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| 1 | Comparison between combination therapy of percutaneous ethanol injection and radiofrequency ablation and radiofrequency ablation alone for patients with hepatocellular carcinoma显示文摘AIM: In the present study, the characteristics of PEI-RFA treatment were further elucidated by analyzing the relationship between the volume of coagulated necrosis and the energy requirement for ablation or the amount of ethanol injected into HCC.METHODS: The volume of coagulated necrosis, total energy requirement and energy requirement for coagulation of per unit volume were examined in the groups of PEI-RFA and RFA alone using the Cool-tip RF system.RESULTS: The results showed that the volume of coagulated necrosis induced was significantly larger in PEI-RFA group than in routine RFA group, when the total energy administered was comparable in both groups.In PEI-RFA, enlargement of coagulated necrosis was admitted in 3 dimensions and the amount of energy requirement per unit volume of coagulated necrosis was negatively correlated with the amount of ethanol injected into HCC.CONCLUSION: These results suggest that, compared to RFA alone, PEI-RFA enables to induce comparable coagulated necrosis with smaller energy requirement, and that PEI-RFA is likely to be less invasive than RFA alone irrespective of inducing enhanced coagulated necrosis.Thus, simple prior injection of ethanol may make RFA treatment more effective and less invasive for the treatment of patients with HCC. | Kazutaka Kurokohchi Seishiro Watanabe Tsutomu Masaki Naoki Hosomi Yoshiaki Miyauchi Takashi Himoto Yasuhiko Kimura Seiji Nakai Akihiro Deguchi Hirohito Yoneyama Shuhei Yoshida Shigeki Kuriyama | 2005 | World Journal of Gastroenterology2005，11，10： | 29 |
| 2 | Neoadjuvant chemotherapy for locally advanced cervical cancer显示文摘Neoadjuvant chemotherapy followed by surgery(NCS) has not been fully evaluated clinically. Currently, the main regimen of neoadjuvant chemotherapy(NAC) used in NCS includes cisplatin. The antitumor effects of NAC reduce lymph node metastasis and the tumor diameter in patients prior to surgery, and this can reduce the number of high risk patients who require postoperative radiation therapy. Many randomized controlled trials(RCTs) have examined the long-term prognosis of NCS compared to primary surgery, but the utility of NCS remains uncertain. The advent of concurrent chemoradiotherapy(CCRT) has markedly improved the outcome of radiotherapy(RT), and CCRT is now used as a standard method in many cases of advanced bulky cervical cancer. NCS gives a better treatment outcome than radiation therapy alone, but it is important to verify that NCS gives a similar or better outcome compared to CCRT. | Takashi Iwata Azumi Miyauchi Yukako Suga Hiroshi Nishio Masaru Nakamura Akiko Ohno Nobumaru Hirao Tohru Morisada Kyoko Tanaka Hiroki Ueyama Hidemichi Watari Daisuke Aoki | 2016 | Chinese Journal of Cancer Research2016，28，2： | 20 |
