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| 1 | Clinical Features of Adult/Adolescent Atopic Dermatitis and Chinese Criteria for Atopic Dermatitis显示文摘 | Ping Liu Yan Zhao Zhang-Lei Mu Qian-Jin Lu Qian-Jin L U Li Zhang Xu Yao Min Zheng Yi-Wen Tang Xin-Xiano Lu Xiu-Juan xia You-Kun Lin Yu-Zhen Li Cai-Xia Tu Zhi-Rong Yao Jin-Hua Xu Wei Li Wei Lai Hui-Min Yang Hong-Fu Xie Xiu-Ping Han Zhi-Qiang Xie Xiang Nong Zai-Pei Guo Dan-Qi Deng Tong-Xin Shi Jian-Zhong Zhang | 2016 | Chinese Medical Journal2016，，7： | 64 |
| 2 | Active Faulting Pattern,Present-day Tectonic Stress Field and Block Kinematics in the East Tibetan Plateau显示文摘这篇论文由从出版文学集成可得到的数据在东方西藏的高原检验主要活跃差错和今日的构造压力地并且建议这个区域的一个块 kinematics 模型。它证明东方西藏的高原被罢工滑倒和反向的指责压力政体统治并且最大的水平压力与当代的速度地粗略地一致,除了在哪儿的西方 Qinling 范围它罢工主要罢工滑倒指责的平行。在东方西藏的高原的活跃 tectonics 被三描绘指责系统。指责系统的离开滑倒 Kunlun-Qinling 联合东方 Kunlun 差错地区,沿着 Minshan 范围的左首的倾斜的反向的差错和切西方 Qinling 范围的二个主要旧姓惹人注目的差错,它提供东方运动,在 10 14 mm/a, Chuan-Qing 块。指责系统的离开滑倒 Xianshuihe 顺时针方向提供了 Chuan-Dian 块的旋转。指责系统的 Longmenshan 戳形成东方西藏的高原的东方边缘并且被宣传了到四川盆的 SW。越过 Longmenshan 范围的外壳的弄短似乎低(2 4 mm/a ) 并且吸收了仅仅 Chuan-Qing 块的东方运动的小部分。大多数这个东方运动被传给华南,它是在 7 9 mm/a 的动人的看见病房。东方西藏的高原的外壳和岩石圈更加被变厚,这从地球物理的数据解释被建议并且变阻器逻辑地分层。上面的外壳似乎是从通过在 15 20 km 的深度的一个 d é collement 地区的更低的外壳的 decoupled,它包含了 Longmenshan 差错带并且宣传对四川盆的 SW 东方。Wenchuan 地震就在这个 d é collement 系统的区分的点被形成。一个变阻器逻辑边界应该在在哪儿的 Longmenshan 差错带下面存在东方西藏的高原和石版印刷的更低的外壳 Yangze 块的球的披风被并列。 | ZHANG Yueqiao DONG Shuwen YANG Nong | 2009 | Acta Geologica Sinica(English Edition)2009，83，4： | 34 |
| 3 | UGT1A1 predicts outcome in colorectal cancer treated with irinotecan and fluorouracil显示文摘AIM:To evaluate effects of UDP-glucuronosyltransferase1A1(UGT1A1) and thymidylate synthetase(TS) gene polymorphisms on irinotecan in metastatic colorectal cancer(mCRC).METHODS:Two irinotecan-and fluorouracil-based regimens,FOLFIRI and IFL,were selected as second-line therapy for 138 Chinese mCRC patients.Genomic DNA was extracted from peripheral blood samples before treatment.UGT1A1 and TS gene polymorphisms were determined by direct sequencing and restriction fragment length polymorphism,respectively.Gene polymorphisms of UGT1A1*28,UGT1A1*6 and promoter enhancer region of TS were analyzed.The relationship between genetic polymorphisms and clinical outcome,that is,response,toxicity and survival were assessed.Pharmacokinetic analyses were performed in a subgroup patients based on different UGT1A1 genotypes.Plasma concentration of irinotecan and its active metabolite SN-38 and inactive metabolite SN-38G were determined by high performance liquid chromatography.Differences in irinotecan and its metabolites between UGT1A1 gene variants were compared.RESULTS:One hundred and eight patients received the FOLFIRI regimen,29 the IFL regimen,and one irinotecan monotherapy.One hundred and thirty patients were eligible for toxicity and 111 for efficacy evaluation.One hundred and thirty-six patients were tested for UGT1A1*28 and *6 genotypes and 125 for promoter enhancer region of TS.Patients showed a higher frequency of wild-type UGT1A1*28(TA6/6) compared with a Caucasian population(69.9% vs 45.2%).No significant difference was found between response rates and UGT1A1 genotype,although wild-type showed lower response rates compared with other variants(17.9% vs 24.2% for UGT1A1*28,15.7% vs 26.8% for UGT1A1*6).When TS was considered,the subgroup with homozygous UGT1A1*28(TA7/7) and non-3RG genotypes showed the highest response rate(33.3%),while wild-type UGT1A1*28(TA6/6) with