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| 1 | Hepatitis E: Discovery, global impact, control and cure显示文摘Hepatitis E was identified as an epidemic of non-A, non-B hepatitis from Kashmir, India in 1978. Hepatitis E virus(HEV), the etiological agent is the sole member of family Hepeviridae. The virus has marked heterogeneity and infects many animals like bats, camel, chicken, deer, boar, mongoose, pigs, rats, rabbit and cutthroat trout. Hepatitis E is a disease with a major global impact and has two distinct epidemiological patterns. Hepatitis E is an imperative health issue in developing nations, transmitted through sullied water and happens most every now in young adults. The disease is particularly severe during pregnancy and in people with underlying liver cirrhosis. Autochthonous hepatitis E is increasingly recognized in developed countries. The virus infects domestic pigs, wild boar and Sika deer in these countries. HEV infections in humans occur by eating the undercooked game flesh, raw liver from supermarkets and Figatelli sausages. Blood transfusion-associated HEV infections occur in many countries and screening of donors for HEV RNA is under consideration. Hepatitis E causes a number of extrahepatic diseases, including a wide spectrum of neurological syndromes. HEV genotype 3 causes prolonged viremia, chronic hepatitis, liver fibrosis and cirrhosis in organ transplant patients. The virus is amenable to ribavirin monotherapy and most patients clear the virus in a few weeks. Hepatitis E vaccine-239, marketed in China, has shown high efficacy with sustained protection for over four years. | Mohammad S Khuroo Mehnaaz S Khuroo Naira S Khuroo | 2016 | World Journal of Gastroenterology2016，22，31： | 13 |
| 2 | Portal biliopathy显示文摘Portal biliopathy refers to cholangiographic abnormalities which occur in patients with portal cavernoma. These changes occur as a result of pressure on bile ducts from bridging tortuous paracholedochal, epicholedochal and cholecystic veins. Bile duct ischemia may occur due prolonged venous pressure effect or result from insufficient blood supply. In addition, encasement of ducts may occur due fibrotic cavernoma. Majority of patients are asymptomatic. Portal biliopathy is a progressive disease and patients who have long standing disease and more severe bile duct abnormalities present with recurrent episodes of biliary pain, cholangitis and cholestasis. Serum chemistry, ultrasound with color Doppler imaging, magnetic resonance imaging with magnetic resonance cholangiopancreatography and magnetic resonance portovenography are modalities of choice for evaluation of portal biliopathy. Endoscopic retrograde cholangiography being an invasive procedure is indicated for endotherapy only. Management of portal biliopathy is done in a stepwise manner. First, endotherapy is done for dilation of biliary strictures, placement of biliary stents to facilitate drainage and removal of bile duct calculi. Next portal venous pressure is reduced by formation of surgical porto-systemic shunt or transjugular intrahepatic portosystemic shunt. This causes significant resolution of biliary changes. Patients who persist with biliary symptoms and bile duct changes may benefit from surgical biliary drainage procedures(hepaticojejunostomy or choledechoduodenostomy). | mohammad s khuroo ajaz a rather naira s khuroo mehnaaz s khuroo | 2016 | World Journal of Gastroenterology2016，22，35： | 6 |
