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| 1 | Epigenetic profiles of pre-diabetes transitioning to type 2 diabetes and nephropathy显示文摘AIM: To examine DNA methylation profiles in a longitudinal comparison of pre-diabetes mellitus(Pre-DM) subjects who transitioned to type 2 diabetes mellitus(T2DM).METHODS: We performed DNA methylation study in bisulphite converted DNA from Pre-DM(n = 11) at baseline and at their transition to T2 DM using Illumina Infinium Human Methylation27 Bead Chip, that enables the query of 27578 individual cytosines at Cp G loci throughout the genome, which are focused on the promoter regions of 14495 genes.RESULTS: There were 694 Cp G sites hypomethylated and 174 Cp G sites hypermethylated in progression from Pre-DM to T2 DM, representing putative genes involved in glucose and fructose metabolism, inflammation, oxidative and mitochondrial stress, and fatty acid metabolism. These results suggest that this high throughput platform is able to identify hundreds of prospective Cp G sites associated with diverse genes that may reflect differences in Pre-DM compared with T2 DM. In addition, there were Cp G hypomethylation changes associated with a number of genes that may be associated with development of complications of diabetes, such as nephropathy. These hypomethylation changes were observed in all of the subjects.CONCLUSION: These data suggest that some epigenomic changes that may be involved in the progression of diabetes and/or the development of complications may be apparent at the Pre-DM state or during the transition to diabetes. Hypomethylation of a number of genes related to kidney function may be an early marker for developing diabetic nephropathy. | Thomas A Vander Jagt Monica H Neugebauer Marilee Morgan Donald W Bowden Vallabh O Shah | 2015 | World Journal of Diabetes2015，6，9： | 5 |
| 2 | Surgical correction of tracheo-oesophageal fistula and oesophageal atresia in infants with VACTERL association: a retrospective ease-control study显示文摘 | Morgan RD O'Callaghan JM Wagener S | 2012 | Pediatr Surg Int2012，28，10： | 1 |
| 3 | Principles of CDK regulation显示文摘 | Morgan D O | 1995 | Nature1995，374，6518： | 1 |
| 4 | Infectious disease risks of dead bodies following natural disasters显示文摘 | Morgan O | 2004 | Rev Panam Salud Publica2004，15，5： | 1 |
| 5 | Water relations in grassland and desert ecosystems exposed to elevated atmospheric CO2显示文摘 | Morgan J A Pataki D E K(o)rner C | 2004 | Oecologia2004，140，： | 1 |
| 6 | Molecular characterization of Cryptosporidium isolates from humans and other animals using random amplified polymorphic DNA analysis显示文摘 | Morgan UM Constantine CC O'Donoghue P | 1995 | Am J rrop Med Hyg1995，52，6： | 1 |
| 7 | Modified cuckoo search:a new gradient free optimization algorithm显示文摘 | Alton S Hassan O Morgan K | 2011 | Chaos Solitons & Fractals2011，44，9： | 1 |
| 8 | Debris Flow Defenses in British Columbia显示文摘 | Morgan C Vandine F D | 1987 | Geological Society of America Reviews in Engineering Geology1987，7，2： | 1 |
| 9 | A prospective,randomized comparison of an in-line heat moisture exchange filter and heated wire humidifies:rates of ventilator-associated early-onset (community-acquired) or late-onset (hospital-acquired) pneumonia and incidence of endotracheal tube occlusion显示文摘 | Kirton O C DeHaven B Morgan J | 1997 | Chest1997，112，4： | 1 |
| 10 | Debris Flow Defenses in British Columbia显示文摘 | Hunger O Morgan C Vandine F D | 1987 | Geological Society of Amer- ica Reviews in Engineering Geology1987，7，20： | 1 |
| 11 | A lacticin 3147enriched food ingredient reduces Streptococcus mutans isolatedfrom the human oral cavity in saliva 显示文摘 | O'Connor EB O^Riordan B Morgan SM | 2006 | J Appl Microbiol2006，100，6： | 1 |
| 12 | Evaluation of the Xpert methicillin-resistant Staphylococcus aureus (MRSA) assay using the genexpert Real-Time PCR platform for rapid detection of mrsa from screening specimens显示文摘 | Rossney AS Herra CM Morgan PM Morgan PM O'Connell B | | Journal of Clinical Microbiology0，，： | 1 |
| 13 | Advances in seeded ambient temperature ferrite formation for treatment of acid mine drainage显示文摘 | Morgan B E Lahav O Loewenthal R E | 2005 | Environmental Science& Technology2005，39，19： | 1 |
| 14 | Retroviral vectors containing putative internal ribosome entry sites:development of a polycistronic gene transfer system and applications to human gene therapy显示文摘 | Morgan RA Couture L Elroy-Stein O | 1992 | Nucleic Acids Res1992，20，6： | 1 |
| 15 | Molecular characterization of Cryptosporidium isolates from humans and other animals using random amplified polymorphic DNA analysis 显示文摘 | Morgan UM Constantine CC O'Donoghue P | 1995 | Am J Trop Med Hyg1995，52，6： | 1 |
| 16 | Improved bronchial healing in canine left lung reimplantation using omental pedicle wrap 显示文摘 | Morgan E Lima O Goldberg M | 1983 | J Thorac Cardiovasc Surg1983，85，： | 1 |
| 17 | Insulin and insulin-like growth factors receptors and responses in cultured human muscle cells显示文摘 | Shimizu M Webster C Morgan D O | 1986 | Am J Physiol1986，251，： | 1 |
| 18 | Dynamic stereochemis- try transfer in a transannular reaction: Total synthesis of hypo- crellin A显示文摘 | O' Brien EM Morgan B J Kozlowski MC | 2008 | Angew Chem Int Ed Engl2008，47，36： | 1 |
| 19 | Quereetin, E7 and p53 in papillomavirus oncogenic cell transforma- tion显示文摘 | Beniston R G Morgan I M O'Brien V | 2001 | Carcinogenesis2001，22，7： | 1 |
| 20 | Personal protective equip- ment and risk for avian influenza ( I-I7N3 ) 显示文摘 | Morgan O Kuhne M Nair P | 2009 | Emerg Infect Dis2009，15，1： | 1 |
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