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| 1 | GYY4137 protects against myocardial ischemia and reperfusion injury by attenuating oxidative stress and apoptosis in rats显示文摘Hydrogen sulfide(H_2S) is a gasotransmitter that regulates cardiovascular functions.The present study aimed to determine the protective effect of slow-releasing H_2S donor GYY4137 on myocardial ischemia and reperfusion(I/R) injury and to investigate the possible signaling mechanisms involved.Male Sprague-Dawley rats were treated with GYY4137 at 12.5 mg/(kg·day),25 mg/(kg·day) or 50 mg/(kg·day) intraperitoneally for7 days.Then,rats were subjected to 30 minutes of left anterior descending coronary artery occlusion followed by reperfusion for 24 hours.We found that GYY4137 increased the cardiac ejection fraction and fractional shortening,reduced the ischemia area,alleviated histological injury and decreased plasma creatine kinase after myocardial I/R.Both H_2S concentration in plasma and cystathionine-γ-lyase(CSE) activity in the myocardium were enhanced in the GYY4137 treated groups.GYY4137 also decreased malondialdehyde and myeloperoxidase levels in serum,attenuated superoxide anion level and suppressed phosphorylation of mitogen activated protein kinases in the myocardium after I/R.Meanwhile,GYY4137 increased the expression of Bcl-2 but decreased the expression of Bax,caspase-3 activity and apoptosis in the myocardium.The data suggest that GYY4137 protects against myocardial ischemia and reperfusion injury by attenuating oxidative stress and apoptosis. | Guoliang Meng Jing Wang Yujiao Xiao Wenli Bai Liping Xie Liyang Shan Philip K Moore Yong Ji | 2015 | The Journal of Biomedical Research2015，29，3： | 18 |
| 2 | Hydrogen sutfide protects colon cancer cells from chemopreventative agent β-phenylethyl isothiocvanate induced apoptosis显示文摘AIM: Hydrogen sulfide (H2S) is a prominent gaseous constituent of the gastrointestinal (GI) tract with known cytotoxic properties. Endogenous concentrations of H2S are reported to range between 0.2-3.4 mmol/L in the GI tract of mice and humans. Considering such high levels we speculate that, at non-toxic concentrations, H2S may interact with chemical agents and alter the response of colonic epithelium cells to such compounds. The GI tract is a major site for the absorption of phytochemical constituents such as isothiocyanates, flavonoids, and carotenoids, with each group having a role in the prevention of human diseases such as colon cancer. The chemopreventative properties of the phytochemical agent β-phenyethyl isothiocyanate (PEITC) are well recognized. However, little is currently known about the physiological or biochemical factors present in the GI tract that may influence the biological properties of ITCs. The current study was undertaken to determine the effects of H2S on PEITC mediated apoptosis in colon cancer cells.METHODS: Induction of apoptosis by PEITC in human colon cancer HCT116 cells was assessed using classic apoptotic markers namely SubG1 population analysis,caspase-3 like activity and nuclear fragmentation and condensation coupled with the MTT (3-(4,5-dimethylthiazol2-yl)-2,5-diphenyl tetrasodium bromide) viability assay and LDH leakage.RESULTS: PEITC significantly induced apoptosis in HGT116cells as assessed by SubG1 population formation, nuclear condensation, LDH leakage and caspase-3 activity after 24 h, these data being significant from control groups (P<0.01). In contrast, co-treatment of cells with physiological concentrations of H2S (0.1-1 mmol/L) prevented PEITC mediated apoptosis as assessed using the parameters described.CONCLUSION: PEITC effectively induced cell death in the human adenocarcinoma cell line HCT116 in vitro through classic apoptotic mechanisms. However, in the presence of H2S, apoptosis was abolished. These data suggest that H2S may play a significant role in the response of colonic epithelial cells to beneficial as well as toxic agents present within the GI tract. | Peter Rose Philip K Moore Shen Han Ming Ong Choon Nam Jeffrey S Armstrong Matt Whiteman | 2005 | World Journal of Gastroenterology2005，11，26： | 13 |
