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| 1 | Expression of COX-2, PCNA, Ki-67 and p53 in gastrointestinal stromal tumors and its relationship with histopathological parameters显示文摘AIM: To investigate the expression of Cyclooxygenase-2 (COX-2), proliferating cell nuclear antigen (PCNA), Ki-67 and p53 in gastrointestinal stromal tumors (GISTs) and its relationship with histopathological parameters. METHODS: Twenty-five GISTs were examined by light microscopy and immunohistochemistry. c-kit, CD34, SMA, S-100 protein, COX-2, PCNA, Ki-67 and p53 were detected immunohistochemically and the relationship was evaluated among histopathologic parameters such as mitotic index (MI), tumor grade, tumor size, COX-2, PCNA, Ki-67 and p53. RESULTS: COX-2 protein expression was found in 19 of 25 (76%) of the tumors, and expression was noted in the cytoplasm of the tumor cells. p53 was significantly related to MI and tumor grade but no relationship was found between COX-2, proliferation markers and MI, tumor grade and tumor size. CONCLUSION: COX-2 is expressed in most GISTs and it may play an important role in the proliferation and progression of these tumors or a useful marker to identify GIST. Although immunohistochemical assessment of p53 can be used for distinguishing the risk groups of GISTs, tumor size and mitotic rate should be considered at the same time. | Derya Gumurdulu Seyda Erdogan Fazilet Kayaselcuk Gulsah Seydaoglu Cem K Parsak Orhan Demircan Ilhan Tuncer | 2007 | World Journal of Gastroenterology2007，13，3： | 21 |
| 2 | Pulmonary involvement in inflammatory bowel disease显示文摘AIM:To determine the relationship of pulmonary abnormalities and bowel disease activity in inflammatory bowel disease(IBD).METHODS:Thirty ulcerative colitis(UC)and nine Crohn's disease patients,and 20 control subjects were enrolled in this prospective study.Detailed clinical information was obtained.Extent and activity of the bowel disease were established endoscopically.Each patient underwent pulmonary function tests and high-resolution computed tomography(HRCT).Blood samples for measurement of C-reactive protein(CRP),erythrocyte sedimentation rate(ESR),angiotensin converting enzyme and total IgE were delivered by the patients.RESULTS:Ten(25.6%)patients had respiratory symptoms.A pulmonary function abnormality was present in 22 of 39 patients.Among all patients,the most prevalent abnormalities in lung functions were a decrease in forced expiratory volume in 1 s(FEV1),FEV1/forced vital capacity(FVC),forced expiratory flow(FEF)25%-75%,transfer coefficient for carbon monoxide(DLCO),DLCO/alveolar volume.Increased respiratory symptoms score was associated with high endoscopic activity index in UC patients.Endoscopic and clinical activities in UC patients were correlated with FEV1,FEV1/FVC,and FEF 25%-75%.Smoking status,duration of disease and medication were not correlated with pulmonary physiological test results,HRCT abnormalities,clinical/endoscopic disease activity,CRP,ESR or total IgE level or body mass index.CONCLUSION:It is important that respiratory manifestations are recognized and treated early in IBD.Otherwise,they can lead to destructive and irreversible changes in the airway wall. | Aydin Yilmaz Nilgün Yilmaz Demirci Derya Hosgün Enver ner Yurdanur Erdogan Atila Gkek Atalay aglar | 2010 | World Journal of Gastroenterology2010，16，39： | 15 |
