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| 1 | Clinical significance of serum procalcitonin in patients with ulcerative colitis显示文摘AIM:To investigate the association of procalcitonin(PCT)with ulcerative colitis(UC)activity.METHODS:Serum PCT levels,C-reactive protein(CRP)levels,the erythrocyte sedimentation rate,and the white blood cell count were analyzed in 18 patients with UC and 11 healthy volunteers.Serum PCT levels were analyzed by an electrochemiluminescence immunoassay.Severity assessments were based on Truelove and Witts’severity index.Correlation of serum PCT and CRP levels with UC activity was examined.Moreover,we assessed serum PCT and CRP levels in patients with a Mayo endoscopic subscore.RESULTS:Serum PCT levels in severe UC patients(n=7)(0.096±0.034 ng/mL)were significantly higher than in mild-to-moderate UC patients(n=11)(0.033±0.012 ng/mL)and healthy volunteers(n=11)(0.035±0.005 ng/mL)(P=0.0005 and P<0.0001,respectively).In addition,there was no difference in serum PCT levels between mild-to-moderate UC patients and healthy volunteers.Interestingly,patients with a Mayo endoscopic subscore of 3 points displayed significantly increased levels of serum PCT(0.075±0.043 ng/mL)compared with patients with a subscore of 2 points(0.03±0.011 ng/mL)(P=0.0302).Moreover,CRP levels in patients with severe UC or a Mayo endoscopic subscore of 3 points were not significantly higher than in patients with mild-to-moderate UC or a Mayo endoscopic subscore of 3 points.CONCLUSION:Serum PCT levels were significantly correlated with UC activity. | Shigeo Koido Toshifumi Ohkusa Kazuki Takakura Shunichi Odahara Shintaro Tsukinaga Toyokazu Yukawa Jimi Mitobe Mikio Kajihara Kan Uchiyama Hiroshi Arakawa Hisao Tajiri | 2013 | World Journal of Gastroenterology2013，19，45： | 15 |
| 2 | Current Immunotherapeutic Approaches in Pancreatic Cancer显示文摘 | Shigeo Koido Sadamu Homma Akitaka Takahara Yoshihisa Namiki Shintaro Tsukinaga Jimi Mitobe Shunichi Odahara Toyokazu Yukawa Hiroshi Matsudaira Keisuke Nagatsuma Kan Uchiyama Kenichi Satoh Masaki Ito Hideo Komita Hiroshi Arakawa Toshifumi Ohkusa Jianlin Go | 2011 | Clinical and Developmental Immunology2011，，： | 3 |
| 3 | Oxidative stress decreases klotho expression in a mouse kidney cell line 显示文摘 | Mitobe M Yoshida T Sugiura H | 2005 | Nephron Exp Nephro12005，101，2： | 1 |
| 4 | The effect of aspirin on antioxidant defences of cultured rat gastric mucosal cells显示文摘 | MITOBE Y H IRAISHI H SASAI T | 2000 | Aliment Pharmacol Ther2000，14，1： | 1 |
| 5 | Involvement of RNA-binding protein Hfq in the post-transcriptional regulation of invE gene expression in Shigella sonnei显示文摘 | Watanabe H Mitobe J Morita-Ishihara T | 2008 | Journal of Biolog- ical Chemistry2008，283，9： | 1 |
| 6 | Enhancing activity of mycobacterial cell-derived adjuvants on immunogenicity of recombinant human hepatitis B virus vaccine显示文摘 | Koike Y Yoo YC Mitobe M | | Vaccine0，，： | 1 |
| 7 | Oxidative stress decreases Klotho expression in a mouse kidney cell line显示文摘 | Mitobe M Yoshlda T Sugiura H | 2005 | Nephron Exp Nephrol2005，101，2： | 1 |
| 8 | Multi-arm robot control system for manipulation of flexible materials in sewing operation显示文摘 | Kudo M Nasu Y Mitobe K | 2000 | Mechatronics2000，10，3： | 1 |
| 9 | Inhibition of heat shock protein 90 sensitizes melanoma cel s to thermosensitive ferromagnetic particle-mediated hyperthermia with low Curie temperature显示文摘 | Ito A Saito H Mitobe K | | 0，，03： | 1 |
| 10 | Oxidative stress decreases klotho expression in a mouse kidney cell line显示文摘 | Mitobe M Yoshida T Sugiura H | 2005 | Nephron Exp Nephrol2005，101，2： | 1 |
| 11 | Control of a biped walking robot during the double support phase显示文摘 | Mitobe K Mori N Nasu Y | 1997 | Autonomous Robots1997，4，3： | 1 |
| 12 | Seasonal change of persistent organic pollutant concentrations in air at Niigata area,Japan显示文摘 | Murayama H Takase Y Mitobe H | 2003 | Chemosphere2003，52，： | 1 |
| 13 | Klotho reduces apoptosis in experimental ischaemic acute kidney injury via HSP- 70显示文摘 | Sugiura H Yoshida T Mitobe M | 2010 | Nephrol Dial Transplant2010，25，1： | 1 |
| 14 | Oxidative stress decreases klotho expression in a mouse kidney cell line显示文摘 | MITOBE M YOSHIDA T SUGIURA H | 2005 | Nephron Exp Nephrol2005，101，2： | 1 |
| 15 | Klotho reduces apoptosis in experimental ischaemic acute kidney injury via HSP-70显示文摘 | Sugiura H Yoshida T Mitobe M | 2010 | Nephrol Dial Transplant2010，25，1： | 1 |
| 16 | Monitoring of herbicide in river water by gas chromatography-mass spectrometry and solid-phase extraction显示文摘 | Tanable A Mitobe H Kawaka K | 1996 | Journal of Chromatography A1996，754，： | 1 |
| 17 | IL-27 enhances the expression of TRAIL and TLR3 in human melanomas and inhibits their tumor growth in cooperation with a TLR3 agonist poly( I: C) partly in a TRAIL-dependent manner 显示文摘 | CHIBA Y MIZOGUCHI I MITOBE K | 2013 | PLoS One2013，8，76： | 1 |
| 18 | Klotho reduces apoptosis in experimental ischaemic acute kidney injury via HSP-70 显示文摘 | Sugiura H Yoshida T Mitobe M | 2010 | Nephrol Dial Transplant2010，25，1： | 1 |
| 19 | Klotho reduces apoptosis in experimental ischaemic acute kidney injury via HSP-70显示文摘 | Sugiura H Yoshida Y Mitobe M | 2010 | Nephrol Dial Transplant2010，25，1： | 1 |
| 20 | Seasonal change of persistent organic pollutant concentrations in air at Niigata area, Japan显示文摘 | Murayama H Takase Y Mitobe H | 2003 | Chemosphere2003，52，4： | 1 |
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