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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing显示文摘 | Chan K C Allen Jiang Peiyong Zheng Yama W L Liao Gary J W Sun Hao Wong John Siu Shing Shun N Chan Wing C Chan Stephen L Chan Anthony T C Lai Paul B S Chiu Rossa W K Lo Y M D | 2013 | Clinical Chemistry2013，，1： | 2 |
| 3 | Response of nanocomposite pyroelectric detectors 显示文摘 | CHEN Y CHAN W L H HUI N M | 1998 | Sensors and Actuators A1998，69，1： | 2 |
| 4 | The conversion of procyanidins and prodelphinidins to cuaniding and delphinidin显示文摘 | Porter L J Hrstich L N Chan B G | 1986 | Phytochemistry1986，25，： | 1 |
| 5 | Inhibition of vascular adenosine triphosphate-sensitive potassium channels by sympathetic tone during sepsis显示文摘 | Chan Y L Orie N N Dyson A | 2012 | Crit Care Med2012，40，4： | 1 |
| 6 | Obstctric outcomes aftercervical ripening by multiple doses of vaginal prostaglandin E2 显示文摘 | CHAN L Y FU L LEUNG T N | 2004 | Acta Obstet Gynecol Scand2004，83，1： | 1 |
| 7 | Optimal designs for an additive quadratic mixture-amount model显示文摘 | Zhang C Q Chan L Y Guan Y N | 2005 | Statistical Sinica2005，15，1： | 1 |
| 8 | Undergraduate Medical Education:Comparison of Problem-based Learning and Conventional Teaching显示文摘 | Nandi P L Chan J N F Chan C P K | 2000 | HKMJ2000，6，3： | 1 |
| 9 | Urocortin-induced endothelium dependent relaxation of rat coronary artery:role of nitric oxide and K+ channels显示文摘 | Huang Y Chan F L Lan C N | 2002 | Br J Pharmacol2002，135，6： | 1 |
| 10 | Two-point Estimate Method for Quantifying Transfer Capalibity Uncertainty显示文摘 | Chun L S Chan N L | 2005 | IEEE Transaction on Power Systems2005，20，2： | 1 |
| 11 | Eamings Quality and Stock Returns 显示文摘 | Chan K Chan L Jegadeesh N Lakonishok J | 2006 | Journal of Business2006，79，： | 1 |
| 12 | Effects of estrogen depletion on angiogenesis in estrogen-receptor-positive breast carcinoma-an immunohistochemical study of vasohibin-1 and CD31with correlation to pathobiological response of the patients in neoadjuvant aromatase inhibitor therapy显示文摘 | Chan MS Wang L Chanplakorn N | 2012 | Expert Opin Ther Targets2012，16，1： | 1 |
| 13 | Momentum Strategies显示文摘 | Chan L K C Jegadeesh N Lakonishok J | 1996 | Journal of Finance1996，51，5： | 1 |
| 14 | The conversion of procyanidins and prodelphinidins to cyanidin and delphinidin 显示文摘 | PORTER L J HRSTICH L N CHAN B N | 1986 | Phytochemistry1986，25，1： | 1 |
| 15 | Modelling of rheological behaviour of pummelo juice concentrates using master-curve显示文摘 | Chin N L Chan S M Yusof Y A | 2009 | Journal of Food Engineering2009，93，2： | 1 |
| 16 | Momentum strategies显示文摘 | Jegadeesh N, Lakonishok J | 1996 | Journal of1996，51，： | 1 |
| 17 | Analysis of sharps injuryoccurrences at a hospital in Singapore 显示文摘 | NG L N LIM H L CHAN Y H | 2002 | Int J Nurs Pract2002，8，5： | 1 |
| 18 | Fractalkine deficiency markedly reduces macrophage accumulation and atherosclerotic lesion formation in CCR2-/-mice:evidence for independent chemokine functions in atherogenesis显示文摘 | Saederup N Chan L Lira SA | 2008 | Circulation2008，117，13： | 1 |
| 19 | Additive effect of PPAR- gamma agonist and ARB in treatment of experimental IgA nephropathy 显示文摘 | Lai K N Chan L Y Guo H | 2011 | Pediatr Nephrol2011，26，2： | 1 |
| 20 | A WDM Passive Optical Network With Centralized Light Sources and Multicast Overlay显示文摘 | DENG N CHAN C K CHEN L K | 2008 | IEEE Photonics Technology Letters2008，20，2： | 1 |
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