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| 1 | Functional roles and clinical values of insulin-like growth factor-binding protein-5 in different types of cancers显示文摘Insulin-like growth factor-bindin g proteins (IGFBPs) are critical regulators of the mitogenic activity of insulin-like growth factors (IGFs). IGFBP5, one of these IGFBPs, has special structural features, including a nuclear transport domain, heparin-binding motif, and IGF/extracellular matrix/acid-labile subunit-binding sites. Furthermore, IGFBP5 has several functional effects on carcinogenesis and even normal cell processes, such as cell growth, death, motility, and tissue remodeling. These biological effects are sometimes related with IGF (IGF-dependent effects) and sometimes not (IGF-independent effects). The functional role of IGFBP5 is most likely determined in a cell-type and tissue-type specific manner but also depends on cell context, especially in terms of the diversity of interacting proteins and the potential for nuclear localization. Clinical findings show that IGFBP5 has the potential to be a useful clinical biomarker for predicting response to therapy and clinical outcome of cancer patients. In this review, we summarize the functional diversity and clinical importance of IGFBP5 in different types of cancers. | Gökçe Güllü Sevgi Karabulut Mustafa Akkiprik | 2012 | Chinese Journal of Cancer2012，31，6： | 8 |
| 2 | Prognostic role of sensitive-to-apoptosis gene expression in rectal cancer显示文摘AIM:To investigate the association between prognosis of rectal cancer treated with chemoradiotherapy(CRT) and expression of sensitive-to-apoptosis(SAG),B-cell lymphoma-extra large(Bcl-X L) and Bcl-2 homologous antagonist/killer(Bak).METHODS:Real-time quantitative polymerase chain reaction was used to determine the expression of proteins of interest,namely SAG,Bcl-X L,Bak and β-actin,in rectal carcinoma patients who had a follow-up period of 3 years after CRT.Biopsy specimens were excised from the rectal tumor preceding CRT.RESULTS:SAG,Bcl-X L and Bak proteins showed significant correlations with each other.In multivariate analysis,patients with high vs low SAG expression showed a statistically significant difference in 2-year survival rates:56% vs 73%,respectively(P = 0.056).On the other hand,there were no significant correlations between the expression levels of all three genes and metastatic rates or tumor responses to CRT.Mean overall survival in the patients with elevated SAG expression was 27.1 mo ± 3.9 mo [95% confidence interval(CI):19.3-34.9],and in patients with reduced expression,it was 32.1 mo ± 2.5 mo(95% CI:27.3-36.9).The corresponding values for Bcl-X L were 28.0 mo ± 4.1 mo(95% CI:19.9-36.1) and 31.7 mo ± 2.9 mo(95% CI:26.0-37.5),and those for Bak were 29.8 mo ± 3.7 mo(95% CI:22.5-37.2) and 30.6 mo ± 2.4 mo(95% CI:25.5-35.0),respectively.CONCLUSION:Two-year survival rates significantly correlated with low SAG expression,and SAG may be a candidate gene for good prognosis,independent of therapeutic response of different individuals. | Sevgi A Ozden Hazan Ozyurt Zerrin Ozgen Olca Kilinc Mustafa Oncel Aylin E Gul Nimet Karadayi Nedime Serakinci Beki Kan Oya Orun | 2011 | World Journal of Gastroenterology2011，17，44： | 6 |