non-3RG only had a 13.6% response rate,but no significant difference was found.Logistic regression showed treatment duration was closely linked to clinical response.In toxicity comparison,UGT1A1*28 TA6/6 was associated with lower incidence of grade 2-4 diarrhea(27.8% vs 100%),and significantly reduced the risk of grade 4 neutropenia compared with TA7/7(7.8% vs 37.5%).Wild-type UGT1A1*6(G/G) tended to have a lower incidence of grade 3/4 diarrhea vs homozygous mutant(A/A) genotype(13.0% vs 40.0%).Taking UGT1A1 and TS genotypes together,lower incidence of grade 2-4 diarrhea was found in patients with non-3RG TS genotypes,when TA6/6 was compared with TA7/7(35.3% vs 100.0%).No significant association with time to progression(TTP) and overall survival(OS) was observed with either UGT1A1 or TS gene polymorphisms,although slightly longer TTP and OS were found with UGT1A1*28(TA6/6).Irinotecan PK was investigated in 34 patients,which showed high area under concentration curve(AUC) of irinotecan and SN-38,but low AUC ratio(SN-38G /SN-38) in those patients with UGT1A1*28 TA7/7.CONCLUSION:A distinct distribution pattern of UGT1A1 genotypes in Chinese patients might contribute to relatively low toxicity associated with irinotecan and 5-fluorouracil in mCRC patients. | Yan Wang Lin Shen Nong Xu Jin-Wan Wang Shun-Chang Jiao Ze-Yuan Liu Jian-Ming Xu | 2012 | World Journal of Gastroenterology2012，18，45： | 34 |
| 4 | Efficacy and safety of a novel anti-HER2 therapeutic antibody RC48 in patients with HER2-overexpressing,locally advanced or metastatic gastric or gastroesophageal junction cancer:a single-arm phase II study显示文摘Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit.Further,there is no specific treatment for HER2 immunohistochemistry(IHC)2+and fluorescence in-situ hybridization-negative patients.Here,we report the efficacy and safety of a novel anti-HER2 antibody RC48 for patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer.Methods:Patients with HER2-overexpressing(IHC 2+or 3+),locally advanced or metastatic gastric or gastroesophageal junction cancer who were under at least second-line therapy were eligible and received RC482.5 mg/kg alone every 2 weeks.The primary endpoint was the objective response rate(ORR)assessed by an independent review committee.Secondary endpoints included progressionfree survival(PFS),overall survival(OS),duration of response,time to progression,disease control rate,and safety.Results:Of 179 patients screened,125 were eligible and received RC48 treatment.The ORR was 24.8%(95%confidence interval[CI]:17.5%-33.3%).The median PFS and OS were 4.1 months(95%CI:3.7-4.9 months)and 7.9 months(95%CI:6.7-9.9 months),respectively.The most frequently reported adverse events were decreased white blood cell count(53.6%),asthenia(53.6%),hair loss(53.6%),decreased neutrophil count(52.0%),anemia(49.6%),and increased aspartate aminotransferase level(43.2%).Serious adverse events(SAEs)occurred in 45(36.0%)patients,and RC48-related SAEs were mainly decreased neutrophil count(3.2%).Seven patients had adverse events that led to death were not RC48-related.Conclusions:RC48 showed promising activity with manageable safety,suggesting potential application in patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer who have previously received at least two lines of chemotherapy. | Zhi Peng Tianshu Liu Jia Wei Airong Wang Yifu He Liuzhong Yang Xizhi Zhang Nanfeng Fan Suxia Luo Zhen Li Kangsheng Gu Jianwei Lu Jianming Xu Qingxia Fan Ruihua Xu Liangming Zhang Enxiao Li Yuping Sun Guohua Yu Chunmei Bai Yong Liu Jiangzheng Zeng Jieer Ying Xinjun Liang Nong Xu Chao Gao Yongqian Shu Dong Ma Guanghai Dai Shengmian Li Ting Deng Yuehong Cui Jianmin Fang Yi Ba Lin Shen | 2021 | Cancer Communications2021，41，11： | 29 |
