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| 1 | IL-1α和肿瘤坏死因子α刺激牙龈成纤维细胞产生IL-11的研究显示文摘目的 为了解白细胞介素 (IL) 11在牙周疾病中的作用 ,检测IL 1α和肿瘤坏死因子α(TNF α)刺激牙龈成纤维细胞 (HGFs)IL 11的表达和调控。方法 收集细胞上清液 ,ELISA法测定IL 11的水平 ;提取细胞mRNA ,实时定量RT PCR法定量分析IL 11mRNA和看守基因GAPDHmRNA的表达。结果 IL 1α和TNF α均可显著增加HGFs表达的IL 11水平 (P <0 0 1) ,两者还有明显的协同刺激效应 ,产生的IL 11远高于其单独刺激HGFs产生的IL 11之和 ;吲哚美辛显著抑制了IL 1α和TNF α单独或联合刺激的HGFsIL 11的产生 (P <0 0 1)。HGFs受到IL 1α刺激 6h即有明显的IL 11mRNA(IL 11/GAPDH比值 3 6 )表达 ,同时加入放线菌酮后 ,IL 11mRNA的表达则明显减弱 (IL 11/GAPDH比值 2 4 ) ;2 4h时 ,HGFs受到IL 1α刺激IL 11mRNA表达继续增强 (IL 11/GAPDH比值 5 4 ) ,与TNF α联合刺激IL 11mRNA表达增强最显著 (IL 11/GAPDH比值 8 7) ,但都受到吲哚美辛的显著抑制 (IL 11/GAPDH比值小于 1)。结论 IL 1α和TNF α刺激HGFs显著增加IL 11的产生 。 | 和璐 Nagasawa T Ishikawa I | 2004 | 中华口腔医学杂志2004，39，6： | 2 |
| 2 | Nitrile hydratase of Pseudomonas chlororaphis B23: Purification and characterization 显示文摘 | Nagasawa T Nanba H Ryuno K Takeuchi K Yamada H | 1987 | Eur J Biochem1987，162，： | 1 |
| 3 | ε-Poly-L-lysine: microbial production, biodegradation and application potential显示文摘 | YOSHIDA T NAGASAWA T | 2003 | Appl Microbiol Biot2003，62，： | 1 |
| 4 | Enzymatic synthesis of acrylamide: a success story not yet over显示文摘 | Kobayashi M Nagasawa T Yamada H | 1992 | Trends in Biotechnology1992，10，： | 1 |
| 5 | Characterization of a new cobalt-containing nitrile hydratase purified from urea-induced cells of Rhodococcus rhodochrous J1显示文摘 | Nagasawa T Takeuchi K Yamada H | 1991 | Eur J Biochem1991，196，： | 1 |
| 6 | Polyl lysine: Microbial production biodegradation and application potential显示文摘 | Yoshida T Nagasawa T | 2003 | Appl Microbiol Biotechnol2003，，62： | 1 |
| 7 | Reticulocyte-gated flow cytometric analysis of red blood cells in paroxysreal nocturnal hemoglobinuria显示文摘 | Sato S Hasegawa Y Nagasawa T | 2006 | Lab Hematol2006，12，2： | 1 |
| 8 | rapid resolution of acute extradural snd subdural hematomas:case report 显示文摘 | Kuroiwa T Nagasawa S Ohta T | 1993 | J Neurosurg1993，78，： | 1 |
| 9 | Micropropagation of garlic through in vitro bulblet formation 显示文摘 | NAGAKUBO T NAGASAWA A OHKAWA H | 1993 | Plant Cell Tissue Orgon Culture1993，32，2： | 1 |
| 10 | Endoscopic observation of the syrinx in Chiari malformation -case report 显示文摘 | Nagasawa S Ohta T Onomura T | 1993 | Neurol Med Chir (Tokyo)1993，33，： | 1 |
| 11 | Multi-center interve- ntion study on glycohemoglobin ( HbAlc ) and serum, high-sen- sitivity CRP (hs-CRP)after lc, cal anti-infectious periodontal tr- eatment in type 2 diabetic patients with periodontal disease 显示文摘 | Katagifi S Nitta H Nagasawa T | 2009 | Diabetes Res Clin Pract2009，83，3： | 1 |
| 12 | The induction of adenomyosis in mice by intrauterine pituitary isografts 显示文摘 | Mori T Nagasawa H Takahashi | 1981 | LifeSci1981，29，： | 1 |
| 13 | Detects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1显示文摘 | Nagasawa T Hirota S Tachibana K | | 0，，： | 1 |
| 14 | Cxcl12/sdf-1 and cxcr4显示文摘 | Nagasawa T | 2015 | Front Immunol2015，6，2： | 1 |
| 15 | Low-molecular-mass nitrile hydratase from Rhodococcus rhodochrous Jl: purification, substrate specificity and comparison with the analogous high-molecular-mass enzyme 显示文摘 | Wieser M Takeuchi K Wada Y Yamada H Nagasawa T | 1998 | FEMS Microbiol Lett1998，169，： | 1 |
| 16 | Inhibition of glycation reaction in tissue protein incubations by water soluble rutin derivative显示文摘 | Tabata N Ito Y | 2003 | Mol Cell Biochem2003，249，12： | 1 |
| 17 | Nitrile hydratase of Pseudomonas chlororaphis B23 purification and characterization显示文摘 | Nagasawa T Nanba H Ryuno K | 1987 | Eur J Biochem1987，162，： | 1 |
| 18 | Beneficial effects of teacatechins on diet-induced obesity:stimulation of lipid catabolism in theliver显示文摘 | MURASE T NAGASAWA A SUZUKI J | 2002 | International Journal of Obesity2002，26，11： | 1 |
| 19 | Molecular cloning and structure of a pre-Prcell growth-stimulating factor 显示文摘 | Nagasawa T Kikutani H Kishimoto T | 1994 | Proc Natl Acad Sci USA1994，91，6： | 1 |
| 20 | Expression of MMP-9 in mesangial cells and its changes in anti-GBM glomerulonephritis in WKY rats显示文摘 | Kuroda T Yoshida Y Kamiie J Kovalenko P Nameta M Fujinaka H Yaoita E Endo T Ishizuka S Nakabayashi K Yamada A Nagasawa T Yamamoto T | 2004 | Clin Exp Nephrol2004，8，： | 1 |
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