| 3 | Ovarian stem cells:From basic to clinical applications显示文摘The field of reproductive biology has undergone significant developments in the last decade. The notion that there is a fixed reserve pool of oocytes before birth was established by Zuckerman in 1951. However, in 2004, an article published in nature challenged this central dogma of mammalian reproductive biology. Tilly's group reported the existence of ovarian germline stem cells(GSCs) in postnatal ovaries of mice and suggested that the bone marrow could be an extragonadal source of ovarian GSCs. These findings were strongly criticized; however, several independent groups have sincesuccessfully isolated and characterized ovarian GSCs in postnatal mice. The ovarian GSCs are located in the ovarian surface epithelium and express markers of undifferentiated GSCs. When transplanted into mouse ovaries, mouse ovarian GSCs could differentiate and produce embryos and offspring. Similarly, in a recent study, ovarian GSCs were found to be present in the ovaries of women of reproductive age. Conversely, there is increasing evidence that stem cells responsible for maintaining a healthy state in normal tissue may be a source of some cancers, including ovarian cancer. Cancer stem cells(CSCs) have been found in many tissues, including ovaries. Some researchers have suggested that ovarian cancer may be a result of the transformation and dysfunction of ovarian GSCs with self-renewal properties. Drug resistant and metastasisgenerating CSCs are responsible for many important problems affecting ovarian cancer patients. Therefore, the identification of CSCs will provide opportunities for the development of new therapeutic strategies for treatments for infertility and ovarian cancer. In this article, we summarize the current understanding of ovarian GSCs in adult mammals, and we also discuss whether there is a relationship between GSCs and CSCs. | Ozlem Bingol Ozakpinar Anne-Marie Maurer Derya Ozsavci | 2015 | World Journal of Stem Cells2015，7，4： | 8 |
| 4 | Robotic radical prostatectomy in high-risk prostate -ancer: current perspectives显示文摘 | Abdullah Erdem Canda Mevlana Derya Balbay | 2015 | Asian Journal of Andrology2015，17，6： | 5 |
| 5 | Anti-pancreatic antibody in Turkish patients with inflammatory bowel disease and first-degree relatives显示文摘AIM: To identify the role of anti-pancreatic antibody (PAB) in the diagnosis of inflammatory bowel diseases (IBD) among Turkish patients, and its frequency in firstdegree relatives.METHODS: PAB and anti-Saccharomyces cerevisiae (ASCA) were examined in serum samples of 214 subjects including patients with Crohn's disease (CD, n = 64), ulcerative colitis (UC, n = 63), first-degree relatives of patients with CD (n = 25), first-degree relatives of patients with UC (n = 28),and a control group with gastrointestinal symptoms other than (IBD) (n = 34) by indirect immunofluorescence Positivity of PAB and ASCA was compared in terms of Vienna classification, disease activity and medications used.RESULTS: In terms of PAB positivity, no difference was found between patients with CD (14.1%) and UC (7.9%) however, significant difference was observed between patients with CD and subjects in the control group (P < 0.05). No difference was found between patients with CD and their relatives in terms of ASCA positivity, whereas a significant difference was found between other groups (P < 0.001). Compared to ASCA, the sensitivity of the PAB was 19% (7/37), its specificity was 93% (25/27), positive predictive value was 77% (7/9) and negative predictive value was 45% (25/55). ASCA was found with significantly higher prevalence in patients with CD activity index > 150 (P < 0.05).CONCLUSION: PAB is valuable in the diagnosis of IBD rather than CD, but cannot be used alone for diagnostic purposes. PAB is not superior to ASCA in CD diagnosis and in detecting CD among relatives of patients with CD. | Huseyin Demirsoy Kamil Ozdil Ozdal Ersoy Besir Kesici Cetin Karaca Canan Alkim Nihat Akbayir Levent Kamil Erdem Mehmet Derya Onuk Hulya Tugrul Beyzadeoglu | 2010 | World Journal of Gastroenterology2010，16，45： | 3 |
