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| 1 | Combined therapy with transcatheter arterial chemoembolization and percutaneous microwave coagulation for small hepatocellular carcinoma显示文摘AIM:To assess the efficacy of combined transcatheter arterial chemoembolization(TACE)and percutaneous microwave coagulation therapy(PMCT)for small hepatocellular carcinoma(HCC). METHODS:Thirty-five patients with a total of 41 HCC nodules(≤3 cm in diameter)were treated with TACE followed by computed tomograghy(CT)-guided percutaneous microwave coagulation therapy(PMCT) within 1-3 wk. RESULTS:By biopsies and enhanced CT scans, complete necrosis of the tumor and 3-5 mm of the surrounding non-cancerous area were observed in 34 foci.In seven foci,incomplete necrosis of the surrounding parenchyma was observed.Serum alpha- fetoprotein(AFP)levels returned to normal 10 d after treatment in 25 patients who originally had high serum AFP levels.The follow-up period was 6-31 mo,and all patients remained alive.One patient had a recurrence in the subsegments of the liver,and another patient had a recurrence near the original lesion. CONCLUSION:Combined therapy with TACE and PMCT is a safe and effective treatment without severe complications for small HCC. | Wei-Zhu Yang Na Jiang Ning Huang Jing-Yao Huang Qu-Bin Zheng Quan Shen | 2009 | World Journal of Gastroenterology2009，15，6： | 32 |
| 2 | Crystal structure and biochemical analyses reveal Beclin 1 as a novel membrane binding protein显示文摘Beclin 1 基因是 haplo 不够的肿瘤 suppressor 并且在 autophagy 起一个必要作用。然而, Beclin 1 由工作的分子的机制仍然保持大部分未知。这里,我们在 1.6 Å 报导 Beclin 1 的 evolutionarily 保存的领域(ECD ) 的水晶结构;分辨率。Beclin 1 ECD 展览一以前 unreported 褶层,与在中央轴附近相称性地安排的三次结构的重复。Beclin 1 ECD 定义膜绑定领域的一个新奇的类,与为与 cardiolipin 充实的类脂化合物膜的强壮的偏爱。在 Beclin 1 ECD 的一个表面环的尖端,包括三芳香的氨基酸,与类脂化合物膜充当一根恐水病的手指到伙伴,因而导致膜和 liposomes 的变丑。这些芳香的残余的变化使 Beclin 1 变为不能稳定地在 vitro 与类脂化合物膜联系并且不能充分在 vivo 在 Beclin 1-knockdown 房间救 autophagy。这些观察为译解形成一个重要框架 Beclin 1 的生物功能。 | Weljlao Huang Wooyoung Chol Wanqiu Hu Na Mi Qiang Guo Meisheng Ma Mei Liu Yuan Tian Peilong Lu Feng-Liang Wang Haiteng Deng Lei Liu Ning Gao Li Yu Yigong Shi | 2012 | Cell Research2012，22，3： | 21 |
| 3 | Nickel-exposed Workers in China: A Cohort Study显示文摘There are more than 50 000 workers in Jinchuan Group Co,Ltd(JNMC).Since all staff in JNMC are eligible for a medical examination every two years,only 23 484 nickel-exposed subjects who participated in medical examination were included in this study.Their data,collected from June 22,2011 to September 28,2012,in a | BAI Ya Na YAGN Ai Min PU Hong Quan HE Jie CHENG Ning ZHENG Tong Zhang DAI Min ZHANG Ya Wei BASSING Bryan WANG Qiu Ying | 2014 | Biomedical and Environmental Sciences2014，27，3： | 20 |
| 4 | Robotic anterior resection of rectal cancer: technique and early outcome显示文摘 | DU Xiao-hui SHEN Di LI Rong LI Song-yan NING Ning ZHAO Yun-shan ZOU Zhen-yu LIU Na | 2013 | Chinese Medical Journal2013，，1： | 15 |