| 5 | Comprehensive power-supply planning for active distribution system considering cooling,heating and power load balance显示文摘An active distribution system power-supply planning model considering cooling,heating and power load balance is proposed in this paper.A regional energy service company is assumed to be in charge of the investment and operation for the system in the model.The expansion of substations,building up distributed combined cooling,heating and power(CCHP),gas heating boiler(GHB)and air conditioner(AC)are included as investment planning options.In terms of operation,the load scenarios are divided into heating,cooling and transition periods.Also,the extreme load scene is included to assure the power supply reliability of the system.Numerical results demonstrate the effectiveness of the proposed model and illustrate the economic benefits of applying distributed CCHP in regional power supply on investment and operation. | Xinwei SHEN Yingduo HAN Shouzhen ZHU Jinghong ZHENG Qingsheng LI Jing NONG | 2015 | Journal of Modern Power Systems and Clean Energy2015，3，4： | 24 |
| 6 | Histological Subtypes of Lung Cancer in Chinese Males from 2000 to 2012显示文摘Objective To characterize the histological and epidemiological features of male lung cancer patients in China. Methods The demographic and histological information about male lung cancer patients identified from 2000-01-01 to 2012-12-31,was collected from the Cancer Hospital of the Chinese Academy of Medical Sciences. Relative frequencies(RF) were estimated for major histological subtypes and compared according to the years of diagnosis and birth. Results The RF of adenocarcinoma(ADC) increased from 21.96% to 43.36% and the RF of squamous cell carcinoma(SCC) decreased from 39.11% to 32.23% from 2000 to 2012 in the 15 427 male lung cancer patients included in this study(Z=17.909,P<0.0001; Z=-6.117,P<0.0001). The RF of ADC increased from 28.72% in 2000-2004,36.88% in 2005-2008 to 48.61% in 2009-2012 in patients born after 1960. The age-adjusted RF of ADC in 2007-2012 increased consistently in all the investigated areas. Conclusion The increased RF of ADC in male lung cancer patients highlights the need for further investigation of the etiologic factors of these tumors. Smoke-free policies rather than modifying tobacco products should be enforced. | ZOU Xiao Nong LIN Dong Mei WAN Xia CHAO Ann FENG Qin Fu DAI Zhen YANG Gong Huan LV Ning | 2014 | Biomedical and Environmental Sciences2014，27，1： | 19 |
| 7 | Effectiveness of Different Waist Circumference Cut-off Values in Predicting Metabolic Syndrome Prevalence and Risk Factors in Adults in China显示文摘Objective To study the effectiveness of waist circumference cut-off values in predicting the prevalence of metabolic syndrome(MetS) and risk factors in adults in China. Methods A cross-sectional survey was condcuted in 14 provinces(autonomous region, municipality) in China. A total of 47 325 adults aged ≥20 years were selected by multistage stratified sampling, and questionnaire survey and physical and clinical examination were conducted among them. MetS was defined according to the International Diabetes Federation(IDF) criteria and modified