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| 1 | Nondestructive Testing and Characterization of Residual Stress Field Using an Ultrasonic Method显示文摘To address the difficulty in testing and calibrating the stress gradient in the depth direction of mechanical components, a new technology of nondestructive testing and characterization of the residual stress gradient field by ultrasonic method is proposed based on acoustoelasticity theory. By carrying out theoretical analysis, the sensitivity coefficients of different types of ultrasonic are obtained by taking the low carbon steel(12%C) as a research object. By fixing the interval distance between sending and receiving transducers, the mathematical expressions of the change of stress and the variation of time are established. To design one sending-one receiving and oblique incidence ultrasonic detection probes, according to Snell law, the critically refracted longitudinal wave(LCR wave) is excited at a certain depth of the fixed distance of the tested components. Then, the relationship between the depth of LCR wave detection and the center frequency of the probe in Q235 steel is obtained through experimental study. To detect the stress gradient in the depth direction, a stress gradient LCR wave detection model is established, through which the stress gradient formula is derived by the relationship between center frequency and detecting depth. A C-shaped stress specimen of Q235 steel is designed to conduct stress loading tests, and the stress is measured with the five group probes at different center frequencies. The accuracy of ultrasonic testing is verified by X-ray stress analyzer. The stress value of each specific depth is calculated using the stress gradient formula. Accordingly, the ultrasonic characterization of residual stress field is realized. Characterization results show that the stress gradient distribution is consistent with the simulation in ANSYS. The new technology can be widely applied in the detection of the residual stress gradient field caused by mechanical processing, such as welding and shot peening. | SONG Wentao XU Chunguang PAN Qinxue SONG Jianfeng | 2016 | Chinese Journal of Mechanical Engineering2016，29，2： | 27 |
| 2 | 食品中磷的检测方法显示文摘磷是人体内的重要元素之一,对人体生命活动有十分重要的作用,如何快速、简便、准确、灵敏地检测食品中磷的含量已经引起了世界各国的重视.本文总结了前人的研究工作,概述了近年来食品中总磷及有机磷农药的检测研究进展,分析了各种检测方法的优势和局限性,展望了未来该领域研究的发展趋势. | 卫敏 LIU RuiHai DING Liang CHENG WenLong XU JianFeng LUO Dan 刘钟栋 | 2010 | 中国科学:化学2010，40，7： | 24 |
| 3 | Glucocorticoid receptor and sequential P53 activation by dexamethasone mediates apoptosis and cell cycle arrest of osteoblastic MC3T3-E1 cells显示文摘 | Li Hui Yao Jianfeng Liu Hui Liu Shuguang Xu Peng Ma Jianbing Zhang Yumin | 2012 | 美中国际创伤杂志2012，11，1： | 22 |
| 4 | Identity-based public auditing for cloud storage systems against malicious auditors via blockchain显示文摘Cloud storage systems provide users with convenient data storage services, which allow users to access and update outsourced data remotely. However, these cloud storage services do not guarantee the integrity of the data that users store in the cloud. Thus, public auditing is necessary, in which a third-party auditor(TPA) is delegated to audit the integrity of the outsourced data. This system allows users to enjoy on-demand cloud storage services without the burden of continually auditing their data integrity. However,certain TPAs might deviate from the public auditing protocol and/or collude with the cloud servers. In this article, we propose an identity-based public auditing(IBPA) scheme for cloud storage systems. In IBPA,the nonces in a blockchain are employed to construct unpredictable and easily verified challenge messages,thereby preventing the forging of auditing results by malicious TPAs to deceive users. Users need only to verify the TPAs' auditing results in batches to ensure the integrity of their data that are stored in the cloud.A detailed security analysis shows that IBPA can preserve data integrity against various attacks. In addition,a comprehensive performance evaluation demonstrates that IBPA is feasible and efficient. | Jingting XUE Chunxiang XU Jining ZHAO Jianfeng MA | 2019 | Science China(Information Sciences)2019，62，3： | 17 |