| 5 | The Qitai radio telescope显示文摘This study presents a general outline of the Qitai radio telescope(QTT)project.Qitai,the site of the telescope,is a county of Xinjiang Uygur Autonomous Region of China,located in the east Tianshan Mountains at an elevation of about 1800 m.The QTT is a fully steerable,Gregorian-type telescope with a standard parabolic main reflector of 110 m diameter.The QTT has adopted an umbrella support,homology-symmetric lightweight design.The main reflector is active so that the deformation caused by gravity can be corrected.The structural design aims to ultimately allow high-sensitivity observations from 150 MHz up to115 GHz.To satisfy the requirements for early scientific goals,the QTTwill be equipped with ultra-wideband receivers and large field-of-view multi-beam receivers.A multi-function signal-processing system based on RFSo C and GPU processor chips will be developed.These will enable the QTT to operate in pulsar,spectral line,continuum and Very Long Baseline Interferometer(VLBI)observing modes.Electromagnetic compatibility(EMC)and radio frequency interference(RFI)control techniques are adopted throughout the system design.The QTT will form a world-class observational platform for the detection of lowfrequency(nano Hertz)gravitational waves through pulsar timing array(PTA)techniques,pulsar surveys,the discovery of binary black-hole systems,and exploring dark matter and the origin of life in the universe.The QTT will also play an important role in improving the Chinese and international VLBI networks,allowing high-sensitivity and high-resolution observations of the nuclei of distant galaxies and gravitational lensing systems.Deep astrometric observations will also contribute to improving the accuracy of the celestial reference frame.Potentially,the QTT will be able to support future space activities such as planetary exploration in the solar system and to contribute to the search for extraterrestrial intelligence. | Na Wang Qian Xu Jun Ma Zhiyong Liu Qi Liu Hailong Zhang Xin Pei Maozheng Chen Richard N.Manchester Kejia Lee Xingwu Zheng Hans J.Kärcher Wulin Zhao Hongwei Li Dongwei Li Martin Süss Matthias Reichert Zhongyi Zhu Congsi Wang Mingshuai Li Rui Li Ning Li Guljaina Kazezkhan Wenming Yan Gang Wu Lang Cui Ming Zhang Haitao Li | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，8： | 14 |
| 6 | Piglets cloned from induced pluripotent stem cells显示文摘 | Nana Fan Jijun Chen Zhouchun Shang Hongwei Dou Guangzhen Ji Qingjian Zou Lu Wu Lixiazi He Fang Wang Kai Liu Na Liu Jianyong Han Qi Zhou Dengke Pan Dongshan Yang Bentian Zhao Zhen Ouyang Zhaoming Liu Yu Zhao Lin Lin Chongming Zhong Quanlei Wang Shouqi Wang Ying Xu Jing Luan Yu Liang Zhenzhen Yang Jing Li Chunxia Lu Gabor Vajta Ziyi Li Hongsheng Ouyang Huayan Wang Yong Wang Yang Yang Zhonghua Liu Hong Wei Zhidong Luan Miguel A Esteban Hongkui Deng Huanming Yang Duanqing Pei Ning Li Gang Pei Lin Liu Yutao Du Lei Xiao Liangxue Lai | 2013 | Cell Research2013，23，1： | 12 |
| 7 | Dihydroartemisinin regulates the immune system by promotion of CD8^+T lymphocytes and suppression of B cell responses显示文摘Artemisia annua is an anti-fever herbal medicine first described in traditional Chinese medicine 1,000 years ago.Artemisinin,the extract of A.annua,and its derivatives(dihydroartemisinin(DHA),artemether,and artesunate)have been used for the treatment of malaria with substantial efficacy.Recently,DHA has also been tested for the treatment of lupus erythematosus,indicating that it may function to balance the immune response in immunocompromised individuals.In the present study,the regulatory effect of artemisinin on the murine immune system was