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| 1 | 赤豆荚果总黄酮提取物对原代培养大鼠肝细胞氧化损伤的保护作用显示文摘目的:探讨赤豆荚果总黄酮提取物抗氧化作用以及对培养大鼠原代肝细胞氧化损伤的保护作用。方法:采用Photochem抗氧化测定仪对赤豆荚果总黄酮提取物体外抗氧化作用进行评价,同时评价其对培养大鼠原代肝细胞Fe2+氧化损伤保护作用的量效、时效关系。结果:赤豆荚果总黄酮提取物具有较强的抗氧化作用,在40,80,120ng剂量下,抗氧化作用大于芹菜素(P<0.05)。培养的原代肝细胞中加入100 μmol/L Fe2+后肝细胞活性减弱,培养液中ALT活力升高(P<0.05),脱落明显。加入提取物后,可有效抑制上述损伤作用。论:赤豆荚果总黄酮提取物具有较强的体外抗氧化作用,对Fe2+导致的大鼠原代肝细胞氧化损伤具有保护作用。 | 李波 赵青威 Nadine Weber 楼宜嘉 Peter Proksch | 2005 | 营养学报2005，27，5： | 13 |
| 2 | Combined glucocorticoid and antiviral therapy of hepatitis B virus-related liver failure显示文摘Acute hepatic failure due to hepatitis B virus(HBV)can occur both during primary infection as well as after reactivation of chronic infection.Guidelines recommend considering antiviral therapy in both situations,although evidence supporting this recommendation is weak.Since HBV is not directly cytopathic,the mechanism leading to fulminant hepatitis B is thought to be primarily immunemediated.Therefore,immunosuppression combined with antiviral therapy might be a preferred therapeutic intervention in acute liver failure in hepatitis B.Here wereport our favourable experience in three hepatitis B patients with fulminant hepatic failure who were treated by combining high-dose steroid therapy with standard antiviral treatment,which resulted in a rapid improvement of clinical and liver parameters. | Jan-Hendrik Bockmann Maura Dandri Stefan Lüth Nadine Pannicke Ansgar W Lohse | 2015 | World Journal of Gastroenterology2015，21，7： | 13 |
| 3 | The Translational Apparatus of Plastids and Its Role in Plant Development显示文摘叶绿体(质体) 拥有一个染色体和他们的自己的机械表示它。在质体的翻译在利用完全被编码为质体染色体的一套 tRNAs 的 bacterial-type70S 核糖体上发生。在最近的年里,部件 ofthe 叶绿体翻译仪器被 proteomic 途径并且由反向的遗传强烈地在 themodel 系统烟草(编码质体的部件) 和 Arabidopsis (编码原子核的部件) 学习了。这个工作提供了重要新卓见进结构,功能,和 biogenesisof 叶绿体核糖体,并且也有在 plastids.In 增加在翻译过程的分子的机制上打开新鲜的灯,在质体翻译影响的异种在各种各样的层次为叶绿体基因和基因 productsinfluencing 工厂开发产出充分基因证据,大概经由后退发信号小径。在这评论,我们有叶绿体的部件的功能的分析的 describerecent 进步翻译机械并且讨论支持质体的重要影响的 currentlyavailable 证据工厂解剖和 morphology.Key 词上的翻译活动: | Nadine Tiller Ralph Bock | 2014 | Molecular Plant2014，7，7： | 6 |
| 4 | Is there an association between Helicobacter pylori infection and irritable bowel syndrome? A meta-analysis显示文摘BACKGROUND Irritable bowel syndrome(IBS)is a prevalent and debilitating gastrointestinal condition.Research has reported persistent,low-grade mucosal inflammation and significant overlaps between patients with IBS and those with dyspepsia,suggesting a possible pathogenic role of Helicobacter pylori(H.pylori)in IBS.This study therefore aimed to provide the first systematic review and meta-analysis on the association between H.pylori infection and IBS.AIM To investigate the association between H.pylori infection and IBS.METHODS Using the keywords“H.pylori OR Helicobacter OR Helicobacter pylori OR infection”AND“irritable bowel syndrome OR IBS”,a preliminary search of PubMed,Medline,Embase,Cochrane Database of Systematic Reviews,Web of Science,Google Scholar and WanFang databases yielded 2924 papers published in English between 1 January 1960 and 1 June 2018.Attempts were also made to search grey literature.RESULTS A total of 13 clinical studies were systematically reviewed and nine studies were included in the final