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| 1 | Longitudinal decrease in platelet counts as a surrogate marker of liver fibrosis显示文摘BACKGROUND Liver cirrhosis is a significant source of morbidity and mortality worldwide.The disease is usually indolent and asymptomatic early in its course while many cirrhotic patients are diagnosed late when severe complications occur.A major challenge is to diagnose advanced fibrosis as early as possible,using simple and non-invasive diagnostics tools.Thrombocytopenia represents advanced fibrosis and portal hypertension(HTN)and most non-invasive scores that predict liver fibrosis incorporate platelets as a strong risk factor.However,little is known about the association between longitudinal changes in platelet counts(PTC),when still within the normal range,and the risk of cirrhosis.AIM To explore whether platelet counts trajectories over time,can predict advanced liver fibrosis across the different etiologies of liver diseases.METHODS A nested case-control study utilizing a large computerized database.Cirrhosis cases(n=5258)were compared to controls(n=15744)matched for age and sex at a ratio of 1:3.All participants had multiple laboratory measurements prior to enrollment.We calculated the trends of PTC,liver enzymes,bilirubin,international normalized ratio,albumin and fibrosis scores(fibrosis-4 and aspartate transaminase-to-platelet ratio index)throughout the preceding 20 years prior to cirrhosis diagnosis compared to healthy controls.The association between PTC,cirrhosis complications and fibrosis scores prior to cirrhosis diagnosis was investigated.RESULTS The mean age in both groups was 56(SD 15.8).Cirrhotic patients were more likely to be smokers,diabetic with chronic kidney disease and had a higher prevalence of HTN.The leading cirrhosis etiologies were viral,alcoholic and fatty liver disease.The mean PTC decreased from 240000/μL to 190000/μL up to 15 years prior to cirrhosis diagnosis compared to controls who’s PTC remained stable around the values of 240000/μL.This trend was consistent regardless of sex,cirrhosis etiology and was more pronounced in patients who developed varices and ascites.Compared to controls whose values remained in the normal range,in the cirrhosis group aspartate aminotransferase and alanine aminotransferase,increased from 40 U/L to 75 U/L and FIB-4 increased gradually from 1.3 to 3 prior to cirrhosis diagnosis.In multivariable regression analysis,a decrease of 50 units in PTC was associated with 1.3 times odds of cirrhosis(95%CI 1.25-1.35).CONCLUSION In the preceding years before the diagnosis of cirrhosis,there is a progressive decline in PTC,within the normal range,matched to a gradual increase in fibrosis scores. | Neta Gotlieb Naama Schwartz Shira Zelber-Sagi Gabriel Chodick Varda Shalev Oren Shibolet | 2020 | World Journal of Gastroenterology2020，26，38： | 3 |
| 2 | Exploiting the diversity of tomato:the development of a phenotypically and genetically detailed germplasm collection显示文摘A collection of 163 accessions,including Solanum pimpinellifolium,Solanum lycopersicum var.cerasiforme and Solanum lycopersicum var.lycopersicum,was selected to represent the genetic and morphological variability of tomato at its centers of origin and domestication:Andean regions of Peru and Ecuador and Mesoamerica.The collection is enriched with S.lycopersicum var.cerasiforme from the Amazonian region that has not been analyzed previously nor used extensively.The collection has been morphologically characterized showing diversity for fruit,flower and vegetative traits.Their genomes were sequenced in the Varitome project and are publicly available(solgenomics.net/projects/varitome).The identified SNPs have been annotated with respect to their impact and a total number of 37,974 out of 19,364,146 SNPs have been described as high