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| 1 | Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics显示文摘交往受体的蛋白质 kinase-3 (RIP3 或 RIPK3 ) 是执行 “ 的细胞的机械的必要部分; programmed”或 “ regulated”坏死。这里,我们证明那规划坏死响应许多化学疗法的代理人被激活并且贡献导致化疗的房间死亡。然而,我们证明那 RIP3 表情经常在化学疗法的死亡期间由于它的 transcriptional 开始地点, MLKL 的这样 RIP3 依赖的激活和下游地规划的坏死附近的 genomic methylation 是在癌症房间的 silenced 大部分被镇压。不过,有 hypomethylating 代理人的治疗恢复 RIP3 表示,并且从而以一种 RIP3 依赖的方式把敏感提升到 chemotherapeutics。RIP3 表示在 85% 乳癌病人与正常织物相比在肿瘤被减少,建议那 RIP3 缺乏断然在肿瘤生长 / 发展期间被选择。因为 hypomethylating 代理人在病人是相当容忍得好的,我们建议病人们可以从收到 hypomethylating 代理人与常规 chemotherapeutics 在治疗以前导致 RIP3 表示有益于的那 RIP3 缺乏的癌症。 | Gi-Bang Koo Michael J Morgan Da-Gyum Lee Woo-Jung Kim Jung-Ho Yoon Ja Seung Koo Seung I1 Kim Soo Jung Kim Mi Kwon Son Soon Still Hong Jean M Mulcahy Levy Daniel A Pollyea Craig T Jordan Pearlly Yan David Frankhouser Deedra Nicolet Kati Maharry Guido Marcucci Kyeong Sook Choi Hyeseong Cho ndrew Thorbum You-Sun Kim | 2015 | Cell Research2015，25，6： | 20 |
| 2 | Leukemia:研究鉴定出与34种AML白血病亚群相关联的基因突变显示文摘针对成年急性髓细胞白血病(acute myeloid leukemia,AML)患者的一项新的大型研究将80种癌症相关基因突变与5种AML亚型相关联。这5种AML亚型可通过特异性的染色体异常加以确定。在未来,这些发现可能有助指导基因突变测试和治疗决策。 | A-K Eisfeld K Mrózek J Kohlschmidt D Nicolet S Orwick C J Walker K W Kroll J S Blachly A J Carroll J E Kolitz B L Powell E S Wang R M Stone A de la Chapelle J C Byrd C D Bloomfield | 2017 | 现代生物医学进展2017，17，15： | 7 |
| 3 | Diffusion barriers in thin films显示文摘 | Nicolet M A | 1978 | Thin Solid Films1978，52，： | 1 |
| 4 | The solar spcctral irradiance and its action in the atmospheric photodissociation processes显示文摘 | Nicolet M | | 0，，29： | 1 |
| 5 | Congenital cytomegalovirus infection manifesting as neonatal persis-tent pulmonary hypertension : report of two cases 显示文摘 | WALTER NICOLET E LEBLANC M LERUEZ VILLE M | 2011 | Pulm Med2011，2011，： | 1 |
| 6 | 显示文摘 | Nicolet M A Mayer J W | 1971 | Applied Physics Letter1971，18，： | 1 |
| 7 | Reaction of thin metal films with SiOz substrates显示文摘 | Pretorius R HarrisJ M Nicolet M A | 1978 | Solid State E?lectron1978，21，： | 1 |
| 8 | Antigenic and Genetic Characterization of Lipoprotein LppQ from Mycoplasma mycoides subsp, mycoides SC显示文摘 | Abdo E M Nicolet J Frey J | 2000 | Clin Diagn Lab Immunol2000，7，： | 1 |
| 9 | Spontaneous and iatrogenic spreading of liver-derived cells into peripheral blood of patients with primary liver cancer 显示文摘 | Louha M Poussin K Ganne N Zylberberg H Nalpas B Nicolet J | 1997 | Hepatology1997，26，： | 1 |
| 10 | Prostaglandin E(2 )-loaded microspheres as strategy to inhibit phagocytosis and modulate inflammatory mediators release显示文摘 | Roberto Nicolete R Lima Kde M JOnior JM | 2008 | Eur J Pharm Biop- harm2008，70，3： | 1 |
| 11 | The solar spectral irradiance and its action in the atmospheric photodissociation process 显示文摘 | Nicolet M | 1981 | Planet Space Sci1981，29，： | 1 |
| 12 | Diffusion barriers in lay-ered contacts structures 显示文摘 | M A Nicolet M Bartur | 1981 | Vac sci Technol1981，19，3： | 1 |
| 13 | An enzyme-linked immunosorbent assay,using an EDTA-extracted antigen for serology of Haemophilus pleuropneumoniae显示文摘 | Nicolet J Krawinkler M Baurngartner A | 1981 | Am J Vet Res1981，42，： | 1 |
| 14 | Contact resistivity of Re, Pt and Ta films on n-type β-SiC: preliminary results显示文摘 | Chen J S B(a)chli A Nicolet M A | 1995 | Materials Science and Engineering1995，29，： | 1 |
| 15 | M-cadherin localization in developing adult and regenerating mouse skeletal muscle: possible involvement in secondary myogenesis 显示文摘 | CIFUENTES-DIAZ C NICOLET M ALAMEDDINE H | 1995 | Mech Dev1995，50，： | 1 |
| 16 | Comparison of enzyme-linked immunosorbent assay(ELISA)and indirect hemagglutination(IHA)in experimental Mycoplas-ma hyopneumoniae infection of pigs显示文摘 | KOBISCH M NICOLET J | 1987 | Isr J Med Sci1987，23，6： | 1 |
| 17 | Laparoscopic cervico-isthmic cerclage evaluation显示文摘 | Nicolet G Cohen M Begue L | | 0，，04： | 1 |
| 18 | Detection and identification of Mycoplasma conjunctivae in infectious keratoconjunctivitis by PCR based on the 16S rRNA gene 显示文摘 | Giacometti M Nicolet J Johansson K E | 1999 | J Vet Med B1999，46，： | 1 |
| 19 | The solar spectral irradiance and its action ill the atmospheric photodissociation processes 显示文摘 | Nicolet M | 1981 | Planet Space Sci1981，29，： | 1 |
| 20 | Premedication before tracheal intubation in french neonatal intensive care units and delivery rooms 显示文摘 | Walter - Nicolet E Flamant C Negrea M | 2007 | Arch Pediatr2007，14，2： | 1 |
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