IDF criteria.Results The age-standardized prevalence of MetS was 24.2%(22.1% in men and 25.8% in women) and 19.5%(22.1% in men and 18.0% in women) according to the IDF criteria and modified IDF criteria respectively. The age-standardized prevalence of pre-MetS was 8.1%(8.6% in men and 7.8% in women) according to the modified IDF criteria. The prevalence of MetS was higher in urban residents than rural residents and in northern China residents than in southern China residents. The prevalence of central obesity was about 30% in both men and women according to the ethnicity-specific cut-off values of waist circumference for central obesity(90 cm for men and 85 cm for women). Multivariate regression analysis revealed no significant difference in risk factors between the two MetS definitions. Conclusion Using both the modified IDF criteria and ethnicity-specific cut-off values of waist circumference can provide more useful information about the prevalence of MetS in China. | ZHOU Hai Cheng LAI Ya Xin SHAN Zhong Yan JIA Wei Ping YANG Wen Ying LU Ju Ming WENG Jian Ping JI Li Nong LIU Jie TIAN Hao Ming JI Qiu He ZHU Da Long CHEN Li GUO Xiao Hui ZHAO Zhi Gang Li Qiang ZHOU Zhi Guang GE Jia Pu SHAN Guang Liang | 2014 | Biomedical and Environmental Sciences2014，27，5： | 17 |
| 8 | Estimation Method of State-of-Charge For Lithium-ion Battery Used in Hybrid Electric Vehicles Based on Variable Structure Extended Kalman Filter显示文摘Since the main power source of hybrid electric vehicle(HEV) is supplied by the power battery,the predicted performance of power battery,especially the state-of-charge(SOC) estimation has attracted great attention in the area of HEV.However,the value of SOC estimation could not be greatly precise so that the running performance of HEV is greatly affected.A variable structure extended kalman filter(VSEKF)-based estimation method,which could be used to analyze the SOC of lithium-ion battery in the fixed driving condition,is presented.First,the general lower-order battery equivalent circuit model(GLM),which includes column accumulation model,open circuit voltage model and the SOC output model,is established,and the off-line and online model parameters are calculated with hybrid pulse power characteristics(HPPC) test data.Next,a VSEKF estimation method of SOC,which integrates the ampere-hour(Ah) integration method and the extended Kalman filter(EKF) method,is executed with different adaptive weighting coefficients,which are determined according to the different values of open-circuit voltage obtained in the corresponding charging or discharging processes.According to the experimental analysis,the faster convergence speed and more accurate simulating results could be obtained using the VSEKF method in the running performance of HEV.The error rate of SOC estimation with the VSEKF method is focused in the range of 5% to 10% comparing with the range of 20% to 30% using the EKF method and the Ah integration method.In Summary,the accuracy of the SOC estimation in the lithium-ion battery cell and the pack of lithium-ion battery system,which is obtained utilizing the VSEKF method has been significantly improved comparing with the Ah integration method and the EKF method.The VSEKF method utilizing in the SOC estimation in the lithium-ion pack of HEV can be widely used in practical driving conditions. | SUN Yong MA Zilin TANG Gongyou CHEN Zheng ZHANG Nong | 2016 | Chinese Journal of Mechanical Engineering2016，29，4： | 17 |