systematically investigated in mice infected with two different protozoan parasites(Toxoplasma gondii and Plasmodium berghei).Our results revealed that the mouse spleen index significantly increased(spleen enlargement)in the healthy mice after DHA administration primarily due to the generation of an extra number of lymphocytes and CD8^+T lymphocytes in both the spleen and circulation.DHA could increase the proportion of T helper cells and CD8^+T cells,as well as decrease the number of splenic and circulatory B cells.Further,DHA could reduce the production of proinflammatory cytokines.Our study revealed that apart from their anti-parasitic activity,artemisinin and its derivatives can also actively modulate the immune system to directly benefit the host. | Ting Zhang Yiwei Zhang Ning Jiang Xu Zhao Xiaoyu Sang Na Yang Ying Feng Ran Chen Qijun Chen | 2020 | Science China(Life Sciences)2020，63，5： | 12 |
| 8 | PI3K/AKT/mTOR signaling pathway inhibitors in proliferation of retinal pigment epithelial cells显示文摘AIM: To determine whether the PI3K/AKT/mTOR pathway is activated in proliferative vitreoretinopathy (PVR) in homo- sapiens. METHODS: The retina of controls and patients with PVR were collected and their levels of PI3K, phospho-AKT, phospho-mTOR, phospho-p70S6k and phospho-4EBP-1 were determined by Western blot. The cultured human retinal pigment epithelial cell line D407 was treated with a specific mTOR inhibitor, rapamycin (RAPA) or a PI3K inhibitor, LY294002, of various concentrations and durations. Cell morphology was observed by phase contrast microscopy and the proliferation and apoptosis of treated cells were determined by MTT assay and flow cytometry. RESULTS: Levels of PI3K, phospho-AKT, phospho-mTOR, phospho-P70S6K and phospho-4EBP1 was increased in the retina in PVR (P <0.05). In D407 cells, both RAPA and LY294002 significantly inhibited cell proliferation and cell cycle progression, and promoted apoptosis (P <0.05); mor- phologically, the cells became smaller. Both RAPA and LY294002 reduced levels of phospho-AKT, phospho-mTOR, phospho-p70S6k and phospho-4EBP1 expression (P <0.05). RAPA, but not LY294002, had no significant effect on PI3K expression. CONCLUSION: PI3K/AKT/mTOR signaling pathway is highly activated in the retinal pigment epithelial cells of PVR. The inhibitors of PI3K/AKT/mTOR signaling pathway, RAPA and LY294002, could inhibited the PI3K/AKT/mTOR signaling pathway by reducing the levels of phosphorylation of mTOR pathway components. | Na Cai Shun-Dong Dai Ning-Ning Liu Li-Min Liu Ning Zhao Lei Chen | 2012 | International Journal of Ophthalmology(English edition)2012，5，6： | 12 |
| 9 | Optimal in vitro culture conditions for murine predominant immature CD8a^+ dendritic cells显示文摘背景使用树枝状的房间(DC2 ) 移植建立的不成熟的 CD8a+ 的前景为在未来的自体免疫的疾病的 immunologic 忍耐和处理是有希望的。然而,为导致 DC2 的方法仍然正在被探索。现在的学习被瞄准调查处于为准备大数字 f 的 vitro 条件最佳从鼠科的骨头髓 cells.Methods 的占优势的 DC2 在不同条件下面有教养的三组骨头髓房间被检验,也就是一个 导致cytokine 的试验性的组( cytokine 组),有刺激因素的granulocyte巨噬细胞殖民地的低集中的一个控制组( GM-CSF ,低 GM-CSF 组)并且没有 ndogenous cytokines 的一个控制组。cytokine 组与 5 ng/ml GM-CSF 是有教养的, 25 ng/ml Fit3 ligand (Flt3L ) , 20 ng/ml interleukin 4 (IL-4 ) 并且 100 ng/ml 干细胞因素(SCF ) 。低 GM-CSF 控制组与 0.4 ng/ml GM-CSF, 25 ng/ml FIt3L 和 100 ng/ml SCF 是有教养的,没有 IL-4。没有 dditional cytokines,没有外长的 cytokines 的控制组是有教养的。