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| 1 | Ellagic acid induces apoptosis through inhibition of nuclear factor κB in pancreatic cancer cells显示文摘AIM:To determine the effect of ellagic acid on apop-tosis and proliferation in pancreatic cancer cells and to determine the mechanism of the pro-survival effects of ellagic acid. METHODS:The effect of ellagic acid on apoptosis was assessed by measuring Phosphatidylserine externalization,caspase activity,mitochondrial membrane potential and DNA fragmentation;and proliferation by measuring DNA thymidine incorporation. Mitochondrial membrane potential was measured in permeabilized cells,and in isolated mitochondria. Nuclear factor kB(NF-kB) activity was measured by electromobility shift assay(EMSA) . RESULTS:We show that ellagic acid,a polyphenolic compound in fruits and berries,at concentrations 10 to 50 mmol/L stimulates apoptosis in human pancreatic adenocarcinoma cells. Further,ellagic acid decreases proliferation by up to 20-fold at 50 mmol/L. Ellagic acid stimulates the mitochondrial pathway of apoptosis associated with mitochondrial depolarization,cytochrome C release,and the downstream caspaseactivation. Ellagic acid does not directly affect mitochondria. Ellagic acid dose-dependently decreased NF-kB binding activity. Furthermore,inhibition of NF-kB activity using IkB wild type plasmid prevented the effect of ellagic acid on apoptosis. CONCLUSION:Our data indicate that ellagic acid stimulates apoptosis through inhibition of the prosu-rvival transcription factor NF-kB. | Mouad Edderkaoui Irina Odinokova Izumi Ohno Ilya Gukovsky Vay Liang W Go Stephen J Pandol Anna S Gukovskaya | 2008 | World Journal of Gastroenterology2008，14，23： | 30 |
| 2 | XIAP抑制剂Embelin体外对人胰腺癌细胞株的抑制效应与机制研究显示文摘目的探讨XIAP小分子抑制剂Embelin体外对人胰腺癌细胞株MIAPaCa-2的抑制效应与机制。方法将生长至第4-12代之间的MIAPaca-2细胞分为DMSO对照组与Embelin实验组,在实验组细胞中加入不同浓度的Embelin共孵育72h,收集细胞并裂解后取上清液用细胞凋亡试剂盒检测组蛋白(凋亡指标)的OD值水平。MIAPaca-2细胞加入不同浓度的Embelin共孵育60h后再加入3H胸腺嘧啶继续孵育12h,取细胞裂解液用同位素γ闪烁计数仪检测3H-CPM数值以判断细胞增殖程度。对DMSO对照组与Embelin实验组的组蛋白OD值与3H-CPM数值分别进行比较分析。结果Embelin实验组的MIAPaCa-2细胞株组蛋白OD值显著高于DMSO对照组而3H-CPM数值明显低于DMSO对照组(P<0.01),且实验组Embe-lin的作用浓度与组蛋白OD值呈正相关(r=0.996,P<0.01),而与3H-CPM数值呈负相关(r=-0.993,P<0.01)。结论Embelin呈剂量依赖性地诱导人胰腺癌细胞株MIAPaCa-2凋亡并抑制其增殖,有肿瘤抑制效应。 | 郑玲 吕寒静 Mouad Edderkaoui Stephen J Pandol | 2009 | 山西医科大学学报2009，40，1： | 4 |
| 3 | Quercetiin 3- and chromones from Callrna vulgaris显示文摘 | ALAIN S ALBERT J C MOUAD K | 1994 | Photochemistry1994，36，4： | 1 |
| 4 | Research Development on Sodium-Ion Batteries显示文摘 | YABUUCHI NAOAKI KUBOTA KEI DAHBI MOUAD | 2014 | Chemical Reviews2014，114，11： | 1 |
| 5 | Ellagic Acid and Embelin Affect Key Cellular Components of Pancreatic Adenocarcinoma, Cancer, and Stellate Cells显示文摘 | Mouad Edderkaoui Aurelia Lugea Hongxiang Hui Guido Eibl Qing-Yi Lu Aune Moro Xuyang Lu Gang Li Vay-Liang Go StephenJ. Pandol | 2013 | Nutrition and Cancer2013，，8： | 1 |
| 6 | Extracellular matrix proteins protect pancreatic cancer cells from death via mitochondrial and nonmitochondrial pathways显示文摘 | Eva C Vaquero Mouad Edderkaoui Kyung J Nam Ilya Gukovsky Stephen J Pandol Anna S Gukovskaya | 2003 | Gastroenterology2003，，4： | 1 |
| 7 | Using wavelets to determine paper formation by light transmission image analysis显示文摘 | Mouade B Jose F C Josep P | | Tappi Journal0，82，7： | 1 |