| 3 | Therapeutic target for nephrotic syndrome: Identification of novel slit diaphragm associated molecules显示文摘The slit diaphragm bridging the neighboring foot processes functions as a final barrier of glomerular capillary wall for preventing the leak of plasma proteins into primary urine.It is now accepted that the dysfunction of the sit diaphragm contributes to the development of proteinuria in several glomerular diseases.Nephrin,a gene product of NPHS1,a gene for a congenital nephrotic syndrome of Finnish type,constitutes an extracellular domain of the slit diaphragm.Podocin was identified as a gene product of NPHS2,a gene for a familial steroid-resistant nephrotic syndrome of French.Podocin binds the cytoplasmic domain of nephrin.After then,CD2 associated protein,NEPH1 and transient receptor potential-6 were also found as crucial molecules of the slit diaphragm.In order to explore other novel molecules contributing to the development of proteinuria,we performed a subtraction hybridization assay with a normal rat glomerular RNA and a glomerular RNA of rats with a puromycin aminonucleoside nephropathy,a mimic of a human minimal change type nephrotic syndrome.Then we have found that synaptic vesicle protein 2B,ephrin-B1 and neurexin were already downregulated at the early stage of puromycin amino-nucleoside nephropathy,and that these molecules were localized close to nephrin.It is conceivable that these molecules are the slit diaphragm associated molecules,which participate in the regulation of the barrier function.These molecules could be targets to establish a novel therapy for nephrotic syndrome. | Yoshiyasu Fukusumi Naoko Miyauchi Taeko Hashimoto Akira Saito Hiroshi Kawachi | 2014 | World Journal of Nephrology2014，3，3： | 9 |
| 4 | Anisotropic optical and electronic properties of two- dimensional layered germanium sulfide显示文摘二维(2D ) 分层的材料,转变金属 dichalcogenides,和黑磷从基本物理和设备应用的观点吸引了可观的兴趣。在各向异性的分层的 2D 材料的新功能的建立是挑战性却令人满意的边疆,由于为新设备的这些材料和他们的前景的显著光性质。此处,我们报导各向异性并且厚度依赖者 2D 的光性质金者硫化物(GeS ) 的分层的 monochalcogenide。相应于 B 3g, 的三座散布 Raman 山峰 g 1 ,和 有强壮的极化依赖的 g 2 模式在 GeS 薄片被表明,它为识别各向异性的分层的 GeS 的水晶取向作为一个有效方法验证极化的拉曼光谱学。光致发光(PL ) 在 ~ 与一座山峰被观察在房间温度在 GeS 从直接光的转变发源的 1.66 eV。PL 的极化依赖者特征,第一次被揭示,在 GeS 的乐队边附近显示明显的各向异性的光转变,它被密度支持功能的理论计算。显著地,厚度依赖者 PL 被观察并且讨论。这各向异性的分层的 GeS 为新物理现象和愿望的发现介绍机会发现利用它的各向异性的性质的应用,例如极化敏感的光电探测器。 | Dezhi Tan Hong En Lim Feijiu Wang Nur Baizura Mohamed Shinichiro Mouri Wenjin Zhang Yuhei Miyauchi Mari Ohfuchi Kazunari Matsuda | 2017 | Nano Research2017，10，2： | 7 |
| 5 | Inhibition of citrus flavonoids on 12-O-tetradecanoylphorbol 13-acetate-induced skin inflammation and tumorigenesis in mice显示文摘The inhibitory effects of a formulated product from citrus peel extract,Gold Lotion(GL),on 12-O-tetradecanoylphorbol 13-acetate(TPA)-induced expression of inducible nitric oxide synthase(iNOS)and cyclooxygenase-2(COX-2)in mouse skin was reported in this study.It is found that in the TPA-induced skin inflammation model,the topical application of GL effectively inhibited the transcriptional activation of iNOS and its mRNA and protein in mouse skin.It is also discovered that GL significantly inhibited TPA-induced mouse skin inflammation by decreasing inflammatory gene parameters.Furthermore,GL dramatically inhibited 7,12-dimethylbenez[a]anthracene(DMBA)/TPA-induced skin tumor formation and reduced tumor incidence,tumor weight and tumor multiplicity of papillomas at 20 weeks.In essence,these in vivo data have revealed that GL is an effective anti-tumor agent that functions by down-regulating the protein levels of COX-2,ornithine decarboxylase(ODC),and vascular endothelial growth factor(VEGF)in mouse skin,suggesting that GL is a novel functional natural product capable of preventing inflammation-associated tumorigenesis.