| 3 | 汽车用钢的最新研究进展显示文摘为满足提高燃油效率及汽车'轻量化'等方面持续的需求,学术界及工业领域一直都很重视钢铁及其替代材料的研发,这两类材料之间的竞争始终十分激烈。对汽车用钢在北美的研究现状进行了概述,并重点介绍了几种冷轧和热轧汽车用钢的研究进展及其生产情况。新一代先进高强钢的发展将依然令人关注并充满机遇。 | John G Speer David K Matlock Emmanuel de Moor Grant A Thomas 周澍(译) 李晟(校) | 2013 | 世界钢铁2013，，5： | 10 |
| 4 | Bicuspid aortic valve hemodynamics does not promote remodeling in porcine aortic wall concavity显示文摘AIM: To investigate the role of type-I left-right bicuspid aortic valve(LR-BAV) hemodynamic stresses in the remodeling of the thoracic ascending aorta(AA) concavity, in the absence of underlying genetic or structural defects.METHODS: Transient wall shear stress(WSS) profiles in the concavity of tricuspid aortic valve(TAV) and LR-BAV AAs were obtained computationally. Tissue specimens excised from the concavity of normal(nondilated) porcine AAs were subjected for 48 h to those stress environments using a shear stress bioreactor. Tissue remodeling was characterized in terms of matrix metalloproteinase(MMP) expression and activity via immunostaining and gelatin zymography.RESULTS: Immunostaining semi-quantification results indicated no significant difference in MMP-2 and MMP-9 expression between the tissue groups exposed to TAV and LR-BAV AA WSS(P = 0.80 and P = 0.19, respectively). Zymography densitometry revealed no difference in MMP-2 activity(total activity, active form and latent form) between the groups subjected to TAV AA and LR-BAV AA WSS(P = 0.08, P = 0.15 and P = 0.59, respectively).CONCLUSION: The hemodynamic stress environment present in the concavity of type-I LR-BAV AA does not cause any significant change in proteolytic enzyme expression and activity as compared to that present in the TAV AA. | Samantha K Atkins Alison N Moore Philippe Sucosky | 2016 | World Journal of Cardiology2016，8，1： | 3 |
| 5 | 加拿大PICU和NICU临床医生的道德困境显示文摘目的量化NICU和PICU临床医生的道德困境,并确认相关因素。设计对在NICU或PICU中工作的临床医生进行全国性横断面调查。采用道德困境量表修订版(Moral Distress Scale-Revised,MDS-R)和自我评定法评价道德困境程度。采用Maslach职业倦怠问卷子量表评定去人格化。受访者报告参加6项可能有助于缓解一线员工道德困境的医院支持活动中每一项的具体情况。通过分析受试者特征比较预后,通过分层线性回归评估个体、ICU、医院和地区的影响。场所入组ICUs为加拿大的PICUs和三级NICUs。对象入组受访者已在参与研究的ICUs内工作3个月以上。干预措施无测量方法和主要结果从31家医院中确定了54个符合纳入标准的ICUs。49个(91%)加拿大NICUs和PICUs提供了2852份完整回复,应答率为45.2%。多数受访者为护士(64.9%)或来自NICU(66.5%)。中位MDS-R评分为79(52,113)分,997例(34.2%)的受访者MDS-R得分≥100分,234例(8.3%)受访者强烈认同工作引起的严重道德困境。护士的中位MDS-R评分为85(57,121)分,比内科医生高19分,比呼吸治疗师高8分(P<0.001)。ICU工作年限<1年者MDS-R评分为53(35,79)分,工作30年以上者MDS-R评分升至83(54,120)分(P<0.001);22.5%的受访者报告高度去人格化,这与道德困境有关(P<0.001)。MDS-R评分的变异性个体因素占92%,医院因素占5%,ICU影响占1%。参与可能有缓解作用的医院支持活动的频率对MDS-R平均值影响很小(<10分)。结论道德困境常见于儿童ICUs临床医生。解决道德困境需要针对高危群体的个体化干预措施。 | Dryden-Palmer K Moore G McNeil C 方伯梁(译) 钱素云(校) | 2021 | 中国小儿急救医学2021，28，2： | 2 |
| 6 | Mobilization of Endothelial and Hematopoietic Stem and Progenitor Cells by Adenovector Mediated Elevation of Serum Levels of SDF-1,VEGF and Angiopoietin-l显示文摘 | Moore MA Hattori K Heissig B | 2001 | Ann N Y Acad Sci2001，938，： | 2 |