| 8 | Enhancing Nuclear Security System of Irradiation Facility SIBO INRA/Tangier Morocco显示文摘 | Mouhib Mohammed Chentouf Mouad Guessous Amina Rostislav Vlaev | 2017 | Journal of Chemistry and Chemical Engineering2017，11，3： | 0 |
| 9 | 开罗•金字塔 永不失落的埃及符号显示文摘早在公元前3世纪,埃及金字塔就被列入了'古代世界七大奇迹',且居于首位,声名远播。如今,七大奇迹中的六大奇迹已变为废墟,惟有金字塔昂然屹立,不由得让人想起一句著名的阿拉伯谚语:'人害怕时间,而时间害怕金字塔。' | 谢伟 Arralyn Mouad Alex(图) | 2020 | 城市地理2020，，10： | 0 |
| 10 | Single-bit full adder and logic gate based on synthetic antiferromagnetic bilayer skyrmions显示文摘Skyrmion-based devices are promising candi-dates for non-volatile memory and low-delay time com-putation.Many skyrmion-based devices execute operation by controlling skyrmion trajectory,which can be impeded by the skyrmion Hall effect.Here,the design of skyrmion-based arithmetic devices built on synthetic antiferromag-netic(SyAF)structures is presented,where the structure can greatly suppress skyrmion Hall effect.In this study,the operations of skyrmion-based half adder,full adder,and XOR logic gate are executed by introducing geometric notches and tilted edges,which can annihilate or diverge skyrmion.Performance of these skyrmion-based devices is evaluated,where the delay time and energy-delay product of the single-bit full adder are 1.95 ns and 2.50×10^(-22)Js,which are only 12%and 79%those of the previously proposed skyrmion-based single-bit full adder.This improvement is significant in the construction of ripple-carry adder and ripple-carry adder-subtractor.Therefore,our skyrmion-based SyAF arithmetic device is a promising candidate to develop high-speed spintronic devices. | Kai Yu Mak Jing Xia Xi-Chao Zhang Li Li Mouad Fattouhi Motohiko Ezawa Xiao-Xi Liu Yan Zhou | 2022 | Rare Metals2022，41，7： | 0 |
| 11 | Magnetic,thermal stability and dynamic mechanical properties of beta isotactic polypropylene/natural rubber blends reinforced by NiZn ferrite nanoparticles显示文摘The dispersion of magnetic nanoparticles in matrix is crucial to ensure optimum performance of the composite.The difficulty level of achieving good dispersion is further increase when a multi-phases of matrix is present.A pre-coating technique of magnetic nanoparticles with polypropylene using ball-mill prior to melt-blending process was employed to prepare a multi-phases thermoplastic natural rubber composite.The effect of filler loading(2 wt%-10 wt%) on morphology,structure,magnetic properties,thermal stability and dynamic mechanical properties of the composites were investigated.It was found that the NiZn ferrite nanoparticles act as nucleating agent to form beta isostatic polypropylene thermoplastic composites.The composites’ magnetic properties are directly dependent on the filler concentration.The dispersion of magnetic fillers in polymer matrix plays role in affecting the magnetic properties and thermal stability.The preference of filler to locate at amorphous phase has distorted the chain orientation of natural rubber and polypropylene.Hence,the polymorphism and crystallinity of the matrix varied as the filler loading increased,affecting the dynamic mechanical properties.It was found that 8 wt% NiZn nanocomposite exhibits highest E’ and tanδ,indicating the dynamic mechanical properties of NiZn nanocomposite are affected by β-phase degree. | Lih-Jiun Yu Sahrim Hj Ahmad Ing Kong Mouad ATarawneh Shamsul Bahri Bin Abd Razak Elango Natarajan Chun Kit Ang | 2019 | Defence Technology(防务技术)2019，15，6： | 0 |
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