所有房间在 5% CO2 下面在 37 点是有教养的。在天 3, 7 和 16, 4 颜色流动 cytometry 被执行分析房间显型,和全部的房间数字被认为分析房间收益。阶段对比显微镜学被用来观察到 cytokine 组更高展出了的房间 morphologies.Results 分配 f 典型不成熟的 CD8a+ DC 特别在白天 3 上,但是全部的房间数字和 DC2 比例在延长文化期间减少了。低 GM-CSF 控制组在天显示出象 cytokine 组的一样的趋势 16 和 22,但是生产更高全部的房间数字(P < 0.05 ) 与更低的 DC2 比例和房间数字。没有外长的 cytokines 的控制组自发地产生了 DC2 的某个比例,但是与低全部的房间和 DC2 数字,那很快减少了,特别在延长文化期间(天 7 和 16 , P < 0.05 ) .Conclusions 文化面对 5 ng/ml GM-CSF , 25 ng/ml Flt3L , 20 ng/ml IL-4 和 100 ng/ml SCF 能很快从鼠科的骨头髓房间导致占优势的不成熟的CD8a+ DC 的大数量。因此,这些为在 vitro 准备鼠科的不成熟的 DC2 代表最佳的文化条件。 | NA Ning XU Lin CAO Kai-yuan LUO Yun YUAN Guang-qing XIANG Peng HONG Liang-qing LI Shu-nong | 2009 | Chinese Medical Journal2009，，3： | 11 |
| 10 | MicroRNA Expression Signature in Gastric Cancer显示文摘Objective:To identify the miRNA specific signature as novel diagnostic and prognostic tools for gastric cancer. Methods:miRNAs expression profiling of 3 normal gastric tissues,24 malignant tissues,gastric cancer cell SGC7901 and normal gastric cell GES-1 were detected using microarray technology. The hierarchical clustering algorithm of the Cluster software was used to analyse the miRNAs expression of all samples. The expression levels of miR-433 and miR-9 which were significantly down-regulated in gastric cancer tissues and SGC7901 cells by microarray technology were validated by quantitative Real-time PCR(qRT-PCR). Results:Differential expressions of 26 individual miRNAs between normal samples(including 3 normal gastric tissues and GES-1 cells) and carcinomas(including 24 malignant tissues and SGC7901 cells) were discovered,19 of them showing down-regulation and 7 up-regulation in carcinoma samples. Hierarchical clustering of the cancer samples by their miRNA expression accurately separated the carcinomas from normal samples and further their histotypes of carcinomas. The expression levels of miR-433 and miR-9 were significantly down-regulated in gastric cancer tissues and SGC7901cells Conclusion:The differential expression of miR-433 and miR-9 may be used as a novel diagnostic tool for gastric cancer. | Hong-chun Luo Zhen-zhen Zhang Xia Zhang Bo Ning Jin-jun Guo Na Niel Bo Liu Xiao-ling Wu | 2009 | Chinese Journal of Cancer Research2009，21，1： | 9 |
| 11 | Characterization and allergic role of IL-33-induced neutrophil polarization显示文摘Neutrophils are involved in the pathogenesis of allergy.However,the contribution of the different functionally polarized neutrophils in allergy needs to be clarified.We sought to define the characteristics of interleukin(IL)-33-induced neutrophils and the involvement of this subset of polarized neutrophils in allergic pathogenesis.Freshly isolated neutrophils were treated with different cytokines and the cytokine expression levels were detected by realtime PCR.The gene expression profile of IL-33-induced neutrophils was determined by microarray assay.Adoptive transfer assay was used to investigate the function of IL-33-induced neutrophils in an ovalbumin(OVA)-induced allergic asthma model.IL-33-treated neutrophils selectively produced IL-4,IL-5,IL-9 and IL-13(referred as to N(IL-33)cells)and displayed a distinctive gene expression profile in sharp contrast to resting and lipopolysaccharide(LPS)-treated neutrophils.IL-33-induced neutrophils expressed high Levels of IL-1R2 on cell surface,whereas resting and