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| 1 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 2 | Extracellular BCL2 proteins are danger - associated molecular patterns that re- duce tissue damage in routine models of ischemia - reperfusion injury显示文摘 | Iwata A Morgan - Stevenson V Schwartz B | 2010 | PLoS One2010，5，2： | 1 |
| 3 | The use of neutron activation analy- sis to determine the composition of blended samples of asbestos显示文摘 | Morgan A Timbrell V | 1971 | The International Journal of Applied Radiation and Isotopes1971，22，12： | 1 |
| 4 | The use of neutron activation analysis to determine the composition of blended samples of asbestos显示文摘 | Morgan A Timbrell V | 1971 | The International Journal of Applied Radiation and Isotopes1971，22，12： | 1 |
| 5 | Jump height of overhead - lineeond - uetors after the sudden release of ice loads 显示文摘 | Morgan V T Swift D A | 1964 | Proceedings lEE1964，111，10： | 1 |
| 6 | Targeting vascular endothelial growth factor (VEGF)-recep- tor-signaling in renal cell carcinoma 显示文摘 | Reuter C W Morgan M A Grunwald V | 2007 | World J Urol2007，25，1： | 1 |
| 7 | Scale Modeling of Railway Noise Barriers 显示文摘 | HOTHERSALL D C HOROSHENKOV K V MORGAN P A | 2000 | Journal of Sound and vibration2000，234，2： | 1 |
| 8 | Xenon purity analysis for exo-200 via mass spectrometry 显示文摘 | Dobi A Hall C Slutsky S Yen Y R Aharmin B Auger M Barbeau P S Benitez-Medina C Breidenbach M Cleveland B Conley R Cook J Cook S Counts I Craddock W Daniels T Davis C G Davis J Devoe R Dixit M Dolinski M J Donato K Fairbank Jr W Farine J Fierlinger P Franco D Giroux G Gornea R Graham K Gratta G Green C Hagemann C Hall K Hallman D Hargrove C Herrin S Hughes M Hodgson J Juget F Karelin A Kaufman L J Kuchenkov A Kumar K Leonard D S Lutter G Mackay D Maclellan R Marino M Mong B Montero Diez M Morgan P MUller A R Neilson R Odian A Oullivan K Piepke A Pocar A Prescott C Y Pushkin K Rivas A Rollin E Rowson P C Sabourov A Sinclair D Skarpaas K Stekhanov V Strickland V Swift M Twelker K Vuilleumier J L Vuilleumier J M Weber M Wichoski U Wodin J Wright J D Yang L | 2012 | Nuclear Instruments and Methods in Physics Research Section A: Accelerators Spectrometers Detectors and Associated Equipment2012，675，： | 1 |
| 9 | 显示文摘 | Morgan D Ven A V Cederet G | 2004 | Electrochem and Solid State Lett2004，7，2： | 1 |
| 10 | Jump height of overhead-line conductors after the sudden release of ice loads显示文摘 | MORGAN V T SWIFT D A | 1964 | Proceedings IEEE1964，111，10： | 1 |
| 11 | Late Weichselian potholes near Wolverhampton, England显示文摘 | Morgan A V | 1970 | Journal of Glaciology1970，55，9： | 1 |
| 12 | Isolation and char- acterization of aerobic thermophilic bacteria from the Savusavu hot springs in Fiji显示文摘 | NARAYAN V HATHA M A MORGAN H W | 2008 | Microbes and Environments2008，23，4： | 1 |
| 13 | Real time in vivo non - invasive optical imaging using near - infrared fluorescent quantum dots显示文摘 | Morgan N English S Chen W Chernomordik V Russo A Smith P Gandjbakhche A | 2005 | Academic Radiology2005，12，3： | 1 |
| 14 | Association of MMP - 12 polymorphisms withsevere and very severe COPD:A case controlstudy of MMPs - 1,9 and 12 in a European population 显示文摘 | Haq I Chappell S Johnson S R Lotya J Daly L Morgan K Guetta - Baranes T Roca J Rabinovich R Millar A B Donnelly S C Keatings V MacNee W Stolk J Hiemstra P S Miniati M Monti S Connor C M Kalsheker N | 2010 | BMC Medical Genetics2010，15，11： | 1 |
| 15 | Scale modeling of railway noise barriers显示文摘 | HOTHERSALL D C HOROSHENKOV K V MORGAN P A | 2000 | Joumal of Sound and Vibration2000，234，2： | 1 |
| 16 | Respiratory adaptation to chronic hypoxia in newborn rats显示文摘 | MORTOLA J P MORGAN C A VIRGONA V | 1986 | J Appl Physiol1986，61，4： | 1 |
| 17 | Observer variability in the histopathologlcal reporting of core biopsies of papillary breast lesions is reduced by the use of immunohistochemistry for CK5/6,calponin and p63显示文摘 | Douglas-Jones A Shah V Morgan J | 2005 | Histopathology2005，47，2： | 1 |
| 18 | Diffusion-weighted imaging of peritoneal disease for noninvasive staging of advanced ovarian cancer显示文摘 | Kyriazi S Collins D J Morgan V A | 2010 | Radiographics2010，30，5： | 1 |
| 19 | Electrical Phenomena in Amorphous Oxide Films显示文摘 | Dearnaley G Stoneham A M Morgan D V | 1970 | Progress in Physics1970，33，3： | 1 |
| 20 | Modelling of dynamic material behavior in hot deformation: Forging of Ti-6242 显示文摘 | PRASAD Y V R K GEGEL H L DORAIVELU S M MALAS J C MORGAN J T LARK K A BARKER B R | 1984 | Metallurgical Transactions A1984，15，： | 1 |
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