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| 1 | Colorectal cancer screening in human immunodeficiency virus population:Are they at average risk?显示文摘AIM:To evaluate if human immunodeficiency virus (HIV) population is getting adequate screening for colon cancer in the highly active anti-retroviral treatment (HAART) era with improved longevity, and the prevalence of polyps and adenomas in this population, when compared with the general population. METHODS:We conducted retrospective chart review of average-risk HIV population for colon cancer attending our infectious disease clinic. Individuals who underwent diagnostic colonoscopy were excluded. We extracted various demographic, HIV disease-specific and colonoscopy data including histo-pathological reports in the last 10 years. Total population was divided into a study group, who underwent screening colonoscopy and a control group who did not. We analyzed data using standard statistical methods and software. RESULTS:We found that 25% of average-risk HIVinfected population was screened for colon cancer using colonoscopy. There was no difference in gender and ethnic distribution between the groups. We foundwider distribution of age (50-84 years with mean 56 years) in the control group when compared to (50-73 years with mean 58 years) the study group. However, there were 89% of subjects with well-controlled HIV disease measured by HIV RNA copies of < 75 in the study group when compared with 70% in the control group (P < 0.0001). We noticed polyp detection rate of 55% and adenoma detection rate of 32% in HIV population. CONCLUSION:It is unclear whether HIV or HAART medications play a role in increased prevalence of adenomas. We suggest that when estimating the risk for colonic neoplasms, HIV population should be considered as a high-risk group and screened accordingly. | Suresh Kumar Nayudu Bhavna Balar | 2012 | World Journal of Gastrointestinal Oncology2012，4，12： | 3 |
| 2 | Prevalence of advanced liver fibrosis and steatosis in type-2 diabetics with normal transaminases:A prospective cohort study显示文摘BACKGROUND Nonalcoholic fatty liver disease(NAFLD)and type-2 diabetes mellitus(T2DM)have an intricate bidirectional relationship.Individuals with T2DM,not only have a higher prevalence of non-alcoholic steatosis,but also carry a higher risk of progression to nonalcoholic steatohepatitis.Experts still differ in their recommendations of screening for NAFLD among patients with T2DM.AIM To study the prevalence of NAFLD and advanced fibrosis among our patient population with T2DM.METHODS During the study period(November 2018 to January 2020),59 adult patients with T2DM and 26 non-diabetic control group individuals were recruited prospectively.Patients with known significant liver disease and alcohol use were excluded.Demographic data and lab parameters were recorded.Liver elastography was performed in all patients.RESULTS In the study group comprised of patients with T2DM and normal alanine aminotransferase levels(mean 17.8±7 U/L),81%had hepatic steatosis as diagnosed by elastography.Advanced hepatic fibrosis(stage F3 or F4)was present in 12%of patients with T2DM as compared to none in the control group.Patients with T2DM also had higher number of individuals with grade 3 steatosis[45.8%vs 11.5%,(P<0.00001)and metabolic syndrome(84.7%vs 11.5%,P<0.00001)].CONCLUSION A significant number of patients with T2DM,despite having normal transaminase levels,have NAFLD,grade 3 steatosis and advanced hepatic fibrosis as measured by liver elastography. | Jasbir Makker Hassan Tariq Kishore Kumar Madhavi Ravi Danial Haris Shaikh Vivien Leung Umar Hayat Muhammad T Hassan Harish Patel Suresh Nayudu Sridhar Chilimuri | 2021 | World Journal of Gastroenterology2021，27，6： | 2 |
