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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | A new species of Lepidopteris discovered from the Upper Permian of China with its stratigraphic and biologic implications显示文摘A new species Lepidopteris baodensis sp.nov.belonging to the family Peltaspermaceae and represented by two ultimate pinnae in the collection under study,was recently discovered at the Baijiagou of Baode,Shanxi,China,from the Upper Permian Sunjiagou Formation.The lower surface of the ultimate rachis,the midrib and secondary veins is covered with triangular,trapezoid,rounded,or ligulate subepidermal swellings,which show different natures from intercalary pinnules.Lepidopteris is one of typical elements of the Late Permian Euramerican flora.Since Schimper erected the genus Lepidopteris in 1869,the entire epidermal structure of subepidermal swellings had been unclear.The new species L.baodensis clearly showing the distinguished epidermal structure of subepidermal swellings,not only enlarges and supplements our knowledge in biology and taxonomy of Lepidopteris as well as the Upper Permian stratigraphy of China,but also provides an opportunity to understand the relationship between Euramerican floras and Cathaysian floras in paleoclimatic,paleoenvironmental and paleogeographic context. | ZHANG Yi ZHENG ShaoLin NAUGOLNYKH Serge V | 2012 | Chinese Science Bulletin2012，57，27： | 5 |
| 3 | Characterization and classification of matrix effects in biological samples analyses显示文摘 | Ivano Marchi Véronique Viette Flavia Badoud Marc Fathi Martial Saugy Serge Rudaz Jean-Luc Veuthey | 2009 | Journal of Chromatography A2009，，25： | 1 |
| 4 | A Load Balanced Algorithm for Parallel Digital Image Warping显示文摘 | SYLVAIN C V SERGE M | 1999 | International Journal of Pattern Recognition and Artificial Intelligence1999，13，4： | 1 |
| 5 | Influence of the sol-gel synthesis on the formation of spinel MgAl2O4 显示文摘 | Julien P Mireille R P Serge V | 1998 | Mater Res Bull1998，33，11： | 1 |
| 6 | Jamming phase diagram for attractive particles显示文摘 | Trappe V Prasad V Cipelletti L Serge P N Weitz D A | 2001 | Nature2001，411，： | 1 |
| 7 | Acute effects of right ventricu-lar apical pacing on left ventricular synchrony and mechanics 显示文摘 | Delgado V Tops LF Serge A | 2009 | Circ Arrhythmia Electrophysiol2009，2，： | 1 |
| 8 | Antioxidant flavone glycosides from the leaves of Fargesia robusta 显示文摘 | LAURA V H IZET K SERGE V C | 2010 | J Nat Prod2010，73，9： | 1 |
| 9 | Influence of the sol gel synthesis on the formation of spinel MgAl2 O4 显示文摘 | JULIEN P MIREILLE R P SERGE V | 1998 | Mater Res Bull1998，33，11： | 1 |
| 10 | Management of common bile duct stones in a single operation combining laparos- copic cholecystectomy and peroperation endoscopic sphincterotomy 显示文摘 | Christian M Jacques V Serge R | 2002 | Hepatob- iliary Pancreat Surg2002，9，2： | 1 |
| 11 | Selective involvement of IL-6 in the transcriptional activation of the suppressor of cytokines signaling-3 in the brain during systemic immune challenges 显示文摘 | Eric L Luc V Serge R | 2000 | Endocrinology2000，141，： | 1 |
| 12 | Vascular cognitive impairment显示文摘 | John T O’Brien Timo Erkinjuntti Barry Reisberg Gustavo Roman Tohru Sawada Leonardo Pantoni John V Bowler Clive Ballard Charles DeCarli Philip B Gorelick Kenneth Rockwood Alistair Burns Serge Gauthier Steven T DeKosky | 2003 | Lancet Neurology2003，，2： | 1 |
| 13 | Management of common bile duct stones in a single operation combining laparoscopic cholecystectomy and peroperation endoscopic sphincterotomy显示文摘 | Christian M Jacques V Serge R | 2002 | Hepatobiliary Pancreat Surg2002，9，2： | 1 |
| 14 | Calcitonin gene-related peptide in viscerosensitive response 6to colorectal distension in tats显示文摘 | Serge St | 1997 | Am J Physiol1997，273，11： | 1 |
| 15 | The deviation of bullets passing through windowpanes 显示文摘 | Jan D K Serge L W im V L Els De-mu ynck | 2002 | Fo- rensic Science International2002，125，： | 1 |
| 16 | Effect of photoperiod on body mass, daily energy intake and energy expenditure in young rats 显示文摘 | Polly B Henk V Serge D | 1997 | Physiol Behav1997，62，4： | 1 |
| 17 | Comprehensive study of the influence of total pressure on products yields in fiuidized bed gasifica- tion of wood sawdust显示文摘 | SYLVIE V SERGE R JACQUES GU | 2010 | Fuel Processing Technology2010，91，10： | 1 |
| 18 | Plasma assisted combustion : effect of a coaxial DBD on a methane diffusion flame 显示文摘 | Axel V R Serge L Philippe M | 2007 | Plasma Sources Sci Technol2007，16，： | 1 |
| 19 | Oncogenic β-catenin signaling networks in colorectal cancer显示文摘 | Serge Y Fuchs Andrei V | 2005 | Cell Cycle2005，4，11： | 1 |
| 20 | The evolution of CANMAT Bipolar Disorder Guidelines: past, present, and future显示文摘 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Schaffer Serge Beaulieu Martin Alda Claire O’Donovan Glenda MacQueen Roger S McIntyre Verinder Sharma Arun Ravindran L Trevor Young Roumen Milev David J Bond Benicio N Frey Benjamin I Goldstein | 2013 | Bipolar Disorders2013，，： | 1 |
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