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| 1 | Response evaluation of chemotherapy in metastatic colorectal cancer by contrast enhanced ultrasound显示文摘AIM:To evaluate whether contrast enhanced ultrasound(CEUS) might also be used for response prediction and early response evaluation in patients receiving bevacizumab based chemotherapy for metastasized colorectal cancer.METHODS:Thirty consecutive patients with non primary resectable liver metastases from colorectal cancer underwent CEUS before treatment(CEUS date 1) and before the second(CEUS date 2) and fourth(CEUS date 3) cycle of bevacizumab based chemotherapy.Three parameters [PEAK,Time to peak(TTP) and RISE RATE]were correlated with radiological response.RESULTS:For neoadjuvant purpose a reduction of tumour mass was required to assume clinical response.Based on these response criteria there was a significant(P < 0.001) correlation in TTP between metastases of responders(9.08 s) and non-responders(14.76 s) archived on CEUS date 1.By calculating a standardized quotient(metastases divided by normal liver tissue) we were able to define a cut off,predicting response with a sensitivity of 92.3 % and a specificity of 100 %.To reflect a palliative intention only those patients with progressive disease were classified as non-responders.In this stetting TTP was also significantly(P < 0.01) different between responders and non-responders.In contrast,Peak and Rise rate did not show any significant difference between responder and non-responder.CONCLUSION:CEUS might serve as a surrogate marker to predict treatment response in patients with metastasized colorectal cancer who receive antiangiogenic therapy. | Ramin Schirin-Sokhan Ron Winograd Christoph Roderburg Jhenee Bubenzer Nicole Cabral do ó Dorothee Guggenberger Hartmut Hecker Christian Trautwein Jens J W Tischendorf | 2012 | World Journal of Gastroenterology2012，18，6： | 16 |
| 2 | The mitochondrial genome encodes abundant small noncoding RNAs显示文摘识别的小 noncoding RNA 都被原子染色体远因此编码。这里,我们主要报导鼠科、人的 mitochondrial 染色体编码几千小 noncoding RNA,它是源于 mitochondrial 基因(主人基因) 的感觉抄本,并且我们称为这些小 RNA mitochondrial 编码染色体的小 RNA (mitosRNAs ) 。影响的 DICER inactivation,但是完全没废除 mitosRNA 生产。MitosRNAs 看起来是当前未辩别出的 mitochondrial ribonucleases 的产品。提高的表示在 vitro 他们的主人基因铺平的 mitosRNAs 的 Overexpression,和 dysregulated mitosRNA 表示通常在 vivo 与异常 mitochondrial 基因表示被联系。我们的数据证明除了 37 已知的 mitochondrial 基因,哺乳动物的 mitochondrial 染色体也编码丰富的 mitosRNAs,它可以在房间在 mitochondrial 基因表示的控制起一个重要规章的作用。 | Seungil Ro Hsiu-Yen Ma Chanjae Park Nicole Ortogero Rui Song Grant W Hennig Huili Zheng Yung-Ming Lin2 Loredana Moro Jer-Tsong Hsieh wei Yant | 2013 | Cell Research2013，23，6： | 3 |
| 3 | Central line-associated bloodstream infection among children with biliary atresia listed for liver transplantation显示文摘BACKGROUND Pre-transplant nutrition is a key driver of outcomes following liver transplantation in children.Patients with biliary atresia(BA) may have difficulty achieving satisfactory weight gain with enteral nutrition alone,and parenteral nutrition(PN) may be indicated.While PN has been shown to improve anthropometric parameters of children with BA listed for liver transplantation,less is known about the risks,particularly infectious,associated with this therapy among this specific group of patients.AIM To describe the incidence,microbiology,and risk factors of central line-associated bloodstream infection(CLABSI) among children with BA listed for liver transplantation.METHODS Retrospective review of children aged ≤ 2-years of age with BA who were listed for primary liver transplantation at Texas Children's Hospital from 2008 through2015(n = 96).Patients with a central line for administration of PN(n = 63) were identified and details of each CLABSI event were abstracted.We compared the group of patients who experienced CLABSI to the group who did not,to determine whether demographic,clinical,or laboratory factors correlated with development of CLABSI.RESULTS Nineteen of 63 patients(30%,95%CI:19,43) experienced 29 episodes of CLABSI during 4800 line days(6.04 CLABSI per 1000 line days).CLABSI was predominantly associated with Gram-negative organisms(14/29 