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| 1 | Imaging plaque inflammation in asymptomatic cocaine addicted individuals with simultaneous positron emission tomography/magnetic resonance imaging显示文摘BACKGROUND Chronic cocaine use is associated with stroke, coronary artery disease and myocardial infarction, resulting in severe impairments or sudden mortality. In the absence of clear cardiovascular symptoms, individuals with cocaine use disorder (iCUD) seeking addiction treatment receive mostly psychotherapy and psychiatric pharmacotherapy, with no attention to vascular disease (i.e., atherosclerosis). Little is known about the pre-clinical signs of cardiovascular risk in iCUD and early signs of vascular disease are undetected in this underserved population. AIM To assess inflammation, plaque burden and plaque composition in iCUD aiming to detect markers of atherosclerosis and vascular disease. METHODS The bilateral carotid arteries were imaged with positron emission tomography/magnetic resonance imaging (PET/MRI) in iCUD asymptomatic for cardiovascular disease, healthy controls, and individuals with cardiovascular risk. PET with 18F-fluorodeoxyglucose (18F-FDG) evaluated vascular inflammation and 3-D dark-blood MRI assessed plaque burden including wall area and thickness. Drug use and severity of addiction were assessed with standardized instruments. RESULTS The majority of iCUD and controls had carotid FDG-PET signal greater than 1.6 but lower than 3, indicating the presence of mild to moderate inflammation. However, the MRI measure of wall structure was thicker in iCUD as compared to the controls and cardiovascular risk group, indicating greater carotid plaque burden. iCUD had larger wall area as compared to the healthy controls but not as compared to the cardiovascular risk group, indicating structural wall similarities between the non-control study groups. In iCUD, wall area correlated with greater cocaine withdrawal and craving. CONCLUSION These preliminary results show markers of carotid artery disease burden in cardiovascular disease-asymptomatic iCUD. Broader trials are warranted to develop protocols for early detection of cardiovascular risk and preventive intervention in iCUD. | Keren Bachi Venkatesh Mani Audrey E Kaufman Nadia Alie Rita Z Goldstein Zahi A Fayad Nelly Alia-Klein | 2019 | World Journal of Radiology2019，11，5： | 2 |
| 2 | Security of mobile agents on the Internet显示文摘 | Corradi A Montanari R Nelli E | 2001 | Internet Research-Electronic Networking Applications and Policy2001，11，1： | 1 |
| 3 | Growth factor regulation of enterocyte nutrient transport during intestinal adaptation显示文摘 | Edward C Ray Nelly E Avissar Harry C Sax | 2002 | The American Journal of Surgery2002，，4： | 1 |
| 4 | Utility of positron emission tomography-computed tomography scan in detecting residual hepatocellular carcinoma post treatment:Series of case reports显示文摘BACKGROUND Multi-phase computed tomography(CT)or magnetic resonance imaging(MRI)has been the standard of care for hepatocellular carcinoma(HCC)diagnosis for years.CASE SUMMARY We report a case series of four patients in whom positron emission tomographycomputed tomography(PET-CT)scan complemented the conventional CT/MRI scans in evaluating treatment response.In these four cases the conventional multi-phase CT and MRI failed to identify residual HCC disease post-treatment,while PET-CT complemented and aided in treatment response evaluation.In each case,the addition of PET-CT identified and located residual HCC disease,allowed retreatment,and altered medical management.CONCLUSION This case series suggests that PET-CT should perhaps play a role in the HCC management algorithm,in addition to the conventional contrast-enhanced multiphase scans. | Jason T Cheng Nelly E Tan Michael L Volk | 2020 | World Journal of Gastrointestinal Oncology2020，12，3： | 1 |
| 5 | Long-term tests of HVDC insulators under natural pollution conditions at the big eddy test center显示文摘 | Lampe W Hoglund T K E Nellis C L | 1989 | IEEE Trans on Power Delivery1989，4，1： | 1 |
| 6 | Growth factor regulation of enterocyte nutrient transport during intestinal adaptation 显示文摘 | EDWARD C RAY M D NELLY E | 2002 | The American Journal of Surgery2002，183，： | 1 |
| 7 | Randomized controlled trial of prenatal zinc supplementation and fetal bone growth显示文摘 | Mario M Laura E C Nelly Z | 2004 | Am J Clin Nutr2004，79，： | 1 |
| 8 | Growth factor regulation of enterocyte nutrient transport during intestinal adaptation显示文摘 | Edward C Ray M D Nelly E | 2002 | The American Journal of Surgery2002，183，： | 1 |
| 9 | Sub-ppm NO2 sen- sors based on nanosized thin films of titanium-tungsten oxides显示文摘 | NELLI P DEPERA L E FERRONI M | 1996 | Sensors and Actuators B: Chemical1996，31，12： | 1 |
| 10 | Growth factor regulation of enterocyte nutrient transport during intestinal adaptation显示文摘 | EDWARD C RAY M D NELLY E | 2002 | Amercian Surgery2002，183，： | 1 |
| 11 | Growth factor regulation of enteroeyte nutrient transport during intestinal adaptation显示文摘 | EDWARD C RAY M D NELLY E | 2002 | Amercian Surgery2002，183，： | 1 |
| 12 | Long-term tests of HVDC insulators under natural pollution conditions at the big eddy test center显示文摘 | Lampe W Hoglund T K E Nellis C L | 1989 | IEEE Trans on Power Delivery:1989，4，1： | 1 |
| 13 | Epidermal Growth Factor and/or Growth HormoneInduce Differential,Side-Specific Signal Transduction Protein Phosphorylation in Enterocytes/Discussant/Author's Response 显示文摘 | Nelly E Avissar | 2005 | Journal of Parenteral and Enteral Nutrition2005，5，29： | 1 |
| 14 | Identification of a new mutation in the SRY gene in a 46,XY women with Swyer syndrome显示文摘 | Marchina E Gambera A Spínelli E | | 0，，： | 1 |
| 15 | Contamination transport in immersion lithography显示文摘 | NELLIS G F MORSI M S E PESKI C V | 2006 | Journal of Microlithography Microfabrication and Micro-systems2006，5，1： | 1 |
| 16 | Long-term tests of HVDC insulators under natural pollution conditions at the big eddy test center显示文摘 | Lampe W Hoglund T K E Nellis C L | 1989 | 1EEE Transactions on Power Deliver- y1989，4，1： | 1 |
| 17 | Randomized controlled trial of prenatal zinc supplementation and fetal bone growth显示文摘 | Mario M Laura E C Nelly Z | 2004 | Am J Clin Nutr2004，79，： | 1 |
| 18 | Growth factor regulation of enterocyte nutrient transport during intestinal adaptation显示文摘 | Edward C Ray M D Nelly E | 2002 | The American Journal of Surgery2002，183，： | 1 |
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