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| 1 | Usefulness of Screening Program for Celiac Disease in Autoimmune Thyroiditis显示文摘 | Irene Berti Chiara Trevisiol Alberto Tommasini Angelo Città Elena Neri Onelio Geatti Alberto Giammarini Alessandro Ventura Tarcisio Not | 2000 | Digestive Diseases and Sciences2000，，2： | 1 |
| 2 | Usefulness of Screening Program for Celiac Disease in Autoimmune Thyroiditis显示文摘 | Irene Berti Chiara Trevisiol Alberto Tommasini Angelo Città Elena Neri Onelio Geatti Alberto Giammarini Alessandro Ventura Tarcisio Not | 2000 | Digestive Diseases and Sciences2000，，2： | 1 |
| 3 | Zonulin, a newly discovered modulator of intestinal permeability, and its expression in coeliac disease显示文摘 | Alessio Fasano Tarcisio Not Wenle Wang Sergio Uzzau Irene Berti Alberto Tommasini Simeon E Goldblum | 2000 | The Lancet2000，，9214： | 1 |
| 4 | Zonulin, a newly discovered modulator of intestinal permeability, and its expression in coeliac disease显示文摘 | Alessio Fasano Tarcisio Not Wenle Wang Sergio Uzzau Irene Berti Alberto Tommasini Simeon E Goldblum | 2000 | The Lancet2000，，9214： | 1 |
| 5 | Cost-effective HLA typing with tagging SNPs predicts celiac disease risk haplotypes in the Finnish, Hungarian, and Italian populations显示文摘 | Lotta Koskinen Jihane Romanos Katri Kaukinen Kirsi Mustalahti Ilma Korponay-Szabo Donatella Barisani Maria Teresa Bardella Fabiana Ziberna Serena Vatta Gy?rgy Széles Zsuzsa Pocsai Kati Karell Katri Haimila Róza ádány Tarcisio Not Alessandro Ventura Markku | 2009 | Immunogenetics2009，，4： | 1 |
| 6 | Gliadin, zonulin and gut permeability: Effects on celiac and non-celiac intestinal mucosa and intestinal cell lines显示文摘 | Sandro Drago Ramzi El Asmar Mariarosaria Di Pierro Maria Grazia Clemente Amit Tripathi Anna Sapone Manjusha Thakar Giuseppe Iacono Antonio Carroccio Cinzia D’Agate Tarcisio Not Lucia Zampini Carlo Catassi Alessio Fasano | 2006 | Scandinavian Journal of Gastroenterology2006，，4： | 1 |
| 7 | Host-dependent zonulin secretion causes the impairment of the small intestine barrier function after bacterial exposure显示文摘 | Rahzi El Asmar Pinaki Panigrahi Penelope Bamford Irene Berti Tarcisio Not Giovanni V. Coppa Carlo Catassi Alessio Fasano | 2002 | Gastroenterology2002，，5： | 1 |
| 8 | Ages of celiac disease: From changing environment to improved diagnostics显示文摘From the time of Gee's landmark writings, the recent history of celiac disease (CD) can be divided into many ages, each driven by a diagnostic advance and a deeper knowledge of disease pathogenesis. At the same time, these advances were paralleled by the identification of new clinical patterns associated with CD and by a continuous redefinition of the prevalence of the disease in population. In the beginning, CD was considered a chronic indigestion, even if the causative food was not known; later, the disease was proven to depend on an intolerance to wheat gliadin, leading to typical mucosal changes in the gut and to a malabsorption syndrome. This knowledge led to curing the disease with a gluten-free diet. After the identification of antibodies to gluten (AGA) in the serum of patients and the identification of gluten-specific lymphocytes in the mucosa, CD was described as an immune disorder, resembling a chronic 'gluten infection'. The use of serological testing for AGA allowed identification of the higher prevalence of this disorder, revealing atypical patterns of presentation. More recently, the characterization of autoantibodies to endomysium and to transglutaminase shifted the attention to a complex autoimmune pathogenesis and to the increased risk of developing autoimmune disorders in untreated CD. New diagnostic assays, based on molecular technologies, will introduce new changes, with the promise of better defining the spectrum of gluten reactivity and the real burden of gluten related-disorders in the population. Herein, we describe the different periods of CD experience, and further developments for the next celiac age will be proposed. | Alberto Tommasini Tarcisio Not Alessandro Ventura | 2011 | World Journal of Gastroenterology2011，17，32： | 0 |
| 9 | ntestinal-mucosa anti-transglutaminase antibody assays to test for genetic gluten intolerance显示文摘 | Sara Quaglia Luigina De Leo Fabiana Ziberna Serena Vatta Vincenzo Villanacci Marilena Granzotto Vincenzo Petix Stefano Martelossi Grazia Di Leo Lucio Torelli Tarcisio Not | 2014 | Cellular & Molecular Immunology2014，11，6： | 0 |
| 10 | Ex vivo response to mucosal bacteria and muramyl dipeptide in inflammatory bowel disease显示文摘AIM To evaluate how mucosal bacteria impact on the spontaneous and muramyl dipeptide(MDP)-induced inflammation in Crohn's disease(CD) and ulcerative colitis(UC).METHODS Colonic mucosal biopsies were collected from children with active or remissive CD, UC and controls. Two tissue samples were taken from inflamed mucosal segments(in patients with active disease) or from noninflamed mucosa [in patients in remission or in healthy controls(HC)]. Experiments were performed in the presence or absence of antibiotics, to assess whether the disease-associated microbiota can modulate the cytokine response ex vivo. For this purpose, each specimen was half-cut to compare spontaneous and MDP-induced inflammation in the presence of live bacteria(LB) or antibiotics. After 24 h of culture, an array of 17 cytokines was assessed in supernatants. Statistical analyses were performed to find significant differences in single cytokines or in patterns of cytokine response in the different groups. RESULTS We demonstrated that subjects with CD display a spontaneous production of inflammatory cytokines including granulocyte-colony stimulating factor(G-CSF), interleukin(IL) 6, IL8, IL10 and IL12, that was not significantly influenced by the addition of antibiotics. UC specimens also displayed a trend of increased spontaneous secretion of several cytokines, which however was not significant due to broader variability among patients. After the addition of antibiotics, spontaneous IL8 secretion was significantly higher in UC than in controls. In HC, a trend towards the weakening of spontaneous IL8 production was observed in the presence of live mucosal bacteria with respect to the presence of antibiotics. In contrast, in the presence of LB UC showed an increasing trend of spontaneous IL8 production, while MDP stimulation resulted in lower IL8 production in the presence of antibiotics. We also showed that subjects with CD seem to have a lowered production of IL8 in response to MDP in the presence of LB. Only with the addition of antibiotics, likely reducing the contribution of LB, multivariate statistical analysis could identify the combination of measures of G-CSF, tumor necrosis factor alpha, IL4 and IL17 as a good discriminator between CD and UC.CONCLUSION We showed that the presence of LB or antibiotics can significantly influence the inflammatory response ex vivo in inflammatory bowel diseases. | Claudia Loganes Erica Valencic Alessia Pin Elisa Marini Stefano Martelossi Samuele Naviglio Luigina De Leo Tarcisio Not Lorenzo Monasta Alberto Tommasini Annalisa Marcuzzi | 2016 | World Journal of Gastroenterology2016，22，44： | 0 |
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