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| 1 | Transcranial direct current stimulation in psychiatric disorders显示文摘The interest in non-invasive brain stimulation techniques is increasing in recent years. Among these techniques, transcranial direct current stimulation(t DCS) has been the subject of great interest among researchers because of its easiness to use, low cost, benign profile of side effects and encouraging results of research in the field. This interest has generated several studies and randomized clinical trials, particularly in psychiatry. In this review, we provide a summary of the development of the technique and its mechanism of action as well as a review of the methodological aspects of randomized clinical trials in psychiatry, including studies in affective disorders, schizophrenia, obsessive compulsive disorder, child psychiatry and substance use disorder. Finally,we provide an overview of t DCS use in cognitive enhancement as well as a discussion regarding its clinical use and regulatory and ethical issues. Although many promising results regarding t DCS efficacy were described, the total number of studies is still low, highlighting the need of further studies aiming to replicate these findings in larger samples as to provide a definite picture regarding t DCS efficacy in psychiatry. | Gabriel Tortella Roberta Casati Luana V M Aparicio Antonio Mantovani Natasha Senco Giordano D’Urso Jerome Brunelin Fabiana Guarienti Priscila Mara Lorencini Selingardi Débora Muszkat Bernardo de Sampaio Pereira Junior Leandro Valiengo Adriano H Moffa Marcel Simis Lucas Borrione André R Brunoni | 2015 | World Journal of Psychiatry2015，5，1： | 6 |
| 2 | CYP2C9 genotype-guided warfarin prescribing enhances the efficacy and safety of anticoagu- lation : a prospective randomized controlled study显示文摘 | Caraco Y Blotnick S Muszkat M | 2007 | Clin Pharma- col Ther2007，，3： | 1 |
| 3 | CYP2C9 genotype- guided warfarin prescribing enhances the efficacy and safety of anticoagulation: a prospective randomized contralled study显示文摘 | CARACO Y BLOTNICK S MUSZKAT M | 2008 | Clin Pharmacal Ther2008，83，3： | 1 |
| 4 | Ethnic and genetic determinants of cardiovascular response to the selective 0:2 - adrenoceptor agonist dexmedetomidine显示文摘 | Kurnik D Muszkat M Sofowora GG | 2008 | Hypertension2008，51，2： | 1 |
| 5 | CYP2C9 genotypeguided warfarin prescribing enhances the efficacy and safety of anticoagulation:a prospective randomized controlled study显示文摘 | Caraco Y Blotnick S Muszkat M | 2008 | Clin Pharm Ther2008，83，3： | 1 |
| 6 | Alpha2-adrenergic receptor-induced vascular constriction in blacks and whites显示文摘 | Muszkat M Sofowora GG Wood AJ | | 0，，01： | 1 |
| 7 | Phenytoin metabolic ratio:a putative marker of CYP2C9 activity in vivo显示文摘 | CARACO Y MUSZKAT M WOOD A J | 2001 | Pharmacogenetics2001，11，7： | 1 |
| 8 | CYP2C9 genotype-guided warfarin prescribing enhances the efficacy andsafety of anticoagulation: a prospective randomized controlled study显示文摘 | CARACO Y BLOTNICK S MUSZKAT M | 2007 | Clin Pharmacol Ther2007，83，3： | 1 |
| 9 | Photocatalytic degradation of pesticides and bio-molecules in water显示文摘 | Muszkat L Feigelson L Bir L | 2002 | Pest Manag Sci2002，58，11： | 1 |
| 10 | Desensitization of vascular response in vivo: contribution of genetic variation in the α2B-adrenergic receptor subtype显示文摘 | Mordechai Muszkat Daniel Kurnik Gbenga G Sofowora Joseph Solus Hong-Guang Xie Paul A Harris Scott M Williams Alastair JJ Wood C Michael Stein | 2010 | Journal of Hypertension2010，，2： | 1 |
| 11 | Variation in the α2A adrenoceptor gene and the effect of dexmedetomidine on plasma insulin and glucose显示文摘 | Ghimire LV Muszkat M Sofowora GG | 2013 | Pharmacogenet Genomics2013，23，9： | 1 |
| 12 | Effects of variation in the human alpha2A- and alpha2C-adrenoceptor genes on cognitive tasks and pain pereeptian显示文摘 | Kohli U Muszkat M Sofowora GG | 2010 | Eur J Pain2010，14，2： | 1 |
| 13 | Variation in the 2A-a- drenoeeptor gene and the effect of dexmedetomidine on plasma in- sulin and glucose 显示文摘 | Ghirnire LV Muszkat M Sofowora GG | 2013 | Pharmacogenetics and genomics2013，23，9： | 1 |
| 14 | CYP2A6 genetic variation and dexmedetomidine disposition显示文摘 | KOHLI U PANDHARIPANDE P MUSZKAT M | 2012 | Eur J Clin Pharmacol2012，68，6： | 1 |
| 15 | CYP2C9 genotype-guided warfarin prescribing enhances the efficacy and safety of anticoagulation: a prospective randomized controlled study 显示文摘 | CARACO Y BLOTNICK S MUSZKAT M | 2008 | Clin Pharmacol Ther2008，83，3： | 1 |
| 16 | Opening- wedge high tibial osteotomy with and without bone graft 显示文摘 | Zorzi AR Da Silva HG Muszkat C | 2011 | Artif Organs2011，35，3： | 1 |
| 17 | Identification of mixed O-phenyl alkyl phthalate esters in an agricultural land显示文摘 | Muszkat L Bir L Rancher D | 1997 | Bull Environ Contam Toxicol1997，58，3： | 1 |
| 18 | Opening wedge high tibial osteotomy with and without bone graft显示文摘 | Zorzi AR da Silva HG Muszkat C | 2011 | Artif Organs2011，35，3： | 1 |
| 19 | CYP2C9 genotype-guided war- farin prescribing enhances the efficacy and safety of antieoagulation:a prospective randomized controlled study显示文摘 | Caraeo Y Blotnick S Muszkat M | 2008 | Clin Pharmacol Ther2008，83，3： | 1 |
| 20 | Warfarin metabolism and anticoagulant effect: a prospective, observational study of the impact of CYP2C9 genetic polymorphism in the presence of drug-disease and drug-drug interactions 显示文摘 | Muszkat M Blotnik S Elami A | 2007 | Clin Ther2007，29，： | 1 |
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