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| 1 | Immunotherapy for colorectal cancer显示文摘The incidence of colorectal cancer(CRC)is on the rise,and the prognosis for patients with recurrent or metastatic disease is extremely poor.Although chemotherapy and radiation therapy can improve survival rates,it is imperative to integrate alternative strategies such as immunotherapy to improve outcomes for patients with advanced CRC.In this review,we will discuss the effect of immunotherapy for inducing cytotoxic T lymphocytes and the major immunotherapeutic approaches for CRC that are currently in clinical trials,including peptide vaccines,dendritic cell-based cancer vaccines,whole tumor cell vaccines,viral vector-based cancer vaccines,adoptive cell transfer therapy,antibody-based cancer immunotherapy,and cytokine therapy.The possibility of combination therapies will also be discussed along with the challenges presented by tumor escape mechanisms. | Shigeo Koido Toshifumi Ohkusa Sadamu Homma Yoshihisa Namiki Kazuki Takakura Keisuke Saito Zensho Ito Hiroko Kobayashi Mikio Kajihara Kan Uchiyama Seiji Arihiro Hiroshi Arakawa Masato Okamoto Jianlin Gong Hisao Tajiri | 2013 | World Journal of Gastroenterology2013，19，46： | 11 |
| 2 | Fusions between dendritic cells and whole tumor cells as anticancer vaccines显示文摘 | Shigeo Koido Sadamu Homma Masato Okamoto Yoshihisa Namiki Kazuki Takakura Kan Uchiyama Mikio Kajihara Seiji Arihiro Hiroo Imazu Hiroshi Arakawa Shin Kan Hideo Komita Masaki Ito Toshifumi Ohkusa Jianlin Gong Hisao Tajiri | 2013 | OncoImmunology2013，，： | 3 |
| 3 | Current Immunotherapeutic Approaches in Pancreatic Cancer显示文摘 | Shigeo Koido Sadamu Homma Akitaka Takahara Yoshihisa Namiki Shintaro Tsukinaga Jimi Mitobe Shunichi Odahara Toyokazu Yukawa Hiroshi Matsudaira Keisuke Nagatsuma Kan Uchiyama Kenichi Satoh Masaki Ito Hideo Komita Hiroshi Arakawa Toshifumi Ohkusa Jianlin Go | 2011 | Clinical and Developmental Immunology2011，，： | 3 |
| 4 | Dendritic cell-based vaccine for pancreatic cancer in Japan显示文摘'Vaccell' is a dendritic cell(DC)-based cancer vaccine which has been established in Japan. The DCs play central roles in deciding the direction of host immune reactions as well as antigen presentation. We have demonstrated that DCs treated with a streptococcal immune adjuvant OK-432, produce interleukin-12, induce Th1-dominant state, and elicit anti-tumor effects, more powerful than those treated with the known DCmaturating factors. We therefore decided to mature DCs by the OK-432 for making an effective DC vaccine, Vaccell. The 255 patients with inoperable pancreatic cancer who received standard chemotherapy combined with DC vaccines, were analyzed retrospectively. Survival time of the patients with positive delayed type hypersensitivity(DTH) skin reaction was significantly prolonged as compared with that of the patients with negative DTH. The findings strongly suggest that there may be 'Responders' for the DC vaccine in advanced pancreatic cancer patients. We next conducted a smallscale prospective clinical study. In this trial, we pulsed HLA class Ⅱ-restricted WT1 peptide(WT1-Ⅱ) in addition to HLA class Ⅰ-restricted peptide(WT1-Ⅰ) into the DCs. Survival of the patients received WT1-Ⅰ and-Ⅱ pulsed DC vaccine was significantly extended as compared to that of the patients received DCs pulsed with WT1-Ⅰ or WT1-Ⅱ alone. Furthermore, WT1-specific DTH positive patients showed significantly improved the overall survival as well as progressionfree survival as compared to the DTH negative patients. The activation of antigen-specific immune responses by DC vaccine in combination with standard chemotherapy may be associated with a good clinical outcome in advanced pancreatic cancer. We are now planning a pivotal study of the Vaccell in appropriate protocols in Japan. | Masato Okamoto Masanori Kobayashi Yoshikazu Yonemitsu Shigeo Koido Sadamu Homma | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，1： | 2 |