©2012 Production and hosting by Elsevier B.V.on behalf of Beijing Academy of Food Sciences. | Min-Hsiung Pan Shiming Li Ching-Shu Lai Yutaka Miyauchi Michiko Suzawa Chi-Tang Ho | 2012 | Food Science and Human Wellness2012，1，1： | 7 |
| 6 | 窄轨列车用制动盘和闸片的摩擦磨损特性显示文摘铸铁制动盘自1953年以来就已在日本的列车制动中应用,但在运用中存在耐磨性和热裂方面的一些问题,因此自1975年以来又开发了一些其它种类的制动盘材料。1990年闸片材料由石棉复合材料改为非石棉复合材料,最近各种各样的制动盘和闸片都在应用,因此,对某些制动盘和闸片的摩擦磨损特性作出评定是十分重要的。我们对不同的制动盘和闸片的组合进行了高速摩擦试验和台架试验,并研究了其基本的摩擦磨损特性。 | TORU MIYAUCHI 吴兴方 | 1999 | 国外机车车辆工艺1999，，1： | 5 |
| 7 | Vulnerable atherosclerotic plaque features:findings from coronary imaging显示文摘Pathological studies have suggested that features of vulnerable atherosclerotic plaques likely to progress and lead to acute cardiovascular events have specific characteristics.Given the progress of intravascular coronary imaging technology,some large prospective studies have detected features of vulnerable atherosclerotic plaques using these imaging modalities.However,the rate of cardiovascular events,such as acute coronary syndrome,has been found to be considerably reduced in the limited follow-up period available in the statin era.Additionally,not all disrupted plaques lead to thrombus formation with clinical presentation.If sub-occlusive or occlusive thrombus formation does not occur,a thrombus on a disrupted plaque will organize without any symptoms,forming a'healed plaque'.Although vulnerable plaque detection using intracoronary imaging is focused on'thin-cap fibroatheroma'leading to plaque rupture,superficial plaque erosion is increasingly recognized;however,the underlying mechanism of thrombus formation on eroded plaques is not well understood.One of intravascular imaging,optical coherence tomography(OCT)has the highest image resolution and has enabled detailed characterization of the plaque in vivo.Here,we reviewed the status and limitations of intravascular imaging in terms of detecting vulnerable plaque through mainly OCT studies.We suggested that vulnerable plaque should be reconsidered in terms of eroded plaque and healed plaque and that both plaque and circulating blood should be assessed in greater detail accordingly. | Osamu Kurihara Masamichi Takano Yasushi Miyauchi Kyoichi Mizuno Wataru Shimizu | 2021 | Journal of Geriatric Cardiology2021，18，7： | 5 |