| 3 | Cementomimetics——constructing a cementum-like biomineralized microlayer via amelogenin-derived peptides显示文摘Cementum is the outer-,mineralized-tissue covering the tooth root and an essential part of the system of periodontal tissue that anchors the tooth to the bone. Periodontal disease results from the destructive behavior of the host elicited by an infectious biofilm adhering to the tooth root and left untreated,may lead to tooth loss. We describe a novel protocol for identifying peptide sequences from native proteins with the potential to repair damaged dental tissues by controlling hydroxyapatite biomineralization. Using amelogenin as a case study and a bioinformatics scoring matrix,we identified regions within amelogenin that are shared with a set of hydroxyapatite-binding peptides (HABPs) previously selected by phage display. One 22-amino acid long peptide regions referred to as amelogenin-derived peptide 5 (ADP5) was shown to facilitate cell-free formation of a cementum-like hydroxyapatite mineral layer on demineralized human root dentin that,in turn,supported attachment of periodontal ligament cells in vitro. Our findings have several implications in peptide-assisted mineral formation that mimic biomineralization. By further elaborating the mechanism for protein control over the biomineral formed,we afford new insights into the evolution of protein-mineral interactions. By exploiting small peptide domains of native proteins,our understanding of structure-function relationships of biomineralizing proteins can be extended and these peptides can be utilized to engineer mineral formation. Finally,the cementomimetic layer formed by ADP5 has the potential clinical application to repair diseased root surfaces so as to promote the regeneration of periodontal tissues and thereby reduce the morbidity associated with tooth loss. | Mustafa Gungormus Ersin E Oren Jeremy A Horst Hanson Fong Marketa Hnilova Martha J Somerman Malcolm L Snead Ram Samudrala Candan Tamerler Mehmet Sarikaya | 2012 | International Journal of Oral Science2012，4，2： | 5 |
| 4 | Patients with Inflammatory Bowel Disease Have a Lower Response Rate to HBV Vaccination Compared to Controls显示文摘 | Mustafa Erhan Altun?z Ebubekir ?enate? Atakan Ye?il Turan ?alhan Ay?e Oya Kurda? ?vün? | 2012 | Digestive Diseases and Sciences2012，，4： | 3 |
| 5 | In vitro effect of pantoprazole on lower esophageal sphincter tone in rats显示文摘AIM:To investigate the in vitro effects of pantoprazole on rat lower esophageal sphincter(LES)tone.METHODS:Rats weighing 250-300 g,provided by the Yeditepe University Experimental Research Center(Yü-DETAM),were used throughout the study.They were anesthetized before decapitation.LES tissues whose mucosal lining were removed were placed in a stan-dard 30-mL organ bath with a modif ied Krebs solution and continuously aerated with 95% oxygen-5% carbon dioxide gas mixture and kept at room temperature.The tissues were allowed to stabilize for 60 min.Sub-sequently,the contractile response to 10-6 mol/L carba-chol was obtained.Different concentrations of freshly prepared pantoprazole were added directly to the tis-sue bath to generate cumulative concentrations of 5×10-6 mol/L,5×10-5 mol/L,and 1.5×10-4 mol/L.Activi-ties were recorded on an online computer via a 4-channeltransducer data acquisition system using the software BSL PRO v 3.7,which also analyzed the data.RESULTS:Pantoprazole at 5×10-6 mol/L caused a small,but statistically insignif icant,relaxation in the car-bachol-contracted LES(2.23% vs 3.95%).The 5×10-5 mol/L concentration,however,caused a signif icant relax-ation of 10.47% compared with the control.1.5×10-4 mol/L concentration of pantoprazol caused a 19.89% relaxation in the carbachol contracted LES(P<0.001).CONCLUSION:This is the fi rst study to demonstrate that pantoprazole has a relaxing effect in isolated LESs.These results might have signif icant clinical implications for the subset of patients using proton pump inhibitors who do not receive full symptomatic alleviation from gastroesophageal reflux disease. | Mustafa Duman Mahmut zer Enver Rean Yeliz Demirci Ali E Atιcι Tahsin Dalgι Erdal B Bostancι Ece Gen | 2011 | World Journal of Gastroenterology2011，17，46： | 3 |