| 9 | Rapid Identification and Emergency Investigation of Surface Ruptures and Geohazards Induced by the M_s 7.1 Yushu Earthquake显示文摘基于 InSAR,技术被证明在我们表面破裂和 geohazards 的紧急情况调查有效的快速的鉴定由 Yushu 地震导致了。Yushu 地震的产生地震的差错是 Garz 瑩 ? 慲的 Yushu 节吗? | ZHANG Yongshuang YAO Xin XIONG Tanyu MA Yinsheng HU Daogong YANG Nong GUO Changbao | 2010 | Acta Geologica Sinica(English Edition)2010，84，6： | 17 |
| 10 | Oroxindin inhibits macrophage NLRP3 inflammasome activation in DSS-induced ulcerative colitis in mice via suppressing TXNIP-dependent NF-κB pathway显示文摘Oroxindin is a flavonoid isolated from the traditional Chinese medicine Huang-Qin,which has shown various pharmacological activities including anti-inflammatory,antitumor,antioxidant,etc.Thus far,the effect of oroxindin on colonic inflammation and the underlying mechanism remain unknown.In this study,we investigated the tissue distribution of oroxindin and its therapeutic effects on ulcerative colitis(UC)as well as the underlying mechanisms.UC model was established in mice by administrating dextran sulfate sodium(DSS)in drinking water for 7 d.We first showed that oroxindin was largely absorbed by the colon as an active ingredient after normal mice received Huang-Qin-Tang,a traditional Chinese medicine decoction.UC mice were then treated with oroxindin(12.5,25,50 mg-kg^-1·d^-1,i.g.)for 10 d.We found that oroxindin treatment greatly suppressed massive macrophages infiltration and attenuated pathological changes in colonic tissue.Furthermore,oroxindin treatment significantly inhibited the generation of IL-13 and IL-18 in the colon via inhibiting the nucleotide-binding oligomerization domain-like receptor 3(NLRP3)inflammasome formation and activation.In cultured macrophages,LPS induced NLRp3 inflammasome formation and caspase-1 activation,which were suppressed by oroxindin(12.5-50μM).In LPS-treated macrophages,oroxindin dose-dependently restored the expression of TXNIP protein,leading to suppressing TXNIP-dependent NF-κB activation.In conclusion,these results demonstrate that oroxindin could be absorbed by the colon and attenuate inflammatory responses via inhibiting NLRP3 inflammasome formation and activation,which is related to the inhibitory effect on TXNIP-dependent NF-κB-signaling pathway.Hence,oroxindin has the potential of becoming an effective drug for treating UC. | Qi Liu Rui Zuo Kai Wang Fei-fei Nong Ya-jun Fu Shao-wei Huang Zeng-feng Pan Yi Zhang Xia Luo Xiang-liang Deng Xiao-xue Zhang Lian Zhou Yang Chen | 2020 | Acta Pharmacologica Sinica2020，41，6： | 15 |
| 11 | 新型2-氨基-5-苯亚甲基-4H-咪唑啉-4-酮衍生物的合成及生物活性显示文摘通过烯基膦亚胺1与芳基异氰酸酯的aza-Witig反应得到碳二亚胺2,再用2与亲核试剂的成环反应制得10个新型的2-氨基-5-苯亚甲基-4H-咪唑啉-4-酮衍生物4.探讨了碳二亚胺2与不同亲核试剂反应的活性并分离得到了一个胍中间体3i. | DING Ming Wu *, TU Hai Yang, LIU Zhao Jie, ZHUANG Nong Bo (Institute of Organic Synthesis, Central China Normal University, Wuhan, 430079) | 1998 | 高等学校化学学报1998，19，6： | 15 |
| 12 | RRM1 gene expression in peripheral blood is predictive of shorter survival in Chinese patients with advanced non-small-cell lung cancer treated by gemcitabine and platinum显示文摘Objective:To evaluate the predictive values of gene expressions of ribonucleotide reductase M1(RRM1) and breast cancer susceptibility gene 1(BRCA1) in peripheral blood from Chinese patients with non-small-cell lung cancer(NSCLC) treated with gemcitabine plus platinum.Methods:Forty Chinese patients with advanced NSCLC were recruited and received gemcitabine 1200 mg/m 2 on Days 1 and 8 plus carboplatin AUC 5 on Day 1.RRM1 and BRCA1 