| 5 | Sensitive High Resolution Ion Micro-Probe U-Pb Zircon Geochronology and Geochemistry of Mafic Rocks from the Pulan-Xiangquanhe Ophiolite,Tibet:Constraints on the Evolution of the Neo-tethys显示文摘在西藏的西方的 Yarlung Tsangpo 缝术地区的 Pulan-Xiangquanhe ophiolite 详细为它的地球化学,地球年代学,和构造含意被调查。敏感高分辨率离子标明日期的微探查的锆石 U-Pb 表明在从 Xugugab, Mapam Yum 公司和 La'nga 公司的三个地点的 ophiolite 的辉绿岩在 122.3 点是过时的 ?A?????????????? 畐慬? 楘湡照慵桮? 传桰潩楬整?? | XIA Bin LI Jianfeng XU Lifeng WANG Ran YANG Zhiqing | 2011 | Acta Geologica Sinica(English Edition)2011，85，4： | 16 |
| 6 | A review of the end-effector of large space manipulator with capabilities of misalignment tolerance and soft capture显示文摘The space manipulator which has advantages of high dexterity and universality, is used to the space capturing usually. According to the different types of mechanical interfaces of targets, the on orbit capturing operation includes capturing of cooperative target and capturing of uncooperative target. The performances of the famous large space manipulators named space shuttle remote manipulator system(SRMS), the space station remote manipulator system(SSRMS) and the Europe robotic arm(ERA) are reviewed and studied respectively. Moreover, the space manipulators being developed by China for space station is also surveyed. Based on the performance analysis of the large space manipulators and end-effectors, which are adapted to the construction and daily maintenance for the large space structure such as the space station, the basic requirements of large misalignment tolerance capability, soft capturing capability and hard docking capability for the end-effector of large space manipulator are proposed in this paper. According to these requirements, the capture mechanism and methods that can enable the end-effector to have the capability of misalignment tolerance and soft capturing are presented. The development trend and key technologies of the large space manipulators and the end-effectors are also reviewed. | FENG Fei TANG LiNa XU JianFeng LIU Hong LIU YiWe | 2016 | Science China(Technological Sciences)2016，59，11： | 15 |
| 7 | Effect of stimulating acupoint Guanyuan(CV 4) on lower back pain by burning moxa heat for different time lengths: a randomized controlled clinical trial显示文摘OBJECTIVE: To investigate the effect of different heat-stimulating time lengths on lower back pain.METHODS: Forty participants were randomly assigned to four groups of various heating time lengths. The short heating time length group(SL),moderate heating time length group(ML), and long heating time length group(LL) respectively received 15, 30, and 60 min of moxibustion therapy stimulating the acupoint Guanyuan(CV 4). The conventional acupuncture group(CA) received needle acupuncture treatment as a control group. The participants were treated continuously over a 2-week treatment period for a total of 10 sessions, with five sessions given per week. Participants were assessed weekly by blinded assessors, using the visual analogue scale(VAS) and Roland Morris Questionnaire(RMQ).RESULTS: The VAS and RMQ scores reduced in all four groups during treatment. There were significant differences in VAS scores(P < 0.01) and RMQ scores(P < 0.01) between before treatment and after 2 weeks of treatment in the LL group. After treatment, the LL group reported significantly lower VAS scores compared with the CA group, ML group,and SL group(P < 0.05).CONCLUSION: The long and moderate lengths of heat-stimulating time of 30 and 60 min may be more effective for relieving lower back pain than that of short stimulating time lengths. | Xu Jianfeng Lin Ruizhu Wu Yongli Wang Yingxu Liu Jian Zhang Yanling Zhang Yuequan Xi Chaolei Wu Qiang Li Xinjian | 2015 | Journal of Traditional Chinese Medicine2015，35，1： | 13 |
