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| 1 | 小柴胡汤对鼠实验性肝纤维化的影响显示文摘为探讨小柴胡汤对鼠肝纤维化的抑制作用,腹腔分别注射二甲基亚硝基胺和猪血清复制两种肝纤维化动物模型。预防和治疗性投与小柴胡汤可促进肝维生素A含量恢复,降低肝胶原含量和明显抑制肝前α-Ⅰ型胶原的基因表达。同时免疫组化染色证实小柴胡杨可显著减少Ⅰ、Ⅲ型胶原在肝脏沉积和明显减少α-平滑肌原纤维阳性的伊东细胞(ItoCell)的数目。结果显示小柴胡汤可防治鼠肝纤维化的发生与发展。 | 马跃荣 Ichiro Shimizu Susumu Ito Yoko Mizobuchi Mitugi Yasuda Ever Escobar | 1997 | 泸州医学院学报1997，20，2： | 7 |
| 2 | Low-dose lipopolysaccharide as an immune regulator for homeostasis maintenance in the central nervous system through transformation to neuroprotective microglia显示文摘Microglia,which are tissue-resident macrophages in the brain,play a central role in the brain innate immunity and contribute to the maintenance of brain homeostasis.Lipopolysaccharide is a component of the outer membrane of gram-negative bacteria,and activates immune cells including microglia via Toll-like receptor 4 signaling.Lipopolysaccharide is generally known as an endotoxin,as administration of highdose lipopolysaccharide induces potent systemic inflammation.Also,it has long been recognized that lipopolysaccharide exacerbates neuroinflammation.In contrast,our study revealed that oral administration of lipopolysaccharide ameliorates Alzheimer’s disease pathology and suggested that neuroprotective microglia are involved in this phenomenon.Additionally,other recent studies have accumulated evidence demonstrating that controlled immune training with low-dose lipopolysaccharide prevents neuronal damage by transforming the microglia into a neuroprotective phenotype.Therefore,lipopolysaccharide may not a mere inflammatory inducer,but an immunomodulator that can lead to neuroprotective effects in the brain.In this review,we summarized current studies regarding neuroprotective microglia transformed by immune training with lipopolysaccharide.We state that microglia transformed by lipopolysaccharide preconditioning cannot simply be characterized by their general suppression of proinflammatory mediators and general promotion of anti-inflammatory mediators,but instead must be described by their complex profile comprising various molecules related to inflammatory regulation,phagocytosis,neuroprotection,anti-apoptosis,and antioxidation.In addition,microglial transformation seems to depend on the dose of lipopolysaccharide used during immune training.Immune training of neuroprotective microglia using lowdose lipopolysaccharide,especially through oral lipopolysaccharide administration,may represent an innovative prevention or treatment for neurological diseases;however more vigorous studies are still required to properly modulate these treatments. | Haruka Mizobuchi Gen-Ichiro Soma | 2021 | Neural Regeneration Research2021，16，10： | 3 |
| 3 | 无汞碱锰电池用隔离纸显示文摘介绍了无汞碱锰电池对隔离纸的特性要求以及日本NKK公司自1985年以来其隔离纸的材料和孔径随电池汞含量逐年降低而发生的变化;报导了NKK公司开发的适用于不同用途的4种隔离纸情况;介绍了无汞碱锰电池隔离纸的发展方向和目标。文章认为:隔离纸原材料的纤维径如何调整到合适的程度是成功的关键。 | MIZOBUCHI | 2001 | 电池工业2001，6，4： | 2 |
| 4 | Management of secondary hyperparathyroidism of dialysis patients显示文摘 | AKIZAWA T KAMIMURA M MIZOBUCHI M | 2003 | Nephrology (Carlton)2003，8，2： | 2 |