expression levels in peripheral blood were detected by quantitative reverse transcription-polymerase chain reaction(RT-PCR) .Kaplan-Meier survival curve and log-rank test were performed to evaluate the correlation between gene expression and overall survival for these subjects.Results:No correlation was observed between gene expression of RRM1 and that of BRCA1(P>0.05) ,but there was a strong correlation between the expression of RRM1 and the response to chemotherapy(P=0.003) .Subjects with low RRM1 expression levels in peripheral blood had longer sur-vival time than those with high RRM1 expression levels(16.95 vs.12.76 months,log-rank 3.989,P=0.046) .However,no significant association between BRCA1 expression levels and survival time was found(16.80 vs.13.77 months,log-rank 0.830,P=0.362) .Conclusions:Patients with low RRM1 expression levels in peripheral blood have a greater response to chemotherapy and longer survival time.Advanced NSCLC patients with low RRM1 expression levels may benefit from gemcitabine plus platinum therapy.RRM1 mRNA expression in peripheral blood could be used to predict the prognosis of NSCLC treated by gemcitabine and platinum. | Lin-run WANG Guo-bing ZHANG Jian CHEN Jun LI Ming-wei LI Nong XU Yang WANG Jian-zhong SHEN TU4 | 2011 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2011，12，3： | 14 |
| 13 | Nerve Growth Factor and Vascular Endothelial Growth Factor: Retrospective Analysis of 63 Patients with Salivary Adenoid Cystic Carcinoma显示文摘Aim To detect the expression of nerve growth factor (NGF) and vascular endothelial growth factor (VEGF) in salivary adenoid cystic carcinoma (SACC) tissues, as well as to determine the correlation between growth factor expression and prognosis in SACC. Methodology Medical records of 63 patients surgically treated for SACC between January 1988 and October 2005 were reviewed. Immunohistochemistry was performed to examine the expression of NGF and VEGF in tumor tissues. Kaplan-Meier analysis and Cox's proportional hazard regression model were applied to assess predictors of survival. Results NGF and VEGF were overexpressed in SACC tissues, compared with those in normal salivary tissues (P<0.05), and the staining intensity of these two factors was stronger in groups of solid subtype, advanced TNM stage, perineural invasion and recurrence. Patients with high-expression of NGF and VEGF, solid subtype, advanced stage, perineural invasion, recurrence and extended resection alone had worse survival rates (P<0.05). Conclusion NGF and VEGF are expressed increasingly in the tissues of SACC cases with invasion and metastasis. NGF expression and VEGF expression are independent prognosis factors for survival. | Hao Li Xiao-lin Nong Qi Chen Yi-ping Yang Jia-quan Li Yan-ning Li | 2010 | International Journal of Oral Science2010，2，1： | 12 |
| 14 | Diagnosis and treatment of herpangina:Chinese expert consensus显示文摘Background Herpangina is a common infectious disease in childhood caused by an enterovirus.This consensus is aiming to standardize and improve herpangina prevention and clinical diagnosis.Methods The Subspecialty Group of Infectious Diseases,the Society of Pediatric,Chinese Medical Association and Nation Medical Quality Control Center for Infectious Diseases gathered 20 experts to develop the consensus,who are specialized in diagnosis and treatment of herpangina.Results The main pathogenic serotypes of herpangina include Coxsackievirus-A,Enterovirus-A and Echovirus.Its