| 6 | A case study report of acute renal failure associated with Nigella sativa in a diabetic patient显示文摘1 Introduction Nigella sativa, known as black seed, has analgesic, anti-inflammatory, antioxidant and anticancer effects [1-3] . It has been shown to reduce the development of kidney failure when given prior to the use of nephrotoxic drugs particularly due to its antioxidant action [4-7] . However, as far as the authors could ascertain, there is no human study in literature showing these effects. Here we present a case of acute renal failure after the use of N. sativa, | Erol Arslan Selim Sayin Seref Demirbas Mustafa akar Nazire Gke Somak Sirzat Yesilkaya Kenan Saglam | 2013 | Journal of Integrative Medicine2013，11，1： | 2 |
| 7 | Performance and exhaust emissions of biodiesel engine 显示文摘 | MUSTAFA C AHMET E EROL A | 2006 | Applied Energy2006，，83： | 1 |
| 8 | Lipid vesicles for skin delivery of drugs : Reviewing three decades of re- search 显示文摘 | MUSTAFA M A E OSSAMA Y A V1VIANE F N | 2007 | Int JPharm2007，332，12： | 1 |
| 9 | Effects of feeding forage soybean silage on milk production, nutrient digestion, and ruminal fermentation of lactating dairy cows显示文摘 | Vargas Bello-Perez E Mustafa AF Seguin P | 2008 | J Dairy Sci2008，91，1： | 1 |
| 10 | Harvest date influences superficial scald development in Granny Smith apples during long term storage显示文摘 | Mustafa E Mustafa P | 2004 | Turk J Agric For2004，，28： | 1 |
| 11 | Effectiveness of in- tratympanic dexamethasone in otitis media with effusion re- sistant to conventional therapy显示文摘 | Mustafa P Gokhan A Mehmet E | 2013 | Indian J Otolaryngol Head Neck Surg2013，65，3： | 1 |
| 12 | Synthesis of di-substituted calyx arene-based receptors for extraction of chromate and arsenate anions 显示文摘 | Mevltit B Seref E Mustafa Y | 2009 | Tetrahedron2009，65，38： | 1 |
| 13 | Antioxidant therapies fortraumatic brain injury显示文摘 | Hall E D Vaishnav R A Mustafa A G | 2010 | Neurotherapeutics2010，7，1： | 1 |
| 14 | Frost Resistance and Microstructure of Engineered Cementitious Composites: Influence of Fly Ash and Micro Poly-Vinyl-Alcohol Fiber 显示文摘 | Sahmaran Mustafa Ozbay Erdogan Yucel Hasan E | 2012 | Cement & Concrete Composites2012，34，2： | 1 |
| 15 | Extraction of carcinogenic aromatic amines from aqueous solution using calixarene derivatives as carrier 显示文摘 | Serkan E Mtifit B Mustafa Yz | 2009 | Journal of Hazardous Materials2009，168，23： | 1 |
| 16 | Serum biochemical profile of broiler chickens fed diets containing rosemary and rosemary volatile oil显示文摘 | Umit P Derya Y Mustafa E | | 0，，： | 1 |
| 17 | The production of fatty acid isopropyl esters and their use as a diesel engine fuel显示文摘 | Wang Paul S Tat Mustafa E Van Gerpen Jon | 2005 | Journal of the American Oil Chemists'' Society2005，82，11： | 1 |
| 18 | Polymor- phism in BPM-15 gene and its association with litter size in Anglo-Nubian goat显示文摘 | Abdel-Rahman S M Mustafa Y A Abd E | 2013 | Biotechnology in Animal Husbandry2013，29，： | 1 |
| 19 | Recombinant human erythropoietin administration in cardiac surgery显示文摘 | LEVENT Y SADIK E MUSTAFA S | 2001 | J Thorac Cardiovasc Surg2001，122，： | 1 |
| 20 | Data Aggregation in Wireless Sensor Networks-Exact and Approximate Algorithms显示文摘 | Jamal N Karaki Raza Mustafa Ahmed E Kamal | 2004 | IEEE2004，，： | 1 |
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