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| 1 | Short and long term outcomes of 200 patients supported by continuous-flow left ventricular assist devices显示文摘AIM: To study the institutional experience over 8 years with 200 continuous-flow(CF)- left ventricular assist devices(LVAD).METHODS: We evaluated our institution's LVAD database and analyzed all patients who received a CF LVAD as a bridge to transplant(BTT) or destination therapy from March 2006 until June 2014. We identified 200 patients, of which 179 were implanted with a Heart Mate II device(Thoratec Corp., Pleasanton, CA) and 21 received a Heartware HVAD(Heart Ware Inc., Framingham, MA).RESULTS: The mean age of our LVAD recipients was 59.3 years(range 17-81), 76%(152/200) were males, and 49% were implanted for the indication of BTT. The survival rate for our LVAD patients at 30 d, 6 mo, 12 mo, 2 years, 3 years, and 4 years was 94%, 86%, 78%, 71%, 62% and 45% respectively. The mean duration of LVAD support was 581 d(range 2-2595 d). Gastrointestinal bleeding(was the most common adverse event(43/200, 21%), followed by right ventricular failure(38/200, 19%), stroke(31/200, 15%), re exploration for bleeding(31/200, 15%),ventilator dependent respiratory failure(19/200, 9%) and pneumonia(15/200, 7%). Our driveline infection rate was 7%. Pump thrombosis occurred in 6% of patients. Device exchanged was needed in 6% of patients. On multivariate analysis, preoperative liver dysfunction, ventilator dependent respiratory failure, tracheostomy and right ventricular failure requiring right ventricular assist device support were significant predictors of post LVAD survival.CONCLUSION: Short and long term survival for patients on LVAD support are excellent, although outcomes still remain inferior compared to heart transplantation. The incidence of driveline infections, pump thrombosis and pump exchange have declined significantly in recent years. | Athanasios Tsiouris Gaetano Paone Hassan W Nemeh Jamil Borgi Celeste T Williams David E Lanfear Jeffrey A Morgan | 2015 | World Journal of Cardiology2015，7，11： | 5 |
| 2 | Helicobacter pylori recurrence after eradication in Latin America:Implications for gastric cancer prevention显示文摘AIM To estimate Helicobacter pylori(H. pylori) recurrence rate in Latin America, a region with a significant H. pylori prevalence and gastric cancer burden.METHODS Pub Med, LILACS, Sci ELO, Cochrane databases and abstracts from relevant meetings were reviewed. Information collected included: Participants' characteristics, recruitment strategy, diagnostic modality, treatment arms, follow-up and recurrence rates. Recurrence was calculated using 100-patients-year rates, and data were pooled using a random effects model. The I2 statistic assessed between study heterogeneity. Meta-regression analyses evaluated for effect modifying variables. RESULTS Literature search yielded 163 articles. Twelve studies involving 4848 patients from 9 countries met inclusion criteria. Four hundred and thirty-two reinfections were recorded in 5487 person-years of follow-up. Pooled analysis showed a recurrence rate of 7.9 cases per 100 person-years(95%CI: 5.3-10.5). Meta-regression revealed that neither the antibiotic schema, a second antibiotic course, nor the diagnostic modality had an impact on the observed risk of recurrence. The recurrence rate in the first year after treatment, predominantly recrudescence,was 11.2(6.1-16.4) per 100 patient years. Recurrence in subsequent years, was only 6.2(3.8-8.7).CONCLUSION H. pylori recurrence rates in Latin America are significant, and with geographic variability, yet are acceptable based upon the current literature for consideration of large scale intervention trials. Further research in Latin America is warranted to evaluate the efficacy, cost-effectiveness, and potential adverse outcomes of proposed eradication programs. | Juan E Corral Robertino Mera Corey W Dye Douglas R Morgan | 2017 | World Journal of Gastrointestinal Oncology2017，9，4： | 5 |
