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2篇 您的检索式：作者名="Naibing Gu"

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		题名	作者	年代	出处	被引量
	1	Shuanghuanglian injection downregulates nuclear factor-kappa B expression in mice with viral encephalitis显示文摘A mouse model of viral encephalitis was induced by intracranial injection of a Coxsackie virus B3 suspension. Quantitative real-time reverse transcription-PCR and western blot assay were applied to detect mRNA and protein expression of intelectin-2 and nuclear factor-kappa B in the viral encephalitis and control groups. Nuclear factor-kappa B and intelectin-2 mRNA and protein expression were significantly increased in mice with viral encephalitis. After intraperitoneal injection of Shuanghuanglian at a dose of 1.5 mg/kg for 5 successive days, intelectin-2 and nuclear factor-kappa B protein and mRNA expression were significantly decreased. To elucidate the relationship between intelectin-2 and nuclear factor-kappa B, mice with viral encephalitis were administered an intracerebral injection of 107 pfu recombinant lentivirus expressing intelectin shRNA. Both protein and mRNA levels of intelectin and nuclear factor-kappa B in brain tissue of mice were significantly decreased. Experimental findings suggest that Shuanghuanglian injection may downregulate nuclear factor-kappa B production via suppression of intelectin production, thus inhibiting inflammation associated with viral encephalitis.	Naibing Gu Ye Tian Zhengli Di Caiping Han Hui Lei Gejuan Zhang	2012	Neural Regeneration Research2012，7，33：	7
	2	Inhibitory effects of Shuanghuanglian injection on nuclear factor-kappa B expression in mice with viral encephalitis in a time-and dose-dependent manner显示文摘Previous studies have confirmed that the anti-virus effects of Shuanghuanglian injection may be associated with nuclear factor-kappa B activity.This study observed nuclear factor-kappa B expression in mice with viral encephalitis,and showed significant decreases in nuclear factor-kappa B protein and mRNA levels following Shuanghuanglian injection.The inhibitory effect was more significant with prolonged intervention duration and increased treatment dose.These findings verify that Shuanghuanglian injection plays a therapeutic role in viral encephalitis by reducing expression of nuclear factor-kappa B in a time-and dose-dependent manner.	Ye Tian Caiping Han Naibing Gu Zhengli Di Gejuan Zhang Hui Lei	2011	Neural Regeneration Research2011，6，24：	1

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