| 5 | Combination Therapy with Paricalcitol and Enalapril Ameliorates Cardiac Oxidative Injury in Uremic Rats显示文摘 | Husain Kazim Ferder Leon Mizobuchi Masahide Finch Jane Slatopolsky Eduardo | 2009 | American Journal of Nephrology2009，，5： | 2 |
| 6 | Submucosal territory of the direct lymphatic drainage system to the thoracic duct in the human esophagus显示文摘 | Kenshi Kuge Gen Murakami Shunji Mizobuchi Yoichi Hata Takashi Aikou Shiro Sasaguri | 2003 | The Journal of Thoracic and Cardiovascular Surgery2003，，6： | 2 |
| 7 | Combination therapy with an angiotensin-converting enzyme inhibitor and a vitamin D analog suppresses the progression of renal insufficiency in uremic rats显示文摘 | Mizobuchi M Morrissey J Finch JL | 2007 | J Am Soc Nephrol2007，18，6： | 1 |
| 8 | Mechanism of the drug interaction between valproic acid and carbapenem antibiotics in monkeys and rats显示文摘 | Nakajima Y Mizobuchi M Nakamura M | 2004 | Drug Metab Dispos2004，32，12： | 1 |
| 9 | Clinical significance of parathyroid intervention on CKD-MBD management显示文摘 | Ogata H Mizobuchi M Koiwa F | 2008 | NDT plus2008，1，3： | 1 |
| 10 | Serum superoxide dismutase(SOD) activity in diabetes mellitus显示文摘 | Mizobuchi N Nakata H Horimi T | 1993 | Rinsho Byori1993，41，6： | 1 |
| 11 | ARMET is a soluble ER protein induced by the unfolded protein response via ERSE- H ele- ment 显示文摘 | Mizobuchi N Hoseki J Kubota H | 2007 | Cell Struct Funct2007，32，1： | 1 |
| 12 | Monolithic blue LED series arrays for high-voltage ac operation显示文摘 | AO J P SATO H MIZOBUCHI T etal | 2002 | Physica Status Solidi A2002，194，2： | 1 |
| 13 | Expression changes of the neuregulin 1 isoforms in neuropathic pain model rats显示文摘 | Kanzaki H Mizobuchi S Obata N | 2012 | Neurosci Lett2012，508，： | 1 |
| 14 | Simulation Studies on the CO2 Emission Reduction Efficiency in Spatial Econometrics: A case of Japan 显示文摘 | Mizobuchi KENICHI Kazuhiko KAKAMU | 2007 | Economics Bulletin2007，，18： | 1 |
| 15 | Insulin-like growth factor-I(IGF-I) distribution in the tissue and extracellular compartment in different regions of rat brain显示文摘 | Yarnaguchi F Itano T Mizobuchi M | 1990 | Brain Res1990，19，2： | 1 |
| 16 | Endoscopic clip applica-tion for closure of an esophagomediastinal - tracheal fistula aftersurgery for esophageal cancer 显示文摘 | Mizobuchi S Kuge K Maeda H | 2003 | Gastrointest Endosc2003，57，7： | 1 |
| 17 | Vascular calcification: The killer of patients with chronic kidney disease显示文摘 | Mizobuchi M Towler D Slatopolsky E | 2009 | J Am Soe Nephrol2009，20，7： | 1 |
| 18 | Tin choloride pretreatment privents the renal injury in rats with ischemic acute renal failure显示文摘 | Takahashi T Mizobuchi S | 2002 | Crit Care Med2002，30，7： | 1 |
| 19 | A numerical analysis of the structure of a turbulent hydro- gen jet lifted flame显示文摘 | MIZOBUCHI Y TACH1BANA S SHINIO J | 2002 | Proceedings of the Combustion In- stitute2002，29，2： | 1 |
| 20 | Long-term outcomes of idiopathic membranous nephropathy in Japanese patients treated with low-dose cyclophosphamide and prednisolone 显示文摘 | Eriguchi M Oka H Mizobuchi T | 2009 | Nephrol Dial Transplant2009，24，10： | 1 |
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