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| 1 | Ten-year survival of hepatocellular carcinoma patients undergoing radiofrequency ablation as a first-line treatment显示文摘AIM: To investigate the long-term survival and prognostic factors in hepatocellular carcinoma(HCC) patients undergoing radiofrequency ablation(RFA) as a first-line treatment.METHODS: From 2000 to 2013, 316 consecutivepatients with 404 HCC(1.0-5.0 cm; mean: 3.2 ± 1.1 cm) underwent ultrasonography-guided percutaneous RFA as a first-line treatment. There were 250 males and 66 females with an average age of 60.1 ± 10.8 years(24-87 years). Patients were followed for 1 year to > 10 years after RFA(234, 181, 136, and 71 for 3, 5, 7, and 10 years, respectively). Overall local response rates and long-term survival rates were assessed. Survival results were generated using Kaplan-Meier estimates, and multivariate analysis was performed using the Cox regression model. RESULTS: In total, 548 RFA sessions were performed and major complications occurred in 10 sessions(1.8%). Local tumor progression and/or new tumor development were observed in 43.3%(132/305) of the patients during the follow-up period. Overall 5-and 10-year survival rates were 49.7% and 28.4%, respectively. Based on multivariate analysis, three factors were identified as independent prognostic factors for overall survival: Child-Pugh classification(HR = 4.054, P < 0.001), portal vein hypertension(HR = 2.743, P = 0.002), and tumor number(HR = 2.693, P = 0.003). The local progression-free 5- and 10-year survival rates were 42.7% and 19.5%. In addition to the Child-Pugh classification and the number of tumors, the number of RFA sessions(HR = 1.550, P = 0.002) was associated with local progression-free survival.CONCLUSION: RFA can achieve acceptable outcomes for HCC patients as a first-line treatment, especially for patients with Child-Pugh class A, patients with a single tumor and patients without portal vein hypertension. | Wei Yang Kun Yan S Nahum Goldberg Muneeb Ahmed Jung-Chieh Lee Wei Wu Zhong-Yi Zhang Song Wang Min-Hua Chen | 2016 | World Journal of Gastroenterology2016，22，10： | 20 |
| 2 | Silicon and silicon nitride photonic circuits for spectroscopic sensing on-a-chip [Invited]显示文摘There is a rapidly growing demand to use silicon and silicon nitride(Si3N4) integrated photonics for sensing applications, ranging from refractive index to spectroscopic sensing. By making use of advanced CMOS technology,complex miniaturized circuits can be easily realized on a large scale and at a low cost covering visible to mid-IR wavelengths. In this paper we present our recent work on the development of silicon and Si3N4-based photonic integrated circuits for various spectroscopic sensing applications. We report our findings on waveguide-based absorption, and Raman and surface enhanced Raman spectroscopy. Finally we report on-chip spectrometers and on-chip broadband light sources covering very near-IR to mid-IR wavelengths to realize fully integrated spectroscopic systems on a chip. | Ananth Z.Subramanian Eva Ryckeboer Ashim Dhakal Frédéric Peyskens Aditya Malik Bart Kuyken Haolan Zhao Shibnath Pathak Alfonso Ruocco Andreas De Groote Pieter Wuytens Daan Martens Francois Leo Weiqiang Xie Utsav Deepak Dave Muhammad Muneeb Pol Van Dorpe Joris Van Campenhout Wim Bogaerts Peter Bienstman Nicolas Le Thomas Dries Van Thourhout Zeger Hens Gunther Roelkens Roel Baets | 2015 | Photonics Research2015，3，5： | 7 |
| 3 | In vivo imaging of structural,metabolic and functional brain changes in glaucoma显示文摘Glaucoma, the world's leading cause of irreversible blindness, is a condition for which elevated intraocular pressure is currently the only modifiable risk factor. However, the disorder can continue to progress even at reduced intraocular pressure. This indicates additional key factors that contribute to the etiopathogenesis. There has been a growing amount of literature suggesting glaucoma as a neurodegenerative disease of the visual system. However, it remains debatable whether the observed pathophysiological conditions are causes or consequences. This review summarizes recent in vivo imaging studies that helped advance the understanding of early glaucoma involvements and disease progression in the brains of humans and experimental animal models. In particular, we focused on the non-invasive detection of early structural and functional brain changes before substantial clinical visual field loss in glaucoma patients; the eye-brain interactions across disease severity; the metabolic changes occurring in the brain's visual system in glaucoma; and, the widespread brain involvements beyond the visual pathway as well as the potential behavioral relevance. If the mechanisms of glaucomatous brain changes are reliably identified, novel neurotherapeutics that target parameters beyond intraocular pressure lowering can be the promise of the near future, which would lead to reduced prevalence of this irreversible but preventable disease. | Anisha Kasi Muneeb A.Faiq Kevin C.Chan | 2019 | Neural Regeneration Research2019，14，3： | 3 |