| 6 | Skin disorders in peritoneal dialysis patients:An underdiagnosed subject显示文摘AIM: To examine all skin changes in peritoneal dialysis(PD) patients followed up in our unit.METHODS: Patients on PD program for at least three months without any known chronic skin disease were included in the study. Patients with already diagnosed skin disease, those who have systemic diseases that may cause skin lesions, patients with malignancies and those who did not give informed consent were excluded from the study. All patients were examined by the same predetermined dermatologist with all findings recorded. The demographic, clinical and laboratory data including measures of dialysis adequacy of patients were recorded also. Statistical Package for Social Sciences(SPSS) for Windows 16.0 standard version was used for statistical analysis.RESULTS: Among the patients followed up in our PD unit, those without exclusion criteria who gave informed consent, 38 patients were included in the study with male/female ratio and mean age of 26/12 and 50.3 ± 13.7 years, respectively. The duration of CKD was 7.86 ± 4.16 years and the mean PD duration was 47.1 ± 29.6 mo. Primary kidney disease was diabetic nephropathy in 11, nephrosclerosis in six, uropathologies in four, chronic glomerulonephritis in three, chronic pyelonephritis in three, autosomal dominant polycystic kidney disease in three patients while cause was unknown in eight patients. All patients except for one patient had at least one skin lesion. Loss of lunula, onychomycosis and tinea pedis are the most frequent skin disorders recorded in the study group. Diabetic patients had tinea pedis more frequently(P = 0.045). No relationship of skin findings was detected with primary renal diseases, comorbidities and medications that the patients were using.CONCLUSION: Skin abnormalities are common in in PD patients. The most frequent skin pathologies are onychomycosis and tinea pedis which must not be overlooked. | Meltem Gursu Sami Uzun Derya Topcuoglu Leyli Kadriye Koc Lamiye Yucel Abdullah Sumnu Egemen Cebeci Oktay Ozkan Ahmet Behlul Leyla Koc Savas Ozturk Rumeyza Kazancioglu | 2016 | World Journal of Nephrology2016，5，4： | 3 |
| 7 | One-year experience in the retinopathy of prematurity: frequency and risk factors, short-term results and follow-up显示文摘· AIM: As a result of the increase in premature births and the advances in neonatal intensive care, retinopathy of prematurity (ROP) remains one of the most important causes of childhood blindness worldwide. The main factors in the development of ROP are gestational age, birth weight and oxygen therapy. ROP continues to gain importance due to the increasing survival rates of more immature babies. · METHODS: Between January 2007 and October 2008, 203 premature infants treated at the Neonatal Intensive Care Unit (NNICU) were prospectively enrolled and the relationship between known risk factors and the occurance of ROP was studied. · RESULTS: ROP in various stages developed in 86 cases (42.4%). Statistically significant correlations were found between the development of ROP and birth weight (P < 0.0001) gestational age (P <0.0001), oxygen treatment and its duration (P <0.0001 and P =0.002), mechanical