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| 1 | Gender differences in adolescent dry eye disease:a health problem in girls显示文摘AIM: To evaluate the signs and symptoms of dry eye disease(DED) in adolescents. METHODS: This was a cross-sectional, case-control study and outpatients aged 10 to 19y were recruited from six eye clinics of various practices and locations in Japan, and 253 non-DED subjects and 70 DED patients were enrolled. Participants were examined for DED-related signs. Patients were also interviewed to ascertain the presence or absence of six common DED-related symptoms: dryness, irritation, pain, eye fatigue, blurring, and photophobia. Main outcome measures were differences in signs and symptoms of dry eye disease between boys and girls.RESULTS: Of the 323 adolescents recruited, 70(21.7%) were diagnosed with DED. Significant differences between the non-DED and DED groups were found for short tear break-up time(BUT; ≤5s; P=0.000) and superficial punctate keratopathy(SPK; staining score ≥3; P=0.000). Late adolescent girls reported fewer symptoms than late adolescent boys, although their DED-related signs were worse compared to other groups. The prevalence and severity of DED were similar in the Tokyo area compared with suburban and local areas but myopic errors were worse. CONCLUSION: We find that adolescents reported symptoms of DED similar to those found in adults, and the majority have short BUT-type DED. The prevalence and severity of DED in late adolescent girls is comparable with adults. Adolescents with DED are underserved and we believe that DED is a hidden but potentially serious health problem for this age group. | Masahiko Ayaki Motoko Kawashima Miki Uchino Kazuo Tsubota Kazuno Negishi | 2018 | International Journal of Ophthalmology(English edition)2018，11，2： | 5 |
| 2 | Effect of Pd-photodeposition over TiO2on product selectivity in photocatalytic degradation of vinyl chloride monomer显示文摘 | T SANO S KUTSUNA N NEGISHI | 2002 | J Mol Catal A2002，189，2： | 2 |
| 3 | Trans-cinnamaldehyde promotes nitric oxide release via the protein kinase-B/v-Akt murine thymoma viral oncogene-endothelial nitric oxide synthase pathway to alleviate hypertension in SHR.Cg-Lepr^(cp)/NDmcr rats显示文摘OBJECTIVE:To evaluate whether endothelial dysfunction and hypertension are prevented by trans-cinnamaldehyde(t CA) through the activation of endothelial nitric oxide synthase(e NOS).METHODS:Human umbilical vein endothelial cells(HUVECs) were cultured in vitro and stimulated with t CA to determine cell viability using the methyl thiazolyl tetrazolium assay.The effect of t CA on nitric oxide(NO) production was determined by diaminofluorescein-dyes in the absence or presence of inhibitors of e NOS,AMPK,PKA,and AKT.The effect of t CA on blood pressure was determined by the tail-cuff method in obesity spontaneous hypertension(SHR.Cg-Leprcp/NDmcr) rats.The phosphorylation of e NOS and protein expression of the insulin-signaling pathway(Ins R-IRS1-PI3 K-AKT)were measured by western blot.RESULTS:t CA at concentrations less than 100 μM did not affect cell viability in cultured HUVECs.Stimulation with t CA promoted NO release in a time-dependent manner compared with the control group.t CA-treated HUVECs also significantly increased AKT-Ser473 and e NOS-Ser1177 phosphorylation.In SHR-CP rats,treatment with t CA at a dose of 40 mg/kg/day for 6 weeks markedly reduced the systolic blood pressure and diastolic blood pressure,increased the phosphorylation of AKT and e NOS,and increased urinary nitric oxidation.CONCLUSION:t CA attenuated endothelial dysfunction and reduced blood pressure in SHR-CP rats.The underlying mechanisms may involve the increase in AKT and e NOS phosphorylation and the release of e NOS-derived NO. | Zhang Lu Wu Lili Liu Ximing Yoshitomi Hisae Ikeda Katsumi Negishi Hiroko Pan Yajing Sun Wen Qin Lingling Li Juan-E Xu Tunhai Liu Tonghua Gao Ming | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 2 |