diagnosis can be rendered on the basis of history of epidemiology,typical symptoms,characteristic pharyngeal damage and virological tests.The treatment is mainly symptomatic,and incorporates topical oral spray with antiviral drugs.The course of herpangina generally lasts 4-6 days with a good prognosis.Conclusion The consensus could provide advices and references for the diagnosis,treatment and management of herpangina in children. | Hui Yu Xing-Wang Li Quan-Bo Liu Hui-Ling Deng Gang Liu Rong-Meng Jiang Ji-Kui Deng Ying-Zi Ye Jian-Hua Hao Ying-Hu Chen Guang-Min Nong Zhao-Bo Shen Chang-Shan Liu Ying-Xue Zou Jin-Zhun Wu Xing-Dong Wu Bi-Quan Chen Ru-Ping Luo Ai-Wei Lin Yan Chen Xiao-Dong Liu | 2020 | World Journal of Pediatrics2020，16，2： | 12 |
| 15 | Clinical assessment of awake endotracheal intubation using the lightwand technique alone in patients with difficult airways显示文摘在那里的背景是很少学习决定 lightwand 技术的使用是否能独自完成有效、安全、成功唤醒气管内膜的 intubation ( ETI ),因此,我们设计了未来的临床的研究系统地评估可行性,安全和功效与困难的 airways.Methods 在病人独自用 lightwand 唤醒 ETI 有困难的航线的七十个成年病人在这研究被注册。在有芬太奴和 midazolam 的需要的镇静以后,航线热门麻醉与2% lidocaine 的 9 ml 被执行,它是有序的用 lightwand 和 MADgic atomizer 的一个联合单位在 5 分钟间隔在三 aliquots 喷洒了进 supraglottic (二剂量)和喉气管的区域(一剂量)。在航线以后热门麻醉,醒着 ETI 用 Lightwand 被执行。由用视觉类似物分数(管)的病人和操作符的主观评价,和由用病人的忍耐和反应分数,咳嗽的严厉,把管子插进的条件和心血管的变量的一个独立调查者的客观评价作为 210 朵航线水花的观察 parameters.Results 被拿,(93.8%) 197 成功地在第一次尝试以后被完成。航线水花的全部的时间是(14.6 ??? 趸郥?? ? 髧鲽鳥蒚戠潩慭歲牥 ? 倨 ??????? 蚯裥芀 ? 餸?餸 吗?? | XUE Fu-shan HE Nong LIAO Xu XU Xiu-Zheng XU Ya-chao YANG Quan-yong LUO Mao-ping ZHANG Yan-ming | 2009 | Chinese Medical Journal2009，，4： | 12 |
| 16 | Re-Os geochronology of Cu and W-Mo deposits in the Balkhash metallogenic belt,Kazakhstan and its geological significance显示文摘<正>The Central Asian metallogenic domain(CAMD) is a multi-core metallogenic system controlled by boundary strike-slip fault systems.The Balkhash metallogenic belt in Kazakhstan,in which occur many large and super-large porphyritic Cu—Mo deposits and some quartz vein- and greisen-type W—Mo deposits,is a well-known porphyritic Cu—Mo metallogenic belt in the CAMD.In this paper 11 molybdenite samples from the western segment of the Balkhash metallogenic belt are selected for Re—Os compositional analyses and Re—Os isotopic dating.Molybdenites from the Borly porphyry Cu deposit and the three quartz vein-greisen W—Mo deposits—East Kounrad.Akshatau and Zhanet—all have relatively high Re contents(2712—2772μg/g for Borly and 2.267—31.50μg/g for the other three W—Mo deposits),and lower common Os contents(0.670—2.696 ng/g for Borly and 0.0051—0.056 ng/g for the other three).The molybdenites from the Borly porphyry Cu—Mo deposit and the East Kounrad,Zhanet,and Akshatau quartz vein- and greisen-type W—Mo deposits give average model Re—Os ages of 315.9 Ma,298.0 Ma,295.0 Ma,and 289.3 Ma respectively.Meanwhile,molybdenites from the East Kounrad,Zhanet,and Akshatau W—Mo deposits give a Re—Os isochron age of 297.9 Ma,with an MSWD value of 0.97.Re-Os dating of the molybdenites indicates that Cu—W—Mo metallogenesis in the western Balkhash metallogenic belt occurred during Late Carboniferous to Early Permian(315.9—289.3 Ma),while the porphyry Cu—Mo deposits formed at—316 Ma,and the quartz vein-greisen W—Mo deposits formed at ~298 Ma.The Re—Os model and isochron ages thus suggest that Late Carboniferous porphyry granitoid and pegmatite magmatism took place during the late Hercynian movement.Compared to the Junggar-East Tianshan porphyry Cu metallogenic belt in northwestern