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| 1 | Vitamin D deficiency: Correlation to interleukin-17, interleukin-23 and PⅢNP in hepatitis C virus genotype 4显示文摘AIM: To assess vitamin D (Vit D) abnormalities in hepatitis C infected patients and their relationship with interleukin (IL)-17, IL-23 and N-terminal propeptide of type Ⅲ pro-collagen (PⅢNP) as immune response mediators. METHODS: The study was conducted on 50 Egyptian patients (36 male, 14 female) with hepatitis C virus (HCV) infection, who visited the Hepatology Outpatient Clinic in the Endemic Disease Hospital at Cairo University. Patients were compared with 25 ageand sexmatched healthy individuals. Inclusion criteria were based on a history of liver disease with HCV genotype 4 (HCV-4) infection (as new patients or under followup). Based on ultrasonography, patients were classified into four subgroups; 14 with bright hepatomegaly; 11 with perihepatic fibrosis; 11 with hepatic cirrhosis; and 14 with cirrhosis and hepatocellular carcinoma (HCC).Total Vit D (i.e., 25-OH-Vit D) and active Vit D [i.e., 1,25-(OH) 2 -Vit D] assays were carried out using commercial kits. IL-17, IL-23 and PⅢNP levels were assayed using enzyme linked immunosorbent assay kits, while HCV virus was measured by quantitative and qualitative polymerase chain reaction. RESULTS: Levels of Vit D and its active form were significantly lower in advanced liver disease (hepatic cirrhosis and/or carcinoma) patients, compared to those with bright hepatomegaly and perihepatic fibrosis. IL-17, IL-23 and PⅢNP levels were markedly increased in HCV patients and correlated with the progression of hepatic damage. The decrease in Vit D and active Vit D was concomitant with an increase in viral load, as well as levels of IL-17, IL-23 and PⅢNP among all subgroups of HCV-infected patients, compared to normal healthy controls. A significant negative correlation was evident between active Vit D and each of IL-17, IL-23 and PⅢNP (r = -0.679, -0.801 and -0.920 at P < 0.001, respectively). HCV-infected men and women showed no differences with respect to Vit D levels. The viral load was negatively correlated with Vit D and active Vit D (r = -0.084 and -0.846 at P < 0.001, respectively), and positively correlated with IL-17, IL-23 and PⅢNP (r = 0.951, 0.922 and 0.94 at P < 0.001, respectively). Whether the deficiency in Vit D was related to HCVinduced chronic liver disease or was a predisposing factor for a higher viral load remains to be elucidated. CONCLUSION: The negative correlations between Vit D and IL-17, IL-23 and PⅢNP highlight their involvement in the immune response in patients with HCV-4related liver diseases in Egypt. | Mona F Schaalan Waleed A Mohamed Hesham H Amin | 2012 | World Journal of Gastroenterology2012，18，28： | 12 |
| 2 | Frequency of diabetic retinopathy and associated risk factors in Khartoum,Sudan:population based study显示文摘AIM: To assess the frequency and associated risk factors of diabetic retinopathy among Sudanese individuals with diabetes attending Makka Eye complex in Khartoum, Sudan. METHODS: The cross sectional hospital based study recruited 316 individuals with diabetes from Makkah Eye Complex Retina Clinic. Standard questionnaire was used to collect demographic data, medical history and life style characteristics. Blood samples were taken to measure Hb A1 c and lipid profile. Fundus and slit lamp examination were performed for screening of diabetic retinopathy.RESULTS: Among 316 participants, 187(59.2%) were males and 129(40.8%) were females. The mean age of participants was 58.7±10.5y. The overall frequency of retinopathy was 261(82.6%). The percentages of the total participants with proliferative diabetic retinopathy(PDR) were 126(39.9%) and non-proliferative diabetic retinopathy(NPDR) were 135(42.7%). Importantly, duration of diabetes mellitus(DM)(72.2% of more than 10y), being on oral hypoglycaemic drugs(versus insulin), and hypertension were all significant risk factors for diabetic