| 4 | Endoscopic retrograde cholangiopancreatography guided interventions in the management of pancreatic cancer显示文摘Pancreatic cancer is the leading cause of cancer-related morbidity and mortality with an overall five-year survival of less than 9%in the United States.At presentation,the majority of patients have painless jaundice,pruritis,and malaise,a triad that develops secondary to obstruction,which often occurs late in the course of the disease process.The technical advancements in radiological imaging and endoscopic interventions have played a crucial role in the diagnosis,staging,and management of patients with pancreatic cancer.Endoscopic retrograde cholangiopancreatography(ERCP)-guided diagnosis(with brush cytology,serial pancreatic juice aspiration cytologic examination technique,or biliary biopsy)and therapeutic interventions such as pancreatobiliary decompression,intraductal and relief of gastric outlet obstruction play a pivotal role in the management of advanced pancreatic cancer and are increasingly used due to improved morbidity and complication rates compared to surgical management.In this review,we highlight various ERCP-guided diagnostic and therapeutic interventions for the management of pancreatic cancer. | Muhammad Nadeem Yousaf Hamid Ehsan Ahsan Wahab Ahmad Muneeb Fizah S Chaudhary Richard Williams Christopher J Haas | 2020 | World Journal of Gastrointestinal Endoscopy2020，12，10： | 3 |
| 5 | Hagen-Poiseuille's law:The link between cirrhosis,liver stiffness,portal hypertension and hepatic decompensation显示文摘The onset of hepatic decompensation in cirrhosis heralds an accelerated downhill course with poor outcome. The sole predictor of this decompensationin cirrhosis is increased hepatic vein to portal vein gradient hepatic venous pressure gradient(HVPG). Surrogate markers of liver function or hepatic reserve appear to be less relevant. The hepatic sinusoids become less elastic and more rigid as liver fibrosis and cirrhosis progress. We propose that the HagenPoiseuille's law,which applies to rigid,but not elastic vessels,determines the pressure-flow characteristics in the sinusoids. In the rigid cirrhotic liver,HVPG rises dramatically with any change in net surface area or radius,r4 of the vasculature that follows surgical resection. This review relates liver stiffness to the risk of decompensation in patients with cirrhosis. The liver has a unique dual blood supply comprising a low pressure portal vein and high pressure hepatic artery. We compare the complexity of autoregulation in the normal elastic liver with that in the rigid cirrhotic liver. Therapeutic modalities to reduce portal pressure may reduce the risk of hepatic decompensation and improve outcomes in cirrhosis. | Gerond Lake-Bakaar Muneeb Ahmed Amy Evenson Alan Bonder Salomao Faintuch Vinay Sundaram | 2015 | World Journal of Hepatology2015，7，1： | 2 |
| 6 | Utility of liver biopsy in predicting clinical outcomes after percutaneous angioplasty for hepatic venous obstruction in liver transplant patients显示文摘AIM: To determine utility of transplant liver biopsy in evaluating efficacy of percutaneous transluminal angioplasty(PTA) for hepatic venous obstruction(HVOO). METHODS: Adult liver transplant patients treated with PTA for HVOO(2003-2013) at a single institution were reviewed for pre/post-PTA imaging findings, manometry(gradient with right atrium), presence of HVOO on prePTA and post-PTA early and late biopsy(EB and LB, < or > 60 d after PTA), and clinical outcome, defined as good(no clinical issues, non-HVOO-related death) or poor(surgical correction, recurrent HVOO, or HVOOrelated death). RESULTS: Fifteen patients meeting inclusion criteria underwent 21 PTA, 658 ± 1293 d after transplant.In procedures with pre-PTA biopsy(n = 19), no difference was seen between pre-PTA gradient in 13/19 procedures with HVOO on biopsy and 6/19 procedures without HVOO(8 ± 2.4 mm Hg vs 6.8 ± 4.3 mm Hg; P = 0.35). Post-PTA, 10/21 livers had EB(29 ± 21 d) and 9/21 livers had LB(153 ± 81 d). On clinical follow-up(392 ± 773 d), HVOO on LB resulted in poor outcomes and absence of HVOO on LB resulted good outcomes. Patients with HVOO on EB(3/7 good, 4/7 poor) and no HVOO on EB(2/3 good, 1/3 poor) had mixed outcomes. CONCLUSION: Negative liver biopsy greater than 60 d after PTA accurately identifies patients with good clinical outcomes. | Ammar Sarwar Edward Ahn Ian Brennan Olga R Brook Salomao Faintuch Raza Malik Khalid Khwaja Muneeb Ahmed | 2015 | World Journal of Hepatology2015，7，14： | 2 |
