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| 1 | Prediction of cervical lymph node metastases in papillary thyroid microcarcinoma by sonographic features of the primary site显示文摘Objective: To study the sonographic features of the primary site of papillary thyroid microcarcinoma(PTMC) for the prediction of cervical lymph node metastasis during preoperative diagnosis.Methods: A total of 710 PTMC patients between 2013 and 2016 with a diagnosis of cervical lymph node metastases were reviewed.We analyzed the sonographic features of the PTMC primary site to predict ipsilateral or central lymph node metastases in univariate and multivariate models.The ratio of abutment/perimeter of the PTMC primary site was utilized to evaluate cervical lymph node status.Results: Regarding clinical characteristics, multifocality and extrathyroidal extension were associated with cervical lymph node involvement.In the multivariate regression model, calcification and the abutment/perimeter ratio of lesions were evaluated as independent factors in level Ⅵ, ipsilateral or skip cervical lymph node metastases.The cut-off value of the ratio of abutment/perimeter of the PTMC primary site(25%) was significantly correlated with cervical lymph node metastases(P = 0.000).Conclusions: Independent sonographic features, including lesion size, lesion location, calcification, and the ratio of abutment/perimeter of the primary site, were associated with cervical lymph node metastases in PTMC patients. | Xi Wei Meng Wang Xiaoqing Wang Xiangqian Zheng Ying Li Yi Pan Yueguo Li Jiali Mu Yang Yu Dapeng Li Ming Gao Sheng Zhang | 2019 | Cancer Biology & Medicine2019，16，3： | 22 |
| 2 | Pediatric reference intervals in China(PRINCE):design and rationale for a large,multicenter collaborative cross-sectional study显示文摘There is a lack of accurate pediatric reference intervals(RIs) in China, with most commonly used RIs established without consideration of the effect of age and gender. The Pediatric Reference Intervals in China(PRINCE) project aims to establish and verify pediatric RIs for 31 common laboratory measurands.The project will be a large, multicenter cross-sectional study:14,490 healthy children and adolescents aged up to 19 years will be surveyed by 10 children's hospitals and one pediatric department of a university hospital. To evaluate the feasibility and efficiency of the study methods, 602 children were surveyed in the pilot phase of the PRINCE study in April 2017: it found that some measurands were distinctly age dependent and that there were differences between values for males and females. The results of the pilot study affirmed the necessity of the PRINCE project for Chinese pediatrics. The pilot also indicated potential difficulties in the full survey, e.g., difficulties in recruiting children aged under 3 years and insufficient collection of blood samples from infants. The operation of the PRINCE project has been modified based on the findings in the pilot study toward improving the validity of the PRINCE project and promoting its openness and transparency. | Xin Ni Wenqi Song Xiaoxia Peng Ying Shen Yaguang Peng Qiliang Li Yan Wang Lixin Hu Yanying Cai Hong Shang Min Zhao Hong Jiang Yaoguo Huang Runqing Mu Wenxiang Chen Mingting Peng Chuanbao Zhang Jie Zeng Chenbin Li Hongling Yang Yongmei Jiang Jin Xu Guixia Li Hongbing Chen Yun Xiang Sancheng Cao Zhenxin Guo Dapeng Chen | 2018 | Science Bulletin2018，63，24： | 12 |
| 3 | mTOR regulates TLR-induced c-fos and Th1 responses to HBV and HCV vaccines显示文摘Although IL-12 plays a critical role in priming Th1 and cytotoxic T lymphocyte(CTL) responses, Toll-like receptor(TLR) signaling only induces low amounts of IL-12 in dendritic cells and macrophages, implying the existence of stringent regulatory mechanisms. In this study, we sought to uncover the mechanisms underlying TLR-induced IL-12 expression and the Th1 response. By systemic screening, we identified a number of protein kinases involved in the regulation of TLRinduced IL-12 expression. In particular, PI3 K, ERK, and m TOR play critical roles in the TLR-induced Th1 response by regulating IL-12 and IL-10 production in innate immune cells. Moreover, we identified c-fos as a key molecule that mediates m TOR-regulated IL-12 and IL-10 expression in TLR signaling. Mechanistically, m TOR plays a crucial role in c-fos expression, thereby modulating NFκB binding to promoters of IL-12 and IL-10. By controlling the expression of a special innate gene program, m TOR can specifically regulate the TLR-induced T cell response in vivo. Furthermore, blockade of m TOR by rapamycin efficiently boosted TLR-induced antigen-specific T and B cell responses to HBV and HCV vaccines. Taken together, these results reveal a novel mechanism through which m TOR regulates TLR-induced IL-12 and IL-10 production, contributing new insights for strategies to improve vaccine efficacy. | Li He Aiping Zang Min Du Dapeng Ma Chuanping Yuan Chun Zhou Jing Mu Huanjing Shi Dapeng Li Xulin Huang Qiang Deng Jianhua Xiao Huimin Yan Lijian Hui Ke Lan Sidong Xiong Xiaoxia Li Zhong Huang Hui Xiao | 2015 | Virologica Sinica2015，30，3： | 2 |