| 8 | Chang'E-1 Lunar Mission:An Overview and Primary Science Results显示文摘Chang'E-1 is the first lunar mission in China,which was successfully launched on Oct.24th,2007.It was guided to crash on the Moon on March 1,2009,at 52.36°E,1.50°S,in the north of Mare Fecunditatis.The total mission lasted 495 days,exceeding the designed life-span about four months.1.37Terabytes raw data was received from Chang'E-1.It was then processed into 4Terabytes science data at different levels.A series of science results have been achieved by analyzing and applicating these data,especially 'global image of the Moon of China's first lunar exploration mission'.Four scientific goals of Chang'E-1 have been achieved.It provides abundant materials for the research of lunar sciences and cosmochemistry.Meanwhile these results will serve for China's future lunar missions. | Ouyang Ziyuan Li Chunlai Lu Chang Liu Jianzhong Zou Yongliao Zhang Hongbo Jianjun Zuo Wei Su Yah Wen Weibin Bian Wei Zhao Baochang Wang Jianyu Yang Jianfeng Chang Jin Wang Huanyu Zhang Xiaohui Wang Shijin Wang Min Ren Xin Mu Lingli Kong Deqing Wang Xiaoqian Wang Fang Geng Liang Zhang Zhoubin Zheng Lei Zhu Xinying Zheng Yongchun Li Junduo Zou Xiaoduan Xu Chun Shi Shuobiao Gao Yifei Gao Guannan | 2010 | 空间科学学报2010，30，5： | 11 |
| 9 | Performance of the Prostate Health Index in predicting prostate biopsy outcomes among men with a negative digital rectal examination and transrectal ultrasonography显示文摘[-2]proPSA (p2PSA ) 和它的衍生物, p2PSA-to-free PSA 比率(% p2PSA ) ,和前列腺健康索引(PHI ) 极大地在前列腺活体检视有或没有前列腺癌症(PCa ) 改进了在人之间的辨别。然而,很少在数字直肠的考试(DRE ) 和 transrectal ultrasonography (TRUS ) 是否定的情况中对他们的表演被知道。在有否定 DRE 和 TRUS 的中国的 261 个连续病人的一个未来的队被招募并且经历前列腺活体检视。在活体检视被用来测量各种各样的 PSA 衍生物以前,一件浆液样品收集了,包括总数前列腺特定的抗原(tPSA ) ,免费 PSA,和 p2PSA。为每个病人, free-to-total PSA 比率(% fPSA ) , PSA 密度(PSAD ) , p2PSA-to-free PSA 比率(% p2PSA ) ,和 PHI 是计算的。歧视的性能在在 91% 敏感操作典型曲线(AUC ) 和活体检视率的接收装置下面用区域被估计。在关于年龄, tPSA, % fPSA, PSAD, p2PSA, % p2PSA,和 PHI 的全部队以内的 AUC 分数分别地是 0.598, 0.751, 0.646, 0.789, 0.814, 0.808,和 0.853。PHI 是前列腺活体检视结果的最好的预言者,特别在有 10.1-20 ng ml −1 的 tPSA 的病人。与另外的标记相比,在 91% 的敏感, PHI 为决定哪个人不需要经历活体检视是最有用的,从而避免不必要的过程。PHI 的使用能由在中国与否定 DRE 和 TRUS 在人之中预言前列腺活体检视结果改进 PCa 察觉的精确性。 | Guo-Peng Yu Rong Na Ding-Wei Ye Jun Qi Fang Liu Hai-Tao Chen Yi-Shuo Wu Gui-Ming Zhang Jie-Lin Sun Yao Zhu Li-Qun Huang Shan-Cheng Ren De-Ke Jiang S Lilly Zheng Hao-WenJiang Ying-Hao Sun Qiang Ding Jianfeng Xu | 2016 | Asian Journal of Andrology2016，18，4： | 10 |
| 10 | The Xu's chart for prostate biopsy: a visual presentation of the added value of biomarkers to prostate-specific antigen for estimating detection rates of prostate cancer显示文摘提高的浆液前列腺特定的抗原(PSA ) 水平在现代时代是为为前列腺癌症(PCa ) 的察觉的前列腺活体检视的主要指示。从活体检视的 PCa 的察觉率典型地低于 30% ,特别在有在 4-10 ng ml −1 的 PSA 层次的病人之中。在过去的几年里,另外的 biomarkers PCA3 和从多重 PCa 联系风险的单个核苷酸多型性(SNP ) 导出的基因风险分数(GRS ) 例如前列腺健康索引,被显示了在区别前列腺活体检视结果提供增加的价值给 PSA。然而,在诊所的这些新奇 biomarkers 的采纳率是低的,主要由于新奇 biomarkers 的增加的价值的差的理解。为了探讨这,有关系,我们开发了一份图表视觉上介绍期望的察觉重要地关于 PSA 层次,和更多从活体检视 PCa 评估的(i) ,(ii ) 当新奇 biomarkers 被考虑时,在一样的 PSA 的 PCa 察觉率的一个范围铺平。这份图表,为前列腺活体检视叫了徐的图表,不是一个正式风险预言模型;相反,为泌尿科医师的一个简单视觉工具为另外的 biomarkers 基于他们的 PSA 层次和一个可能的建议评价与他们的病人一起传达 PCa 察觉的起始的评估。一旦另外的 biomarkers 被测量,用象诺模图那样的存在风险评价工具的 PCa 风险的更全面的评估能被跟随。图表的当前的版本仅仅是一个原型并且应该进一步发展了包括好攻击的 PCa 的察觉率,并且在更大的研究验证了。 | Jianfeng Xu | 2014 | Asian Journal of Andrology2014，16，4： | 10 |