LPS-treated neutrophils did not,indicating IL-1R2 might be used as a biomarker for N(IL-33)cells.Importantly,N(IL-33)neutrophils exist in the lungs of OVA-induced allergic asthma mice.Adoptive transfer of N(IL-33)neutrophils significantly promotes the severity of the lung pathogenesis in this model.IL-33 induces neutrophil polarization through c-Jun N-terminal kinase-and nuclear factor-κB-dependent pathways.A previously unappreciated neutrophil polarization driven by IL-33 with unique cell surface markers and cytokine/chemokineproducing gene profile was defined.The newly identified N(IL-33)subpopulation may have significant contribution to IL-33-related pathogenesis. | Bo Sun Linnan Zhu Yaling Tao Hai-Xi Sun Yang Li Peng Wang Yuzhu Hou Yang Zhao Xiaodong Zhang Lianfeng Zhang Ning Na Yong Zhao | 2018 | Cellular & Molecular Immunology2018，15，8： | 9 |
| 12 | Nano/Micro HKUST-1 Fabricated by Coordination Modulation Method at Room Temperature显示文摘A simple and fast route for the synthesis of metal-organic framework(MOF) particles was presented.Cu 3(BTC) 2(HKUST-1,BTC=1,3,5-benzenetricarboxylate),one of the most well-known MOFs,was synthesized at room temperature via coordination modulation method.By adding different modulators(monocarboxylic acids) into the reaction system,the morphologies of HKUST-1 crystals were tuned from nano spheres to micro octahedrons at room temperature without any complex equipment.X-Ray diffractions and gas sorption measurements revealed highly crystalline particles with large Brunauer-Emmett-Teller(BET) surface areas(1116―1273 m 2 /g) and total pore volumes(0.62―0.73 cm 3 /g).The significantly small particle sizes and high capacity of gas sorption are considered advantageous for envisaged application in practical industrial process. | NA Li-yan HUA Rui-nian NING Gui-ling OU Xiao-xia | 2012 | Chemical Research in Chinese Universities2012，28，4： | 8 |
| 13 | The Huashan risk calculators performed better in prediction of prostate cancer in Chinese population: a training study followed by a validation study显示文摘前列腺癌症预防试用(PCPT ) 的表演冒险计算器和其它风险计算器因为在中国人口的前列腺癌症(PCa ) 预言糟糕被理解。我们执行了这研究基于中国人口造风险计算器(Huashan 风险计算器) 并且验证了前列腺特定的抗原(PSA ) 的性能, PCPT 风险计算器,和在一个确认队的 Huashan 风险计算器。我们从在一个训练的队从 2006 年 1 月经历了起始的前列腺活体检视到 2010 年 12 月的 1059 个人基于数据造了 Huashan 风险计算器。然后,我们从 2011 年 1 月在观察确认研究验证了 PSA, PCPT 风险计算器,和 Huashan 风险计算器的性能到 2014 年 12 月。所有必要临床的信息在活体检视前被收集。结果证明 Huashan 冒险 1 和 2 超过了的计算器为在全部训练的队和成层的人口预言 PCa 的 PCPT 风险计算器(与到 20.0 ng m 的从 2.0 ng ml −1 的 PSA ) 。在确认学习, Huashan 风险计算器 1 仍然在全部确认队超过了 PCPT 风险计算器(0.849 对 0.779 在在操作特征的接收装置下面的区域弯[AUC ] 并且成层的人口。当 Huashan 风险计算器被使用时,不必要的活体检视(约 30%) 的可观的减小也被观察。因此,我们相信 Huashan 风险计算器(特别 Huashan 风险计算器 1 ) 可能为在中国人口预言 PCa 增加了价值。然而,这些结果仍然在更大的人口需要进一步的评估。 | Yi-Shuo Wu Ning Zhang Sheng-Hua Liu Jian-Feng Xu Shi-Jun Tong Ye-Hua Cai Li-Min Zhang Pei-De Bai Meng-Bo HU Hao-Wen Jiang Rong Na Qiang Ding Ying-Hao Sun | 2016 | Asian Journal of Andrology2016，18，6： | 7 |
| 14 | Characteristics of ectopic adrenocorticotropic hormone syndrome due to thymic carcinoid and analysis of the molecular mechanism显示文摘 | BI Yu-fang YE Lei CHEN Yu-hong NING Guang SUN Shou-yue JIANG Lei ZHU Na ZHOU Wei-wei WANG Wei-qing | 2008 | Chinese Medical Journal2008，，7： | 7 |