impact by the SnpEeff analysis.GWAS has shown associations for different traits,demonstrating the potential of this collection for this kind of analysis.We have not only identified known QTLs and genes,but also new regions associated with traits such as fruit color,number of flowers per inflorescence or inflorescence architecture.To speed up and facilitate the use of this information,F2 populations were constructed by crossing the whole collection with three different parents.This F2 collection is useful for testing SNPs identified by GWAs,selection sweeps or any other candidate gene.All data is available on Solanaceae Genomics Network and the accession and F2 seeds are freely available at COMAV and at TGRC genebanks.All these resources together make this collection a good candidate for genetic studies. | Estefanía Mata-Nicolás Javier Montero-Pau Esther Gimeno-Paez Víctor Garcia-Carpintero Peio Ziarsolo Naama Menda Lukas A.Mueller JoséBlanca Joaquín Cañizares Esther van der Knaap María JoséDíez | 2020 | Horticulture Research2020，7，1： | 2 |
| 3 | Barrett's esophagus with high grade dysplasia is associated with non-esophageal cancer显示文摘AIM To study factors associated with esophageal and nonesophageal cancer morbidity among Barrett's esophagus(BE) patients. METHODS A cohort study within a single tertiary center included 386 consecutive patients with biopsy proven BE, who were recruited between 2004-2014. Endoscopic and histologic data were prospectively recorded. Cancer morbidity was obtained from the national cancer registry. Main outcomes were BE related(defined as esophagus and cardia) and non-BE related cancers(all other cancers). Cancer incidence and all-causemortality were compared between patients with highgrade dysplasia(HGD) and with low-grade or no dysplasia(non-HGD) using Kaplan-Meier curves and cox regression models.RESULTS Of the 386 patients, 12 had HGD, 7 had a BE related cancer. There were 75(19.4%) patients with 86 cases of lifetime cancers, 76 of these cases were non-BE cancers. Seven(1.8%) and 18(4.7%) patients had BE and non-BE incident cancers, respectively. Twelve(3.1%) patients had HGD as worst histologic result. Two(16.7%) and 16(4.4%) incident non-BE cancers occurred in the HGD and non-HGD group, respectively. Ten-year any cancer and non-BE cancer free survival was 63% and 82% in the HGD group compared to 93% and 95% at the non-HGD group, respectively. Log-rank test for patients with more than one endoscopy, assuring longer follow up, showed a significant difference(P < 0.001 and P = 0.017 respectively). All-cause mortality was not significantly associated with BE HGD.CONCLUSION Patients with BE and HGD, may have a higher risk for all-cause cancer morbidity. The implications on cancer prevention recommendations should be further studied. | Nir Bar Naama Schwartz Michal Nissim Naomi Fliss-Isacov Shira Zelber-Sagi Revital Kariv | 2018 | World Journal of Gastroenterology2018，24，39： | 2 |
| 4 | Malnutrition-induced macrophage apoptosis 显示文摘 | Rivadeneira DE Grobmyer SR Naama HA | 2001 | Surgery2001，129，5： | 1 |
| 5 | Imaging of Recurrent Lung Cancer显示文摘 | Naama RB Leslie EQ | 2004 | Cancer Imaging2004，4，2： | 1 |
| 6 | Malnutrition-induced macrophage apoptosis显示文摘 | Rivadeneira DE Grobmyer SR Naama HA | 2001 | Surgery2001，129，5： | 1 |
| 7 | In vivo adenoviral-mediatedgene transfer in the treatment of pancreatic cancer显示文摘 | Hirschowitz EA Naama HA | 1997 | J Surg Res1997，69，1： | 1 |
| 8 | Rose Scent: C, enomics approach to discovering novel floral fragrance related genes显示文摘 | Inna G Moshe S Naama rn | 2002 | The Plant Ce112002，14，： | 1 |
| 9 | Single port la- paroscopic sacrohysteropexy in a young patient presentingwith grade III uterine prolapse and rectocele显示文摘 | Marcus-Braun Naama Peter von Theobald | 2013 | Interna- tional urogynecology journal2013，24，9： | 1 |