| 11 | Centimeter-scale-diameter Co-based bulk metallic glasses with fracture strength exceeding 5000 MPa显示文摘Co48-xFexCr15Mo14C15B6Er2 (x = 2.5 and 5) bulk metallic glasses (BMGs) with critical size (dc) up to 15 mm in diameter were synthesized by copper mold casting. Co43Fe5Cr15Mo14C15B6Er2 BMG has a wide supercooled liquid region (84 K) and ultrahigh fracture strength exceeding 5000 MPa,which is the highest value for reported metallic glasses with dc exceeding 1 cm. Furthermore,the Poisson ratio,Young modulus,shear modulus and bulk modulus of this alloy were evaluated to be 0.31,217 GPa,82 GPa and 214 GPa,respectively. The ideal configurational entropy of Co48-xFexCr15Mo14C15B6Er2 (x = 0 and 5) has been calculated. The introduction of the similar element Fe in the Fe-free Co-Cr-Mo-C-B-Er alloy will be beneficial to increasing the ideal config-urational entropy and depressing the critical cooling rate to achieve greater glass-forming ability. The combination of superior glass-forming ability and ultrahigh fracture strength makes the present Co48-xFexCr15Mo14C15B6Er2 (x = 2.5 and 5) BMGs promising candidates as advanced structural materials. | ZHANG Tao YANG Qin JI YunFei LI Ran PANG ShuJie WANG JianFeng XU Tao | 2011 | Chinese Science Bulletin2011，56，36： | 10 |
| 12 | miR-210 over-expression enhances mesenchymal stem cell survival in an oxidative stress environment through antioxidation and c-Met pathway activation显示文摘microRNA-210(miR-210)has generally been reported to be associated with cell survival under hypoxia.However,there are few data regarding the role of miR-210 in the survival of mesenchymal stem cells(MSCs)under oxidative stress conditions.Thus,we sought to investigate whether miR-210 over-expression could protect MSCs against oxidative stress injury and what the primary mechanisms involved are.The results showed that over-expression of miR-210 significantly reduced the apoptosis of MSCs under oxidative stress,accompanied by obvious increases in cell viability and superoxide dismutase activity and remarkable decreases in malonaldehyde content and reactive oxygen species production,resulting in a noticeable reduction of apoptotic indices when compared with the control.Moreover,the above beneficial effects of miR-210 could be significantly reduced by c-Met pathway repression.Collectively,these results showed that miR-210 over-expression improved MSC survival under oxidative stress through antioxidation and c-Met pathway activation,indicating the potential development of a novel approach to enhance the efficacy of MSC-based therapy for injured myocardium. | XU JianFeng HUANG ZheYong LIN Li FU MingQiang GAO YanHua SHEN YunLi ZOU YunZeng SUN AiJun QIAN JuYing GE JunBo | 2014 | Science China(Life Sciences)2014，57，10： | 10 |
| 13 | The High Energy X-ray telescope (HE) onboard the Insight-HXMT astronomy satellite显示文摘The Insight-Hard X-ray Modulation Telescope(Insight-HXMT) is a broadband X-ray and γ-ray(1-3000 ke V) astronomy satellite. One of its three main telescopes is the High Energy X-ray telescope(HE). The main detector plane of HE comprises 18 Na I(Tl)/Cs I(Na) phoswich detectors, where Na I(Tl) is used as the primary detector to measure ~ 20-250 ke V photons incident from the field of view(FOV) defined by collimators, and Cs I(Na) is used as the active shielding detector to Na I(Tl) by pulse shape discrimination. Additionally, Cs I(Na) is used as an omnidirectional γ-ray monitor. The HE collimators have a diverse FOV,i.e. 1.1°×5.7°(15 units), 5.7°×5.7°(2 units), and blocked(1 unit). Therefore, the combined FOV of HE is approximately5.7°×5.7°. Each HE detector has a diameter of 190 mm resulting in a total geometrical area of approximately 5100 cm2, and