| 15 | Immature CD4+ dendritic cells conditioned with donor kidney antigen prolong renal allograft survival in rats显示文摘 | WANG Tao XU Lin LI Heng HUANG Zheng-yu ZHANG Sheng-ping MIAO Bin NA Ning | 2012 | Chinese Medical Journal2012，，14： | 6 |
| 16 | The association between the genetic polymorphisms of LMP2/LMP7 and the outcomes of HCV infection among drug users显示文摘Objective:To investigate a possible association of LMP2/LMP7 genes with chronic hepatitis C virus(HCV) infection,and to assess whether LMP2/LMP7 genes could influence the outcomes of HCV infection among drug users.Methods:Genomic DNAs of 362 anti-HCV sero-positive drug users and 225 control drug users were extracted from the peripheral blood leukocytes.The sero-positive patients were divided into those who had persistent infection and those who had spontaneously cleared the infection.Polymorphisms of LMP genes were determined by PCR combined with restriction fragment length polymorphism(RFLP).Results:The distribution of LMP2 genotypes among the control,persistent infection and spontaneous clearance groups were not different.However,the LMP7 codon 145 Gln/Lys,Lys/Lys,and Gln/Lys+Lys/Lys genotypes were found significantly more frequent in the persistent infection group than in control group(OR=1.75,95%CI=1.06~2.90;OR=3.16,95%CI=1.23-8.12;OR=1.94,95%CI=1.21-3.12,respectively).Similarly,the frequencies of the codon 145 Gln/Lys,Lys/Lys,and Gln/Lys+Lys/Lys genotypes were found significantly more frequent in the persistent infection group than in the spontaneous clearance group(OR=1.64,95%CI=1.04-2.57;OR=2.40,95%CI=1.09-5.28;OR=1.76,95%CI=1.152.69,respectively).Stratified analysis indicated that combined genotype Gln/Lys+Lys/Lys of the LMP7 gene was related to an increasing susceptibility to HCV infection(OR=1.91,95%CI=1.02-3.55;OR=2.19,95%CI=1.243.89;OR=1.91,95%CI=1.05-3.48,OR=2.86,95%CI=1.41-5.78,respectively)and the risk of persistent HCV infection(OR=1.94,95%CI=1.12-3.34;OR=2.02,95%CI=1.21-3.38;OR=1.78,95%CI=1.12-2.85,OR=2.23,95%CI=1.09-4.58,respectively)among>30-year-old,males,the injection drug user(IDU)subjects and/or the shorter duration drug users(≤5 y).Conclusion:These results suggest that polymorphism of the LMP7 gene may have an influence on the outcomes of HCV infection,and is one of the factors accounting for the genetic susceptibility to HCV infection among drug users. | Qian Cui Yongxiang Zhang Jing Su Chao Shi Na Lei Keqin Ding Jun Li Rongbin Yu L u Wang Ning Wang | 2010 | The Journal of Biomedical Research2010，24，5： | 6 |
| 17 | A novel wheat NAC transcription factor,Ta NAC_(30), negatively regulates resistance of wheat to stripe rust显示文摘NAC transcription factors are widespread in the plant kingdom and play essential roles in the transcriptional regulation of defense responses. In this study, we isolated a novel NAC transcription factor gene, Ta NAC_(30),from a c DNA library constructed from wheat(Triticum aestivum) plants inoculated with the stripe rust pathogen Puccinia striiformis f. sp. tritici(Pst). Ta NAC_(30) contains a typical NAM domain and localizes to the nucleus. Yeast one-hybrid assays revealed that Ta NAC_(30) exhibits transcriptional activity and that its C-terminus is necessary for the activation of transcription. Expression of Ta NAC_(30) increased when host plants were infected with a virulent race(CYR_(31)) of the rust fungus Pst. Silencing of Ta