retinopathy(P=0.00, 0.01 and 0.00 respectively). Complications ofdiabetes like diabetic foot(17.7%), history of amputation(6.7%) and clinically significant macular edema(CSME)(47.4%) of the eyes were all significant risk factors(P<0.05). Logistic regression analysis showed that duration of diabetes, hypertension and CSME were found to be absolute risk factors(P=0.007, 0.003 and 0.000 respectively). Duration of DM of more than 10 y have more than double risk(OR=2.8), while having hypertension triples the risk of retinopathy(OR=3.1).CONCLUSION: High rates of diabetic retinopathy are noted among individuals with diabetes attending Makkah Eye hospital in capital Khartoum. Urgent strategies are needed to monitor and treat hypertension and optimize diabetes control in individuals with diabetes. More investment in diabetes services is urgently needed. | Einas S Elwali Ahmed O Almobarak Mona A Hassan Amir A Mahmooud Heitham Awadalla Mohamed H Ahmed | 2017 | International Journal of Ophthalmology(English edition)2017，10，6： | 2 |
| 3 | Quantitative Estimation of Sucrose Esters of Palmitic Acid显示文摘 | Weiss T Brown Mona Zeringue H | 1967 | Journal of the American Oil Chemists'' Society1967，48，： | 1 |
| 4 | Environmental lead exposure during early childhood显示文摘 | BRUCE P L RICHARD H MONA H | 2002 | J Pediatr2002，，： | 1 |
| 5 | Hydrophobins from Aspergillus species cannot be clearly divided into two classes显示文摘 | Britt G Jensen Mikael R Andersen Mona H Pedersen | 2010 | BMC Research Notes2010，3，： | 1 |
| 6 | A Review of RFO Induction Mo- tor Parameter Estimation Techniques 显示文摘 | Toliyat H A Emil L Mona R | 2003 | IEEE Transactions on Energy Conversion2003，18，2： | 1 |
| 7 | A Direct Synthesis of Nitfiles and Amides from Aldehydes Using Dry or Wet Alumina in Solvent Free Conditions 显示文摘 | Hashem S Mona H S | 2002 | Tetrahedron2002，58，10： | 1 |
| 8 | Effect of CeO2 on the Crystallization Behavior and Magnetic Properties of Zn-ferrite Glass Ceramics显示文摘 | Salwa A M Abdel-Hameed Fatma H Margha Mona A Ouis | 2013 | Journal of Alloys and Compounds2013，554，： | 1 |
| 9 | Varicella prevention in the United States : A Review of successes and challenges 显示文摘 | Mona Marin H Cody Meissner Jane F Seward | 2008 | Pediatrics2008，122，： | 1 |
| 10 | Antibodies to several citrullinated antigens are enriched in the joints of rheumatoid arthritis patients显示文摘 | Omri S Mona W Monika H | 2010 | Arthritis Rheum2010，62，1： | 1 |
| 11 | Flavonol glycosides from Eschscholtzia californica显示文摘 | Mona A B Hanns H | 1999 | Phytochemistry1999，50，： | 1 |
| 12 | Sonographic gallbladder wall thickness measurement and the prediction of esophageal varices among cirrhotics显示文摘Acute variceal bleeding in patients with liver cirrhosis and portal hypertension(PHT) is the most serious emergency complication among those patients and could have catastrophic outcomes if not timely managed. Early screening by esophago-gastro-duodenoscopy(EGD) for the presence of esophageal varices(EVs) is currently recommended by the practice guidelines for all cirrhotic patients. Meanwhile, EGD is not readily accepted or preferred by many patients. The literature is rich in studies to investigate and validate non-invasive markers of EVs prediction aiming at reducing the unneeded endoscopic procedures. Gallbladder(GB) wall thickness(GBWT) measurement has been found promising in many published research articles. We aim to highlight the validity of sonographic GBWT measurement in the prediction of EVs based on the available evidence. We searched databases including Cochrane library, Pub Med, Web of Science and many others for relevant articles. GBWT is associated with the presence of EVs in cirrhotic patients with PHT of different etiologies. The cut-off of GBWT that can predict the presence of EVs varied in the literature and ranges from 3.1 mm to 4.35 mm with variable sensitivities of 46%-90.9% and lower cutoffs in viral cirrhosis compared to non-viral, however GBWT > 4 mm in many studies is associated with