| 8 | CuPd催化剂调节中间反应能垒提高电催化CO_(2)生成二碳产物的选择性显示文摘过度的碳排放已造成了严重的全球环境问题,电催化CO_(2)还原是一种利用间歇性过剩电能将CO_(2)转化为有价值的化学物质的有效策略.在多种CO_(2)还原产物中,二碳(C2)产物(如乙烯、乙醇)因其比一碳产物(如甲酸、甲烷、甲醇)具有更高的能量密度而备受关注.Cu是唯一能用电化学方法将CO_(2)转化为多碳产物的单金属催化剂.如何提高Cu基催化剂上CO_(2)还原为C2产物的效率已引起了极大关注.电催化还原CO_(2)生成C2产物有两个重要步骤:一是参与碳碳偶联反应的CO*中间体的量(*代表中间体吸附在基底表面),二是碳碳偶联步骤的能垒.对于Cu单金属催化剂,虽然其表面碳碳偶联步骤的能垒相对较低,但是Cu对CO_(2)的吸附能力和CO_(2)*加氢能力并不高,导致在Cu表面不能生成足量的CO*中间体参与碳碳偶联反应,因而对C2产物的选择性和活性并不理想.与Cu单金属催化剂相反,在Pd单金属催化剂表面,CO*中间体的形成具有超快的反应动力学,但是CO*易在Pd表面中毒且后续碳碳偶联步骤的能垒极高,使其表面不能生成C2产物.为了充分发挥Cu(碳碳偶联步骤能垒较低)和Pd(CO*形成具有超快反应动力学)的双重优势,本文构建了一种紧密的CuPd(100)界面,以调节中间反应能垒,从而提高C2产率.密度泛函理论(DFT)计算表明,CuPd(100)界面增强了CO_(2)的吸附,且降低了CO_(2)*加氢步骤的能垒,从而能够催化生成更多的CO*中间体参与碳碳偶联反应.且CuPd(100)界面上CO_(2)还原为C2产物的电位决定步骤能垒为0.61 eV,低于Cu(100)表面的(0.72 eV).本文采用了一种简便的湿化学法制备了CuPd(100)界面催化剂.X射线衍射和X射线光电子能谱测试以及扩展X射线吸收精细结构光谱结果表明,合成的是相分离的CuPd双金属催化剂,而非CuPd合金催化剂.同时高分辨透射电镜可以观察到清晰的CuPd(100)界面.由此可见,本文成功合成了CuPd(100)界面催化剂.程序升温脱附实验结果表明,CuPd(100)界面对CO_(2)和CO*的吸附比Cu强,结果与理论预测一致.气体传感实验结果表明,CuPd(100)界面CO_(2)*加氢能力比Cu强.为评估CuPd(100)界面催化剂的催化活性,进行了CO_(2)电化学还原实验.结果表明,在0.1 mol/L的KHCO3电解液中,CuPd(100)界面催化剂在‒1.4 VRHE下,C2产物的法拉第效率为50.3%±1.2%,是同电位下Cu催化剂的(23.6%±1.5%)的2.1倍,C2产物的选择性是Cu催化剂的2.4倍,且具有更高的电流密度和更大的电化学活性面积.本文通过调控中间反应能垒以合理设计铜基CO_(2)还原电催化剂提供了参考. | 朱莉 林翌阳 刘康 Emiliano Cortés 李红梅 胡俊华 Akira Yamaguchi 刘小良 Masahiro Miyauchi 傅俊伟 刘敏 | 2021 | Chinese Journal of Catalysis2021，42，9： | 4 |
| 9 | Biomimetic Riblets Inspired by Sharkskin Denticles: Digitizing, Modeling and Flow Simulation显示文摘 | Mariko Miyazaki Yuji Hirai Hiroshi Moriya Masatsugu Shimomura Akihiro Miyauchi Hao Liu | 2018 | Journal of Bionic Engineering2018，15，6： | 3 |
| 10 | 为与窒息肠塞痛联系的肠的局部缺血的察觉的动态 CT 的动脉的阶段的用途显示文摘 AIM:To clarify the usefulness of arterial phase scans in contrast computed tomography (CT) imaging of stran-gulation ileus in order to make an early diagnosis. METHODS:A comparative examination was carried out with respect to the CT value of the intestinal tract wall in each scanning phase, the CT value of the content in the intestinal tract, and the CT value of ascites fluid in the portal vein phase for a group in which ischemia was observed (Group Ⅰ) and a group in which ischemia was not observed (Group N) based on the pathological findings or intra-surgical findings. Moreover, a comparative examination was carried out in Group Ⅰ subjects for each scanning phase with respect to average differences in the CT values of the intestinal tract wall where ischemia was suspected and in the intestinal tract wall in non-ischemic areas. RESULTS:There were 15 subjects in Group Ⅰ and 30 subjects in Group N. The CT value of the intestinal tract wall was 41.8 ± 11.2 Hounsfield Unit (HU) in Group Ⅰ and 69.6 ± 18.4 HU in Group N in the arterial phase, with the CT value of the ischemic bowel wall being significantly lower in Group Ⅰ. In the portal vein phase, the CT value of the ischemic bowel wall was 60.6 ± 14.6 HU in Group Ⅰ and 80.7 ± 17.7 HU in Group N, with the CT value of the ischemic bowel wall being significantly lower in Group Ⅰ; however, no significant differences were observed in the equilibrium phase. The CT value of the solution in the intestine was 18.6 ± 9.5 HU in Group Ⅰ and 10.4 ± 5.1 HU in Group N, being signifi-cantly higher in Group Ⅰ. No significant differences were observed in the CT value of the accumulation of ascites fluid. The average difference in the CT values between the ischemic bowel wall and the non-ischemic bowel wall for each subject in Group Ⅰ was 33.7 ± 20.1 HU in the arterial phase, being significantly larger compared to the other two phases. CONCLUSION:This is a retrospective study using a small number of subjects; however, it suggests that there is a possibility that CT scanning in the arterial phase is useful for the early diagnosis of strangulation ileus. | Gaku Ohira Kiyohiko Shuto Tsuguaki Kono Takayuki Tohma Hisashi Gunji Kazuo Narushima Shunsuke Imanishi Takeshi Fujishiro Tohru Tochigi Toshiharu Hanaoka Hideaki Miyauchi Naoyuki Hanari Hisahiro Matsubara Noriyuki Yanagawa | 2012 | World Journal of Radiology2012，4，11： | 2 |