| 7 | Glymphatic imaging and modulation of the optic nerve显示文摘Optic nerve health is essential for proper function of the visual system.However,the pathophysiology of certain neurodegenerative disease processes affecting the optic nerve,such as glaucoma,is not fully understood.Recently,it was hypothesized that a lack of proper clearance of neurotoxins contributes to neurodegenerative diseases.The ability to clear metabolic waste is essential for tissue homeostasis in mammals,including humans.While the brain lacks the traditional lymphatic drainage system identified in other anatomical regions,there is growing evidence of a glymphatic system in the central nervous system,which structurally includes the optic nerve.Named to acknowledge the supportive role of astroglial cells,this perivascular fluid drainage system is essential to remove toxic metabolites from the central nervous system.Herein,we review existing literature describing the physiology and dysfunction of the glymphatic system specifically as it relates to the optic nerve.We summarize key imaging studies demonstrating the existence of a glymphatic system in the optic nerves of wild-type rodents,aquaporin 4-null rodents,and humans;glymphatic imaging studies in diseases where the optic nerve is impaired;and current evidence regarding pharmacological and lifestyle interventions that may help promote glymphatic function to improve optic nerve health.We conclude by highlighting future research directions that could be applied to improve imaging detection and guide therapeutic interventions for diseases affecting the optic nerve. | Anisha Kasi Crystal Liu Muneeb A.Faiq Kevin C.Chan | 2022 | Neural Regeneration Research2022，17，5： | 1 |
| 8 | Chrysin protects against cisplatin-induced colon. toxicity via amelioration of oxidative stress and apoptosis: Probable role of p38MAPK and p53显示文摘 | Rehan Khan Abdul Quaiyoom Khan Wajhul Qamar Abdul Lateef Mir Tahir Muneeb U Rehman Farrah Ali Sarwat Sultana | 2011 | Toxicology and Applied Pharmacology2011，，： | 1 |
| 9 | Principles of and advances in percutaneous ablation 显示文摘 | Muneeb A Christopher L B Fred T L etal | 2011 | Radiology2011，258，2： | 1 |
| 10 | Basic Science Research in Thermal Ablation显示文摘 | Muneeb Ahmed S. Nahum Goldberg | 2011 | Surgical Oncology Clinics of North America2011，，2： | 1 |
| 11 | Principles of and advances in percutaneous ablation 显示文摘 | Muneeb A Christopher L B FRED T L | 2011 | Radiology2011，258，2： | 1 |
| 12 | Silicon-on-insulator spe ctrometers with integrated GaInAsSb photodiodes for wide-band spectroscopy from 1510to 2300nm 显示文摘 | Ryckeboer E Gassenq A Muneeb M | 2013 | Optics Express2013，21，5： | 1 |
| 13 | Improved coagulation with saline solution pretreatment during radiofrequency tumor ablation in a canine model显示文摘 | Muneeb AS Meivyn L Joseph W | 2002 | JVIR2002，13，： | 1 |
| 14 | Mi- crophthalmia, persistent hyperplastic hyaloid vascula ture and lens anomalies following over expression of VEGF-A188 from the aA-crystallin promoter显示文摘 | Catrin SR Christopher AM Muneeb N | 2007 | Mol Vis2007，19，： | 1 |
| 15 | Dynamic Hand Gesture Recognition Using 3D-CNN and LSTM Networks显示文摘Recognition of dynamic hand gestures in real-time is a difficult task because the system can never know when or from where the gesture starts and ends in a video stream.Many researchers have been working on visionbased gesture recognition due to its various applications.This paper proposes a deep learning architecture based on the combination of a 3D Convolutional Neural Network(3D-CNN)and a Long Short-Term Memory(LSTM)network.The proposed architecture extracts spatial-temporal information from video sequences input while avoiding extensive computation.The 3D-CNN is used for the extraction of spectral and spatial features which are then given to the LSTM network through which classification is carried out.The proposed model is a light-weight architecture with only 3.7 million training parameters.The model has been evaluated on 15 classes from the 20BN-jester dataset available publicly.The model was trained on 2000 video-clips per class which were separated into 80%training and 20%validation sets.An accuracy of 99%and 97%was achieved on training and testing data,respectively.We further show that the combination of 3D-CNN with LSTM gives superior results as compared to MobileNetv2+LSTM. | Muneeb Ur Rehman Fawad Ahmed Muhammad Attique Khan Usman Tariq Faisal Abdulaziz Alfouzan Nouf M.Alzahrani Jawad Ahmad | 2022 | Computers, Materials & Continua2022，，3： | 0 |
