|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Differing coping mechanisms, stress level and anorectal physiology in patients with functional constipation显示文摘AIM: To investigate coping mechanisms, constipation symptoms and anorectal physiology in 80 constipated subjects and 18 controls.METHODS: Constipation was diagnosed by Rome Ⅱ criteria.Coping ability and anxiety/depression were assessed by validated questionnaires. Transit time and balloon distension test were performed.RESULTS: 34.5% patients were classified as slow transit type of constipation. The total colonic transit time (56 h vs 10 h, P<0.0001) and rectal sensation including urge sensation (79 mL vs 63 mL, P = 0.019) and maximum tolerable volume (110 mL vs95 mL, P = 0.03) differed in patients and controls. Constipated subjects had significantly higher anxiety and depression scores and lower SF-36 scores in all categories. They also demonstrated higher scores of'monitoring' coping strategy (14+6 vs9+3, P = 0.001),which correlated with the rectal distension sensation (P = 0.005), urge sensation (P=0.002), and maximum tolerable volume (P = 0.035). The less use of blunting strategy predicted slow transit constipation in both univariate (P = 0.01) and multivariate analysis (P = 0.03).CONCLUSION: Defective or ineffective use of coping strategies may be an important etiology in functional constipation and subsequently reflected in abnormal anorectal physiology. | Annie OO Chan Cecilia Cheng Wai Mo Hui Wayne HC Hu Nina YH Wong KF Lam Wai Man Wong Kam Chuen Lai Shiu Kum Lam Benjamin CY Wong | 2005 | World Journal of Gastroenterology2005，11，34： | 92 |
| 2 | Structure-based design of a thiazolidinedione which targets the mitochondrial protein mitoNEET显示文摘 | Geldenhuys WJ Funk MO Barnes KF | 2010 | Bioorg Med Chem Left2010，20，3： | 1 |
| 3 | Lymphedema and quality of life in Chinese women after treatment for breast cancer显示文摘 | Mak SS Mo KF Suen JJ | 2009 | Eur J Oncol Nurs2009，13，2： | 1 |
| 4 | Thre-dimentional Volume XII-dering of muhidetector-row CT data: applicable for emergency radiology显示文摘 | Philipp MO Kubin K Euiot KF el al | 2003 | Eur J Radiol2003，48，： | 1 |
| 5 | Lymphedema and quality of lifein Chinese women after treatment forbreast cancer显示文摘 | SS Mak KF Mo JJS Suen^r al | 2009 | 13:110 - 1112009，13，： | 1 |
| 6 | D-dimer test for early detection of HELLP syndrome 显示文摘 | Neiger Trofatter MO Trofatter KF Jr | 2005 | South Med J2005，88，4： | 1 |
| 7 | In vivo response of the normal and regenerating adrenal glands to thyroid manipulation in rats显示文摘 | Nonavinakere VK Soliman KF | 1997 | Res Commun Mol Pathol Pharmacol1997，95，： | 1 |
| 8 | D-dimer test for early detection of HELLP syndrome 显示文摘 | Neiger Trofatter MO Trofatter KF Jr | 2005 | South Med J2005，85，4： | 1 |
| 9 | D-dimer test for early detection of HELLP syndrome显示文摘 | Neiger R Trofatter MO Trofatter KF Jr | 2005 | South Med J2005，88，4： | 1 |
| 10 | Lymphedema and quality of life in Chinese women after treatment for breast cancer显示文摘 | Mak SS Mo KF Suen JJ | 2009 | Eur J Oncol Nurs2009，13，2： | 1 |
| 11 | The surgical treatment of acetabular fractures 显示文摘 | Moed BR Dickson KF Kregor PJ | 2010 | Instr Course Lect2010，59，： | 1 |
| 12 | Identification of optimal contemporary antiemetic prophylaxis for doxorubicin-cyclophosphamide chemotherapy in Chinese cancer patients: post-hoc analysis of 3 prospective studies显示文摘Objective:Chemotherapy-induced nausea and vomiting(CINV)are common with doxorubicin-cyclophosphamide(AC)chemotherapy.Recommended antiemetic regimens incorporate neurokinin-1 receptor antagonist(NK1 RA),5-hydroxytryptamine type-3 receptor antagonist(5 HT3 RA),corticosteroid,and dopamine antagonists.This post-hoc analysis compared results of 3 prospective antiemetic studies conducted among Chinese breast cancer patients who received(neo)adjuvant AC,in order to identify optimal antiemetic prophylaxis.Methods:A total of 304 patients were included:Group 1,ondansetron/dexamethasone(D1);Group 2,aprepitant/ondansetron/dexamethasone(D1);Group 3,aprepitant/ondansetron/dexamethasone(D1–3);Group 4,aprepitant/ondansetron/dexamethasone(D1–3)/olanzapine;and Group 5,netupitant/palonosetron/dexamethasone(D1–3).Antiemetic efficacies of Groups 3,4,and 5 during cycle 1 of AC were individually compared with Group 1.In addition,emesis outcomes of patients in Groups 3 and 5,and those of Groups 2 and 3,were compared.Results:When comparing efficacies of a historical doublet(5 HT3 RA/dexamethasone)with triplet antiemetic regimens(NK1 RA/5 HT3 RA/dexamethasone)with/without olanzapine,complete response(CR)percentages and quality of life(QOL)in overall phase of cycle 1 AC were compared between Group 1 and the other groups:Group 1 vs.3,41.9%vs.38.3%(P=0.6849);Group 1 vs.4,41.9%vs.65.0%(P=0.0107);and Group 1 vs.5,41.9%vs.60.0%(P=0.0460).Groups 4 and 5 achieved a better QOL.When comparing netupitant-based(Group 3)with aprepitant-based(Group 5)triplet antiemetics,CR percentages were 38.3%vs.60.0%,respectively(P=0.0176);Group 5 achieved a better QOL.When comparing 1 day(Group 2)vs.3 day(Group 3)dexamethasone,CR percentages were 46.8%and 38.3%,respectively(P=0.3459);Group 3 had a worse QOL.Conclusions:Aprepitant-containing triplets were non-superior to doublet antiemetics.Netupitant-containing triplets and adding olanzapine to aprepitant-containing triplets were superior to doublets.Netupitant/palonosetron/dexamethasone was superior to aprepitant/ondansetron/dexamethasone.Protracted administration of dexamethasone provided limited additional benefit. | Winnie Yeo Leung Li Thomas KH Lau Kwai T Lai Vicky,TC Chan Kwan H Wong Christopher CH Yip Elizabeth Pang Maggie Cheung Vivian Chan Carol CH Kwok Joyce JS Suen Frankie KF Mo | 2021 | Cancer Biology & Medicine2021，18，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员