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98篇 您的检索式：作者名="Mitsuno"

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	题名	作者	年代	出处	被引量
1	NF-κB and ERK-signaling pathways contribute to the gene expression induced by cag PAI-positive-Helicobacter pylori infection显示文摘AIM: To elucidate the sequential gene expression profile in AGS cells co-cultured with wild-type Hellcobacter pylori (Hpylon) as a model of H pylori-infected gastric epithelium, and to further examine the contribution of cag-pathogenicity islands (cagPAI)-coding type Ⅳ secretion system and the two pathways, nuclear factor kappa B (NF-κB) and extracellular signal-regulated kinases (ERK) on wild-type H pylori-induced gene expression. METHODS: Gene expression profiles induced by H pylori were evaluated in AGS gastric epithelial cells using cDNA microarray, which were present in the 4 600 independent clones picked up from the human gastric tissue. We also analyzed the contribution of NF-κB and ERK signaling on H pylori-induced gene expression by using inhibitors of specific signal pathways. The isogenic mutant with disrupted capE (△cagE) was used to elucidate the role of capPAI-encoding type Ⅳ secretion system in the gene expression profile. RESULTS: According to the expression profile, the genes were classified into four clusters. Among them, the clusters characterized by continuous upregulation were most conspicuous, and it contained many signal transducer activity-associated genes. The role of cagPAI on cultured cells was also investigated using isogenic mutant cagE, which carries non-functional cagPAI. Then the upregulation of more than 80% of the induced genes (476/566) was found to depend on cagPAI. Signal transducer pathway through NF-κB or ERK are the major pathways which are known to be activated by cagPAI-positive H pylori. The role of these pathways in the whole signal activation by cagPAI- positive H pylori was analyzed. The specific inhibitors against NF-κB or ERK pathway blocked the activation of gene expression in 65% (367/566) or 76% (429/566) of the genes whose activation appealed to depend on cagPAI. CONCLUSION: These results suggest that more than half of the genes induced by cagPAI-positive H pylori depend on NF-κB and ERK signaling activation, and these pathways may play a role in the gene expression induced by host-bacterial interaction which may associate with H pylori-related gastro-duodenal diseases.	Wataru Shibata Yoshihiro Hirata Haruhiko Yoshida Motoyuki Otsuka Yujin Hoshida Keiji Ogura Shin Maeda Tomoya Ohmae Ayako Yanai Yuzo Mitsuno Naohiko Seki Takao Kawabe Masao Omata	2005	World Journal of Gastroenterology2005，11，39：	12
2	Effect of covered area at the waist on clothing pressure显示文摘	Makabe H Momota H Mitsuno T	1993	Sen-i Gakkaishi1993，49，10：	1
3	Helicobacter pylori activates the proto-oncogene c-fos through SRE transactivation显示文摘	Mitsuno Y Maeda S Yoshida H	2002	Biochem Biophys Res Commun2002，291，4：	1
4	Identification and functional characterization of a sex pheromone receptor in the silkworm Bombyx mori显示文摘	Sakural T Nakagawa T Mitsuno H	2004	Proc Natl Acad Sci USA2004，101，16：	1
5	Helicobacter pylori induced transactivation of SRE and AP-1 through the ERK signalling pathway in gastric cancer cells显示文摘	Mitsuno Y Yoshida H Maeda S	2001	Gut2001，49，1：	1
6	Wound therapy by marrow mesenchymal cell transplantation显示文摘	Yoshikawa T Mitsuno H Nonaka I	2008	Plast Re- constr Surg2008，121，3：	1
7	Analysis of apoptotic and antiapoptotic signaling pathways induced by Helicobacter pylori显示文摘	Maeda S Yoshida H Mitsuno Y	2002	Gut2002，50，：	1
8	A Study of clothing pressure caused by Japanese men's sock显示文摘	MOMOTA H MAKEBE H MITSUNO T	1993	Journal of the Japan Research Association for Textile End-Uses1993，，34：	1
9	Analysis of apoptotic and antiapoptotic sígnalling pathways induced by Helicobacter pylori显示文摘	MAEDA S YOSHIDA H MITSUNO Y	2002	Gut2002，50，：	1
10	Distinct mechanism of Helicobacter pylori-mediated NF-κB activation between gastric cancer cells and monocytic cells显示文摘	Shin Maeda Masao Akanuma Yuzo Mitsuno	2001	J Biolo Chem2001，276，44：	1
11	Effect of covered area at the waist on clothing pressure显示文摘	Makabe H Momota H Mitsuno T	1993	Sen''i Gakkaishi1993，49，：	1
12	Analysis of apoptotic and antiapoptotic signalling pathways induced by Helicobacter pylori 显示文摘	Maeda S Yoshida H Mitsuno Y	2002	Mol Pathol2002，55，5：	1
13	Helicobacter pyloriinduces antiapoptosis through buclear factor-kappa Bactivation显示文摘	Yanai A Hirata Y Mitsuno Y	2003	J Infect Dis2003，，：	1
14	Helicobacter pylori infection is an independent risk factor for Runx3 methylationin gastric cancer 显示文摘	Kitajima Y Ohtaka K Mitsuno M	2008	Oncol Rep2008，19，1：	1
15	Analysis of apoptotic and antiapoptotic signalling pathways induced by Helicobacter pylori 显示文摘	Maeda S Yoshida H Mitsuno Y	2002	Gut2002，50，：	1
16	Clinical studies of perfluorochemical whole substitute (Fluosol - DA )显示文摘	Harumasa Ohyanagi MD	1982	Ann Surg Jan1982，195，：	1
17	Clinical studies of perfluorochemical whole substitute (Fluosol-DA)显示文摘	Takao Mitsuno MD Harumasa Ohyanagi MD	1982	Ann Surg Jan1982，195，：	1
18	Edaravone suppresses reperfusion injury following leg ischemia in rats: a transmission electron microscopic study 显示文摘	Yamamura M Miyamoto Y Mitsuno M	2013	Int J Angiol2013，22，4：	1
19	Endoscopic submucosal dissection is an effective and safe therapy for early gastric neoplasm:A multicenter feasible study显示文摘	Sugimoto T Okamoto M Mitsuno Y		0，，02：	1
20	Late reoperations after repair of acute type A aortic dissection显示文摘	Nishi H Mitsuno M Tanaka H		0，，：	1

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