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| 1 | Risk factors of haemorrhagic transformation for acute ischaemic stroke in Chinese patients receiving intravenous recombinant tissue plasminogen activator:a systematic review and meta-analysis显示文摘Objective To identify risk factors for haemorrhagic transformation in Chinese patients with acute ischaemic stroke treated with recombinant tissue plasminogen activator.Methods We searched electronic databases including PubMed,EMBASE,CNKI and WanFang Data for studies reporting risk factors of haemorrhagic transformation after intravenous thrombolysis.Pooled OR,weighted mean difference(WMD)and 95%CI were estimated.Meta-analysis was performed by using Stata V.14.0 software.results A total of 14 studies were included.The results indicated that older age(WMD=3.46,95%CI 2.26 to 4.66,I^(2)=47),atrial fibrillation(OR 2.66,95%CI 1.85 to 3.81,I^(2)=28),previous stroke(OR 1.68,95%CI 1.08 to 2.60,I^(2)=14),previous antiplatelet treatment(OR 1.67,95%CI 1.17 to 2.38,I^(2)=0),higher National Institute of Health stroke scale scores(OR 1.10,95%CI 1.05 to 1.15,I^(2)=36),systolic(WMD=4.75,95%CI 2.50 to 7.00,I^(2)=42)or diastolic(WMD=2.67,95%CI 1.08 to 4.26,I^(2)=35)pressure,and serum glucose level(WMD=1.44,95%CI 0.62 to 2.26,I^(2)=66)were associated with increased risk of post-thrombolysis haemorrhagic transformation.Conclusion The current meta-analysis identified eight risk factors for post-thrombolysis haemorrhagic transformation in Chinese patients with acute ischaemic stroke.Given the risk of bias,these results should be explained with caution and do not justify withholding intravenous thrombolysis. | Yijia Guo Yaqiong Yang Muke Zhou Li He | 2018 | Stroke & Vascular Neurology2018，3，4： | 18 |
| 2 | Validation of risk scoring models for predicting stroke-associated pneumonia in patients with ischaemic stroke显示文摘Objective:Various risk scoring models have been developed to predict stroke-associated pneumonia(SAP).We aim to determine whether these risk models could effectively predict SAP in Chinese patients with ischaemic stroke(IS).Methods:Consecutive patients with IS in West China hospital between January 2011 and September 2013 were included to assess the predictive performance of risk scoring models,including Chumbler’s score,A^(2)DS^(2) and AISAPS.The area under the receiver operating characteristic curve(AUROC)was used to evaluate the performance of each risk model in predicting pneumonia.Results:A total of 1569 consecutive patients with IS within 30 days of onset in West China hospital were included.The incidence of pneumonia is 15.3%.The AUROC of Chumbler’s score,A^(2)DS^(2) and AISAPS was 0.659,0.728 and 0.758,respectively,and AISAPS had the highest AUROC.Conclusions:A^(2)DS^(2) and AISAPS had acceptable discriminatory abilities to predict SAP in Chinese patients with IS within 30 days of onset. | Siyin Gong Zhiwei Zhou Muke Zhou Zhao Lei Jian Guo Ning Chen Li He | 2016 | Stroke & Vascular Neurology2016，1，3： | 11 |
| 3 | 中国脑梗死患者静脉溶栓后出血转化危险因素的系统评价及Meta分析显示文摘Stroke&Vascular Neurology(SVN)新近上线的文章“Risk factors of haemorrhagic transformation for acute ischemic stroke in Chinese patients receiving intravenous recombinant tissue plasminogen activator:a systematic review and meta-analysis”,由四川大学华西医院神经内科何俐教授团队共同完成。 | YIJIA GUO YAQIONG YANG MUKE ZHOU 何俐 | 2018 | 中国卒中杂志2018，13，11： | 8 |
