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| 1 | Salvage transjugular intrahepatic portosystemic shunt for uncontrolled variceal bleeding in patients with decompensated cirrhosis显示文摘 | Daniel Azoulay Denis Castaing Pietro Majno Faouzi Saliba Philippe Icha?? Allaoua Smail Valérie Delvart Monzer Danaoui Didier Samuel Henri Bismuth | 2001 | Journal of Hepatology2001，，5： | 1 |
| 2 | Novel therapeutic diiminoquinone exhibits anticancer effects on human colorectal cancer cells in two-dimensional and threedimensional in vitro models显示文摘BACKGROUND Colorectal cancer(CRC) is the second leading cause of cancer-related mortality.Cancer stem cells(CSCs) in CRC, which are spared by many chemotherapeutics,have tumorigenic capacity and are believed to be the reason behind cancer relapse. So far, there have been no effective drugs to target colon CSCs. Diiminoquinone(DIQ) has shown promising effects on targeting colon cancer.However, there is limited research on the effects of DIQ on eradicating CSCs in CRC.AIM To investigate the anticancer potential of DIQ on colon CSCs in two-dimensional(2D) and three-dimensional(3D) models using colonospheres and patient-derived organoids.METHODS Various 2D methods have been used to assess the effect and the mechanism of DIQ on HCT116and HT29 cell lines including cell proliferation and viability assays, migration and invasion assays,immunofluorescence staining, and flow cytometry. The potency of DIQ was also assessed in 3D culture using the sphere formation assay and colon cancer patient-derived organoid model.RESULTS Our results showed that DIQ significantly inhibited cell proliferation, migration, and invasion in HCT116 and HT29 cell lines. DIQ treatment induced apoptosis along with an accumulation of HCT116 and HT29 cancer cells in the sub-G1 region and an increase in reactive oxygen species in both CRC cell lines. DIQ reduced sphere-forming and self-renewal ability of colon cancer HCT116and HT29 stem/progenitor cells at sub-toxic doses of 1 μmol/L. Mechanistically, DIQ targets CSCs by downregulating the main components of stem cell-related-catenin, AKT, and ERK oncogenic signaling pathways. Potently, DIQ displayed a highly significant decrease in both the count and the size of the organoids derived from colon cancer patients as compared to control and 5-fluorouracil conditions.CONCLUSION This study is the first documentation of the molecular mechanism of the novel anticancer therapeutic DIQ via targeting CSC, a promising compound that needs further investigation. | Alissar Monzer Kevork Wakimian Farah Ballout Samar Al Bitar Amani Yehya Mariam Kanso Nour Saheb Ayman Tawil Samer Doughan Maher Hussein Deborah Mukherji Walid Faraj Hala Gali-Muhtasib Wassim Abou-Kheir | 2022 | World Journal of Gastroenterology2022，28，33： | 1 |
| 3 | Phase behavior, transport, diffusion and structural parameters of nonionic surfactants micro-emulsions 显示文摘 | Monzer Fanun | 2007 | Journal of Molecular Liquids2007，，： | 1 |
| 4 | Ocular toxicity study of trypan blue injected into the vitreous cavity of rabbit eyes显示文摘 | Veckeneer M van Overdam K Monzer J | 2001 | Graefe''s Arch Clin Exp Ophthalmol2001，239，： | 1 |