NAC_(30) byvirus-induced gene silencing inhibited colonization of the virulent Pst isolate CYR_(31). Moreover, detailed histological analyses showed that silencing of Ta NAC_(30) enhanced resistance to Pst by inducing a significant increase in the accumulation of H_2O_2. Finally, we overexpressed Ta NAC_(30) in fission yeast and determined that cell viability was severely reduced in Ta NAC_(30)-transformed cells grown on medium containing H_2O_2. These results suggest that Ta NAC_(30) negatively regulates plant resistance in a compatible wheat-Pst interaction. | Bing Wang Jinping Wei Na Song Ning Wang Jing Zhao Zhensheng Kang | 2018 | Journal of Integrative Plant Biology2018，60，5： | 6 |
| 18 | Phi-based risk calculators performed better in the prediction of prostate cancer in the Chinese population显示文摘Risk prediction models including the Prostate Health Index(phi)for prostate cancer have been well established and evaluated in the Western population.The aim of this study is to build phi-based risk calculators in a prostate biopsy population and evaluate their performanee in predicting prostate cancer(PCa)and high-grade PCa(Gleason score 27)in the Chinese population.We developed risk calculators based on 635 men who underwent initial prostate biopsy.Then,we validated the performance of prostate-specific antigen(PSA),phi,and the risk calculators in an additional observational cohort of 1045 men.We observed that the phi-based risk calculators(risk calculators 2 and 4)outperformed the PSA-based risk calculator for predicting PCa and high-grade PCa in the training cohort.In the validation study,the area under the receiver operating characteristic curve(AUC)for risk calculators 2 and 4 reached 0.91 and 0.92,respectively,for predicting PCa and high-grade PCa,respectively;the AUC values were better than those for risk calculator 1(PSA-based model with an AUC of 0.81 and 0.82,respectively)(all P<0.001).Such superiority was also observed in the stratified population with PSA ranging from 2.0 ng ml^-1 to 10.0 ng ml^-1.Decision curves confirmed that a considerable proportion of unnecessary biopsies could be avoided while applying phi-based risk calculators.In this study,we showed that,compared to risk calculators without phi,phi-based risk calculators exhibited superior discrimination and calibration for PCa in the Chinese biopsy population.Applying these risk calculators also considerably reduced the number of unnecessary biopsies for PCa. | Yi-Shuo Wu Xiao-Jian Fu Rong Na Ding-Wei Ye Jun Qi Xiao-Ling Lin Fang Liu Jian Gong Ning Zhang Guang-Liang Jiang Hao-Wen Jiang Qiang Ding Jianfeng Xu Ying-Hao Sun | 2019 | Asian Journal of Andrology2019，21，6： | 6 |
| 19 | Chemoprophylaxis, diagnosis, treatments, and discharge management of COVID-19: An evidence-based clinical practice guideline(updated version)显示文摘The novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is the cause of a rapidly spreading illness,coronavirus disease 2019(COVID-19),affecting more than seventeen million people around the world.Diagnosis and treatment guidelines for clinicians caring for patients are needed.In the early stage,we have issued'A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV)infected pneumonia(standard version)';now there are many direct evidences emerged and may change some