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| 1 | NF-kappaB pathways in hematological malignancies显示文摘 | Gasparini C Celeqhini C Monasta L | 2014 | Cell Mol Life Sci2014，71，11： | 1 |
| 2 | NF-kappa B pathways in hematological malignancies显示文摘 | Gasparini C Celeghini C Monasta L | 2014 | Cell Mol Life Sci2014，71，11： | 1 |
| 3 | NF-κB pathways in hematological malignancies显示文摘 | Chiara Gasparini Claudio Celeghini Lorenzo Monasta Giorgio Zauli | 2014 | Cellular and Molecular Life Sciences2014，，： | 1 |
| 4 | The levels of cir- culating TRAIL at the onset of type 1 diabetes are markedly decreased in patients with ketoacidosis and with the highest insulin requirement显示文摘 | Tornese G Iafusco D Monasta L | 2014 | Acta Diabetol2014，51，2： | 1 |
| 5 | First trimester maternal serum PIGF, free β-hCG, PAPP-A, PP-13, uterine artery Doppler and maternal history for the prediction of preeclampsia显示文摘 | G. Di Lorenzo M. Ceccarello V. Cecotti L. Ronfani L. Monasta L. Vecchi Brumatti M. Montico G. D’Ottavio | 2012 | Placenta2012，，6： | 1 |
| 6 | NF-kB pathways inhematological malignancies 显示文摘 | Gasparini C Celeghini C Monasta L | 2014 | Cell Mol Life Sci2014，71，11： | 1 |
| 7 | Potential role ofcirculating microRNAs as early markers of preeclampsia显示文摘 | Ura B Feriotto G Monasta L | 2014 | Taiwan J Obstet Gynecol2014，53，2： | 1 |
| 8 | NF-κB pathways in hematological malignancies显示文摘 | Gasparini C Celeghini C Monasta L | 2014 | Cell Mol Life Sci2014，71，11： | 1 |
| 9 | Risk-adjusted operative delivery rates and maternal-neonatal outcomes as measures of quality assessment in obstetric care:a multicenter prospective study显示文摘 | Maso G Monasta L Piccoli M | 2015 | BMC Pregnancy Childbirth2015，15，1： | 1 |
| 10 | Human papillomavirus infection is associated with decreased levels of GM-CSF in cervico-vaginal fluid of infected women显示文摘 | Comar M Monasta L Zanotta N | 2013 | J Clin Virol2013，58，2： | 1 |
| 11 | Interventions for the prevention of overweight and obesity in preschool children: a sys- tematic review of randomzed controlled trials 显示文摘 | Monasta L Batty GD Maealuso A | 2011 | Ohes Rev2011，12，5： | 1 |
| 12 | Ex vivo response to mucosal bacteria and muramyl dipeptide in inflammatory bowel disease显示文摘AIM To evaluate how mucosal bacteria impact on the spontaneous and muramyl dipeptide(MDP)-induced inflammation in Crohn's disease(CD) and ulcerative colitis(UC).METHODS Colonic mucosal biopsies were collected from children with active or remissive CD, UC and controls. Two tissue samples were taken from inflamed mucosal segments(in patients with active disease) or from noninflamed mucosa [in patients in remission or in healthy controls(HC)]. Experiments were performed in the presence or absence of antibiotics, to assess whether the disease-associated microbiota can modulate the cytokine response ex vivo. For this purpose, each specimen was half-cut to compare spontaneous and MDP-induced inflammation in the presence of live bacteria(LB) or antibiotics. After 24 h of culture, an array of 17 cytokines was assessed in supernatants. Statistical analyses were performed to find significant differences in single cytokines or in patterns of cytokine response in the different groups. RESULTS We demonstrated that subjects with CD display a spontaneous production of inflammatory cytokines including granulocyte-colony stimulating factor(G-CSF), interleukin(IL) 6, IL8, IL10 and IL12, that was not significantly influenced by the addition of antibiotics. UC specimens also displayed a trend of increased spontaneous secretion of several cytokines, which however was not significant due to broader variability among patients. After the addition of antibiotics, spontaneous IL8 secretion was significantly higher in UC than in controls. In HC, a trend towards the weakening of spontaneous IL8 production was observed in the presence of live mucosal bacteria with respect to the presence of antibiotics. In contrast, in the presence of LB UC showed an increasing trend of spontaneous IL8 production, while MDP stimulation resulted in lower IL8 production in the presence of antibiotics. We also showed that subjects with CD seem to have a lowered production of IL8 in response to MDP in the presence of LB. Only with the addition of antibiotics, likely reducing the contribution of LB, multivariate statistical analysis could identify the combination of measures of G-CSF, tumor necrosis factor alpha, IL4 and IL17 as a good discriminator between CD and UC.CONCLUSION We showed that the presence of LB or antibiotics can significantly influence the inflammatory response ex vivo in inflammatory bowel diseases. | Claudia Loganes Erica Valencic Alessia Pin Elisa Marini Stefano Martelossi Samuele Naviglio Luigina De Leo Tarcisio Not Lorenzo Monasta Alberto Tommasini Annalisa Marcuzzi | 2016 | World Journal of Gastroenterology2016，22，44： | 0 |
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