| 11 | Molecular weight-dependent effects of hyaluronate on the arthriticsynovium显示文摘 | Asari A Miyauchi S Matsuzaka S | | Archives of Histology and Cytology0，，： | 2 |
| 12 | Anaplastic carcinoma of the pancreas: Case report and literature review of reported cases in Japan显示文摘We report a case of a 64-year-old woman with anaplastic carcinoma of the pancreas(ACP) with cyst formation and review 60 ACP cases reported in Japan. In 20% of cases, laboratory tests revealed severe anemia(hemoglobin level < 10.0 g/d L) and elevated leucocyte counts(> 12000/mm3), which were likely attributable to rapid tumor growth, intratumoral hemorrhage, and necrosis. Elevated serum CA19-9 levels were observed in 55% of cases. Cyst-like structures were observed on imaging in 47% of cases, and this finding appears to reflect subsequent cystic degeneration in the lesion. Macroscopically, hemorrhagic necrosis was observed in 77% of cases, and cyst formation was observed in 33% of cases. ACP should be considered when diagnosing pancreatic tumors with a cyst-like appearance, especially in the presence of severe anemia, elevated leucocyte counts, or elevated serum CA19-9 levels. | Sojun Hoshimoto Junichi Matsui Ryohei Miyata Yutaka Takigawa Jun Miyauchi | 2016 | World Journal of Gastroenterology2016，22，38： | 2 |
| 13 | Human cerebellar activi ty reflecting an acquired internal model of a new tool显示文摘 | Imamizu H Miyauchi S Tamada T | 2000 | Nature2000，403，： | 1 |
| 14 | Super-hydrophilic and transparent thin films of TiO2 nanotube arrays by a hydrothermal reaction 显示文摘 | Miyauchi M Tokudome H | 2007 | Journal of Materials Chemistry2007，17，20： | 1 |
| 15 | Distinct anabolic response of osteoblast to low-intensity pulsed ultrasound 显示文摘 | Miyauchi A Itoman M | 2003 | J Bone Miner Res2003，18，2： | 1 |
| 16 | Inhibition of myocardial endothelin pathway improves long-term survival in heart failure 显示文摘 | MIYAUCHI T KOBAYASHI M | 1996 | Nature1996，384，： | 1 |
| 17 | Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21- dependent pathway显示文摘 | Miyauchi H Minamino T Tateno K | 2004 | EMBO J2004，23，1： | 1 |
| 18 | Oxygen-Ion Con-duction in the Sm2Zr2O7 Pyrochlore Phase显示文摘 | Shinozaki K Miyauchi M Kuroda K | 1979 | Journal of the A-merican Ceramic Society1979，62，910： | 1 |
| 19 | Decreased circulating lipoprotein-associated phospholipase A2 levels are associated with coronary plaque regression in patients with acute coronary syndrome显示文摘 | Dohi T Miyauchi K Okazaki S | 2011 | Atherosclerosis2011，10，： | 1 |
| 20 | Inhibition of myocardial endothelin pathway improves long-term survival in heart failure显示文摘 | Sakai S Miyauchi T Kobayashi M | 1996 | Nature1996，384，6607： | 1 |
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