meta-analysis.Random-effects meta-analysis found a slight increased likelihood of H.pylori infection in patients with IBS,albeit this was not statistically significant(pooled odds ratio 1.47,95%confidence interval:0.90-2.40,P=0.123).It must also be acknowledged that all of the available studies reported only crude odd ratios.H.pylori eradication therapy also does not appear to improve IBS symptoms.Although publication bias was not observed in the funnel plot,there was a high degree of heterogeneity amongst the studies included in the meta-analysis(I2=87.38%).CONCLUSION Overall,current evidence does not support an association between IBS and H.pylori infection.Further rigorous and detailed studies with larger sample sizes and after H.pylori eradication therapy are warranted. | Qin Xiang Ng Nadine Xinhui Foo Wayren Loke Yun Qing Koh Vanessa Jing Min Seah Alex Yu Sen Soh Wee Song Yeo | 2019 | World Journal of Gastroenterology2019，25，37： | 5 |
| 5 | NOBOX is a key FOXL2 partner involved in ovarian folliculogenesis显示文摘 | Justine Bouilly1,2, Reiner A. Veitia3,4 Nadine Binart1,2,* | 2014 | Journal of Molecular Cell Biology2014，8，2： | 5 |
| 6 | IPOP:体验偏好理论显示文摘IPOP理论与实践来源自20世纪90年代至今的华盛顿史密森尼博物馆的观众调查,包括基础性的观察以及深入访谈,这些数据构成了一个具有长远意义的数据库。此研究的主要目的在于:能够更好地服务博物馆观众,即给观众带来高于平均水平的独特、有意义以及值得纪念的博物馆体验。在16年间的无数研究和访谈中,观众对于史密森尼博物馆展览的反应按照他们的原始兴趣可以被分为四个类型:I=观点,P=人,O=物,P=身体。事实证明展览若能引起四类观众的强烈共鸣,那么该展览在观众层面上是成功的。 | Andrew J.Pekarik James B.Schreiber Nadine Hanemann Kelly Richmond Barbara Mogel 王思怡 | 2017 | 中国博物馆2017，，2： | 5 |
| 7 | 基于小型电磁动力驱动器的微流道混合控制研究显示文摘对于许多微流体应用系统来说,流体的混合是至关重要的。本文研究了基于电磁流体动力混合器的微流道主动混合控制方法,建立了该微流道混合系统的理论模型并进行了数值模拟。在交变Lorentz驱动下,流经混合器流道的流体及其分界面在混合器流道内往复运动,流体界面的反复折叠与流体局部流动使流体混合,流体的横向往复运动使流体分界面反复折叠从而使流体间的接触面积大大增加。对流体混合过程进行了讨论并给出了流体混合程度评价方法。 | 刘庆明 白春华 Nadine Aubry | 2009 | 计算力学学报2009，26，1： | 4 |
| 8 | Electro-Magnetic Control of Vortex Shedding Behind a Circular Cylinder显示文摘开环、靠近环的控制算法为旋涡在电子上低进行的液体在圆形的柱体后面流压制被开发了。为开环的控制,局部性的 Lorentz 力量是到柱体表面的产生平行,它有加速的效果到液体。而且,二个靠近环的控制方法从能够一直决定 Lorentz 力量的茶碱紧张控制柱体流的旋涡的运动的方程被导出。 | 陈志华 范宝春 Nadine AUBRY 周本谋 | 2006 | Chinese Physics Letters2006，23，1： | 4 |
| 9 | Restoration of HCV-specific CD8+ T-cell function by Interferon-free therapy显示文摘 | Bianca Martin Nadine Hennecke Volker Lohmann Antonin Kayser Christoph Neumann-Haefelin George Kukolj Wulf-Otto B?cher Robert Thimme | 2014 | Journal of Hepatology2014，，： | 3 |
| 10 | CYLD deletion triggers nuclear factor-κB-signaling and increases cell death resistance in murine hepatocytes显示文摘AIM:To analyze the role of CYLD for receptor-mediated cell death of murine hepatocytes in acute liver injury models.METHODS:Hepatocyte cell death in CYLD knockout mice(CYLD-/-)was analyzed by application of liver injury models for CD95-(Jo2)and tumor necrosis factor(TNF)-α-[D-Gal N/lipopolysaccharide(LPS)]induced apoptosis.Liver injury was assessed by measurement of serum transaminases and histological analysis.Apoptosis induction was quantified by cleaved PARP staining and Western blotting of activated caspases.Nuclear factor(NF)-κB,ERK,Akt and jun amino-terminal kinases signaling were assessed.Primary Hepatocytes were isolated by two step-collagenase perfusion and treated with recombinant TNF-αand with the CD95-ligand Jo2.Cell viability was analyzed by