| 16 | Home Automation-Based Health Assessment Along Gesture Recognition via Inertial Sensors显示文摘Hand gesture recognition (HGR) is used in a numerous applications,including medical health-care, industrial purpose and sports detection.We have developed a real-time hand gesture recognition system using inertialsensors for the smart home application. Developing such a model facilitatesthe medical health field (elders or disabled ones). Home automation has alsobeen proven to be a tremendous benefit for the elderly and disabled. Residentsare admitted to smart homes for comfort, luxury, improved quality of life,and protection against intrusion and burglars. This paper proposes a novelsystem that uses principal component analysis, linear discrimination analysisfeature extraction, and random forest as a classifier to improveHGRaccuracy.We have achieved an accuracy of 94% over the publicly benchmarked HGRdataset. The proposed system can be used to detect hand gestures in thehealthcare industry as well as in the industrial and educational sectors. | Hammad Rustam Muhammad Muneeb Suliman A.Alsuhibany Yazeed Yasin Ghadi Tamara Al Shloul Ahmad Jalal Jeongmin Park | 2023 | Computers, Materials & Continua2023，，4： | 0 |
| 17 | Ocular manifestations of central insulin resistance显示文摘Central insulin resistance, the diminished cellular sensitivity to insulin in the brain, has been implicated in diabetes mellitus, Alzheimer’s disease and other neurological disorders. However, whether and how central insulin resistance plays a role in the eye remains unclear. Here, we performed intracerebroventricular injection of S961, a potent and specific blocker of insulin receptor in adult Wistar rats to test if central insulin resistance leads to pathological changes in ocular structures. 80 mg of S961 was stereotaxically injected into the lateral ventricle of the experimental group twice at 7 days apart, whereas buffer solution was injected to the sham control group. Blood samples, intraocular pressure, trabecular meshwork morphology, ciliary body markers, retinal and optic nerve integrity, and whole genome expression patterns were then evaluated. While neither blood glucose nor serum insulin level was significantly altered in the experimental or control group, we found that injection of S961 but not buffer solution significantly increased intraocular pressure at 14 and 24 days after first injection, along with reduced porosity and aquaporin 4 expression in the trabecular meshwork, and increased tumor necrosis factor α and aquaporin 4 expression in the ciliary body. In the retina, cell density and insulin receptor expression decreased in the retinal ganglion cell layer upon S961 injection. Fundus photography revealed peripapillary atrophy with vascular dysregulation in the experimental group. These retinal changes were accompanied by upregulation of pro-inflammatory and pro-apoptotic genes, downregulation of anti-inflammatory, anti-apoptotic, and neurotrophic genes, as well as dysregulation of genes involved in insulin signaling. Optic nerve histology indicated microglial activation and changes in the expression of glial fibrillary acidic protein, tumor necrosis factor α, and aquaporin 4. Molecular pathway architecture of the retina revealed the three most significant pathways involved being inflammation/cell stress, insulin signaling, and extracellular matrix regulation relevant to neurodegeneration. There was also a multimodal crosstalk between insulin signaling derangement and inflammation-related genes. Taken together, our results indicate that blocking insulin receptor signaling in the central nervous system can lead to trabecular meshwork and ciliary body dysfunction, intraocular pressure elevation, as well as inflammation, glial activation, and apoptosis in the retina and optic nerve. Given that central insulin resistance my lead to neurodegenerative phenotype in the visual system, targeting insulin signaling may hold promise for vision disorders involving the retina and optic nerve. | Muneeb A.Faiq Trina Sengupta Madhu Nath Thirumurthy Velpandian Daman Saluja Rima Dada Tanuj Dada Kevin C.Chan | 2023 | Neural Regeneration Research2023，18，5： | 0 |