| 4 | Equivalent Water Height Extracted from GRACE Gravity Field Model with Robust Independent Component Analysis显示文摘 | GUO Jinyun MU Dapeng LIU Xin | 2014 | Acta Geophysica2014，62，4： | 1 |
| 5 | Zero drift and solid Earth tide extracted from relative gravimetric data with principal component analysis显示文摘Zero drift and solid Earth tide corrections to static relative gravimetric data cannot be ignored. In this paper, a new principal component analysis(PCA) algorithm is presented to extract the zero drift and the solid Earth tide, as signals, from static relative gravimetric data assuming that the components contained in the relative gravimetric data are uncorrelated. Static relative gravity observations from Aug. 15 to Aug. 23, 2014 are used as statistical variables to separate the signal and noise with PCA to obtain desired signals. The results of the linear drift extracted by PCA are consistent with those calculated by the least squares linear fitting, and the differences only reach to 10 2mG al/day order of magnitude.Furthermore, PCA is used to estimate the solid Earth tide from the relative gravimetric data corrected by the zero drift. The statistical results are consistent with the results derived from the solid Earth tide correction provided by the internal software of the CG-5 gravimeter(SCINTREX Limited Ontario Canada). The statistical results of the differences between the two methods are both less than 8 m Gal, and the RMSs for 9 days are all less than5 m Gal. | Yu Hongjuan Guo Jinyun Li Jiulong Mu Dapeng Kong Qiaoli | 2015 | Geodesy and Geodynamics2015，6，2： | 1 |
| 6 | Detecting Regional Deep Ocean Warming below 2000 Meter Based on Altimetry,GRACE,Argo,and CTD Data显示文摘The deep ocean below 2000 m is a large water body with the sparsest data coverage,challenging the closure of the sea-level budget and the estimation of the Earth’s energy imbalance.Whether the deep ocean below 2000 m is warming globally has been debated in the recent decade.However,as the regional signals are generally larger than the global average,it is intriguing to investigate the regional temperature changes.Here,we adopt an indirect method that combines altimetry,GRACE,and Argo data to examine the global and regional deep ocean temperature changes below 2000 m.The consistency between high-quality conductivity-temperature-depth(CTD)data from repeated hydrographic sections and our results confirms the validity of the indirect method.We find that the deep oceans are warming in the Middle East Indian Ocean,the subtropical North and Southwest Pacific,and the Northeast Atlantic,but cooling in the Northwest Atlantic and Southern oceans from 2005 to 2015. | Yuanyuan YANG Min ZHONG Wei FENG Dapeng MU | 2021 | Advances in Atmospheric Sciences2021，38，10： | 1 |
| 7 | Sea level rise along China coast from 1950 to 2020显示文摘Global mean sea level rise has been reconstructed using tide gauges. However, long-term sea level rise along the China coast is unclear. To address this issue, a data assimilation approach is developed to reconstruct sea level rise along the China coast from 1950 to 2020 using a global distribution of tide gauges(TGs). This approach combines climate models and sea level fingerprints. The climate models provide stereodynamic sea level changes. The sea level fingerprints include increases in ocean mass due to global ice melting and changes in water storage on land. The reconstructed global mean sea level rise agrees well with previous studies. We quantify sea level rise at 20 TGs along the China coast. The results suggest that sea level rise along the China coast(1.95±0.33 mm yr^(-1)) is greater than the global mean(1.71±0.17 mm yr^(-1)). We also find that China's coastal sea level rise is more than three times faster after 1980, increasing from 0.84±0.28 mm yr^(-1)for 1950–1980 to3.12±0.21 mm yr^(-1)for 1980–2020. This finding implies a significant sea level acceleration along the China coast. Our results advance the understanding of long-term sea level changes along the China coast. | Dapeng MU Tianhe XU Haoming YAN | 2024 | Science China Earth Sciences2024，67，3： | 0 |
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