| 5 | Cell-to-cell transport of proteins,requirement for unfolding and characterization of binding to putative plasmodesmal receptor显示文摘 | Kragler F Monzer J Shansh K | 1998 | Science1998，15，3： | 1 |
| 6 | Ocular toxicity study of trypan blue injected into the vitreous cavity of rabbit eyes显示文摘 | Veckeneer M van Overdam K Monzer J Kobinh K van Marle W Spekreijse H | 2001 | Graefe Arch Clin Exp Ophthalmol2001，239，9： | 1 |
| 7 | Ocular toxicity study of trypan blue injected into the vitreous cavity of rabbit eyes显示文摘 | Veckeneer M van Overdam K Monzer J Kobuch K van Marie W Spekreijse H | 2001 | Graefes Arch Clin Exp Ophthalmol2001，239，9： | 1 |
| 8 | Industrial silicon wafer solar cells 显示文摘 | NEUHAUS D H MONZER A | 2007 | Advances in Opto Electronics2007，2007，： | 1 |
| 9 | Plant cell graft chimeras obtained by co-culture of isolated protoplasts显示文摘 | BINDING H WITT D MONZER J | 1987 | Protoplasma1987，141，1： | 1 |
| 10 | Neoadjuvant transjugular intrahepatic portosystemic shunt: a solution for extrahepatic abdominal operation in cirrhotic patients with severe portal hypertension 1 1 No competing interests declared.显示文摘 | Daniel Azoulay Fernando Buabse Ivana Damiano Alaoua Smail Philippe Ichai Monzer Dannaoui Denis Castaing Henri Bismuth | 2001 | Journal of the American College of Surgeons2001，，1： | 1 |
| 11 | Ocular toxicity study of trypan blue injected into the vitreous cavity of rabbit eyes 显示文摘 | Veckeneer M Overdam K Monzer J | 2001 | Graefes Arch Clin Exp Ophthalmol2001，239，： | 1 |
| 12 | Plant cell graft chimeras obtained by co-culture of isolated protoplasts 显示文摘 | Binding H Witt D Monzer J Mordhorst G Kollmann R | 1987 | Protoplasma1987，141，： | 1 |
| 13 | Charcoal emissions as a source of CO and carcinogenic PAH in mainstream narghile waterpipe smoke显示文摘 | Monzer B Sepetdjian E Saliba N | 2008 | Food Chem Toxicol2008，46，： | 1 |
| 14 | Conductivity, viscosity, NMR and diclofenac solubilization capacity studies of mixed nonionic surfactants microemulsions 显示文摘 | Monzer Fanun | 2007 | Journal of Molecular Liquids2007，135，： | 1 |
| 15 | 撒哈拉地台的地质和构造特征以及沉积盆地演化轮廓显示文摘在撒哈拉地台上,从南部的霍加尔山开始,可以观察到许多南北走的隆起(阿姨吉德尔比亚德-哈西边斯欧德,提克赫姆伯卡-扎尔扎伊廷-阿勒拉尔,伊贾伦-姆扎卡等),这些隆起之间是宽阔的复向斜,下伏许多与其同走向的坳陷。因此,东撒哈拉复向斜可以分为两个坳陷,南部是伊利济坳陷,北部是东大沙漠坳陷(古达迷斯坳陷)。中撒哈拉复向斜也下伏两个坳陷,其中,穆维迪尔坳陷位于南部,瓦德米亚坳陷们于北部。在西撒哈拉复向斜内发现了阿赫奈特、拉甘、廷杜夫、提米蒙和贝沙尔等缺陷(图1和2)。Guiraud等(1987)把这些盆地分为北撒啦 盆地和南撒啦盆地,而Legrand(1985)和Whiteman(1972)则对这些盆地的地层作了详细描述。 | Monzer Makhous 白振端 | 2001 | 石油地质科技动态2001，，1： | 0 |
| 16 | 三叠地区含油气地层的岩相和沉积环境显示文摘对伊利济和古达米斯盆地复杂地层的研究使我们能够详细恢复古生代沉积的古地理条件。古地理恢复和相应的结论是根据以下研究结果得出的。 | Monzer Makhous 白振瑞 | 2001 | 石油地质科技动态2001，，1： | 0 |
| 17 | 非构造圈闭及其成因显示文摘地质研究经验表明:非北撒哈拉地台中的坳陷,如瓦德米亚、古达米斯和伊利济等坳陷,为研究地层不整合带内的油气藏和由于岩相变化产生的岩性模式提供了最好的场所。如上所述,在三叠地区(Triassic Province),沉积层中有两个主要的构造层,即被区域性海西斯不整合面分隔的古生界和中生界构造层(图1)。在哈西边斯欧德穹隆顶部,寒武纪沉积层出露在海西斯不整合面上,而在提勒盖姆特隆起上甚至发现更古老的下寒武统地层(图1),在这些大型隆起斜坡的海西期不整合而之上牟代较新的古生代岩层所覆盖。这套古生代储层的顶部被不渗透的中生代岩层不整合遮挡,从而形成了与不整面有关的地层圈闭。 | 李彦兰 Monzer Makhous | 2001 | 石油地质科技动态2001，，1： | 0 |
| 18 | 非构造圈闭及其成因显示文摘地质研究经验表明:北非撒哈拉地台中的坳陷。如瓦得米亚、古达米斯和伊利济等坳陷,为研究地层不整合地带内的油气藏和由于岩相变化产生的岩性模式提供了最好的场所。如上所述,在三叠地区,沉积层中发育有两个主要的构造层,即被区域性海西期不整合面分隔的古生界和中生界构造层(图1)。在哈西迈斯欧德穹隆顶部,寒武纪沉积层出露在海西期不整合面上,而在提勒盖姆特隆起上甚至可发现更古老的下寒武统地层(图1)。在这些大型隆起斜坡的海西期不整合面之上被地质年代较新且连续沉积的古生代岩层所覆盖。 | Monzer Makhous 李彦兰 | 2001 | 吐哈油气2001，0，3： | 0 |