the energy resolution is ~15% at 60 ke V. For each recorded X-ray event by HE, the timing accuracy is less than 10 μs and the deadtime is less than 10 μs. HE is used for observing spectra and temporal variability of X-ray sources in the 20-250 ke V band either by pointing observations for known sources or scanning observations to unveil new sources. Additionally, HE is used for monitoring the γ-ray burst in 0.2-3 Me V band. This paper not only presents the design and performance of HE instruments but also reports results of the on-ground calibration experiments. | CongZhan Liu YiFei Zhang XuFang Li XueFeng Lu Zhi Chang ZhengWei Li AiMei Zhang YongJie Jin HuiMing Yu Zhao Zhang MinXue Fu YiBao Chen JianFeng Ji YuPeng Xu JingKang Deng RenCheng Shang GuoQing Liu FangJun Lu ShuangNan Zhang YongWei Dong TiPei Li Mei Wu YanGuo Li HuanYu Wang BoBing Wu YongJie Zhang Zhi Zhang ShaoLin Xiong Yuan Liu Shu Zhang HongWei Liu YiJung Yang Fan Zhang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 9 |
| 14 | Olivine-norite rock detected by the lunar rover Yutu-2 likely crystallized from the SPA-impact melt pool显示文摘Chang’E-4 landed in the South Pole-Aitken(SPA)basin,providing a unique chance to probe the composition of the lunar interior.Its landing site is located on ejecta strips in Von Karm´an crater that´possibly originate from the neighboring Finsen crater.A surface rock and the lunar regolith at 10 sites along the rover Yutu-2 track were measured by the onboard Visible and Near-Infrared Imaging Spectrometer in the first three lunar days of mission operations.In situ spectra of the regolith have peak band positions at 1 and 2μm,similar to the spectral data of Finsen ejecta from the Moon Mineralogy Mapper,which confirms that the regolith’s composition of the landing area is mostly similar to that of Finsen ejecta.The rock spectrum shows similar band peak positions,but stronger absorptions,suggesting relatively fresh exposure.The rock may consist of 38.1±5.4%low-Ca pyroxene,13.9±5.1%olivine and 48.0±3.1%plagioclase,referred to as olivine-norite.The plagioclase-abundant and olivine-poor modal composition of the rock is inconsistent with the origin of the mantle,but representative of the lunar lower crust.Alternatively,the rock crystallized from the impact-derived melt pool formed by the SPA-impact event via mixing the lunar crust and mantle materials.This scenario is consistent with fast-cooling thermal conditions of a shallow melt pool,indicated by the fine to medium-sized texture(<3 mm)of the rock and the SPA-impact melting model[Icarus 2012;220:730–43]. | Honglei Lin Zhiping He Wei Yang Yangting Lin Rui Xu Chi Zhang Meng-Hua Zhu Rui Chang Jinhai Zhang Chunlai Li Hongyu Lin Yang Liu Sheng Gou Yong Wei Sen Hu Changbin Xue Jianfeng Yang Jie Zhong Xiaohui Fu Weixing Wan Yongliao Zou | 2020 | National Science Review2020，7，5： | 9 |
| 15 | The Pengguan tectonic dome of Longmen Mountains, Sichuan Province:Mesozoic denudation of a Neoproterozoic magmatic arc-basin system显示文摘Neoproterozoic igneous and metamorphic complexes occur as tectonic domes in the Longmen Mountains of the western margin of the Yangtze Block, and are important in reconstructing the Rodinian supercontinent and constraining the timing and mechanism of tectonic denudational processes. The Pengguan dome consists of granitic intrusions and metamorphic rocks of the Huangshuihe Group and is tectonically overlain by ductilly deformed Sinian to Paleozoic strata. The plutonic intrusions consist of granites with abundant amphibolite enclaves. New LA-ICP-MS zircon U-Pb dating yielded an emplacement age of 809±3 Ma and a protolith age of 844±6 Ma for the granite. The granitic rocks have geochemical signatures typical of A-type granites, indicating their formation under an extensional environment, by melting of newly formed tonalite-trondhjemite-granodiorite (TTG) rocks. A detachment fault, characterized by variable ductile shear deformation of S-C fabric and ESE-ward kinematics, separates the Pengguan dome from the Sinian-Paleozoic cover. 