| 3 | 14-day triple, 5-day concomitant, and 10-day sequential therapies for Helicobacter pylori infection in seven Latin American sites: a randomised trial显示文摘 | E Robert Greenberg Garnet L Anderson Douglas R Morgan Javier Torres William D Chey Luis Eduardo Bravo Ricardo L Dominguez Catterina Ferreccio Rolando Herrero Eduardo C Lazcano-Ponce María Mercedes Meza-Montenegro Rodolfo Pe?a Edgar M Pe?a Eduardo Salazar- | 2011 | The Lancet2011，，9790： | 2 |
| 4 | Hematopoietic AMPK [Beta]1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity显示文摘 | Galic Sandra Fullerton Morgan D Schertzer Jonathan D Sikkema Sarah Marcinko Katarina Walkley Carl R Izon David Honeyman Jane Chen Zhi-Ping van Denderen Bryce J Kemp Bruce E Steinberg Gregory R | 2011 | Journal of Clinical Investigation2011，，12： | 2 |
| 5 | Causes of encephalitis and differences in their clinical presentations in England: a multicentre, population-based prospective study显示文摘 | Julia Granerod Helen E Ambrose Nicholas WS Davies Jonathan P Clewley Amanda L Walsh Dilys Morgan Richard Cunningham Mark Zuckerman Ken J Mutton Tom Solomon Katherine N Ward Michael PT Lunn Sarosh R Irani Angela Vincent David WG Brown Natasha S Crowcroft | 2010 | The Lancet Infectious Diseases2010，，12： | 2 |
| 6 | The European soil erosion model (EUROSEM) : A dynamic approach for predicting sediment transport from fields and small catch ments 显示文摘 | Morgan R P C Quinton T N Smith R E | 1998 | Earth Surface Processes and Land forms1998，23，： | 1 |
| 7 | The european soil erosion model (EUROSEM):a dynamic approach for predicting sediment transport from fields and small catchments 显示文摘 | Morgan R P C Quinton J N Smith R E | 1998 | Earth Surf Processed1998，23，： | 1 |
| 8 | Molecular genetic analysis of FIH-1, FH, and SDHB candidate tumour suppressor genes in renal cell carcinoma显示文摘 | Morris MR Maina E Morgan NV | 2004 | J Clin Pathol2004，57，7： | 1 |
| 9 | Analysis of azadirachtin by supercritical-fluid chromatography 显示文摘 | HUANG Hui-ping MORGAN E D | 1990 | J of Chromatography1990，，519： | 1 |
| 10 | Clinical progression and out- come of dysphagia following paediatric traumatic brain injury: a prospective study 显示文摘 | Morgan A Ward E Murdoch B | 2004 | Brain Inj2004，18，4： | 1 |
| 11 | Partitioning evapotranspiration fluxes from a Colorado grassland using stable isotopes: Seasonal variations and ecosystem implications ofelevated atmospheric C02 显示文摘 | Ferretti DF Pendall E Morgan JA Nelson JA Lecain D Mosier AR | 2003 | Plant Soil2003，254，： | 1 |
| 12 | Correction of subnormal fertility with copper and magnesium supplementation显示文摘 | Ingraham R H Kappel L C Morgan E B | 1987 | Journal of Dairy Science1987，701，： | 1 |
| 13 | The Eu- ropean soil erosion model(EUROSEM) : A dynamic ap- proach for predicting sediment transport from fields and small catchments 显示文摘 | Morgan R P C Quinton J N Smith R E | 1998 | Earth Surface Processes and Landforms1998，23，6： | 1 |
| 14 | Pathological features and inhaled corticosteroid response of eosinophilic and non-eosinophilic asthma显示文摘 | Berry M Morgan A Shaw D E | 2007 | Thorax2007，62，12： | 1 |
| 15 | Bortezomib (Velcade TM) in the treatment of multiple myeloma显示文摘 | Field Smith A Morgan G J Davies F E | 2006 | Ther Clin Risk Manag2006，2，3： | 1 |
| 16 | Water relations in grassland and desert ecosystems exposed to elevated atmospheric CO2显示文摘 | Morgan J A Pataki D E K(o)rner C | 2004 | Oecologia2004，140，： | 1 |
| 17 | 显示文摘 | Morgan J D Lusvardi K M Kaler E W | 1997 | Macromolecules1997，30，7： | 1 |
| 18 | Conversion of triglycerides to hydrocarbons over supported metal catalysts 显示文摘 | MORGAN T GRUBB D SANTILLAN-JIMENEZ E CROCKER M | 2010 | Top Catal2010，53，1112： | 1 |
| 19 | Hypersensitivity reactions to crustacea and mollusk 显示文摘 | Daul C B Morgan J E Lehrer S B | 1993 | Clin Rev Allergy1993，11，： | 1 |
| 20 | Limited choroidal hemorrhage mistaken for a choroidal melanomal 显示文摘 | Morgan C M Gragoudas E S | 1987 | Ophthalmology1987，94，1： | 1 |
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