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| 1 | Indirect printing of hierarchical patient-specific scaffolds for meniscus tissue engineering显示文摘The complex meniscus tissue plays a critical role in the knee. The high susceptibility to injury has led to an intense pursuit for better tissue engineering regenerative strategies, where scaffolds play a major role. In this study, indirect printed hierarchical multilayered sca ffolds composed by a silk fibroin (SF) upper layer and an 80/20 (w/w) ratio of SF/ionic-doped β-tricalcium phosphate (TCP) bottom layer were developed. Furthermore, a comparative analysis between two types of sca ffolds pro- duced using di fferent SF concentrations, i.e., 8% (w/v) (Hi8) and 16% (w/v) (Hi16) was performed. In terms of architecture and morphology, the produced sca ffolds presented homogeneous porosity in both layers and no di fferences were observed when comparing both sca ffolds. A decrease in terms of mechanical performance of the sca ffolds was observed when SF concentration decreased from 16 to 8% (w/v). Hi16 revealed a static compressive modulus of 0.66 ± 0.05 MPa and dynamical mechanical properties ranging from 2.17 ± 0.25 to 3.19 ± 0.38 MPa. By its turn, Hi8 presented a compressive modulus of 0.27 ± 0.08 MPa and dynamical mechanical properties ranging from 1.03 ± 0.08 MPa to 1.56 ± 0.13 MPa. In vitro bioactivity studies showed formation of apatite crystals onto the surface of Hi8 and Hi16 bottom layers. Human meniscus cells (hMCs) and human primary osteoblasts were cultured separately onto the top layer (SF8 and SF16) and bottom layer (SF8/TCP and SF16/TCP) of the hierarchical sca ffolds Hi8 and Hi16, respectively. Both cell types showed good adhesion and proliferation as denoted by the live/dead staining, Alamar Blue assay and DNA quanti fication analysis. Subcutaneous implantation in mice revealed weak in flammation and sca ffold’s integrity. The hierarchical indirect printed SF sca ffolds can be promising candidate for meniscus TE sca ffolding applications due their suitable mechanical properties, good biological performance and possibility of being applied in a patient-speci fic approach. | Joao BCosta Joana Silva-Correia Sandra Pina Alain da Silva Morais Sílvia Vieira Hélder Pereira Joao Espregueira-Mendes Rui LReis Joaquim M.Oliveira | 2019 | Bio-Design and Manufacturing2019，2，4： | 2 |
| 2 | The structure of the potassium channel :Molecular basis of K conduction and selectivity显示文摘 | Doyle DA Morais Cabral J Pfuetzner RA | 1998 | Science1998，280，： | 1 |
| 3 | Use of high - dose eryth- ropoietin for repair after injury : A comparison of outcomes in heart and kidney显示文摘 | Gobe GC Morais C Vesey DA | 2013 | J Nephropatho12013，2，3： | 1 |
| 4 | The structure of the potassium channel:molecular basis of K^ + conduction and selectivity显示文摘 | Doyle DA Morais Cabral J Pfuetzner RA | 1998 | Science1998，280，5360： | 1 |
| 5 | Comparison among clomipramine, fluoxetine, and placebo for the treatment of anxiety disorders in children and adolescents 显示文摘 | da Costa CZ de Morais RM Zanetta DM | 2013 | J Child Adolesc Psychopharmacol2013，23，10： | 1 |