40Ar/39Ar dating of muscovite from the mylonite in the detachment fault of the dome demonstrates that ductile deformation occurred at ~160 Ma. This study indicates the existence of a Neoproterozoic magmatic arc-basin system, which was denudated by a Jurassic middle crustal ductile channel flow along the Longmenshan thrust belt. | YAN DanPing ZHOU MeiFu WEI GuoQing GAO JianFeng LIU ShaoFeng XU Ping SHI XiaoYing | 2008 | Science China Earth Sciences2008，51，11： | 9 |
| 16 | A Localization Algorithm Using a Mobile Anchor Node Based on Region Determination in Underwater Wireless Sensor Networks显示文摘At present, most underwater positioning algorithms improve the positioning accuracy by increasing the number of anchor nodes which resulting in the increasing energy consumption. To solve this problem, the paper proposes a localization algorithm assisted by mobile anchor node and based on region determination(LMRD), which not only improves the positioning accuracy of nodes positioning but also reduces the energy consumption. This algorithm is divided into two stages: region determination stage and location positioning stage. In the region determination stage, the target region is divided into several sub-regions by the region division strategy with the smallest overlap rate which can reduce the number of virtual anchor nodes and lock the target node to a sub-region, and then through the planning of mobile nodes to optimize the travel path, reduce the moving distance, and reduce system energy consumption. In the location positioning stage, the target node location can be calculated using the HILBERT path planning and trilateration. The simulation results show that the proposed algorithm can improve the positioning accuracy when the energy consumption is reduced. | XU Tingting WANG Jingjing SHI Wei WANG Jianfeng CHEN Zhe | 2019 | Journal of Ocean University of China2019，18，2： | 8 |
| 17 | Correlation of CD105 and Vascular Endothelial Growth Factor in Laser-induced Choroidal Neovascularization in Rats显示文摘Purpose: Choroidal neovascularization (CNV) plays an important role in pathogenesis of age-related macular degeneration (AMD), ocular histoplasmosis syndrome (OHS) and so on. However, mechanisms of CNV formation are not fully understood. The aim of this study is to investigate the correlation between expressions of CD105 and vascular endothelial growth factor (VEGF) in experimental laser-induced CNV in rats. Methods: CNV model was established by 532 nm laser photocoagulation in Brown-Norway rats. The expression of CD105 and VEGF in CNV was observed by immunohistochemistry at 3, 7, 14, 21, 28 and 56 days after laser photocoagulation. The image analysis was performed with the professional software of Image-Pro Plus. Results: Fluorescein angiography showed fluorescein leakage in CNV from days 7 to 56 after photocoagulation. VEGF expression was mainly observed in vascular endothelial cells, ganglion cells, inner nuclear layers and retinal pigment epithelial cells in normal retina and vascular endothelial cells in normal choroid of the rats. On day 3 after photocoagulation, VEGF began to express in laser-induced lesions. VEGF was strongly expressed in CNV after 7 days (P<0.05) and decreased after 14 days (P>0.05). CD105 was initially presented in CNV at 7 days and obviously expressed at 14 days after photocoagulation (P<0.05). Four weeks later, when angiogenesis tended toward inactive status, expression of CD105 was markedly decreased (P>0.05). There was notablely direct correlation between CD105-positive-microvessel density and positively semiquantitative scoring of VEGF in the CNV(r=0.989, P<0.01). Conclusions: There is direct correlation between the expression of CD105 and VEGF in the laser-induced CNV in rat. It suggests that CD105 and VEGF might participate in the new blood vessel formation and promote the growth of CNV. | Jianfeng Xu Yusheng Wang Xiumei Yang Peng Zhang Lijun Chen | 2006 | 眼科学报2006，22，3： | 8 |
