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| 1 | MicroRNA-21 targets tumor suppressor genes in invasion and metastasis显示文摘MicroRNAs (miRNAs ) 是在 post-transcriptional 指向编码蛋白质的 mRNAs 的小非编码的 RNA 铺平的自然地发生的一个班。我们的以前的研究建议 mir-21 作为 oncogene 工作并且在 tumorigenesis 有一个角色,部分地通过肿瘤的规定压制或基因对流肌浆球蛋白 1 (TPM1 ) 。给那 TPM1 在房间移植被含有,在我们进一步调查了的这研究在房间侵略和肿瘤转移的 mir-21 的角色。我们发现在变形乳癌 MDA-MB-231 房间的 mir-21 的抑制显著地减少了侵略和肺转移。与这一致, TPM1 的宫外的表示显著地减少了房间侵略。而且,我们识别了二个另外的直接 mir-21 目标,规划房间死亡 4 (PDCD4 ) 并且妈大头针,哪个在侵略和转移被含有。象 TPM1 一样, PDCD4 和妈大头针也减少了 MDA-MB-231 房间的侵略海角。最后, PDCD4 的表示和妈大头针相反地在人的胸肿瘤标本与 mir-21 表示相关,显示由在这些肿瘤的 mir-21 的 PDCD4 和妈大头针的潜在的规定。总起来说,结果建议作为 oncogenic miRNA, mir-21 由指向多重肿瘤 / 转移不仅在肿瘤生长而且在侵略和肿瘤转移有一个角色压制或基因。因此, mir-21 的抑制可以为先进癌症的治疗提供一条新奇途径。 | Shuomin Zhu Hailong Wu Fangting Wu Daotai Nie Shijie Sheng Yin-Yuan Mo | 2008 | Cell Research2008，18，3： | 205 |
| 2 | Suppression of cell growth and invasion by miR-205 in breast cancer显示文摘MicroRNAs (miRNAs ) 内长的、小、非编码的 RNA,它能够在 post-transcriptional 的 silencing 基因表示铺平。在这研究,我们报导 miR-205 是显著地在与匹配的正常的胸织物相比的胸肿瘤的 underexpressed。同样,包括 MCF-7 和 MDA-MB-231,乳癌房间行比非恶意的 MCF-10A 房间表示低级 miR-205。兴趣, miR-205 的宫外的表示显著地禁止房间增长和抛锚独立人士生长,以及房间侵略。而且, miR-205 被显示在一个动物模型压制肺转移。最后,西方的污点与试金表明的酶记者结合了那 ErbB3 和脉管的 endothelial 生长因素 A ( VEGF --一)是为 miR-205 的直接目标,并且这 miR-205-mediated 抑制通过和在 ErbB3 和 VEGF 的 3 鈥? untranslated 区域( 3 鈥? UTR )的通常认为的 miR-205 绑定地点的直接相互作用是可能的--一。一起,这些结果建议 miR-205 是在乳癌的肿瘤 suppressor。 | Hailong Wu Shoumin Zhu Yin-Yuan Mo | 2009 | Cell Research2009，19，4： | 56 |
| 3 | Light-absorbing Particles in Snow and Ice: Measurement and Modeling of Climatic and Hydrological impact显示文摘Light absorbing particles(LAP, e.g., black carbon, brown carbon, and dust) influence water and energy budgets of the atmosphere and snowpack in multiple ways. In addition to their effects associated with atmospheric heating by absorption of solar radiation and interactions with clouds, LAP in snow on land and ice can reduce the surface reflectance(a.k.a., surface darkening), which is likely to accelerate the snow aging process and further reduces snow albedo and increases the speed of snowpack melt. LAP in snow and ice(LAPSI) has been identified as one of major forcings affecting climate change, e.g.in the fourth and fifth assessment reports of IPCC. However, the uncertainty level in quantifying this effect remains very high. In this review paper, we document various technical methods of measuring LAPSI and review the progress made in measuring the LAPSI in Arctic, Tibetan Plateau and other mid-latitude regions. We also report the progress in modeling the mass concentrations, albedo reduction, radiative forcing, and climatic and hydrological impact of LAPSI at global and regional scales. Finally we identify some research needs for reducing the uncertainties in the impact of LAPSI on global and regional climate and the hydrological cycle. | Yun QIAN Teppei J.YASUNARI Sarah J.DOHERTY Mark G.FLANNER William K.M.LAU MING Jing Hailong WANG Mo WANG Stephen G.WARREN Rudong ZHANG | 2015 | Advances in Atmospheric Sciences2015，32，1： | 16 |
| 4 | Application of particle image velocimetry for the measurement of the airflow characteristics in an aircraft cabin显示文摘 | Mo Hailong Hosni M H Jones B W | 2003 | ASHRAETransactions2003，109，2： | 1 |
| 5 | LncRNA-POIR knockdown promotes hepatocellular carcinoma sensitivity to sorafenib through upregulating miR-182-5p and inhibiting autophagy显示文摘Although sorafenib has been found to prolong the survival time of patients with hepatocellular carcinoma(HCC),sorafenib resistance remains an important challenge.Increasing studies have demonstrated that long noncoding RNAs(lncRNAs)contribute to drug resistance in a wide number of cancers.Human periodontal ligament stem cell(PDLSC)osteogenesis impairment-related lncRNA(POIR)is a recently defined lncRNA for which little is known regarding its function.Our study aimed to reveal the role of POIR in the development of HCC cell sorafenib resistance.The level of POIR expression in patients and tumor cells was examined by Reverse transcription-quantitative polymerase chain reaction(RT-qPCR)assay.CCK-8,EdU,and flow cytometry assay were adopted to examine cell viability,proliferation,and apoptosis,respectively.The autophagy-associated protein expressions were determined by western blotting and autophagic flux analysis.The results of this study exhibited increased POIR in HCC tissues and cells and may be correlated with sorafenib resistance.Knockdown of POIR elevated sorafenib sensitivity by suppressing autophagy in HCC cells.Mechanically,POIR knockdown upregulated miR-182-5p,implying that miR-182-5p mediates POIR regulation.MiR-182-5p overexpression significantly enhanced chemosensitivity to sorafenib,whereas miR-182-5p inhibition had the opposite effect.The sensitization of POIR siRNA to sorafenib was abolished by co-transfection with miR-182-5p inhibitor.Our findings provide a potential target for further clinical treatment of sorafenib-resistant HCC patients. | JIAN XU HAILONG GE CHEN CHAO FENG MO YU WANG DENGKUI ZHANG XIAOXIAO ZHENG LI ZHENG XUEMEI LU WEI CHEN QUN XU WEIXIN YU | 2022 | BIOCELL2022，46，6： | 0 |
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