acceptable sensitivity up to 90%. Furthermore, a relation was also noticed with the degree of varices and portal hypertensive gastropathy.Among cirrhotics, GBWT > 3.5 mm predicts the presence of advanced(grade Ⅲ-Ⅳ) EVs with a sensitivity of 45%, the sensitivity increased to 92% when a cut-off ≥ 3.95 mm was used in another cohort. Analysis of these results should carefully be revised in the context of ascites, hypoalbuminemia and other intrinsic GB diseases among cirrhotic patients. The sensitivity for prediction of EVs improved upon combining GBWT measurement with other non-invasive predictors, e.g., platelets/GBWT. | Mohamed H Emara Mariam Zaghloul Ibrahim F Amer Aya M Mahros Mohammed Hussien Ahmed Mahmoud A Elkerdawy Eslam Elshenawy Abdelrahman M Ahmed Rasheda Tarik I Zaher Mona Talaat Haseeb Emad Hassan Emara Hassan Elbatae | 2023 | World Journal of Hepatology2023，15，2： | 1 |
| 13 | Environmental lead exposure during early childhood显示文摘 | Bruce PL Richard H Mona H | 2002 | J Pediatr2002，140，1： | 1 |
| 14 | What is Beautiful Is Good? But? a Meta-analytic Review of Research on the Physical Attractiveness Stereo Type 显示文摘 | Richard D H Ashmore Mona G Makhijani Laura C | 1991 | Psychological Bulletin1991，，1： | 1 |
| 15 | A Bkm-related DNA sequence gives individual DNA fingerprints in turbot (Scophthalmus maximus) 显示文摘 | Harald H Svein L Mona M | 1994 | Comparative Biochemistry and Physiology1994，107，1： | 1 |
| 16 | High sensitivity C-reactive protein:Its correlation with sputum cell counts in bronchial asthma显示文摘 | Mona H Alla M | 2009 | Respiratory Medi-cine2009，103，1： | 1 |
| 17 | Thermo- mechanical Properties of Devulcanized Rubber/High Crys- talline Polypropylene Blends Modified by Ionizing Radia- tion 显示文摘 | Medhat M H Nagwa A B Mona Y E | 2013 | Journal of Industrial and Engineering Chemistry2013，19，4： | 1 |
| 18 | Impact of the socioeconomic status on the severity and outcome of community-acquired pneumonia among Egyptian children: a cohort study显示文摘Background:Community-acquired pneumonia(CAP)is one of the five leading causes of death among children in developing countries,accounting for approximately three million deaths per year.Identification of the modifiable risk factors of CAP may help to reduce the burden of this disease.In this study,the impact of the socioeconomic status(SES)on the severity and outcome of CAP among Egyptian children was studied.Methods:This was a prospective longitudinal cohort study which included 1,470 children diagnosed with CAP,aged two to 15 years(median age 5.4 years).The diagnosis of CAP was based on clinical and radiological findings.A structured questionnaire and the patients’medical records were used for the data collection.The subjects were divided into two groups:mild and severe CAP.Social and demographic variables were compared,and a multivariate logistic regression analysis was performed.Results:The multivariate analysis showed that a low maternal education level(OR:3.8;95%CI:2.12-6.70;P=.0001),unavailability of adequate medical care(OR:3.1;95%CI:1.99-4.88;P=.0001),a low family income(OR:2.2;95%CI:0.99-4.78;P=.047),and parents’smoking habits(OR:2.0;95%CI:1.15-3.55;P=.014)were significant independent predictive risk factors for severe CAP among Egyptian children.Conclusion:Public health measures against these socio-demographic risk factors should be identified as priorities in order to help reduce the disease burden of deaths from severe CAP among Egyptian children. | Seham Fathy Abdel Hameed Azab Laila M Sherief Safaa H Saleh Wafaa F Elsaeed Mona A Elshafie Sanaa M Abdelsalam | 2014 | Infectious Diseases of Poverty2014，3，1： | 1 |
| 19 | Proinflammatory cytokines in heart failure:double-edged swords显示文摘 | MONA H MOHAMMAD J M NOEL R | 2010 | Heart Fail Rev2010，15，： | 1 |
| 20 | High sensitivity C-reactive protein:Its correlation with sputum cell counts in bronchial asthma显示文摘 | Mona H Allam | 2009 | Respiratory Medicine2009，103，1： | 1 |
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