| 3 | 糖尿病酮症酸中毒患者发生胃肠道出血的预测因素:一项回顾性的观察研究显示文摘背景酮症酸中毒(DKA)是糖尿病一种常见的急性并发症,需要积极的药物治疗。我们旨在研究DKA患者急性胃肠道出血(AGIB)和急性上消化道出血(AUGIB)的发生率及其相关危险因素。方法:我们对本中心2010年1月至2015年12月间收治的DKA病例进行回顾性分析,通过电子病历库收集其人口统计学、临床、实验室、内镜及住院资料。根据有无发生胃肠道出血将患者分为两组。结果:共计234例DKA患者纳入研究,其中27例(11.5%)有AGIB的记录。除2例直肠出血和3例隐匿性出血外,22例(9.4%)表现为呕血。AGIB组与非AGIB组患者年龄、性别和种族的分布无显著差异。两组患者电解质水平、阴离子间隙、pH值及糖化血红蛋白HbA1c的差异亦无统计学意义。然而,AGIB组患者初始血糖水平显著高于非AGIB组(738 mg/dL vs 613 mg/dL,P=0.014)。AGIB组患者病死率也有所升高(7.4%vs 4.8%),尽管差异未达到统计学意义。结论:初始高血糖水平会增加DKA患者发生AGIB的风险。我们还注意到发生AGIB的DKA患者病死率增加,尽管这个增加未达到统计学意义。临床上应更加积极地纠正DKA患者的血糖水平以降低AGIB发生率,从而降低住院病死率。 | Kanthi Rekha Badipatla Preeti Jadhav Sushma Vaddigiri Bharat Bajantri Amandeep Singh Chaitanya Chandrala Vijay S Are Suresh Kumar Nayudu | 2017 | Gastroenterology Report2017，5，4： | 2 |
| 4 | Effect of cryoprotectant concentration,equilibration time and thawing procedure on survival and development of rapid frozen-thawed mature mouse oocytes显示文摘 | NOWSHARI M A NAYUDU P L HODGES J K | 1994 | Theriogenology1994，42，： | 1 |
| 5 | Mapping the RP2 locus for X-linked retinitis pigmentosa on proximal Xp:a genetically defined 5-cM critical region and exclusion of candidate genes by physical mapping显示文摘 | Thiselton DL Hampson RM Nayudu M | | 0，，： | 1 |
| 6 | Luteinizing hormone has a stage-limited effect on preantral follicle development in vitro显示文摘 | Wu J Nayudu P L Kiesel P S | 2000 | Biol Reprod2000，63，： | 1 |
| 7 | Patterns of growth oestradiol and progesterone released by in vitro cultured mouse ovarian follicles indicate consecut Jve selective events during follicle development显示文摘 | Fehrenbach A N Nayudu PI | 1998 | J Reprod Fertit1998，113，： | 1 |
| 8 | Groundwater quality in the Niva River basin, Chittoor district, Andhra Pradesh, India显示文摘 | Y. S. Rao T. V. K. Reddy P. T. Nayudu | 1997 | Environmental Geology1997，，1： | 1 |
| 9 | Factors influencing the rate of preantral and antral growth of mouse ovarian follicles in vitro显示文摘 | Nayudu P L Osbom S M | 1992 | J Reprod Fert1992，95，2： | 1 |
| 10 | Attaining dominance in vivo:distinguishing dominant from challenger gollicles in humans显示文摘 | Gore MA Nayudu PL Vlaisavljevic V | 1997 | Hum Reprod1997，12，： | 1 |
| 11 | Luteinizing hormone has a stage-limited effect on preantral follicle development in vitro 显示文摘 | WU J NAYUDU P L KIESEL P S | 2000 | Biol Reprod2000，63，1： | 1 |
| 12 | Cholestatic hepatitis with small duct injury associated with celecoxib 显示文摘 | Nayudu SK Badipatla S Niazi M | 2013 | Case Rep Med2013，2013，31： | 1 |
| 13 | Protamine-1 represents a sperm specific gene transcript:a study in Callithrixjacchus and Bos Taurus显示文摘 | Hecht N Cavalcanti M C Nayudu P | 2011 | Andrologia2011，43，3： | 1 |
| 14 | Luteinizing hormone has a stage-limited effect on preantral follicle development in Vitro 显示文摘 | JI W U PENELOPE L NAYUDU | 2000 | Biology of Reproduction2000，63，7： | 1 |
| 15 | Attaining dominance in vivo:distinguishing dominant from challenger follicles in humans显示文摘 | Gore MA Nayudu PL Vlaisavljevic V | 1997 | Hum Reprod1997，12，12： | 1 |
| 16 | The use of in vitro fertilization to evaluate putative tests of human sperm function 显示文摘 | Liu DY Du Plessis YP Nayudu PL | 1988 | Fertil Steril1988，49，2： | 1 |
| 17 | Lutein- izing hormone has a stage-limited effect on preantralfollicle development in vitro显示文摘 | JI W U NAYUDU P L KIESEL P S | 2000 | Biol Reprod2000，63，1： | 1 |
| 18 | Progress toward understanding follicle development in vitro:appearances are not deceiving显示文摘 | Nayudu P L Fehrenbach A Kiesel P | 2001 | Archives of Medical Research2001，32，： | 1 |
| 19 | UV-B irradiation induces differential leaf damage,ultrastructural changes and accumula-tion of specific phenollic compounds in rice cultivars显示文摘 | Cassi-LIT M Whitecross M J Nayudu M | 1997 | Plant Physiol1997，24，： | 1 |
| 20 | Factors influencing the rate of preantral and antral growth of mouse ovarian follicles in vitro显示文摘 | Nayudu PL Osborn SM | 1992 | J Reprod Fertil1992，95，2： | 1 |
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