| 4 | Thymic hyperplasia inpatientswith Graves disease:Identification of thyrotropin receptors in human thymus显示文摘 | Murakami M Hosoi Y Negishi T | 1996 | J Clin Invest1996，98，10： | 1 |
| 5 | Photorejuvenation for Asian skin by intense pulsed light显示文摘 | Tezuka Y Kushikata N | 2001 | Dermatol Surg2001，27，7： | 1 |
| 6 | Photorejuvenation for Asian skin by intense pulsed light 显示文摘 | Negishi K Tezuka Y Kushikata N | 2001 | Dermatol Surg2001，27，7： | 1 |
| 7 | Factors affecting contrastsensitivity with the Artisan phakic intraocular lens for high myopia显示文摘 | Yamaguchi T Negishi K Kato N | 2009 | J Refract Surg2009，25，1： | 1 |
| 8 | An automatic process ing system for broadcasting earthquake alarms显示文摘 | Horiuchi S H Negishi K Abe | 2005 | Bulletin of the Seismological Society of America2005，95，： | 1 |
| 9 | Enhanced self-renewal of hematopoietic stem cells mediated by the polycomb gene product Bmi-1显示文摘 | Iwama A Oguro H Negishi M | 2004 | Immunity2004，21，6： | 1 |
| 10 | Differentia- tion of neural cells in the fetal cerebral cortex of cynomol- gus monkeys ( Macaca fascicularis) 显示文摘 | Toyoshima Y Sekiguchi S Negishi T | 2012 | Comp Med2012，62，1： | 1 |
| 11 | Simple and accurate alignment of toric intraocular lenses and evaluation of their rotation errors using anterior segment optical coherence tomography显示文摘 | Watanabe K Negishi K Torii H Saiki M Dogru M Tsubota K | | 0，，01： | 1 |
| 12 | SJWD14092200000366显示文摘 | Hirotaka Akita Ryosuke Sasaki Yusuke Yokoyama Kei Negishi Kayoko Matsunaga | 2014 | Exp Dermatol2014，，： | 1 |
| 13 | Evaluation of new acute kidney injury biomarkers in a mixed intensive care unit 显示文摘 | Doi K Negishi K Ishizu T | 2011 | Crit Care Med2011，39，11： | 1 |
| 14 | A super-smooth polishing for aspherical surfaces high precision coordinate measuring and polishing systems显示文摘 | Ando M Takimoto M | 1995 | SPIE1995，2576，： | 1 |
| 15 | Isolation of Iron-Oxidizing Bacteria Corroded of Sewage Treatment Plants显示文摘 | Maeda T Negishi A Komodo H | 1999 | Journal of Bioscience and Bioengineering1999，88，3： | 1 |
| 16 | Antioxidative compounds from Crotalaria sessiliflora 显示文摘 | Mun'im A Negishi O Ozawa T | 2003 | Biosci Biotechnol Biochem2003，67，2： | 1 |
| 17 | Phase diagrams of magnesium-rice portion,aging characteristics and tensile properties of Mg heavy rare earth metal (Gd,Dy)-Nd alloys显示文摘 | Negishi Y Nishimura T Kiryuu M | 1995 | Journal of Japan Institute of Light Metals1995，45，2： | 1 |
| 18 | Optic nerve regeneration within artificial Schwann cell graft in the adult rat显示文摘 | Negishi H Dezawa M Oshitari T | 2001 | Brain Res Bull2001，55，3： | 1 |
| 19 | Phenobarbital-elicited activation of nuclear receptor CAR in induction of cytochrome P450 genes显示文摘 | Zelko I Negishi M | 2000 | Biochem Biophys Res Commun2000，277，1： | 1 |
| 20 | Behavioral alterations in response to fear-provoking stimuli and tranylcypromine induced by perinatal exposure to bisphenol A and nonylphenol in male rats 显示文摘 | Negishi T Kawasaki K Suzaki S | 2004 | Environ Health Perspect2004，112，11： | 1 |
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