MTT-assay.RESULTS:Livers of CYLD-/-mice showed increased anti-apoptotic NF-κB signaling.In both applied liver injury models CYLD-/-mice showed a significantly reduced apoptosis sensitivity.After D-Gal N/LPS treatment CYLD-/-mice exhibited significantly lower levels of alanine aminotransferase(ALT)(295 U/L vs 859 U/L,P<0.05)and aspartate aminotransferase(AST)(560 U/L vs 1025 U/L,P<0.01).After Jo injection CYLD-/-mice showed 2-fold lower ALT(50 U/L vs 110 U/L,P<0.01)and lower AST(250 U/L vs 435 U/L,P<0.01)serumlevels compared to WT mice.In addition,isolated CYLD-/-primary murine hepatocytes(PMH)were less sensitive towards death receptor-mediated apoptosis and showed increased levels of Bcl-2,XIAP,c IAP1/2,survivin and c-FLIP expression upon TNF-and CD95-receptor triggering,respectively.Inhibition of NF-κB activation by the inhibitor of NF-κB phosphorylation inhibitor BAY 11-7085 inhibited the expression of antiapoptotic proteins and re-sensitized CYLD-/-PMH towards TNF-and CD95-receptor mediated cell death.CONCLUSION:CYLD is a central regulator of apoptotic cell death in murine hepatocytes by controlling NF-κB dependent anti-apoptotic signaling. | Toni Urbanik Bruno Christian Koehler Laura Wolpert Christin Elbner Anna-Lena Scherr Thomas Longerich Nicole Kautz Stefan Welte Nadine Hovelmeyer Dirk Jager Ari Waisman Henning Schulze-Bergkamen | 2014 | World Journal of Gastroenterology2014，20，45： | 3 |
| 11 | Heart rate deceleration runs for postinfarction risk prediction显示文摘 | Przemyslaw Guzik Jaroslaw Piskorski Petra Barthel Axel Bauer Alexander Müller Nadine Junk Kurt Ulm Marek Malik Georg Schmidt | 2012 | Journal of Electrocardiology2012，，1： | 3 |
| 12 | Specific and cross-reactive immune response against Mycobacterium tuberculosis antigens in mice immunized with proteoliposomes from Mycobacterium bovis BCG显示文摘Objective: To characterize the immunogenicity and the induction of cross-reactive responses against Mycobacterium tuberculosis(M. tuberculosis) of a proteoliposome(PL)from Mycobacterium bovis Bacillus Calmette–Guerin(BCG) with and without alum hydroxide(AL) as adjuvant(PLBCG-AL and PLBCG, respectively) in BALB/c mice.Methods: BALB/c mice were inoculated with phosphate buffer solution, BCG, PLBCG and PLBCG-AL. The humoral immunogenicity was determined by ELISA [immunoglobulin G(Ig G), Ig G1 and Ig G2a] and the cellular immunogenicity was evaluated in vivo by delayed type hypersensitivity. The humoral cross-reactive response against M. tuberculosis was determined by Western blot.Results: Sera from animals immunized with PLBCG-AL and PLBCG showed significant increase in specific total Ig G and Ig G1 antibodies and the presence of cross-reactive antibodies against M. tuberculosis antigens, which were more intense with the use of alum as adjuvant. Mice immunized with PLBCG and PLBCG-AL also showed a specific cellular response in vivo.Conclusions: The cellular and humoral immunogenicity of PLBCG and the capacity to induce cross-reactive responses against M. tuberculosis is in agreement with the protective capacity previously demonstrated by this vaccine candidate and supports the continuation of its evaluation in further stages. | Nadine Alvarez DaymíSerpa Ramlah Kadir Yanely Tirado Reinier Borrero Sonsire Fernández Rubén Cabrera Yolanda Valdes Caridad Zayas Reinaldo Acevedo Luis Izquierdo María Elena Sarmiento Mohd-Nor Norazmi JoséLuis Pérez Armando Acosta | 2017 | Asian Pacific Journal of Tropical Biomedicine2017，7，3： | 3 |