| 7 | Impact of gut microbiome in the development and treatment of pancreatic cancer:Newer insights显示文摘The gut microbiome plays an important role in the variation of pharmacologic response.This aspect is especially important in the era of precision medicine,where understanding how and to what extent the gut microbiome interacts with drugs and their actions will be key to individualizing therapy.The impact of the composition of the gut microbiome on the efficacy of newer cancer therapies such as immune checkpoint inhibitors and chimeric antigen receptor T-cell treatment has become an active area of research.Pancreatic adenocarcinoma(PAC)has a poor prognosis even in those with potentially resectable disease,and treatment options are very limited.Newer studies have concluded that there is a synergistic effect for immunotherapy in combination with cytotoxic drugs,in the treatment of PAC.A variety of commensal microbiota can affect the efficacy of conventional chemotherapy and immunotherapy by modulating the tumor microenvironment in the treatment of PAC.This review will provide newer insights on the impact that alterations made in the gut microbial system have in the development and treatment of PAC. | Ayrton I Bangolo Chinmay Trivedi Ishan Jani Silvanna Pender Hirra Khalid Budoor Alqinai Alina Intisar Karamvir Randhawa Joseph Moore Nicoleta De Deugd Shaji Faisal SuchithBoodgere Suresh Parva Gopani Vignesh K Nagesh Tracy Proverbs-Singh Simcha Weissman | 2023 | World Journal of Gastroenterology2023，29，25： | 2 |
| 8 | Corrosion protection of magnesium by electroactive polypyrrole/paint coatings显示文摘 | Truong V T Lai P K Moore B T | 2000 | Synthetic Metals2000，111，： | 2 |
| 9 | Fresh-water/See-water Relationship within a Groundwater Flow System, Northeastern Coast of the Yucatan Peninsula 显示文摘 | MOOR Y H STOESELL R K EASLEY D H | 1992 | Ground Water1992，30，3： | 1 |
| 10 | Plasma endothelin immunoreactivity in liver disease and the hepatorenal syndrome显示文摘 | Wendon J Frazer M | 1992 | N Engl J Med1992，327，25： | 1 |
| 11 | Hemicellulose monosaccharide composition and in vitro disappearance of orchard grass and alfalfa hay 显示文摘 | Wedig C L Jaster E H Moore K J | 1987 | Journal of Agricultural Food Chemistry1987，35，2： | 1 |
| 12 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 13 | Modularity,strategic flexibility,and firm performance:A study of the home appliance industry显示文摘 | WORREN N MOORE K CARDONA P | 2002 | Strategic Management Journal2002，，23： | 1 |
| 14 | GMP -140, a platelet alph a granule membrane protein is also synthesized by vascular endothelial cells and islocalized in Weibel - Palade bodies显示文摘 | MCEVER R P BECKSTEAD J H MOORE K L | 1989 | J Clin Invest1989，84，1： | 1 |
| 15 | Improved distal distribution of n - butyl cyanoacrylate glue by simultaneous injection of dextrose 5 through the guiding catheter: Technical note显示文摘 | Moore C Murphy K Gailloud P | 2006 | Neuroradiology2006，48，： | 1 |
| 16 | Eliminating side products and increasing succinate yields in engineered strains of Escherichia coli C显示文摘 | Jantama K Zhang X Moore J | 2008 | Biotechnol Bioeng2008，101，： | 1 |
| 17 | 21st century extravehicular activities: synergizing past and present training methods for future space walking success显示文摘 | Moore S K Gast M A | 2010 | Aeta Astronautiea2010，67，： | 1 |
| 18 | The genomic organization of retrotransposons in Brassica oleracea 显示文摘 | Alix K Ryder C D Moore J | 2005 | Plant Molecular Biology2005，59，： | 1 |
| 19 | Metabolic evolution of energy-conserving pathways for succinate production in Escherichia coli显示文摘 | Zhang X Jantama K Moore J C | 2009 | Proc Natl Acad Sci U S A2009，106，20： | 1 |
| 20 | Comparisonof Approaches for Spatial Interpolation of Daily AirTemperature in a Large Region with Complex To-pography and Highly Variable Station Density 显示文摘 | Stahl K Moore R D Floyer J A | 2006 | Agricultural and Forest Meteorology2006，139，3： | 1 |
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