China,the formation of the Cu—Mo metallogenesis in the Balkhash metallogenic belt occurred between that of the Tuwu-Yandong in East Tianshan and the Baogutu porphyry Cu deposits in West Junggar. Collectively,the large-scale Late Carboniferous porphyry Cu—Mo metallogenesis in the Central Asian metallogenic domain is related to Hercynian tectono-magmatic activities. | Xuanhua Chen Wenjun Qu Shuqin Han Seitmuratova Eleonora Nong Yang Zhengle Chen Fagang Zeng Andao Du Zhihong Wang | 2010 | Geoscience Frontiers2010，1，1： | 10 |
| 17 | Mining-induced movement properties and fissure time-space evolution law in overlying strata显示文摘Mining-induced fracture zone will be produced in the overlying strata after the coal was mined.In this article,the mining-induced deformation of overlying strata and the time-space evolution law of fissure were studied by the methods of physical simulation and field measurement.The results show that bed separation fissure and vertical fissure will appear in the overlying strata above mining face,which form the wedge-shaped fissure zone.The open degree of fissure depends on the size of uncoordinated deformation between neighbor layers,and the absolute strata sinking controls both the width of bed separation zone and the open degree of vertical breakage fissure.At last,the calculating formula was deducted based on theoretical analysis. | Xu Xingliang Zhang Nong Tian Suchuan | 2012 | International Journal of Mining Science and Technology2012，22，6： | 10 |
| 18 | Research on optimal immunization strategies for hepatitis B in different endemic areas in China显示文摘INTRODUCTION At present hepatitis B vaccine immunization is an unique effective measure for controlling hepatitis B.It is important o determine optimal immunization | Li H Wang L Wang SS Gong J Zeng XJ Li RC Nong Y Huang YK Chen XR Huang ZN | 2000 | World Journal of Gastroenterology2000，6，3： | 9 |
| 19 | Fourth C hinese National Consensus Report on the management of H elicobacter pylori infection显示文摘 | Wen Zhong Liu Yong Xie Hong Cheng Nong Hua Lu Fu Lian Hu Wan Dai Zhang Li Ya Zhou Ye Chen Zhi Rong Zeng Chong Wen Wang Shu Dong Xiao Guo Zong Pan Pin Jin Hu | 2013 | Journal of Digestive Diseases2013，，5： | 9 |
| 20 | High-performance computing environment: a review of twenty years of experiments in China显示文摘A high-performance computing environment, also known as a supercomputing environment, e-Science environment or cyberinfrastructure, is a crucial system that connects users' applications to supercomputers,and provides usability, eiciency, sharing, and collaboration capabilities. his review presents important lessons drawn from China's nationwide eforts to build and use a high-performance computing environment over the past 20 years(1995–2015), including three observations and two open problems. We present evidence that such an environment helps to grow China's nationwide supercomputing ecosystem by orders of magnitude, where a loosely coupled architecture accommodates diversity. An important open problem is why technology for global networked supercomputing has not yet become as widespread as the Internet or Web. In the next 20 years, high-performance computing environments will need to provide zetalops computing capability and 10 000 times beter energy eiciency, and support seamless human-cyber-physical ternary computing. | Zhiwei Xu Xuebin Chi Nong Xiao | 2016 | National Science Review2016，3，1： | 8 |
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