| 4 | A Longitudinal Functional Magnetic Resonance Imaging Study of Working Memory in Patients Following a Transient Ischemic Attack: A Preliminary Study显示文摘In this study, we used functional magnetic resonance imaging(fMRI) to investigate longitudinal changes in brain activation during a verbal working memory(VWM) task performed by patients who had experienced a transient ischemic attack(TIA). Twenty-five first-ever TIA patients without visible lesions in conventional MRI and 25 healthy volunteers were enrolled. VWM task-related fMRI was conducted 1 week and 3 months post-TIA. The brain activity evoked by the task and changes over time were assessed. We found that, compared with controls, patients exhibited an increased activation in the bilateral inferior frontal gyrus(IFG), right dorsolateral prefrontal cortex(DLPFC), insula, inferior parietal lobe(IPL), and cerebellum during the task performed 1 week post-TIA. But only the right IFG still exhibited an increased activation at 3 months post-TIA. A direct comparison of fMRI data between 1 week and 3 months post-TIA showed greater activation in the bilateral middle temporal gyrus, right DLPFC, IPL, cerebellum, and left IFG in patients at 1 week post-TIA. We conclude that brain activity patterns induced by a VWM task remain dynamic for a period of time after a TIA, despite the cessation of clinical symptoms. Normalization of the VWM activation pattern may be progressively achieved after transient episodes of ischemia in TIA patients. | Wei Su Jian Guo Yun Zhang Jie Zhou Ning Chen Muke Zhou Rong Li Huafu Chen Li He | 2018 | Neuroscience Bulletin2018，34，6： | 3 |
| 5 | Establishment of a rhesus monkey model of middle cerebral artery ischemia and reperfusion using a microcatheter embolization method显示文摘Nonhuman primates are closest to humans in terms of lineage,and middle cerebral artery ischemia/reperfusion responses of nonhuman primates are most similar to ischemic stroke in humans.Therefore,nonhuman primates could be utilized to simulate the process of ischemic stroke in the human.Few studies,however,have reported the use of endovascular technology to establish a rhesus monkey stroke model.In the present study,seven adult,male,rhesus monkeys were selected and,following anesthesia,a microcatheter was inserted into one side of the middle cerebral artery via the femoral artery to block blood flow,thereby resulting in middle cerebral artery occlusion.After 2 hours,the microcatheter was withdrawn to restore the middle cerebral artery blood flow and to establish ischemia/reperfusion.Results from angiography and magnetic resonance angiography confirmed occlusion and reopening of the middle cerebral artery.Magnetic resonance imaging revealed the existence of ischemic brain lesions,and neurological examination showed sustained functional deficits following surgery.The rhesus monkey middle cerebral artery ischemia/reperfusion models established by microcatheter embolization had the advantage of non-craniotomy invasion and reproducibility.The scope and degree of ischemic damage using this model was controllable.Therefore,this nonhuman primate model is an ideal model for cerebral ischemia and reperfusion. | Jie Yang Jian Guo Hongbo Zheng Muke Zhou Li He Wenying Cao Li Xiao Jiachuan Duan Qiyong Gong Xiaoqi Huang Hongxia Li Li Wang Jingqiu Cheng | 2010 | Neural Regeneration Research2010，5，15： | 2 |
| 6 | Inter-rater reliability of the A-S-C-O classification system for ischemic stroke显示文摘 | Ning Chen Muke Zhou Yucai Wang Hui Wang Mi Yang Jian Guo Xue Yang Hongbo Zheng Dong Zhou Li He | 2012 | Journal of Clinical Neuroscience2012，，： | 1 |