ventilation (MV) and its duration (P =0,0001 and P =0.0001), apnea(P = 0.001), intraventricular hemorrhage (IVH) (P =0.046), sepsis (P =0.0001), use of erythropoietin (EPO) (P =0.003), the number of blood transfusions and frequency (P =0.0001 and P =0.0001), surfactant application (P =0.0001), the presence of patent ductus arteriosus (PDA) (P =0.001) or bronchopu- lmonary dysplasia (BPD) (P =0.0001). No significant correlations were found between the occurance of ROP and maternal pre-eclampsia (P =0.293), multiple pregnancy (P = 0.218), or hyperbilirubinemia (P =0.494). Severity of ROP was related significantly with birth weight (P =0.0001), but no significant correlation between severity of ROP and gestational age was present. · CONCLUSION: Early description and reduction of the risk factors related with the occurance of ROP with the help of routine screening programs may warrant the prevention of visual loss, however early ophthalmic diagnosis and treatment are still mandatory to provide better visual rehabilitation. · | Sariaydin Mehmet Atlihan Fusun Calkavur Sebnem Olukman Ozgur Ercan Gulten Ozturk Arif Taylan Kaya Kilic Fatma Gokaslan Filiz Altinyaprak Derya Malatyali Rana | 2011 | International Journal of Ophthalmology(English edition)2011，4，6： | 2 |
| 8 | Reconstruction of the urethral defects with autologous fascial tube graft in a rabbit model显示文摘瞄准:在尿道缺点重建调查自体同源的筋膜移植片的可行性。方法:在 24 只成年雄的兔子,一个标准化缺点(17 公里) 在每个尿道的中间的部分以内被创造。二厘米的长筋膜管状移植物在尿道的切割结束之间被干预。24 只兔子被划分成 12 个组。在 0, 3, 10, 15, 21, 30, 45, 60, 90, 120, 150,和 180 天手术后地,一个组被打死。在开始的四个组,兔子被打死,标本为组织学的检查被获得。在 21 手术后的天以后,在里面随后八个组,后退 urethrograms 被执行评估尿道的明显和口径,然后,兔子被打死,标本被获得。结果:在组织学的学习,沿着筋膜接枝提供的支架的尿道的变移上皮的前进是坚定的。在第 30 天,新尿道完全被变移上皮盖住。管形成在 24 只兔子中的二个被观察。在 urethrograms,变窄在 16 只兔子中的三个是坚定的。结论:为部分尿道的重建,因为它的快速的上皮的新生能力,低收缩度和薄,筋膜接枝是一个好尿道的代用品。我们因此在人为男性尿道的缺点的重建建议筋膜接枝的使用。 | Cagn Sade Kemal Ugurlu Derya Ozcelik Ilkay Huthut Kursat Ozer Nil Ustundag Ibrahim Saglam Lutfu Bas | 2007 | Asian Journal of Andrology2007，9，6： | 2 |
| 9 | Albendazole versus metronidazole treatment of adult giardiasis:An open randomized clinical study显示文摘To investigate the efficacy and tolerability of albendazoleand metranidazole treatment in giardiasis. | OguzKarabay AliTamer HuseyinGunduz HuseyinArinc HarikaCelebi Derya Kayas | 2004 | World Journal of Gastroenterology2004，10，8： | 2 |
| 10 | 酶法制备含ω-3多不饱和脂肪酸油脂的国际研究进展显示文摘综述ω-3多不饱和脂肪酸(polyunsaturated fatty acids,PUFA)作为一类必需脂肪酸(essential fatty acids,EFAs),主要来源为海产品中的鱼油,对多种人体疾病治疗和/或预防具有的积极作用。梳理了酶法制备富含ω-3多不饱和脂肪酸油脂的研究最新进展(截至2019年),讨论很多不同产品的营养功效、不同脂肪酸组成的结构脂质、ω-3多不饱和脂肪酸浓缩液、磷脂的酶促酯交换制备技术及应用,历年研究发现,可以通过改善油脂中ω-3多不饱和脂肪酸含量的方式提高其在饮食中的摄入量。由于酶法反应条件温和,尤其是脂肪酶特异性强,且从生物利用度角度ω-3多不饱和脂肪酸在脂质分子上的位置与其含量同等重要,因此相对于化学法,酶法制备含ω-3多不饱和脂肪酸的油脂因安全高效而更受青睐。 | Dilay Sen Derya Kahveci | 2020 | 粮油食品科技2020，28，4： | 2 |
| 11 | Effect of ionizing radiation on the pteridine metabolic pathway and evaluation of its cytotoxicity in exposed hospital staff显示文摘 | Ayse Basak Engin Mehmet Ali Ergun Erkan Yurtcu Derya Kan Gonul Sahin | 2005 | Mut.Res.-Genetic Toxicology and Environmental Mutagenesis2005，，1： | 2 |
| 12 | Comparison of retrograde intrarenal surgery, shockwave lithotripsy, and percutaneous nephrolithotomy for treatment of medium-sized radiolucent renal stones显示文摘 | Berkan Resorlu Ali Unsal Tevfik Ziypak Akif Diri Gokhan Atis Selcuk Guven Ahmet Ali Sancaktutar Abdulkadir Tepeler Omer Faruk Bozkurt Derya Oztuna | 2013 | World Journal of Urology2013，，6： | 2 |
