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| 1 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 2 | Biocompatibility of b-tricalcium phosphate root replicas in porcine tooth extraction sockets-A correlative histological,ultrastructural,and Xray microanalytical pilot study显示文摘 | Nair P N R Luder H U Maspero F A | 2006 | J Biomater Appl2006，20，： | 1 |
| 3 | A randomized controlled trial to assess the optimal dose and effect of nebulized albuterol in acute exacerbations of COPD 显示文摘 | Nair S Thomas F Dphil P | 2005 | Chest2005，128，： | 1 |
| 4 | Soluble proteins delivered to dendritic cells via pH-sensitive liposomes induces primary cytotoxic T lymphocyte responses in vitro显示文摘 | Nair S Zhou F Reddy R | 1992 | J Exp Med1992，175，： | 1 |
| 5 | Microstructure analysis and discontinuities in the braze zone of copper tubes 显示文摘 | Karamis M B Tasdemirci A Nair F | 2003 | Journal of Materials Processing Technology2003，，4： | 1 |
| 6 | Efficient conservative gtobal transport schemes for climate and atmospheric chemis try models 显示文摘 | Nair R D Scroggs J S Semazzi F H | 2002 | Mon Wea Rev2002，130，： | 1 |
| 7 | Microstructural analysis and discontinuities in the brazes zone of copper tubes 显示文摘 | Karamis M B Tasdemirci A Nair F | 2003 | Journal of Materials Processing Technology2003，，4： | 1 |
| 8 | Intracranial haemorrhage in severe haemophilia: prevalence and outcome in a developing country 显示文摘 | GHOSH K NAIR AP JIJINA F | 2005 | Haemophilia2005，11，： | 1 |
| 9 | Use of Marek's disease vaccines: could they be driving the virus to increasing virulence? 显示文摘 | Davison F Nair V | 2005 | Vaccines2005，4，1： | 1 |
| 10 | Increased growth and germina- tion success in plants following hydrogen sulfide administration 显示文摘 | Dooley F D Nair S P Ward P D | 2013 | PLoS ONE2013，8，62： | 1 |
| 11 | Structure-performance correlation of nanocellulose-based polymer electrolytes for efficient quasi-solid DSSCs显示文摘 | Chiappone A Bella F Nair J R | 2014 | Chemelectrochem2014，1，8： | 1 |
| 12 | Graphene-based liquid crystal device 显示文摘 | BLAKE P BRIMICOMBE P D NAIR R R BOOTH T J JIANG D SCHEDIN F PONOMARENKO L A MOROZOV S V GLEESON H F HILL E W GEIM A K NOVOSELOV K S | 2008 | Nano Letters2008，8，6： | 1 |
| 13 | Hyperandrogenism sensi- tizes mononuclear cells to promote glucose-induced inflammation in lean reproductive-age women 显示文摘 | Gonz61ez F Nair K S Daniels J K | 2012 | Am J Physiol Endocrinol Metab2012，302，3： | 1 |
| 14 | HIV-1 Tat protein exits from cells via a leaderless secretory pathway and binds to extracellular matrix associated heparan sulphate proteoglycans through its basic region显示文摘 | Chang HC Samaniego F Nair BC | 1997 | AIDS1997，11，： | 1 |
| 15 | Coronary heart disease,hypertension,and angiotensinogen gene variants in Indian population显示文摘 | Nair K G Shalia K K Ashavaid T F | 2003 | J Clin Lab Anal2003，17，5： | 1 |
| 16 | Feedback control under data rate constraints:an overview显示文摘 | Nair G N Fagnani F Zampieri S Evans R J | | 0，，01： | 1 |
| 17 | Sandhoffdisease in an extreme preterm baby with bilateralsyndactyly 显示文摘 | NAIR P M BATACLAN F GANESH A | 2003 | Saudi Med J2003，24，4： | 1 |
| 18 | The impact of landilling and composting on greenhouse gas emissions-A review显示文摘 | Lou X F Nair J | 2009 | Bioresource technology2009，100，37： | 1 |
| 19 | Imaging correlates of motor recovery from cerebral infarction and their physiological significance in well-recovered patients显示文摘 | Nair DG Hutchinson S Fregni F | 2007 | Neuroimage2007，34，： | 1 |
| 20 | Imaging correlates of motor recovery from cerebral infarction and their physiological significance in well-recovered patients 显示文摘 | Nair DG Hutchinson S Fregni F | 2007 | Neuroimage2007，34，： | 1 |
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