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| 1 | Relationship between the exocrine and endocrine pancreas after acute pancreatitis显示文摘AIM:To determine the prevalence and time course of pancreatic exocrine insufficiency in individuals with newly diagnosed prediabetes or diabetes mellitus after acute pancreatitis.METHODS:Relevant literature cited in three major biomedical journal databases(EMBASE,MEDLINE,and Scopus)was reviewed independently by two authors.There were no language constraints but the search was limited to human studies.Studies included were cohort studies of adult patients who were discharged after an attack of acute pancreatitis.Patients were excluded if they were under 18 years of age or had a previous diagnosis of prediabetes or diabetes mellitus,pancreatic exocrine insufficiency,or chronic pancreatitis.The main outcome measure was the prevalence of concomitant pancreatic exocrine insufficiency in patients who were diagnosed with prediabetes and diabetes mellitus after an attack of acute pancreatitis.Subgroup analysis was conducted for patients who were diagnosed with prediabetes only and those who were diagnosed withdiabetes mellitus only.Subgroup analysis looking at the time course of concomitant pancreatic exocrine and endocrine insufficiency was also conducted.Pooled prevalence and corresponding 95%confidence intervals were calculated for all outcome measures and P-values<0.05 were deemed statistically significant.RESULTS:Eight clinical studies comprising of 234patients met all eligibility criteria.The pooled prevalence of newly diagnosed prediabetes or diabetes in individuals after acute pancreatitis was 43%(95%CI:30%-56%).The pooled prevalence of pancreatic exocrine insufficiency in individuals after acute pancreatitis was 29%(95%CI:19%-39%).The prevalence of concomitant pancreatic exocrine insufficiency in individuals with newly diagnosed prediabetes or diabetes was 40%(95%CI:25%-55%).The prevalence of concomitant pancreatic exocrine insufficiency among individuals with prediabetes alone and diabetes mellitus alone was 41%(95%CI:12%-75%)and 39%(95%CI:28%-51%),respectively.Further analysis showed that the prevalence of concomitant pancreatic exocrine insufficiency in individuals with prediabetes or diabetes decreases over time after an attack of acute pancreatitis.CONCLUSION:Pancreatic exocrine insufficiency occurs in 40%of individuals with newly diagnosed prediabetes or diabetes mellitus after acute pancreatitis.Further studies are needed to investigate the pathogenesis of diabetes in this setting. | Stephanie L M Das James I C Kennedy Rinki Murphy Anthony R J Phillips John A Windsor Maxim S Petrov | 2014 | World Journal of Gastroenterology2014，20，45： | 9 |
| 2 | 系统性药物治疗儿童银屑病的安全性显示文摘银屑病是一种常见的慢性炎症性皮肤病。成年人的发病率为2%~3%,其中大约有三分之一的患者在18岁之前发病。在儿童期,该病的发病率呈线性增长。从1970年至2000年,儿童银屑病的发病率增加了一倍多。尽管对许多轻度银屑病患儿而言,局部治疗已足够,但对更多可能影响生活质量的重度或顽固性的银屑病患儿,则往往需要系统性治疗。 | bronckers imgj seyger mmb west dp lara-corrales i tollefson m tom wl hogeling m belazarian l zachariae c mahé e siegfried e philipp s szalai z vleugels ra holland k murphy r baselga e cordoro k lambert j alexopoulos a mrowietz u kievit w paller as 邓婕(编译) 张锡宝(审校) 无 | 2017 | 皮肤性病诊疗学杂志2017，24，5： | 3 |
| 3 | Combination therapy with Abciximab reduces angiographically evident thrombus in acute myocardial infarction: A TIMI 14 substudy显示文摘 | Gibson C M de Lemos J A Murphy S A | 2001 | Circulation2001，103，21： | 1 |
| 4 | Suppression subtractive hybridization identifies high glucose levels as a stimulus for expression of connective tissue growth factor and other genes in human mesangial cells显示文摘 | Murphy M Godson C Cannon S | 1999 | J Biol Chem1999，274，9： | 1 |
| 5 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 6 | Combination therapy with abciximab reduces an giographieally evident thrombus in acute myocardial infarc tion: aTIMI 14 substudy显示文摘 | GIBSON C M DE LEMOS J A MURPHY S A | 2001 | Circulation2001，103，21： | 1 |
| 7 | BAG-1 expression correlates with Bcl 2,p53,differentiation,estrogen and progesterone receptors in invasive breast carcinoma显示文摘 | Tang S C Beck J Murphy S | 2004 | Breast Cancer Res Treat2004，84，3： | 1 |
| 8 | A comparison of urinary biomarkers of tobacco and carcinogen exposure in smokers 显示文摘 | MURPHY S E LINK C A JENSEN J | 2004 | Cancer Epidemiol Biomarkers Prey2004，13，10： | 1 |
| 9 | Expression cloning of the STRL33/BONZO/TYMSTR ligand reveals elements of CC ,CXC,and CX3C chemokines显示文摘 | Zondlo S C Murphy K | 2001 | J Immunol2001，166，： | 1 |
| 10 | Impact of triglyceride levels beyond low-density lipoprotein cholesterol after acute coronary syndrome in the PROVE IT-TIMI 22 trial 显示文摘 | Miller M Cannon C P Murphy S A | 2008 | J Am Coil Cardiol2008，51，7： | 1 |
| 11 | Characterization of regulatory events associated with membrane targeting of p90 ribosoreal S6 kinase 1显示文摘 | Richards S A Dreisbach V C Murphy L O | 2001 | Mol Cell Biol2001，21，21： | 1 |
| 12 | Field test results of standoff chemical detection using the FTIRS 显示文摘 | Spisz T S Murphy P K Carter C C | 2007 | Chemical and Biological Sensing VIII2007，6554，： | 1 |
| 13 | Tracking Spore-Forming Bacterial Contaminants in Fluid Milk-Processing Sys- tems 显示文摘 | HUCK J R HAMMOND B H MURPHY S C | 2007 | Journal of Dairy Science2007，90，： | 1 |
| 14 | The effect of low concentrations versus high concentrations of local anesthetics for labour analgesia on obstetric and anesthetic outcomes:a metaanalysis显示文摘 | Sultan P Murphy C Halpern S | 2013 | Can J Anaesth2013，60，9： | 1 |
| 15 | Monoener- getic beams of relativistic electrons from intense laser-plasma interac- tions显示文摘 | MANGLES S P D MURPHY C D NAJMUDIN Z | 2004 | Nature2004，431，7008： | 1 |
| 16 | Influence of mineral-bound humic substances on the sorption of hydrophobic organic compounds显示文摘 | Murphy E M Zachara J M Smith S C | 1990 | Environmental Science & Technology1990，24，10： | 1 |
| 17 | Modeling conifer tree crown radius and estimating canopy cover显示文摘 | GILL S J BIGING G S MURPHY A C | 2000 | For Ecol Manage2000，126，3： | 1 |
| 18 | Weed science beyond the weeds: the role of integrated weed management (IWM) in a- gro ecosystem health显示文摘 | SWANTON C J MURPHY S D | 1996 | Weed Science1996，44，： | 1 |
| 19 | Mate pair se- quencing of whole- genome- amplified DNA following laser capture microdissection of prostate cancer 显示文摘 | MURPHY S J CHEVILLE J C ZAREI S | 2012 | DNA Res2012，19，5： | 1 |
| 20 | The cellular basis of GABAB-mediated interhemispheric inhibition 显示文摘 | Palmer L M Schulz J M Murphy S C | 2012 | Science2012，335，6071： | 1 |
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