| 19 | Survival of rat sciatic nerve segments preserved in storage solutions ex vivo assessed by novel electrophysiological and morphological criteria显示文摘Most organ or tissue allografts with viable cells are sto red in solutions ex vivo for hours to seve ral days.Most allografts then require rapid host revascula rization upon transplantation to maintain donor-cell functions(e.g.,cardiac muscle contra ctions,hepatic secretions).In contrast,peripheral nerve allografts stored ex vivo do not require revascularization to act as scaffolds to guide outgrowth by host axons at 1-2 mm/d,likely aided by viable donor Schwann cells.Using current storage solutions and protocols,axons in all these donor orga n/tissue/nerve transplants are expected to rapidly become non-viable due to Wallerian degeneration within days.Therefore,ex vivo storage solutions have not been assessed for preserving normal axonal functions,i.e.,conducting action potentials or maintaining myelin sheaths.We hypothesized that most or all organ storage solutions would maintain axonal viability.We examined several common organ/tissue storage solutions(University of Wisconsin Cold Storage Solution,Normosol-R,Normal Saline,and La ctated Ringe rs) for axonal viability in rat sciatic nerves ex vivo as assessed by maintaining:(1) conduction of artificially-induced compound action potentials;and(2) axonal and myelin morphology in a novel assay method.The ten diffe rent storage solution conditions for peripheral nerves with viable axons(PNVAs) diffe red in their solution composition,osmolarity(250-318 mOsm),temperature(4℃ vs.25℃),and presence of calcium.Compound action potentials and axonal morphology in PNVAs were best maintained for up to 9 days ex vivo in calcium-free hypotonic diluted(250 mOsm) Normosol-R(dNR) at 4℃.Surprisingly,compound action potentials were maintained for only 1-2 days in UW and NS at 4℃,a much shorter duration than PNVAs maintained in 4℃ dNR(9 days) or even in 25℃ dNR(5 days).Viable axons in peripheral nerve allografts are critical for successful polyethylene glycol(PEG)-fusion of viable proximal and distal ends of host axons with viable donor axons to repair segmental-loss peripheral nerve injuries.PEG-fusion repair using PNVAs prevents Wallerian degeneration of many axons within and distal to the graft and results in excellent recovery of sensory/motor functions and voluntary behaviors within weeks.Such PEG-fused PNVAs,unlike all other types of conventional donor transplants,are immune-tolerated without tissue matching or immune suppression.Preserving axonal viability in sto red PNVAs would enable the establishment of PNVA tissue banks to address the current shortage of transplantable nerve grafts and the use of stored PEG-fused PNVAs to repair segmentalloss peripheral nerve injuries.Furthermore,PNVA storage solutions may enable the optimization of ex vivo storage solutions to maintain axons in other types of organ/tissue transplants. | Liwen Zhou Monzer Alatrach Ted Zhao Paul Oliphint George D.Bittner | 2023 | Neural Regeneration Research2023，18，9： | 0 |
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