| 13 | Corrosion rate determination of rare-earth Mg alloys in a Na_(2)SO_(4)solution by electrochemical measurements and inductive coupled plasma-optical emission spectroscopy显示文摘The corrosion resistance of three Mg alloys containing rare-earth elements(WE43,EV31 and ZE41)was studied and compared to that of two Mg-Al alloys(AZ31 and AZ91)and of pure Mg(99.95 wt.%).Current-voltage curves and electrochemical impedance measurements were performed with rotating disk electrodes in an aerated 0.1 M Na_(2)SO_(4)solution.For all the alloys,it was confirmed that the intermetallic particles acted as local cathodes and that more protective films were formed on the alloys surface by comparison with the pure Mg.Corrosion rates were determined from inductive coupled plasma-optical emission spectroscopy measurements and from the electrochemical measurements.Higher corrosion rates were observed for the rare-earth Mg alloys compared to the AZ series alloys.These data allowed the corrosion mechanisms to be discussed. | Samuel Leleu Bertrand Rives Nicolas Causse Nadine Pébère | 2019 | Journal of Magnesium and Alloys2019，7，1： | 3 |
| 14 | Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner显示文摘遇到 hypoxic 应力的房间由 downregulating 保存资源和精力蛋白质合成。这里我们 demonstratethat 在这回答的一机制是最高的 mRNAs 的翻译压抑编码 translationalapparatus 的部件。规定的这个模式包含 TSC 和 Rheb,当 Rheb 的 TSC1 或 TSC2 或 overexpression 的大美人在剥夺氧的房间救了最高的 mRNA 翻译。导致压力的翻译 repressionof 这些 mRNAs 密切与 4E-BP 的 hypophosphorylated 状态相关,一个翻译抑压者。然而, seriesof 4E-BP loss-of-function 和 gain-of-function 实验在氧或生长因素剥夺下面反驳在 phosphorylation statusof 4E-BP 和最高的 mRNAs 的翻译压抑之间的一种 cause-and-effect 关系。而且,血缺氧的 repressiveeffect 类似于由 Torin 1,而是更多 pronouncedthan 猛禽或 rictor 大美人由 mTOR 活动的有效抑制到达了那。同样,猛禽或 rictor 的缺乏它温和地 downregulated TOPmRNAs 的基础翻译效率,没能压制最高的 mRNAs 的调停氧的翻译激活。最后, TIA-1 和 TIAR co 击倒,二 RNA 有约束力的蛋白质以前在氨基的酸饥饿的房间在最高的 mRNAs 的翻译压抑含有, failedto 在另外的压力条件下面减轻最高的 mRNA 翻译。因此,近似翻译管理者 ofTOP mRNAs 的性质留下逃犯。 | Rachel Miloslavski Elad Cohen Adam Avraham Yifat I luz Zvi Hayouka Judith Kasir Rajini Mudhasani Stephen N. Jones Nadine Cybulski Markus A. Ruegg Ola Larsson Valentina Gandin Arjuna Rajakumar Ivan Topisirovic Oded Meyuhas | 2014 | Journal of Molecular Cell Biology2014，8，3： | 3 |
| 15 | 电磁流体动力驱动流体搅拌混合器特性研究显示文摘对小型电磁流体动力搅拌混合器的特性进行了理论分析和实验研究。该小型电磁动力混合器由聚碳酸脂和黄铜采用常规机械加工方法加工而成。研究采用的流体为氯化钠水溶液。为了观察流体的搅拌混合运动,在流体中加入微量微细玻璃珠作为示踪粒子。采用显微观测及图像采集技术记录流体的搅拌混合过程,用数字图像处理技术对流体速度场进行分析。建立了搅拌混合器的理论模型,并对其动力特性进行了数值分析,理论结果与实验结果相吻合。该小型电磁动力混合器已应用于微管道流动的混合控制并可应用于其它微流体控制系统中。 | 刘庆明 BATTON John AUBRY Nadine | 2006 | 实验流体力学2006，20，1： | 3 |
| 16 | Stiffening of sickle cell trait red blood cells under simulated strenuous exercise conditions显示文摘The higher risk of vaso-occlusion events and sudden death for sickle-cell trait(SCT)athletes has been speculatively ascribed to SCT red blood cell(RBC)stiffening during strenuous exercise.However,the microenvironmental changes that could induce the stiffening of SCT RBCs are unknown.To address this question,we measured the mechanical properties of and changes in SCT RBCs under deoxygenated