| 13 | Truncus arteriosus:Diagnosis with dual-source computed tomography angiography and low radiation dose显示文摘Truncus arteriosus is an uncommon congenital cardiac abnormality which is characterized by a single arterial trunk origin from the heart that supplies both the systemic,pulmonary and coronary circulation.We present a preterm newborn female patient with type 2 truncusarteriosus,left superior vena cava and aberrant subclavian artery diagnosed with low dose dual-source cardiac computed tomography(CT).We discuss that low dose dual-source cardiac CT has more advantages than other imaging methods and it is an important modality for assessment of patients with conotruncal anomalies such as truncusarteriosus. | Mustafa Koplay Derya Cimen Mesut Sivri Osman Güvenc Derya Arslan Alaaddin Nayman Bulent Oran | 2014 | World Journal of Radiology2014，6，11： | 2 |
| 14 | Radical prostatectomy in patients aged 75 years or older:review of the literature显示文摘Given the demographic trends toward a considerably longer life expectancy,the percentage of elderly patients with prostate cancer will increase further in the upcoming decades.Therefore,the question arises,should patients ≥75 years old be offered radical prostatectomy and under which circumstances? For treatment decision-making,life expectancy is more important than biological age.As a result,a patient's health and mental status has to be determined and radical treatment should only be offered to those who are fit.As perioperative morbidity and mortality in these patients is increased relative to younger patients,patient selection according to comorbidities is a key issue that needs to be addressed.It is known from the literature that elderly men show notably worse tumor characteristics,leading to worse oncologic outcomes after treatment.Moreover,elderly patients also demonstrate worse postoperative recovery of continence and erectile function.As the absolute rates of both oncological and functional outcomes are still very reasonable in patients ≥75 years,a radical prostatectomy can be offered to highly selected and healthy elderly patients. Nevertheless,patients clearly need to be informed about the worse outcomes and higher perioperative risks compared to younger patients. | Philipp Mandel Thenappan Chandrasekar Felix K Chun Hartwig Huland Derya Tilki | 2019 | Asian Journal of Andrology2019，21，1： | 2 |
| 15 | An incremental genetic algorithm for classification and sensitivity analysis of its parameters显示文摘 | GOZDE B DERYA B ALP K | 2011 | System with Appli- cation2011，38，3： | 1 |
| 16 | Clinical significance of serum interleukin-18 (IL-18) levels in patients with gastric cancer显示文摘 | Faruk Tas Ceren Tilgen Yasasever Senem Karabulut Didem Tastekin Derya Duranyildiz | 2015 | Biomedicine & Pharmacotherapy2015，，： | 1 |
| 17 | Influence of different dietary oil sources on performance and cholesterol content of egg yolk in laying hens显示文摘 | KEMAL K DERYA Y SEHER K | 2010 | Journal of Biological Environment Science2010，4，12： | 1 |
| 18 | Preparation and characterization of UV-curable epoxy/silica nanocomposite coatings 显示文摘 | DERYA I NILHAN K A ATILLA G | 2009 | Progress in Organic Coatings2009，65，： | 1 |
| 19 | Asphyxial deaths- A retrospective study and review of the literature 显示文摘 | Derya Azmak | 2006 | Am J Forensic Med Patho2006，27，2： | 1 |
| 20 | Low serum bilirubin levels are independently and inversely related to impaired flow-mediated vasodilation and increased carotid intima-media thickness in both men and women显示文摘 | Dogan Erdogan Hakan Gullu Erkan Yildirim Derya Tok Ismail Kirbas Ozgur Ciftci Semra Topcu Baycan Haldun Muderrisoglu | 2005 | Atherosclerosis2005，，2： | 1 |
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