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| 1 | Prognostic value of cortisol and thyroid function tests in poisoned patients admitted to toxicology ICU显示文摘BACKGROUND: Prognostic value of cortisol and thyroid function tests(TFTs) has previously been evaluated in medical ICUs. We aimed to evaluate prognostic efficacy of cortisol and TFTs in critically ill poisoned patients admitted to toxicology intensive care unit(ICU).METHODS: In a prospective study of consecutively enrolled subjects admitted to the toxicology ICU, lab analyses included TFTs(total T3 and T4 as well as TSH) and cortisol levels drawn between 8 am–10 am during period of the first 24 hours post-ingestion/exposure. Simplified Acute Physiology Score Ⅱ(SAPS Ⅱ) and Acute Physiology and Chronic Health Evaluation Ⅱ(APACHE Ⅱ) were recorded. All scores were compared to detect the best prognostic factor. Type of poisoning was also included.RESULTS: In 200 patients evaluated, 129 were male and mean age was 31 years. In general, SAPS Ⅱ, T4, and cortisol could prognosticate death. After regression analysis, only cortisol had such efficacy(P=0.04; OR=1.06; 95%CI=1.05–1.08; cut-off=42 μg/d L; sensitivity=70%; specificity=82%). Between aluminium phosphide(ALP)-and non ALP-poisoned patients, level of consciousness, mean arterial pressure, and cortisol level could prognosticate death in ALP poisoning(all Ps<0.001 in both uni and multivariate analyses). Median(interquartile range; IQR) GCS was 7(6, 10) and 15(8, 15) in non-ALP and ALP-poisoned patients(P<0.003). SAPS Ⅱ and APACHE Ⅱ could not prognosticate death at all.CONCLUSION: Cortisol best prognosticated outcomes for subjects admitted to the toxicology ICU. Its level is higher in ALP-poisoned patients probably due to the higher stress while they remain conscious till the final stages of toxicity and are aware of deterioration of their clinical condition or may be due to their significantly lower blood pressures. | Shahin Shadnia Nasim Zamani Hossein Hassanian-Moghaddam Hamed Shafaroodi Mina Padandar Mohammad Hasan Rezaeizadeh | 2018 | World Journal of Emergency Medicine2018，9，1： | 6 |
| 2 | Novel technique of penetrating keratoplasty in high-risk grafts with significant corneal neovascularization显示文摘Dear Editor,We write to introduce a novel technique of penetrating keratoplasty(PK)with lower risk of graft rejection in high-risk grafts.Corneal transplantation may be required in a variety of conditions such as keratoconus,pseudophakic bullous keratopathy(PBK),and corneal scars or dystrophies[1]. | Mohammad Soleimani Nader Mohammadi Mansoor Shahriari Morteza Karimi Ahmed Alshaheeb Atefeh Khalili Mohammad Hossein Zamani Kasra Cheraqpour | 2022 | International Journal of Ophthalmology(English edition)2022，15，9： | 1 |
| 3 | Effects of Zataria oxymel on obesity, insulin resistance and lipid profile:A randomized, controlled, triple-blind trial显示文摘Background: Obesity is a major public health problem and its occurrence is markedly increasing in developed and developing countries. However, few studies have investigated the use of natural products to treat obesity. The effects of taking a combination of oxymel and Zataria multiflora Boiss.(ZM), herein referred to as Zataria oxymel(ZO), on obesity, lipid profile and insulin resistance have not yet been studied.Objective: This study evaluates the effects of oxymel and ZO on obesity, lipid profile and insulin resistance.Design, setting, participants and interventions: In this randomized, controlled, triple-blind trial, overweight patients were randomly divided into three groups and received doses of study compounds twice per day for twelve weeks. Group A received 0.75 g ZM in 10 mL oxymel in each treatment;group B received 1.5 g ZM in 10 m L of oxymel in each treatment and group C(control) only received 10 mL of oxymel in each treatment.Main outcome measures: Anthropometric parameters, including body mass index(BMI), waist circumference and hip circumference, were measured at the time of registration. Blood tests were carried out at the beginning and once again at end of the study. Blood parameters included fasting blood sugar(FBS), insulin levels, serum lipid profile(total cholesterol, triglyceride, low-density lipoprotein cholesterol and highdensity lipoprotein cholesterol) and liver enzymes(aspartate transaminase and alanine transaminase).Serum creatinine was also measured at the beginning of the project and in monthly intervals for three months. The homeostasis model assessment index was calculated as fasting insulin(μIU/mL)×FBS(mg/dL)/405.Results: The results showed that patients receiving ZO experienced significant reduction in waist circumference in groups A, B and C, respectively(P < 0.001) but no significant change in BMI. Group A also experienced reduction in hip circumference(P = 0.01). Groups B and C had reduction in the homeostatic model assessment of insulin resistance(P = 0.05 and P = 0.01, respectively), with no significant reduction in FBS.No effect on lipid profile, liver enzymes or serum creatinine was observed in the three groups.Conclusion: In this study, treatment with ZO and oxymel reduced insulin resistance, and waist and hip circumferences in overweight patients. Nonetheless, the traditional Persian use of ZO as a beverage to improve the anthropometric indices in overweight individuals still requires further research with a larger sample size.Trial registration: Iranian Registry of Clinical Trials Code IRCT20171220037976 N1. | Jafar Abolghasemi Mohammad Ali Farboodniay Jahromi Mohammad Hossein Sharifi Zohreh Mazloom Leila Hosseini Nasrindokht Zamani Majid Nimrouzi | 2020 | Journal of Integrative Medicine2020，18，5： | 1 |
| 4 | Non-alcoholic fatty liver disease is not independent risk factor for cardiovascular disease event:A cohort study显示文摘BACKGROUND There are no consistent results between previous studies for an independent association between non-alcoholic fatty liver disease(NAFLD)and cardiovascular disease(CVD)events.AIM To determine if there is an independent association between NAFLD and CVD events.METHODS In the present study,valid outcome data of 4808 subjects were available for phase 2 of our cohort study.These subjects had been followed up for seven years from phase 1,beginning in 2009-2010 to phase 2 during 2016-2017.Simple and multiple Cox proportional models were used to determine the association between NAFLD in the primary phase of the cohort and subsequent fatal and non-fatal CVD events during follow-up.RESULTS The incidence of non-fatal CVD events in males with NAFLD was significantly higher(P=0.004)than in males without NAFLD.A positive association was demonstrated between NAFLD and non-fatal CVD events in males(Hazard ratio=1.606;95%CI:1.166-2.212;P=0.004)by the simple Cox proportional hazard model,but no independent association was detected between these in the multiple Cox models.CONCLUSION No independent association was detected between NAFLD and CVD.It is likely that diabetes mellitus and age may be the principle mediators in this regard. | Nima Motamed Hossein Ajdarkosh Maral Ahmadi Dhayaneethie Perumal G Hossein Ashrafi Mehdi Nikkhah Amir Hossein Faraji Mansooreh Maadi Mahmoodreza Khoonsari Nader Rezaie Behzad Farahani Fahimeh Safarnezhad Tameshkel Mitra Ameli Mahshid Panahi Mohammad Hadi Karbalaie Niya Farhad Zamani | 2020 | World Journal of Hepatology2020，12，6： | 0 |
| 5 | Outbreak of methanol-induced optic neuropathy in early COVID-19 era;effectiveness of erythropoietin and methylprednisolone therapy显示文摘BACKGROUND Methanol is a highly toxic,non-potable alcohol.Outbreaks of methanol toxicity occur due to its fraudulent addition to alcoholic beverages as a cheaper substitute for ethanol.Recently,alongside the coronavirus disease 2019(COVID-19)pandemic,rumors circulated on social media that consuming alcohol can prevent or cure the virus,leading to a COVID-19 and methanol-induced optic neuropathy(MON)syndemic.AIM To investigate the impact of erythropoietin(EPO)on the outcomes of patients diagnosed with MON.METHODS In this prospective study,105 patients presenting with acute bilateral visual loss secondary to methanol intoxication were enrolled from March to May 2020 at Farabi Eye Hospital.A comprehensive ocular examination was conducted for all participants.Recombinant human EPO and methylprednisolone were administered intravenously to all patients for three consecutive days.RESULTS The mean age of the participants was 39.9 years(±12.6).Ninety-four patients were male and eleven were female.The mean pre-treatment best corrected visual acuity(BCVA)improved from 2.0±0.86 to 1.39±0.69 logarithm of the minimum angle of resolution post-treatment(P<0.001),with significant improvement observed in all age categories and genders(P<0.001).Visual acuity improvement was also significant regardless of whether the patient presented before or after 72 h(P<0.001),and the post-treatment BCVA remained significant at all monthly follow-up visits(P<0.001).CONCLUSION EPO and methylprednisolone therapy have been shown to be effective in improving visual outcomes in patients with MON when administrated within the first month of exposure.Public awareness efforts are necessary to prevent further outbreaks of methanol toxicity in the current COVID-19 era. | Seyed Ali Tabatabaei Mohammad Amini Ali A Haydar Mohammad Soleimani Kasra Cheraqpour Mansoor Shahriari Hossein Hassanian-Moghaddam Nasim Zamani Mohammad Reza AkbariDepartment of Ophthalmology Eye Research Center Farabi Eye | 2023 | World Journal of Clinical Cases2023，11，15： | 0 |
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