| 7 | Rhizoma Chuanxiong regulates vascular endothelial growth factor production in hypoxic human umbilical vein endothelial cells in vitro and in peri-infarct rat brain tissue显示文摘BACKGROUND:Vascular endothelial growth factor(VEGF) acts as'molecular bridge'following ischemic stroke to improve and restore blood supply and reduce infarction volume.Clinical studies have demonstrated the efficacy of Rhizoma Chuanxiong(Chuanxiong) in the treatment of ischemic cerebrovascular diseases.However,whether it promotes endogenous VEGF expression in ischemic stroke remains unknown. OBJECTIVE:To investigate the influence of Rhizoma Chuanxiong on VEGF production in vitro cultured human umbilical vein endothelial cells and on VEGF expression in ischemic cerebral tissues to explore its role in angiogenesis. DESIGN,TIME AND SETTING:In vitro basic comparison of traditional Chinese drug-containing serum pharmacology;in vivo randomized,controlled,animal experiment.This study was performed at the Medical Laboratory of West China Hospital,Sichuan University between December 2002 and April 2004. MATERIALS:Two Chinese rabbits were selected.One was intragastrically perfused with 5.8 g/kg Rhizoma Chuanxiong extract twice per day for three consecutive days to prepare Rhizoma Chuanxiong extract-containing serum.The remaining rabbit was intragastrically perfused with the same volume of normal saline twice per day for three consecutive days.Rhizoma Chuanxiong extract was provided by Beijing Traditional Chinese Medicine Research Institute,predominantly composed of ligustrazine,ligustilide,and ferulic acid.ChemiKine^(TM) human VEGF Kit was purchased from Chemicon,USA;mouse anti-VEGF monoclonal antibody and biotin-goat anti-mouse IgG were purchased from Santa Cruz Biotechnology.Inc.,USA. METHODS:(1) In vitro experiment:in vitro cultured human umbilical vein endothelial cells were separately incubated in rabbit serum with 10%Rhizoma Chuanxiong extract,normal medium without rabbit serum,and rabbit serum without Rhizoma Chuanxiong extract(blank control).In addition,cells from the three groups were incubated under normoxia(5%CO_2,95%air) and hypoxia (1%O_2,5%CO_2,94%N_2),respectively,for 24 hours.(2) In vivo experiment:a total of 4/44 Sprague Dawley rats were selected for the sham-operated group(no occlusion),and the remaining rats were used to establish a cerebral ischemia/reperfusion model by suture occlusion.32 animals with ischemia/reperfusion injury were randomly divided into treatment and model groups,with 16 rats in each group.Both groups were intraperitoneally infused with 0.58 g/kg Rhizoma Chuanxiong extract and normal saline two hours following reperfusion.The sham-operated group was administrated normal saline.Animals were treated with saline or Chuanxiong extracts(0.58 g/kg) twice per day for three consecutive days. MAIN OUTCOME MEASURES:In vitro experiment:VEGF concentration was detected in each group by enzyme-linked immunosorbent assay.In vivo experiment:behavioral alterations of rats were evaluated by neurological function scale;infarct volume was assessed by hematoxylin-eosin staining;VEGF protein expression in the infarct regions was determined by immunohistochemistry. RESULTS:(1) VEGF levels were similar between the three groups under normoxic condition(P>0.05);while hypoxia induced VEGF production(P<0.01).VEGF levels in the drug-containing serum group were particularly higher compared with the other groups(P<0.01).(2) Compared with normal saline treatment,Rhizoma Chuanxiong extract significantly improved the neurological scale and reduced cerebral infarct volumes(P<0.05).The percent of VEGF-positive cells was significantly greater than the model group(P<0.05).The sham-operated group exhibited normal neurological function,with no infarct focus. CONCLUSION:Rhizoma Chuanxiong extract-containing rabbit serum effectively promoted in vitro cultured VEGF production under hypoxia.Rhizoma Chuanxiong extract upregulated VEGF expression in the infarct region,improved neurological function,and reduced infarct size. | Muke Zhou Mi Yang Ning Chen Yucai Wang Jian Guo Xue Yang Zhijian Zhang Dong Zhou Li He | 2009 | Neural Regeneration Research2009，4，5： | 0 |
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