| 18 | RNA-binding protein LIN28B inhibits apoptosis through regulation of the AKT2/FOXO3A/BIM axis in ovarian cancer cells显示文摘LIN28B is an evolutionarily conserved RNA-binding protein that regulates mRNA translation and miRNA let-7 maturation in embryonic stem cells and developing tissues.Increasing evidence demonstrates that LIN28B is activated in cancer and serves as a critical oncogene.However,the underlying molecular mechanisms of LIN28B function in tumorigenesis are still largely unknown.Here we report that LIN28B was expressed in over half of the patients with epithelial ovarian cancer who were examined(n=584).Functional experiments demonstrated that LIN28B inhibited ovarian cancer cell apoptosis.Furthermore,we showed that the proapoptotic factor BIM played an essential role in the antiapoptotic function of LIN28B.RNA-IP microarray analysis suggested that LIN28B binds to mRNAs that are associated with the DNA damage pathway,such as AKT2,in ovarian cancer cells.By binding to AKT2 mRNA and enhancing its protein expression,LIN28B regulated FOXO3A protein phosphorylation and decreased the transcriptional level of BIM,which antagonized the antiapoptosis activity of LIN28B.Taken together,these results mechanistically linked LIN28B and the AKT2/FOXO3A/BIM axis to the apoptosis pathway.The findings may have important implications in the diagnosis and therapeutics of ovarian cancer. | Xiaojuan Lin Jianfeng Shen Dan Peng Xinhong He Congjian Xu Xiaojun Chen Janos LTanyi Kathleen Montone Yi Fan Qihong Huang Lin Zhang Xiaomin Zhong | 2018 | Signal Transduction and Targeted Therapy2018，3，1： | 8 |
| 19 | Indication from finite-frequency tomography beneath the North China Craton: The heterogeneity of craton destruction显示文摘We picked new traveltime residual datasets in three frequency bands(0.02–0.1, 0.1–0.8, and 0.8–2.0 Hz) for P-waves from 793 teleseismic events and two frequency bands(0.02–0.1 and 0.1–0.8 Hz) for S-waves from 310 teleseismic events,recorded by 389 permanent stations of the China National Seismic Network and 832 broadband stations of 10 temporary arrays deployed in the North China Craton(NCC) region. The final datasets are composed of 65628 P-arrivals and 47050 S-arrivals.Based on previous research and our team's 2012 tomographic work, we constructed new three-dimensional P-velocity and Svelocity models of the NCC through some improvements, such as augmenting a much denser station coverage in the western NCC, considering the incident angle effect in crustal correction and using a multi-frequency joint inversion tomographic technique. The new velocity models provide several salient features, from which we draw possible inferences on regional dynamic processes. We observed high-velocity anomalies in the mantle transition zone(MTZ). Obvious morphological heterogeneities suggest buckling and/or fragmentation of the subducted Pacific slab, and some of the slab materials are visible below 660-km discontinuities. The velocity structure of the eastern NCC is dominated by small-scale lateral heterogeneities. At shallow depths, high-velocity anomalies beneath the southern part of the eastern NCC and the Yanshan region likely represent a remnant of cratonic lithosphere, which may suggest that the NCC destruction is spatially