| 5 | Production of corticotropin-releasing factor and urocortin from human monocyte-derived dendritic cells is stimulated by commensal bacteria in intestine显示文摘AIM:To examine whether commensal bacteria are a contributing cause of stress-related mucosal inflammation.METHODS:Human peripheral blood monocyte-deriveddendritic cells(MoDCs)were stimulated by commensal bacterial strains,including Escherichia coli,Clostridium clostridioforme,Bacteroides vulgatus(B.vulgatus),Fusobacterium varium(F.varium),and Lactobacillus delbrueckii subsp.bulgaricus.After incubation,corticotropin-releasing factor(CRF)and urocortin 1(UCN1)mRNA in the cells was examined by real-time reverse transcription polymerase chain reaction.Supernatants from the cells were tested for CRF and UCN1 using an enzyme-linked immunosorbent assay.RESULTS:Both CRF and UCN1 were significantly augmented by B.vulgatus and F.varium at both the mRNA and protein levels.In particular,B.vulgatus stimulated human MoDCs,resulting in extremely high levels of CRF and UCN1.CONCLUSION:Stimulation of MoDCs by B.vulgatus and F.varium may be associated with CRF/UCN1-related intestinal disorders,such as irritable bowel syndrome and inflammatory bowel disease. | Shigeo Koido Toshifumi Ohkusa Shin Kan Kazuki Takakura Keisuke Saito Hideo Komita Zensho Ito Hiroko Kobayashi Shinichiro Takami Kan Uchiyama Hiroshi Arakawa Masaki Ito Masato Okamoto Mikio Kajihara Sadamu Homma Hisao Tajiri | 2014 | World Journal of Gastroenterology2014，20，39： | 2 |
| 6 | Immunotherapy synergizes with chemotherapy targeting pancreatic cancer显示文摘 | Shigeo Koido Sadamu Homma Akitaka Takahara Yoshihisa Namiki Hideo Komita Kan Uchiyama Masaki Ito Jianlin Gong Toshifumi Ohkusa Hisao Tajiri | 2012 | Immunotherapy2012，，1： | 2 |
| 7 | Chemoimmunotherapy targeting Wilms’ tumor 1 (WT1)-specific cytotoxic T lymphocyte and helper T cell responses for patients with pancreatic cancer显示文摘 | Shigeo Koido Sadamu Homma Masato Okamoto Kazuki Takakura Jianlin Gong Haruo Sugiyama Toshifumi Ohkusa Hisao Tajiri | 2014 | OncoImmunology2014，，10： | 2 |
| 8 | Regulation of Tumor Immunity by Tumor/Dendritic Cell Fusions显示文摘 | Shigeo Koido Sadamu Homma Eiichi Hara Yoshihisa Namiki Akitaka Takahara Hideo Komita Eijiro Nagasaki Masaki Ito Toshifumi Ohkusa Jianlin Gong Hisao Tajiri E. Shevach | 2010 | Clinical and Developmental Immunology2010，，： | 2 |
| 9 | Cancer Vaccine by Fusions of Dendritic and Cancer Cells显示文摘 | Shigeo Koido Eiichi Hara Sadamu Homma Yoshihisa Namiki Toshifumi Ohkusa Jianlin Gong Hisao Tajiri Mario Clerici | 2010 | Clinical and Developmental Immunology2010，，： | 1 |
| 10 | Comfort pressure evaluation of men's socks using an elastic optical fiber显示文摘 | Toyonori Nishimatsu Kenichi Ohmura Sadamu Sekiguchi | 1998 | Textile Res J1998，68，6： | 1 |
| 11 | Comparative studies with various substrains of Mycobacterium bovis BCG on the production of an antigenic protein,MPB70显示文摘 | Kaoru Miura Sadamu Nagai Masamichi Kinomoto | 1983 | Infect Immun1983，39，： | 1 |
| 12 | Flavone glycosides from Asplenium normale显示文摘 | Tsukasa I Sadamu M Kazutoshi O | 1990 | Phytochemistry1990，29，11： | 1 |
| 13 | Properties of proteins MPB64, MPB70, and MPBS0 of Mycobacterium bovis BCG 显示文摘 | Morten Harboe Sadamu Nagai Manuel E PataiToyo | 1986 | Infect Imm1986，52，1： | 1 |
| 14 | Flavonoids in the species of Cyrtomium (Dryopteridaceae) and related genera显示文摘 | Tsukasa lwashina Junichi Kitajima Sadamu Matsumoto | 2006 | Biochem Syst Ecol2006，34，： | 1 |
| 15 | Immunotherapy using fusions of autologous dendritic cells and tumor cells showed effective clinical response in a patient with advanced gastric carcinoma显示文摘 | Sadamu Homma Kazuo Matai Masaki Irie Tsuneya Ohno Donald Kufe Gotaro Toda | 2003 | Journal of Gastroenterology2003，，10： | 1 |
| 16 | Preventive antitumor activity against hepatocellular carcinoma (HCC) induced by immunization with fusions of dendritic cells and HCC cells in mice显示文摘 | Sadamu Homma Gotaro Toda Jianlin Gong Donald Kufe Tsuneya Ohno | 2001 | Journal of Gastroenterology2001，，11： | 1 |
| 17 | Results of a phase I clinical trial of vaccination of glioma patients with fusions of dendritic and glioma cells显示文摘 | Tetsuro Kikuchi Yasuharu Akasaki Masaki Irie Sadamu Homma Toshiaki Abe Tsuneya Ohno | 2001 | Cancer ImmunologyImmunotherapy2001，，7： | 1 |
| 18 | Purification and Characterization of a Low-Molecular-Mass T-Cell Antigen Secreted by Mycobacterium tuberculosis 显示文摘 | Anne L Srensen Sadamu Nagai | 1995 | Infection and Immunity1995，63，5： | 1 |
| 19 | Isolation and partial characterization of major protein antigens in the culture fluid of Mycobacterium tuberculosis显示文摘 | Sadamu N Harald GW Morten H | 1991 | Infect Immun1991，59，1： | 1 |
| 20 | Dendritic/pancreatic carcinoma fusions for clinical use: Comparative functional analysis of healthy- versus patient-derived fusions显示文摘 | Shigeo Koido Eiichi Hara Sadamu Homma Yoshihisa Namiki Hideo Komita Akitaka Takahara Eijiro Nagasaki Masaki Ito Yukiko Sagawa Makoto Mitsunaga Kan Uchiyama Kenichi Satoh Seiji Arihiro Toshifumi Ohkusa Jianlin Gong Hisao Tajiri | 2010 | Clinical Immunology2010，，3： | 1 |
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