| 18 | Significantly enhanced flashover voltage of epoxy in vacuum by graded surface roughness modification显示文摘The flashover strength of epoxy(EP)insulations in the High voltage direct current applications of future energy grids can be improved by tailoring their surface condition.This work aims to improve the DC surface flashover characteristics of EP after being treated with sandpaper of different gradings.Samples with virgin EP and homogenously modified EP considering varying surface roughness(R_(a)=0.54,3.16,5.24,and 8.35μm)are prepared.Different experimental characterisations,such as water contact angle,surface intrinsic conductivity,surface voltages,flashover strength,and trap distributions are conducted and evaluated to analyse the difference between virgin and treated EP.Moreover,based on the obtained experimental results of homogenously treated EP and theoretical analysis,the concept of surface functionally graded materials(SFGMs)is put forward.The flashover voltages of homogenously treated EP are augmented significantly compared to virgin EP regardless of the voltage polarity and enhanced by enhancing the surface roughness.The sample T_(Model‐C) with SFGM design shows a 45.02%and 43.75%improvement in the negative and positive flashover voltages than that of the virgin EP.In the end,COMSOL simulations are conducted to justify the experimental findings and to analyse the difference between virgin and modified samples in terms of electric field distribution. | Inzamam Ul Haq Feipeng Wang Shakeel Akram Muneeb Ahmed Muhammad Tariq Nazir | 2023 | High Voltage2023，8，5： | 0 |
| 19 | Portal vein thrombosis following percutaneous transhepatic cholangiography-An unusual presentation of Prothrombin (Factor Ⅱ) gene mutation显示文摘Portal vein thrombosis is an uncommonly reported complication of percutaneous transhepatic cholangiography (PTC). A thorough review of the available literature shows no reported cases. In this case, a 29 year old female presented on two separate occasions with portal vein thrombosis following PTC without drain placement. This unusual complication of image guided percutaneous biliary access is unreported in the literature and prompted evaluation of the patient's coagulation parameters. A thrombophilia screen demonstrated a mutation in the Prothrombin (Factor Ⅱ) gene. A thorough literature review shows no reported cases of portal vein thrombosis following percutaneous biliary access, is an unusual complication, and should raise suspicion of an underlying pro-coagulant state. | Ian M Brennan Muneeb Ahmed | 2012 | World Journal of Radiology2012，4，5： | 0 |
| 20 | Ergonomics of gastrointestinal endoscopies:Musculoskeletal injury among endoscopy physicians,nurses,and technicians显示文摘BACKGROUND Musculoskeletal injuries(MSI)have plagued endoscopists and ancillary staff for decades without any innovative and strong ergonomic guidelines.It has placed a physical and mental strain on our endoscopists and ancillary staff.We have very have limited data supporting this claim in our region and most data is supported by western literature.AIM To document the prevalence of MSI,and awareness and practices of ergonomics by endoscopists and ancillary staff.METHODS This is an observational cross-sectional study,conducted in Karachi,a city that boasts the maximum number of daily endoscopies in the country.An eleven-point self-administered questionnaire was distributed and used to evaluate MSI and ergonomic adjustments amongst three tertiary care setups in Karachi.An onsite survey via a 13-point checklist for endoscopy suite facilities was used to assess the ergonomically friendly conveniences at five tertiary care setups in Karachi.A total of 56 participants replied with a filled survey.RESULTS There were 56 participants in total with 39(69.6%)males.Pain and numbness were documented by 75%of the patients,with pain in the neck(41.1%),lower back(32.1%),shoulder(21.4%),thumb(12.5%),hand(23.2%),elbow(8.9%),and carpal tunnel syndrome(CTS)(7.1%).Of those,33.3%attributed their symptoms to endoscopy, 14.2% said that symptoms were not caused by endoscopy, and 52.4% were notcertain whether endoscopy had caused their symptoms. Twenty-one point four percent of patientshad to take time off their work, while 33.9% took medications for pain. Ergonomic modifications toprevent musculoskeletal injury, including placement of endoscopic monitor at eye level and thecardiac monitor in front, stopping the procedure to move patients, sitting while performingcolonoscopy, and navigating height-adjustable bed were used by 21.4%. Nine out of 13 ergonomicfacilities were not present in all five tertiary care hospitals. Conveniences, such as anti-fatiguemats, height-adjustable computer stations, and time out between patients were not present.CONCLUSIONThree-fourth of our endoscopists reported MSI, of which more than half were not sure orattributed this problem to endoscopy. The prevalence of MSI warrants urgent attention. | Samana Zainab Shah Syed Tabish Rehman Aysha Khan Muhammad Muneeb Hussain Mohsin Ali Sonaila Sarwar Shahab Abid | 2022 | World Journal of Gastrointestinal Endoscopy2022，14，3： | 0 |
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