| 10 | Candida infection following severe rauma exacerbates:Th2 cytokines and increases mortality显示文摘 | Mack VE McCarter MD Naama HA | 1997 | J Surg Res1997，69，2： | 1 |
| 11 | Dominance of Thelper 2-type cytokines after severe injury显示文摘 | Mack VE McCarter MD Naama HA | 1995 | Arch Surg1995，131，： | 1 |
| 12 | Dominance of T-helper 2-type cytokines after severe injury显示文摘 | McCarter MD Naama HA | 1996 | Arch Surg1996，131，12： | 1 |
| 13 | Regional treatment of hepatic micrometastasis by adenovirus vector-mediated delivery of interleukin-2 and interleukin-12 cDNAs to the hepatic parenchyma显示文摘 | Hirschowitz EA Naama HA Evoy D | 1999 | Cancer Gene Ther1999，6，6： | 1 |
| 14 | Treatment of As- pirin-Resistant Patients With Omega-3 Fatty Acids Ver-sus Aspirin Dose Escalation 显示文摘 | Eli I L Alejandro S Naama H | 2010 | Journal of the American College of Cardiology2010，55，2： | 1 |
| 15 | Elec- tive induction of labor in women with gestational diabetes mellitus: an intervention that modifies the risk of cesarean section 显示文摘 | Maayan Bas - lando Naama Srebnik Rivka Farkash | 2014 | Ar- chives of Gynecology and Obstetrics2014，290，5： | 1 |
| 16 | Cavernous hemangi- omaof the skull: 3 case reports 显示文摘 | Naama O Gazzaz M Akhaddar A | 2008 | Surg Neurol2008，70，： | 1 |
| 17 | In Vivo Adenoviral-mediated Gene Transfer in the Treatment of Pancreatic Cancer显示文摘 | Evoy D Hirschowitz E A Naama H A | 1997 | J Surg Res1997，69，： | 1 |
| 18 | Factors associated with surgery in patients with intra-abdominal fistulizing Crohn's disease显示文摘AIM To characterize radiological and clinical factors associated with subsequent surgical intervention in Crohn's disease(CD) patients with intra-abdominal fistulae.METHODS From a cohort of 1244 CD patients seen over an eight year period(2006 to 2014), 126 patients were identified as having intra-abdominal fistulae, and included in the study. Baseline patient information was collected from the medical records. Imaging studies were assessed for: anatomic type and number of fistulae; diameter of the inflammatory conglomerate; length of diseased bowel; presence of a stricture with pre-stenotic dilatation; presence of an abscess; lymphadenopathy; and the degree of bowel enhancement. Multivariate analysis for the prediction of abdominal surgery was calculated via Generalized Linear Models.RESULTS In total, there were 193 fistulae in 132 patients, the majority(52%) being entero-enteric. Fifty-nine(47%) patients underwent surgery within one year of the imaging study, of which 36(29%) underwent surgery within one month. Radiologic features that were associated with subsequent surgery included: multiple fistulae(P = 0.009), presence of stricture(P = 0.02), and an entero-vesical fistula(P = 0.01). Evidence of an abscess, lymphadenopathy, or intense bowel enhancement as well as C-reactive protein levels was not associated with an increased rate of surgery. Patients who were treated after the imaging study with combination immunomodulatory and anti-TNF therapy had significantly lower rates of surgery(P = 0.01). In the multivariate analysis, presence of a stricture [RR 4.5(1.23-16.3), P = 0.02] was the only factor that increased surgery rate.CONCLUSION A bowel stricture is the only factor predicting an increased rate of surgery. Radiological parameters may guide in selecting treatment options in patients with fistulizing CD. | Shaul Yaari Ariel Benson Eyal Aviran Naama Lev Cohain Ran Oren Jacob Sosna Eran Israeli | 2016 | World Journal of Gastroenterology2016，22，47： | 1 |
| 19 | Dominance of T-helper 2-type cytokines after severe injury显示文摘 | Mack VE McCarter MD Naama HA | 1996 | Archives of Surgery1996，131，12： | 1 |
| 20 | Malnutrition- induced macrophage apoptosis显示文摘 | Rivadeneira DE Grobmyer SR Naama HA | 2001 | Surgery2001，129，5： | 1 |
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