and acidic environments,which are two typical conditions present in the circulation of athletes undertaking strenuous exercise.The results reveal that SCT RBCs are inherently stiffer than RBCs from non-SCT healthy subjects,and a lower pH further stiffens the SCT cells.Furthermore,at both normal and low pH levels,deoxygenation was found to not be the cause of the stiffness of SCT RBCs.This study confirms that the stiffening of SCT RBCs occurs at a low pH and implies that SCT RBC stiffening could be responsible for vaso-occlusion in SCT athletes during strenuous exercise. | Zhensong Xu Yi Zheng Xian Wang Nadine Shehata Chen Wang Shaorong Xie Yu Sun | 2016 | Microsystems & Nanoengineering2016，2，1： | 2 |
| 17 | Variants in the Netrin-1 Receptor UNC5C Prevent Apoptosis and Increase Risk of Familial Colorectal Cancer显示文摘 | Marie–May Coissieux Jerneja Tomsic Marie Castets Heather Hampel Sari Tuupanen Nadine Andrieu Ilene Comeras Youenn Drouet Christine Lasset Sandya Liyanarachchi Laetitia Mazelin Alain Puisieux Jean–Christophe Saurin Jean–Yves Scoazec Qing Wang Lauri Aaltone | 2012 | Gastroenterology2012，，6： | 2 |
| 18 | Efficient IL-2R signaling differentially affects the stability,function,and composition of the regulatory T-cell pool显示文摘Signaling via interleukin-2 receptor(IL-2R)is a requisite for regulatory T(Treg)cell identity and function.However,it is not completely understood to what degree IL-2R signaling is required for Treg cell homeostasis,lineage stability and function in both resting and inflammatory conditions.Here,we characterized a spontaneous mutant mouse strain endowed with a hypomorphic Tyr129His variant of CD25,theα-chain of IL-2R,which resulted in diminished receptor expression and reduced IL-2R signaling.Under noninflammatory conditions,Cd25Y129H mice harbored substantially lower numbers of peripheral Treg cells with stable Foxp3 expression that prevented the development of spontaneous autoimmune disease.In contrast,Cd25^(Y^(129H))Treg cells failed to efficiently induce immune suppression and lost lineage commitment in a T-cell transfer colitis model,indicating that unimpaired IL-2R signaling is critical for Treg cell function in inflammatory environments.Moreover,single-cell RNA sequencing of Treg cells revealed that impaired IL-2R signaling profoundly affected the balance of central and effector Treg cell subsets.Thus,partial loss of IL-2R signaling differentially interferes with the maintenance,heterogeneity,and suppressive function of the Treg cell pool. | Marc Permanyer Berislav Bošnjak Silke Glage Michaela Friedrichsen Stefan Floess Jochen Huehn Gwendolyn E.Patzer Ivan Odak Nadine Eckert Razieh Zargari Laura Ospina-Quintero Hristo Georgiev Reinhold Förster | 2021 | Cellular & Molecular Immunology2021，18，2： | 2 |
| 19 | Description of Relational Processes: Recent Changes in DSM‐5 and Proposals for ICD‐11显示文摘 | Marianne Wamboldt Nadine Kaslow David Reiss | 2015 | Fam. Proc2015，，： | 2 |
| 20 | Designing a spectral index to estimate vegetation water content from remote sensing data: Part 1显示文摘 | Pietro Ceccato Nadine Gobron Stéphane Flasse Bernard Pinty Stefano Tarantola | 2002 | Remote Sensing of Environment2002，，2： | 2 |
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