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2篇 您的检索式:作者名="Muliang Ding"
    题名 作者 年代 出处 被引量
1Bioprinted constructs that simulate nerve-bone crosstalk to improve microenvironment for bone repair显示文摘Crosstalk between nerves and bone is essential for bone repair,for which Schwann cells(SCs)are crucial in the regulation of the microenvironment.Considering that exosomes are critical paracrine mediators for intercellular communication that exert important effects in tissue repair,the aim of this study is to confirm the function and molecular mechanisms of Schwann cell-derived exosomes(SC-exos)on bone regeneration and to propose engineered constructs that simulate SC-mediated nerve-bone crosstalk.SCs promoted the proliferation and differentiation of bone marrow mesenchymal stem cells(BMSCs)through exosomes.Subsequent molecular mechanism studies demonstrated that SC-exos promoted BMSC osteogenesis by regulating the TGF-βsignaling pathway via let-7c-5p.Interestingly,SC-exos promoted the migration and tube formation performance of endothelial progenitor cells.Furthermore,the SC-exos@G/S constructs were developed by bioprinting technology that simulated SC-mediated nerve-bone crosstalk and improved the bone regeneration microenvironment by releasing SC-exos,exerting the regulatory effect of SCs in the microenvironment to promote innervation,vascularization,and osteogenesis and thus effectively improving bone repair in a cranial defect model.This study demonstrates the important role and underlying mechanism of SCs in regulating bone regeneration through SC-exos and provides a new engineered strategy for bone repair.Tianchang Wang Wentao Li Yuxin Zhang Xiang Xu Lei Qiang Weiqiang Miao Xiaokun Yue Xin Jiao Xianhao Zhou Zhenjiang Ma Shuai Li Muliang Ding Junfeng Zhu Chi Yang Hui Wang Tao Li Xin Sun Jinwu Wang 2023Bioactive Materials2023,,9:1
2On the stability of two-step predictive controller based on state observer显示文摘For input saturated Hammerstein systems, the two-step predictive control strategy is adopted. The first step calculates the desired intermediate variable applying unconstrained linear model and predictive control. The second step obtains the real-time control action by solving algebraic equation and desaturation. The case of immeasurable state is considered where the observer gain matrix is solved by Sylvester equation. The sufficient closed-loop stability condition is given and the designing and tuning algorithm for the domain of attraction is proposed. The theoretical results are validated by an example.Cao Muliang Wu Zhiming Ding Baocang Wang Chuanxu 2006Journal of Systems Engineering and Electronics2006,17,1:0
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