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| 1 | Endoscopic submucosal dissection training with pig models in a Western country显示文摘AIM:To test a strategy for endoscopic submucosal dissection(ESD) training in animal models designed to overcome the initial learning curve.METHODS:ESD was attempted in ex vivo and in vivo pig models.Thirty ESD procedures were attempted in the esophagus(n=9) or the stomach(n=21).The ex vivo model was used until initial competence was achieved.In the in vivo model,several ESD procedures were performed in up to 3 sessions.The following variables were analyzed:specimen size,complete and en bloc resection rate,time for circumferential incision,time for submucosal dissection,total ESD duration,and complications.RESULTS:Complete resection was achieved in 28 cases(en bloc 27);2 could not be completed(one perforation,one technical diff iculty).The mean ± SD time for circumferential incision was 36.2±16.8 min(range:8-87 min),and the mean±SD time for submucosal dissection was 45.1±35.7 min(range:9-196 min).The mean±SD size of the resected specimens was 45.2±17.8 mm.The mean±SD total resection time was signif icantly increased for the gastric cases performed in the f irst half of the study(n=13) than in the second half(n=8)(98.9±62.4 min vs 61.7±17.6 min,P=0.04),although the specimen size did not differ.CONCLUSION:Training in animal models could help endoscopists overcome the learning curve before starting ESD in humans. | Adolfo Parra-Blanco María Rosa Arnau David Nicolás-Pérez Antonio Z Gimeno-García Nicolás González Juan A Díaz-Acosta Alejandro Jiménez Enrique Quintero | 2010 | World Journal of Gastroenterology2010，16，23： | 9 |
| 2 | Direct evidence for glutathione as mediator of apoptosis in neuronal cells 显示文摘 | Santiard-Baron D Caballos-Pical 1 | 1998 | Biomed Pharmacother1998，52，9： | 1 |
| 3 | Myc Family Oncogenes in the Development of Normal and Neoplastic Cell显示文摘 | Ronald A D Nicole S A Fredrck W A | 1991 | Adv Cancer Res1991，57，： | 1 |
| 4 | Interaction between prion protein and toxic amyloid beta assemblies can be therapeutically targeted at multiple sites显示文摘 | Freir D B Nicoll A J Klyubin I | | 0，，： | 1 |
| 5 | Mitochondrial impairment as an early event in the process of apoptosis induced by glutathione depletion in neuronal cells:relevance to Parkinson's disease显示文摘 | Merad-Boudia M Nicole A Santiard-Baron D | 1998 | Biochem Pharmacol1998，56，： | 1 |
| 6 | Effects of vent ducts on the reduced pressure from explosion in dust collectors显示文摘 | Lunn G A Nicol A M Coliins P D | 1998 | Journal of Loss Prevention in the Process Industries1998，11，： | 1 |
| 7 | Transplantation of mouonue- lear cells from human umbilical cord blood promotes functional recovery after traumatic spinal cord injury in Wistarrats显示文摘 | Rodrigues LP Iglesias D Nicol a FC | 2012 | Braz J Mcd Bio Res2012，45，1： | 1 |
| 8 | Risk factors for dental caries in young children显示文摘 | HARRIS R NICOLL A D PINE C M | 2004 | A systematic review of the literature2004，21，1： | 1 |
| 9 | The role of leadership in in- stilling a culture of safety: lessons from the literature显示文摘 | Hirsch R R Nicole L D Mark A C | 2004 | Journal of Health- care Management2004，49，1： | 1 |
| 10 | The human BTG2/TIS21/PC3 gene:genomic structure,transcriptional regulation and evaluation as a candidate tumor suppressor gene显示文摘 | Cyril D Nicole F Carole A | 2002 | Gene2002，282，12： | 1 |
| 11 | Real-time prediction of hand trajectory by ensemblesof cortical neurons in primates显示文摘 | Wessberg J Stambaugh C R Kralik J D Beck P D Laubach M Chapin J K Kim J Biggs J Srinivasan M A Nicolelis M A L | 2000 | Nature2000，408，： | 1 |
| 12 | Cooperative organization of inorganic-surfactant and biomimetic assemblies显示文摘 | FIROUZI A KUMAR D BULL L BESIER T SIEGER P HUO Q WALKER S ZASADZINSKI J GLINKA C NICOL J | 1995 | Science1995，267，5201： | 1 |
| 13 | Measles-Mumps-Rubella vaccination and autism 1998 显示文摘 | Nicoll A Elliman D Ross E | 1998 | BMJ1998，316，7133： | 1 |
| 14 | Measles-Mumps-Rubella vaccination and autism 1998 显示文摘 | Nicoll A Elliman D Ross E | 1998 | BMJ1998，316，7133： | 1 |
| 15 | Stable carbon and nitrogen isotope ratios of Eucalyptus and Acacia species along a seasonal rainfall gradient in Western Australia显示文摘 | SCHULZE E D NICOLLE D BOERNER A | 2014 | Trees2014，228，4： | 1 |
| 16 | Righthemisphere auditory cortex is dominant for coding syllable patterns in speech显示文摘 | ABRAMS D A NICOL T ZECKER S | 2008 | J Neurosci2008，28，： | 1 |
| 17 | The effect of volatile fatty acids on enhanced biological phosphorus removal and population structure in anaerobic/aerobic sequencing batch reactors显示文摘 | Randall A A Benet2eld L D Nicol J P | 1997 | Water Science And Technology1997，35，1： | 1 |
| 18 | Burden of adhesions in abdominal and pelvic surgery: systematic review and met-analysis显示文摘 | Richard P G ten Broek Yama Issa Evert J P van Santbrink Nicole D Bouvy Roy F P M Kruitwagen Johannes Jeekel Erica A Bakkum Maroeska M Rovers Harry van Goor | 2013 | BMJ (oct )2013，，031： | 1 |
| 19 | An automated method for themeasurement of folate activity显示文摘 | DAVIS R E NICOL D J KELLY A | 1970 | J Clin Path1970，23，： | 1 |
| 20 | Modeling the global Internet显示文摘 | Cowie J H Nicol D M Ogielski A T | 1999 | Computing in Science & Engineering1999，1，1： | 1 |
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