| 3 | Hepatobiliary and pancreatic ascariasis显示文摘Hepatobiliary and pancreatic ascariasis(HPA) was described as a clinical entity from Kashmir,India in 1985. HPA is caused by invasion and migration of nematode,Ascaris lumbricoides,in to the biliary tract and pancreatic duct. Patients present with biliary colic,cholangitis,cholecystitis,hepatic abscesses and acute pancreatitis. Ascarides traverse the ducts repeatedly,get trapped and die,leading to formation of hepatolithiasis. HPA is ubiquitous in endemic regions and in Kashmir,one such region,HPA is the etiological factor for 36.7%,23%,14.5% and 12.5% of all biliary diseases,acute pancreatitis,liver abscesses and biliary lithiasis respectively. Ultrasonography is an excellent diagnostic tool in visualizing worms in gut lumen and ductal system. The rational treatment for HPA is to give appropriate treatment for clinical syndromes along with effective anthelmintic therapy. Endotherapy in HPA is indicated if patients continue to have symptoms on medical therapy or when worms do not move out of ductal lumen by 3 wk or die within the ducts. The worms can be removed from the ductal system in most of the patients and such patients get regression of symptoms of hepatobiliary and pancreatic disease. | Mohammad S Khuroo Ajaz A Rather Naira S Khuroo Mehnaaz S Khuroo | 2016 | World Journal of Gastroenterology2016，22，33： | 4 |
| 4 | The Mg-carbonate-Fe interaction:Implication for the fate of subducted carbonates and formation of diamond in the lower mantle显示文摘The fate of subducted carbonates in the lower mantle and at the core-mantle boundary was modelled via experiments in the MgCO3-Fe^0 system at 70-150 GPa and 800-2600 Kin a laser-heated diamond anvil cell.Using in situ synchrotro n X-ray diffraction and ex situ transmission electron microscopy we show that the reduction of Mg-carbonate can be exemplified by:6 MgCO3+19 Fe=8 FeO+10(Mg0.6Fe^0.4)O+Fe7 C3+3 C.The presented results suggest that the interaction of carbonates with Fe^0 or Fe^0-bearing rocks can produce Fe-carbide and diamond,which can accumulate in the D'region,depending on its carbon to Fe ratio.Due to the sluggish kinetics of the transformation,diamond can remain metastable at the core-mantle boundary(CMB)unless it is in a direct contact with Fe-metal.In addition,it can be remobilized by redox melting accompanying the generation of mantle plumes. | Naira S.Martirosyan Konstantin D. Litasov Sergey S. Lobanov Alexander F. Goncharov Anton Shatskiy Hiroaki Ohfuji Vitali Prakapenka | 2019 | Geoscience Frontiers2019，10，4： | 2 |
| 5 | Hydrogen sulfide intervention in cystathionine-β-synthase mutant mouse helps restore ocular homeostasis显示文摘AIM: To investigate the applications of hydrogen sulfide(H2 S) in eye-specific ailments in mice.METHODS: Heterozygous cystathionine-β-synthase(CBS+/-) and wild-type C57 BL/6 J(WT) mice fed with or without high methionine diet(HMD) were administered either phosphate buffered saline(PBS) or the slow-release H2 S donor: GYY4137. Several analyses were performed to study GYY4137 effects by examining retinal lysates for key protein expressions along with plasma glutamate and glutathione estimations. Intraocular pressure(IOP) was monitored during GYY4137 treatment; barium sulfate and bovine serum albumin conjugated fluorescein isothiocyanate(BSA-FITC) angiographies were performed for examining vasculature and its permeability post-treatment. Visionguided behavior was also tested employing novel object recognition test(NORT) and light-dark box test(LDBT) recordings.RESULTS: CBS deficiency(CBS+/-) coupled with HMD led disruption of methionine/homocysteine(Hcy) metabolism leading to hyperhomocysteinemia(HHcy) in CBS+/-mice as reflected by increased Hcy, and s-adenosylhomocysteine hydrolase(SAHH) levels. Unlike CBS, cystathionine-γ lyase(CSE), methylenetetrahydrofolate reductase(MTHFR) levels which were reduced but compensated by GYY4137intervention. Heightened oxidative and endoplasmic reticulum(ER) stress responses were mitigated by GYY4137 effects along with enhanced glutathione(GSH) levels. Increased glutamate levels in CBS+/-strain were prominent than WT mice and these mice also exhibited higher IOP that was lowered by GYY4137 treatment. CBS