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| 1 | Incidence and mortality of primary liver cancer in England and Wales: Changing patterns and ethnic variations显示文摘AIM: To explore recent trends, modes of diagnosis, ethnic distribution and the mortality to incidence ratio of primary liver cancer by subtypes in England and Wales. METHODS: We obtained incidence(1979-2008) and mortality(1968-2008) data for primary liver cancer for England and Wales and calculated age-standardised incidence and mortality rates. Trends in age-standardised mortality(ASMR) and incidence(ASIR) rates and basis of diagnosis of primary liver cancer and subcategories: hepatocellular carcinoma, intrahepatic bile duct and unspecified liver tumours, were analysed over the study period. Changes in guidelines for the diagnosis of primary liver cancer(PLC) may impact changing trends in the rates that may be obtained. We thus explored changes in the mode of diagnosis as reported to cancer registries. Furthermore, we examined the distribution of these tumours by ethnicity. Most of the statistical manipulations of these data was carried out in Microsoft excel(Seattle, Washington, United Sttaes). Additional epidemiological statistics were done in Epi Info software(Atlanta, GA, United Sttaes). To define patterns of change over time, we evaluated trends in ASMR and ASIR of PLC and intrahepatic bile duct carcinoma(IHBD) using a least squares regression line fitted to the natural logarithm of the mortality and incidence rates. We estimated the patterns of survival over subsequent 5 and 10 years using complement of mortality to incidence ratio(1-MIR). RESULTS: Age-standardised mortality rate of primary liver cancer increased in both sexes: from 2.56 and 1.29/100000 in 1968 to 5.10 and 2.63/100000 in 2008 for men and women respectively. The use of histology for diagnostic confirmation of primary liver cancer increased from 35.7% of registered cases in 1993 to plateau at about 50% during 2005 to 2008. Reliance on cytology as a basis of diagnosis has maintained a downward trend throughout the study period. Although approximately 30% of the PLC registrations had information on ethnicity, there was a relatively higher registration of the major tumour subtypes in patients whose ethnic backgrounds were from high incident regions of the world. Survival from PLC is estimated to get poorer in 10 years(2018) relative to 2008, particularly as a result of IHBD. CONCLUSION: Incidence and mortality of PLC, and particularly IHBD, have continued to rise in England and Wales. Changes in the modes of diagnosis may be contributing. | Nimzing G Ladep Shahid A Khan Mary ME Crossey Andrew V Thillainayagam Simon D Taylor-Robinson Mireille B Toledano | 2014 | World Journal of Gastroenterology2014，20，6： | 15 |
| 2 | Risk factors for acute re- spiratory morbidity in moderately preterm infants 显示文摘 | Maria A Mireille V Sven C | 2013 | Paediatr Perinat Epidemiol2013，27，2： | 1 |
| 3 | Motivations of physicians and nurses to practice voluntary euthanasia: a systematic review显示文摘 | Lydi-Anne Vézina-Im Mireille Lavoie Pawel Krol | 2014 | BMC Palliat Care2014，13，： | 1 |
| 4 | Influence of the sol-gel synthesis on the formation of spinel MgAl2O4 显示文摘 | Julien P Mireille R P Serge V | 1998 | Mater Res Bull1998，33，11： | 1 |
| 5 | Influence of the sol gel synthesis on the formation of spinel MgAl2 O4 显示文摘 | JULIEN P MIREILLE R P SERGE V | 1998 | Mater Res Bull1998，33，11： | 1 |
| 6 | Noelle Richard-Mercier sex reversal and aromatase in chicken显示文摘 | Severine V Mireille D Claude P | 2001 | Journal of Experimental Zoology2001，290，7： | 1 |
| 7 | Carbohydrate-derived surfactants 显示文摘 | Mauro V de A Mireille Le H | 2005 | Mini-Reviews in Organic Chemistry2005，2，： | 1 |
| 8 | Carbohydrate-derived surfactants显示文摘 | Mauro V de A Mireille Le H | 2005 | Mini-review in Organic Chemistry2005，2，： | 1 |
| 9 | Influence of the sol-gel synthesis on the formation of spinel MgAl2O2显示文摘 | Julien P Mireille R P Serge V | 1998 | MaterResBull1998，33，11： | 1 |
| 10 | Magnesium deficiency in sugar beets alters sugar partitioningand phloem loadingin youngmature leaves 显示文摘 | Christian H Fabienne B Mireille F Reto J S Serge D Nathalie V | 2005 | Planta2005，220，： | 1 |
| 11 | Carbohydrate-derived surfaetants显示文摘 | Mauto V de A Mireille Le H | 2005 | Mini-Reviews in Organie Chemistry2005，，2： | 1 |
| 12 | Lessepsian invasion without bottleneck: example of two rabbitfish species (Siganus rivulatus and Siganus luridus) 显示文摘 | Mohamad H Mireille H V Francois B | 2003 | Journal of Experimental Marine Biology and Ecology2003，291，23： | 1 |
| 13 | Design of a polypeptide FRET substrate that facilitates study of the antimicrohial protease lysostaphin 显示文摘 | Philip B Mireille V Zhang Y | 2009 | BJ Disease2009，418，： | 1 |
| 14 | Persistence of Mycoplasma gallisepticum in chickens after treatment with enrofloxacin without development of resistance显示文摘 | Anita K R Anne V G Mireille G | 2005 | Veterinary Microbiology2005，，106： | 1 |
| 15 | Structure and rheological prop-erties of acid-induced egg white protein gels显示文摘 | Mireille W J Fred V D V Ann S | | 0，，01： | 1 |
| 16 | High-protein diet differently modifies intestinal goblet cell characteristics and mucosal cytokine expression in ileum and colon显示文摘 | Anna?g Lan Mireille Andriamihaja Jean-Marc Blouin Xinxin Liu Véronique Descatoire Caroline Desclée de Maredsous Anne-Marie Davila Francine Walker Daniel Tomé Fran?ois Blachier | 2014 | The Journal of Nutritional Biochemistry2014，，： | 1 |
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