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| 1 | Immunological roulette: Luck or something more? Considering the connections between host and environment in TB显示文摘Accurate prediction of which patient will progress from a sub-clinical Mycobacterium tuberculosis infection to active tuberculosis represents an elusive,yet critical,clinical research objective.From the individual perspective,progression can be considered to be the product of a series of unfortunate events or even a run of bad luck.Here,we identify the subtle physiological relationships that can influence the odds of progression to active TB and how this progression may reflect directed dysbiosis in a number of interrelated systems.Most infected individuals who progress to disease have apparently good immune responses,but these responses are,at times,compromised by either local or systemic environmental factors.Obvious disease promoting processes,such as tissue-damaging granulomata,usually manifest in the lung,but illness is systemic.This apparent dichotomy between local and systemic reflects a clear need to define the factors that promote progression to active disease within the context of the body as a physiological whole.We discuss aspects of the host environment that can impact expression of immunity,including the microbiome,glucocorticoid-mediated regulation,catecholamines and interaction between the gut,liver and lung.We suggest the importance of integrating precision medicine into our analyses of experimental outcomes such that apparently conflicting results are not contentious,but rather reflect the impact of these subtle relationships with our environment and microbiota. | John E Pearl Mrinal Das Andrea M Cooper | 2018 | Cellular & Molecular Immunology2018，15，3： | 3 |
| 2 | Approximation al gorithms for node deletion problems on bipartite graphs with finite forbidden sub graph characterization显示文摘 | Mrinal K Sounaka M Safina D N | 2014 | Theoretical Computer Science2014，526，： | 1 |
| 3 | The magnitude of arsenic contamination in ground- water and its health effects to the inhabitants of the Jalangi--one of the 85 arsenic affected blocks in West Bengal, India 显示文摘 | Monhammad M R Mrinal K S Sad A | 2005 | Science of the Total Environment2005，338，： | 1 |
| 4 | A novel defected ground structure for planar circuits显示文摘 | Mrinal K M Sanyal S | 2006 | IEEE Microwave and Wireless Components Letters2006，16，2： | 1 |
| 5 | Improving Data Recovery in MPEG - 4 显示文摘 | Liyang XU Sunil K Mrinal M | 2005 | IEICE Trans D : Information2005，88，： | 1 |
| 6 | Processing and perform- ance evaluation of hollow mierospheres filled epoxy composites 显示文摘 | Mrinal C S Sahrina N Mosi M etal | 2008 | Polymer Composites2008，29，3： | 1 |
| 7 | A novel defected ground structure for planar circuits 显示文摘 | MRINAL K M SUBRATA S | 2006 | IEEE Microwave and Wireless Components Letters2006，16，2： | 1 |
| 8 | Properties of injection molded blends of starch and biodegradable polyesters显示文摘 | ROMASWAMY M MRINAL B | 2001 | Eur Polym J2001，37，3： | 1 |
| 9 | Evaluation of Compatibly and Properties of Biodegradable Polyester Blends 显示文摘 | Jacob J Ramaswamy M Mrinal B | 2002 | Journal of Polymer Science: Part A: Polymer Chemistry2002，40，12： | 1 |
| 10 | An image encryption process based on Chaotic logistic map显示文摘 | Mrinal K M Gourab D B Debasish C | | 0，，05： | 1 |
| 11 | 显示文摘 | Vitor M Correlo Luciano F Boesel Mrinal Bhattacharya | 2005 | Macromolecular Materials and Engineering2005，290，12： | 1 |
| 12 | Projective modules over smooth real atone varieties 显示文摘 | Bhatwadekar S M Das Mrinal Kanti Satya Mandal | 2006 | Invent Math2006，166，： | 1 |
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