deficiency also resulted in vision-guided behavioral impairment as revealed by NORT and LDBT findings. Interestingly, GYY4137 was able to improve CBS+/-mice behavior together with lowering their glutamate levels. Blood-retinal barrier(BRB) appeared compromised in CBS+/-with vessels' leakage that was mitigated in GYY4137 treated group. This corroborated the results for occludin(an integral plasma membrane protein of the cellular tight junctions) stabilization.CONCLUSION: Findings reveal that HHcy-induced glutamate excitotoxicity, oxidative damage, ER-stress and vascular permeability alone or together can compromise ocular health and that GYY4137 could serve as a potential therapeutic agent for treating HHcy induced ocular disorders. | Akash K.George Rubens P.Homme Avisek Majumder Anwesha Laha Naira Metreveli Harpal S.SANDhu Suresh C.Tyagi Mahavir Singh | 2019 | International Journal of Ophthalmology(English edition)2019，12，5： | 2 |
| 6 | Asynchronous task execution in networked control systems using decentralized e- vent-triggering 显示文摘 | WANG Xiaofeng SUN Yu NAIRA H | 2012 | Systems Control Letters2012，61，1： | 1 |
| 7 | Rapamycin-mediated enrichment of T cells with regulatory activity in stimulated CD4+T cell cultures is not due to the selective expansion of naturally occurring regulatory T cells but to the induction of regulatory functions in conventional CD4+T cells显示文摘 | Valmori D Tosello V Naira E | 2006 | J Immunol2006，177，4： | 1 |
| 8 | A review on self- e]eaning coatings显示文摘 | Anand Ganesh V Raut H K Naira A S | 2011 | Journal of Materials Chemistry2011，21，16： | 1 |
| 9 | Adaptive output feedback control of uncertain multi-input multi-output systems using single hidden layer neural networks 显示文摘 | NAIRA H ANTHONY J C | 2002 | International Journal of Control2002，77，15： | 1 |
| 10 | L1 adaptive controller for systems with unknown time-varying parameters and disturbances in the presence of non-zero trajectory initialization error显示文摘 | Chengyu Cao Naira Hovakimyan | 2008 | International Journal of Control2008，81，7： | 1 |
| 11 | Biodegradable polymers as biomaterials 显示文摘 | Lakshmi S Naira Cato T Laurencina | 2007 | Progress in Polymer Science2007，32，： | 1 |
| 12 | Dual-energy CT for imaging of pulmonary hypertension:challenges and opportunities显示文摘 | Ameli-RenaniS RahmanF NairA | 2014 | Radio Graphics2014，34，17： | 1 |
| 13 | Adaptive output feedback control methodology applicable to non-minimum phase nonlinear systems显示文摘 | Hovakimyan Naira Yang Bongjun Calise Anthony J | 2006 | Automatica2006，42，4： | 1 |
| 14 | Novel chitin and chitosan nanofibers in biomedical applications显示文摘 | Jayakumar R Prabaharan M Naira SV | 2010 | Biotechnology Advances2010，28，： | 1 |
| 15 | Finite size effects on the structural and magnetic properties of sol-gel synthesized NiFe2O4 powders 显示文摘 | Georgea M Johna A M Naira S S | 2006 | J Magn Magn Mater2006，302，： | 1 |
| 16 | Evaluation of promising and released mangy hybrids for multiple pest resistance 显示文摘 | Sushil K Naira G Bhatt RI | 2002 | Journal of Applied Zoological Researches2002，13，1： | 1 |
| 17 | Phosphazene-modified polyurethanes:synthesis,mechanical and thermal characteristics 显示文摘 | Nair P R Naira C P R Francis D J | 1996 | European Polymer Journal1996，32，12： | 1 |
| 18 | Automated coronary plaque characterisation with intravascular ultrasound backscatter: ex vivo validation显示文摘 | NairA Margolis MP Kuban BD | 2007 | EuroIntervention2007，3，1： | 1 |
| 19 | 显示文摘 | Chennazhia K P Naira S P Tamurab H | 2011 | Carbohy &ate Polymers2011，83，： | 1 |
| 20 | Trichuris dysentery syndrome: a common cause of chronic iron deficiency anemia in adults in an endemic area (with videos)显示文摘 | Mohammad S. Khuroo Mehnaaz S. Khuroo Naira S. Khuroo | 2010 | Gastrointestinal Endoscopy2010，，1： | 1 |
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