episodes,48%)including Klebsiella spp.,Enterobacter spp.,and Escherichia coli.The sole polymicrobial infection grew Enterobacter cloacae and Klebsiella pneumoniae.Grampositive organisms(all Staphylococcus spp.) and fungus(all Candida spp.)comprised 9/29(31%) and 6/29(21%) episodes,respectively.No demographic,clinical,or laboratory factors were significantly associated with an increased risk for the first CLABSI event in Cox proportional hazards regression analysis CONCLUSION There is substantial risk for CLABSI among children with BA listed for liver transplantation.No clinical,demographic,or laboratory factor we tested emerged as an independent predictor of CLABSI.While our data did not show an impact of CLABSI on the short-term clinical outcome,it would seem prudent to implement CLABSI reduction strategies in this population to the extent that each CLABSI event represents potentially preventable hospitalization,unnecessary healthcare dollar expenditures,and may exact an opportunity cost,in terms of missed allograft offers. | Nicole D Triggs Stacey Beer Sonam Mokha Kat Hosek Danielle Guffey Charles G Minard Flor M Munoz Ryan W Himes | 2019 | World Journal of Hepatology2019，11，2： | 2 |
| 4 | 显示文摘 | Bos G W Nicole M | 1999 | Biomed Mater Res1999，44，： | 1 |
| 5 | activity and temperature responses of ammonia-oxidizing archaea and bacteria in soil microcosms 显示文摘 | Tourna M Freitag T E Nicol G W | 2008 | Environmental Microbiology2008，10，5： | 1 |
| 6 | Myc Family Oncogenes in the Development of Normal and Neoplastic Cell显示文摘 | Ronald A D Nicole S A Fredrck W A | 1991 | Adv Cancer Res1991，57，： | 1 |
| 7 | Dandy-Walker malfor- mation:prenatal diagnosis and outcome显示文摘 | Nicole K Josef W Josef K | 2000 | Prenat Diagn2000，20，4： | 1 |
| 8 | Antarctic krill (Euphausia superba) acquire a UV- absorbing mycosporine-like aminoacid from dietary algae显示文摘 | NEWMAN S J DUNLAP W C NICOL S | 2000 | Journal of Experimental Marine Biology and Ecology2000，255，： | 1 |
| 9 | Formation of crystalloid inclusions in the small intestine of neonatal pigs:an immunocytochemical study using colloidal gold显示文摘 | Komüves L G Nicols B L Hutchens T W | 1993 | Histochemical Journal1993，25，1： | 1 |
| 10 | Accuracy of the Xpert MTB/RIF test for the diagnosis of pulmonary tuberculosis in chil- dren admitted to hospital in Cape Town, South Africa: a descrip- tive study显示文摘 | Nicol MP Workman L Isaacs W | 2011 | Lancet Infect Dis2011，11，11： | 1 |
| 11 | Homologues of nitrite reductases in ammonia-oxidizing archaea:diversity and genomic context 显示文摘 | Bartossek R Nicol G W Lanzen A | 2010 | Environ Microbiol2010，12，4： | 1 |
| 12 | A general approach to desalting oligosaccharides released from glycoproteins显示文摘 | Nicolle H Packer Margaret A Lawson Daniel R Jardine John W Redmond | 1998 | Glycoconjugate Journal1998，，8： | 1 |
| 13 | Analysis of centromere structure in the fly Megaselia scalaris(Phoridae,Diptera)using CREST sera,antihistone antibodies,and a repetitive DNA probe显示文摘 | Wolf K W Mitchell A Nicol L | 1994 | Biol Cell1994，80，： | 1 |
| 14 | Ginsenosides stimulate the growth of soilborne pathogens of American ginseng显示文摘 | Nicol R W Yousefa L Traquairb J A | 2003 | Phytochemistry2003，64，： | 1 |
| 15 | Oxygen Phase Equilibria near 298 K 显示文摘 | Nicol M Hirsch K R Holzapfel W B | 1979 | Chem Phys Lett1979，68，： | 1 |
| 16 | Radiotherapy for highgrade gliomas does altered fractionafion improve the out-come?显示文摘 | CARSTEN N NICOLAUS A NICOLE W | 2004 | Strahlentherapieund Oncologie2004，7，： | 1 |
| 17 | Beta-blockade improves adjacent regional sympathetic innervation during postinfarction remodeling 显示文摘 | Kramer CM Nicol PD Rogers W J | 1999 | Am J Physiol1999，277，9： | 1 |
| 18 | Radiotherapy for high-grade gliomas显示文摘 | Carsten N Nicolaus A Nicole W | 2004 | Strahlenther Oncol2004，180，7： | 1 |
| 19 | Health Benefits of Physical Activity:The Evidence显示文摘 | Warburton D E Nicol C W Bredin S S | 2006 | Canadian Medical Association Journal2006，174，6： | 1 |
| 20 | Nutrition education for children-results and perspectives显示文摘 | NICOLE W DIRK M WILHELM K | 2005 | J Public Health2005，13，2： | 1 |
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