non-uniform. We also detected a highvelocity anomaly in the Sulu Orogen extending downward to ~300 km, which is seemingly controlled by the Tan-Lu Fault. The northern boundary of this anomaly spatially coincides with the Yantai-Qingdao-Wulian Fault, and is likely a remnant of the Yangtze cratonic lithosphere subducting northwestward. Significant low-velocity anomalies imaged beneath the central NCC show a spatial discordance between their northern and southern parts. The northern low-velocity anomaly extends downward to the top of MTZ with a lateral NW-SE strike, whereas the southern one tapers off at ~200–300 km. Low-velocity anomalies are present beneath the Phanerozoic orogenic belts surrounding the NCC, the Paleoproterozoic Trans-North China Orogen, and the Tan-Lu Fault. This feature not only shows excellent spatial correlation with the orogens at the surface, it also exhibits a consistent vertical continuity in a depth range of 60–250 km. This intriguing feature suggests that the collisional orogenic belts and Tan-Lu Fault are inherited weak zones, which may play a key role in craton destruction. By combining multidisciplinary results in this area, we suggest that the spatial heterogeneities associated with the NCC destruction most likely result from the combined effects of a spatially non-uniform distribution of wet upwellings triggered by the subducted Pacific slab and pre-existing weak zones in the cratonic lithosphere. | Xiaobing XU Liang ZHAO Kun WANG Jianfeng YANG | 2018 | Science China Earth Sciences2018，61，9： | 7 |
| 20 | Zea mays(L.) P1 locus for cob glume color identified as a post-domestication selection target with an effect on temperate maize genomes显示文摘Artificial selection during domestication and post-domestication improvement results in loss of genetic diversity near target loci. However, the genetic locus associated with cob glume color and the nature of the genomic pattern surrounding it was elusive and the selection effect in that region was not clear. An association mapping panel consisting of 283 diverse modern temperate maize elite lines was genotyped by a chip containing over 55,000 evenly distributed SNPs. Ten-fold resequencing at the target region on 40 of the panel lines and 47 tropical lines was also undertaken. A genome-wide association study(GWAS) for cob glume color confirmed the P1 locus, which is located on the short arm of chromosome 1, with a-log10 P value for surrounding SNPs higher than the Bonferroni threshold(α/n, α < 0.001) when a mixed linear model(MLM) was implemented. A total of 26 markers were identified in a 0.78 Mb region surrounding the P1 locus, including 0.73 Mb and 0.05 Mb upstream and downstream of the P1 gene, respectively. A clear linkage disequilibrium(LD) block was found and LD decayed very rapidly with increasing physical distance surrounding the P1 locus. The estimates of π and Tajima's D were significantly(P < 0.001) lower at both ends compared to the locus. Upon comparison of temperate and tropical lines at much finer resolution by resequencing(180-fold finer than chip SNPs), a more structured LD block pattern was found among the 40 resequenced temperate lines. All evidence indicates that the P1 locus in temperate maize has not undergone neutral evolution but has been subjected to artificial selection during post-domestication selection or improvement. The information and analytical results generated in this study provide insights as to how breeding efforts have affected genome evolution in crop plants. | Chuanxiao Xie Jianfeng Weng Wenguo Liu Cheng Zou Zhuanfang Hao Wenxue Li Minshun Li Xiaosen Guo Gengyun Zhang Yunbi Xu Xinhai Li Shihuang Zhang | 2013 | The Crop Journal2013，1，1： | 6 |
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