of previous recommendations and it is ripe for develop an evidence-based guideline.We formed a working group of clinical experts and methodologists.The steering group members proposed 29 questions that are relevant to the management of COVID-19 covering the following areas:chemoprophylaxis,diagnosis,treatments,and discharge management.We searched the literature for direct evidence on the management of COVID-19,and assessed its certainty generated recommendations using the Grading of Recommendations,Assessment,Development and Evaluation(GRADE)approach.Recommendations were either strong or weak,or in the form of ungraded consensus-based statement.Finally,we issued 34 statements.Among them,6 were strong recommendations for,14 were weak recommendations for,3 were weak recommendations against and 11 were ungraded consensus-based statement.They covered topics of chemoprophylaxis(including agents and Traditional Chinese Medicine(TCM)agents),diagnosis(including clinical manifestations,reverse transcription-polymerase chain reaction(RT-PCR),respiratory tract specimens,IgM and IgG antibody tests,chest computed tomography,chest X-ray,and CT features of asymptomatic infections),treatments(including lopinavirritonavir,umifenovir,favipiravir,interferon,remdesivir,combination of antiviral drugs,hydroxychloroquine/chloroquine,interleukin-6 inhibitors,interleukin-1 inhibitors,glucocorticoid,qingfei paidu decoction,lianhua qingwen granules/capsules,convalescent plasma,lung transplantation,invasive or noninvasive ventilation,and extracorporeal membrane oxygenation(ECMO)),and discharge management(including discharge criteria and management plan in patients whose RT-PCR retesting shows SARS-CoV-2 positive after discharge).We also created two figures of these recommendations for the implementation purpose.We hope these recommendations can help support healthcare workers caring for COVID-19 patients. | Ying-Hui Jin Qing-Yuan Zhan Zhi-Yong Peng Xue-Qun Ren Xun-Tao Yin Lin Cai Yu-Feng Yuan Ji-Rong Yue Xiao-Chun Zhang Qi-Wen Yang Jianguang Ji Jian Xia Yi-Rong Li Fu-Xiang Zhou Ya-Dong Gao Zhui Yu Feng Xu Ming-Li Tu Li-Ming Tan Min Yang Fang Chen Xiao-Ju Zhang Mei Zeng Yu Zhu Xin-Can Liu Jian Yang Dong-Chi Zhao Yu-Feng Ding Ning Hou Fu-Bing Wang Hao Chen Yong-Gang Zhang Wei Li Wen Chen Yue-Xian Shi Xiu-Zhi Yang Xue-Jun Wang Yan-Jun Zhong Ming-Juan Zhao Bing-Hui Li Lin-Lu Ma Hao Zi Na Wang Yun-Yun Wang Shao-Fu Yu Lu-Yao Li Qiao Huang Hong Weng Xiang-Ying Ren Li-Sha Luo Man-Ru Fan Di Huang Hong-Yang Xue Lin-Xin Yu Jin-Ping Gao Tong Deng Xian-Tao Zeng Hong-Jun Li Zhen-Shun Cheng Xiao-Mei Yao Xing-Huan Wang | 2020 | Military Medical Research2020，7，3： | 6 |
| 20 | The Mechanism of Acute Lung Injury Induced by Nickel Carbonyl in Rats显示文摘Nickel carbonyl is a highly toxic metal compound produced from the reaction that occurs between nickel and carbon monoxide under pressure. As previously reported, nickel carbonyl can cause acute aspiration pneumonia, and animal experiments showed it was toxic to animal lung, liver, brain, and other vital organs [1] . However, few studies | BAI Ya Na MA Li WANG Qiu Ying PU Hong Quan ZHANG Xiao Pei WU Xi Jiang XUAN Xiao Qiang CHENG Ning | 2013 | Biomedical and Environmental Sciences2013，26，7： | 5 |
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