| 6 | Neurobehavioral and genotoxic parameters of antipsychotic agent aripiprazole in mice显示文摘目的: Aripiprazole 是一个抑制精神的代理人对待精神分裂症,它通过多巴胺 D 2 扮演部分 agonism,血清素 5-HT 1A 部分 agonism 和 5-HT 2A 对抗。这研究被设计在 lipoperoxidation 上评估 neurobehavioral 效果和代理人,以及它的效果的 genotoxic/mutagenic 活动。 | Jaqueline Nascimento PICADA Bruna de Jesus Neto DOS SANTOS Franciele CELSO Jessica Dias MONTEIRO Kelly Morais DA ROSA Leandro Rosa CAMACHO Luciana Rodrigues VIEIRA Tars Madelon FREITAS Tatiana Grasiela DA SILVA Viviane Minuzzo PONTES Patricia PEREIRA | 2011 | Acta Pharmacologica Sinica2011，32，10： | 1 |
| 7 | A randomized study on the effect of vitamin D sup- plementation on skeletal muscle morphology and vitamin D receptor concentration in older women 显示文摘 | Ceglia L Niramitmahapanya S da Silva Morais M | 2013 | J Clin Endocrinol Metab2013，98，： | 1 |
| 8 | Increased oxidative stress in prefrontal cortex and hippocampus is related to depressive-like behavior in streptozotocin-diabetic rats显示文摘 | Helen de Morais Camila P. de Souza Luisa M. da Silva Daniele M. Ferreira Maria Fernanda Werner Roberto Andreatini Joice M. da Cunha Janaina M. Zanoveli | 2014 | Behavioural Brain Research2014，，： | 1 |
| 9 | Addition of propolis or monensin in the diet: Behavior and productivity of lambs in feedlot显示文摘 | C.C.B.F. ítavo M.G. Morais C. Costa L.C.V. ítavo G.L. Franco J.A. da Silva F.A. Reis | 2011 | Animal Feed Science and Technology2011，，3： | 1 |
| 10 | The structure of the potassium channel:molecular basis of K+ conduction and selectivity显示文摘 | Doyle DA Morais Cabral J Pfuetzner RA | | 0，，5360： | 1 |
| 11 | The structure of the potassium channel: molecular basis of K+ conduction and selectivity 显示文摘 | Doyle DA Morais Cabral J Pfuetzner RA | 1998 | Science1998，280，5360： | 1 |
| 12 | Insulin resistance in hepatocytes and sinusoidal liver cells: Mechanisms and consequences显示文摘 | LECLERCQ I A DA SILVA MORAIS A SCHROYEN B | 2007 | J Hepatol2007，47，1： | 1 |
| 13 | Charcoal, renewable energy source for steelmaking process 显示文摘 | Teodoro da Costa R Mayrink Morais F | 2006 | Review de Metallurgie-CIT2006，105，： | 1 |
| 14 | Insulin resistance in hepatocytes and sinusoidal liver cells: mechanisms and consequences 显示文摘 | Leclercq IA Da Silva Morais A Schroyen B | 2007 | J Hepatol2007，47，1： | 1 |
| 15 | Increased oxidative stress in prefrontal cortex and hippocampus is re- lated to depressive-like behavior in streptozotocin-diabetic rats 显示文摘 | De Morais H De Souza C P Da Silva L M | 2014 | Behav Brain Res2014，258，： | 1 |
| 16 | Nitriding of titanium disks and industrial dental implants using hollow cathode discharge显示文摘 | Alves Jr C Guerra Nero C L B Morais G H S Silva da C F I-Iajek V | 2005 | Surface & Coatings Technology2005，194，： | 1 |
| 17 | Enhancement of the antioxidant activity of orange and lime juices by flavonoid enzymatic de-glycosylation显示文摘 | Camila Morais Gon?alves da Silva Fabiano Jares Contesini Alexandra C.H. Frankland Sawaya Elaine Cristina Cabral Ildenize Barbosa da Silva Cunha Marcos Nogueira Eberlin Patrícia de Oliveira Carvalho | 2013 | Food Research International2013，，1： | 1 |
| 18 | Insulin resistance in hepatocytes and sinusoidal liver cells: mechanisms and consequences显示文摘 | Leclercq IA Da Silva Morais A Schroyen B | 2007 | J Hepatol2007，47，1： | 1 |
| 19 | Gln3p and Niltp regulation of invertase activity and SUC2 expression in saccharomyces cerevisiae显示文摘 | Edna Morais Oliveira Jose Joao Mansure Elba Pinto da Silva Bon | 2005 | FEMS Yeast Research2005，，5： | 1 |
| 20 | Stability of zirconium silicate films on Si under vacuum and 02 annealing 显示文摘 | MORAIS J DA ROSA E B O MIOTTI L | 2001 | Applied Physics Letters2001，78，17： | 1 |
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