellver Amit Tiwari Josef Jiricny Giancarlo Marra | 2011 | EMBO Mol Med2011，，6： | 1 |
| 15 | Effects of 0.005% Latanoprost on Ocular Anterior Structures and Ciliary Body Thickness显示文摘 | Giorgio Marchini Giuseppe Ghilotti Mirco Bonadimani Silvia Babighian | 2003 | Journal of Glaucoma2003，，4： | 1 |
| 16 | Dynamic load balancing for network intrusion detection systems based on distributed architectures 显示文摘 | Mauru Andreolini Sara Casolari Michele Colajanni Mirco Marchetti | 2007 | Sixth IEEE International Symposium on Network Computing and Applications2007，，： | 1 |
| 17 | Designing mobility models based on social network theory 显示文摘 | Mirco Musolesi Cecilia Mascolo | 2007 | ACM SIGMOBILE Mobile Computing and Communications Review (S1559-1662)2007，11，3： | 1 |
| 18 | Posterior spinal artery infaret显示文摘 | Mario M Mirco C Giampiero F | 1998 | Am J Neuroradiol1998，19，： | 1 |
| 19 | Medication errors in an internal medlcme department: Evaluation of a computerized prescription system 显示文摘 | Mirco AL Campos L | 2005 | Pharm World Sci2005，27，4： | 1 |
| 20 | Application of a threshold curve model to high-cycle fatigue behavior of small cracks induced by foreign-object damage in Ti-6Al-4V显示文摘 | Chapetti | 2005 | International Journal of Fa-tigue2005，27，5： | 1 |
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