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| 1 | Risk stratification in symptomatic intracranial atherosclerotic disease with conventional vascular risk factors and cerebral haemodynamics显示文摘Background and purpose Symptomatic intracranial atherosclerotic stenosis(sICAS)is associated with a considerable risk of recurrent stroke despite contemporarily optimal medical treatment.Severity of luminal stenosis in sICAS and its haemodynamic significance quantified with computational fluid dynamics(CFD)models were associated with the risk of stroke recurrence.We aimed to develop and compare stroke risk prediction nomograms in sICAS,based on vascular risk factors and these metrics.Methods Patients with 50%-99%sICAS confirmed in CT angiography(CTA)were enrolled.Conventional vascular risk factors were collected.Severity of luminal stenosis in sICAS was dichotomised as moderate(50%-69%)and severe(70%-99%).Translesional pressure ratio(PR)and wall shear stress ratio(WSSR)were quantified via CTA-based CFD modelling;the haemodynamic status of sICAS was classified as normal(normal PR&WSSR),intermediate(otherwise)and abnormal(abnormal PR&WSSR).All patients received guideline-recommended medical treatment.We developed and compared performance of nomograms composed of these variables and independent predictors identified in multivariate logistic regression,in predicting the primary outcome,recurrent ischaemic stroke in the same territory(SIT)within 1 year.Results Among 245 sICAS patients,20(8.2%)had SIT.The D2H2A nomogram,incorporating diabetes,dyslipidaemia,haemodynamic status of sICAS,hypertension and age≥50 years,showed good calibration(P for Hosmer-Lemeshow test=0.560)and discrimination(C-statistic 0.73,95%CI 0.60 to 0.85).It also had better performance in risk reclassification and provided larger net benefits in decision curve analysis,compared with nomograms composed of conventional vascular risk factors only,and plus the severity of luminal stenosis in sICAS.Sensitivity analysis in patients with anterior-circulation sICAS showed similar results.Conclusions The D2H2A nomogram,incorporating conventional vascular risk factors and the haemodynamic significance of sICAS as assessed in CFD models,could be a useful tool to stratify sICAS patients for the risk of recurrent stroke under contemporarily optimal medical treatment. | Xuan Tian Hui Fang Linfang Lan Hing Lung Ip Jill Abrigo Haipeng Liu Lina Zheng Florence S Y Fan Sze Ho Ma Bonaventure Ip Bo Song Yuming Xu Jingwei Li Bing Zhang Yun Xu Yannie O Y Soo Vincent Mok Ka Sing Wong Thomas W Leung Xinyi Leng | 2023 | Stroke & Vascular Neurology2023，8，1： | 2 |
| 2 | Randomized, placebo-controlled, phase II study of sequential erlotinib and chemotherapy as first-line treatment for advanced non-small-cell lung cancer显示文摘 | Mok T S Wu Y L Yu C J | 2009 | J ClinOneol2009，27，30： | 1 |
| 3 | Ovarian cancer durring pregnancy : clinical and pregnancy outcome 显示文摘 | Kwon Y Mok J Lira K | 2010 | J Korean Med Sci2010，25，2： | 1 |
| 4 | Decomposition of volatile organic compounds and nitric oxide by non thermal plasma discharge process显示文摘 | Mok Y S Nam C M Cho M H | 2002 | IEEE Transaction on Plasma Science2002，30，1： | 1 |
| 5 | Cancer of the stomach:a review of two hospitals in Korea and Japan显示文摘 | Mok Y J Koo B W Whang C W | 1993 | World J Surg1993，17，6： | 1 |
| 6 | Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma显示文摘 | MOK T S WU Y L THONGPRASERT S | 2009 | N Engl J Med2009，361，10： | 1 |
| 7 | Underpricing and aftermarket performance of IPOs in Shanghai,China显示文摘 | Mok H Hui Y | | 0，，05： | 1 |
| 8 | Statins for asymptomatic middle cerebral artery stenosis: The Regression of Cerebral Artery Stenosis Study显示文摘 | Mok V C Lam W W Chen X Y | 2009 | Cerebrovasc Dis2009，28，1： | 1 |
| 9 | Flue gas treatment using pulsed corona discharge generated by magnetic pulse compression modulator 显示文摘 | MOK Y S LEE H W HYUN Y J | 2001 | Journal of Electrostatics2001，53，3： | 1 |
| 10 | Adjacent segment motion after anterior cervical discectomy and fusion versus Prodisc-c cervical total disk arthroplasty:analysis from a randomized,control ed trial显示文摘 | Kel y MP Mok JM Frisch RF | | 0，，1976： | 1 |
| 11 | Venous thromboembolism in southern Chinese patients with systemic lupus erythematosus显示文摘 | Mok C C Ho L Y Yu K L | | 0，，06： | 1 |
| 12 | Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma显示文摘 | Mok T S Wu Y L Thongprasert S | 2009 | N Engl J Med2009，361，10： | 1 |
| 13 | A new simulation model of PMSM motor with real back EMF waveform显示文摘 | | 2000 | Proceeding from Computers in Power Electronics2000，，1618： | 1 |
| 14 | Conversion of NO to NO2 in air by a pulsed corona discharge process显示文摘 | Ham S W | 1998 | Chemical Engineering Science1998，53，9： | 1 |
| 15 | Effects of music on patient anxiety显示文摘 | MOK E WONG K Y | 2003 | AORN J2003，77，2： | 1 |
| 16 | New criterion for internal crack fomlation in continuously cast steels显示文摘 | Mok W Y Jung Y T Jin S D | 2000 | Metallurgical and Materials Transactions B2000，31，8： | 1 |
| 17 | Prospectively versus retro- spectively ECG-gated 256-slice CT angiography to assess coro- nary artery bypass gralts comparison of image quality and radia- tion dose显示文摘 | Lee Y W Yang C C Mok G S | 2012 | PLoS one2012，7，49： | 1 |
| 18 | Delayed recovery from er- tapeneminduced encephalopathy:case-report and a possible mecha- nism显示文摘 | Shea Y F Mok M Y Cheng K C | 2013 | Int J Clin Pharm2013，5，4： | 1 |
| 19 | Gefitinib or carboplatin --paclitaxel in pulmonary adenocarcinoma显示文摘 | Mok T S Wu Y L Thongprasert S | 2009 | N Engl J Med2009，361，10： | 1 |
| 20 | Numerical and experimental analysis of penetration grouting in jointed rock masses显示文摘 | LEE J S BANG C S MOK Y J | 2000 | International Journal of Rock Mechanics & Mining Sciences2000，37，： | 1 |
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